Personal information

Keywords

Structural Biology, Cancer Research, Drug Discovery, DNA repair

Countries

United Kingdom

Biography

Abimael Cruz-Migoni is a structural biologist and protein biochemist currently based at the Weatherall Institute for Molecular Medicine, Oncology Department, University of Oxford. He received a BSc degree in Biotechnology at the National Polytechnic Institute (IPN-Mexico) and an MSc degree in Biotechnology and Bioengineering at CINVESTAV-Mexico. Abimael earned his PhD in Structural Biology from The University of Sheffield.

Activities

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Employment (2)

University of Oxford: Oxford, Oxfordshire, GB

2012-04 to present | Research Scientist (WIMM, Oncology Department)
Employment
Source: Self-asserted source
Abimael Cruz Migoni

University of Leeds: Leeds, West Yorkshire, GB

2011-06 to 2012-03 | Postdoctoral Research Fellow (Leeds Institute of Molecular Medicine)
Employment
Source: Self-asserted source
Abimael Cruz Migoni

Education and qualifications (1)

University of Sheffield: Sheffield, South Yorkshire, GB

2006-09 to 2010-11 | PhD (Molecular Biology and Biotechnology Department)
Education
Source: Self-asserted source
Abimael Cruz Migoni

Works (18)

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

2024-11-26 | Preprint
DOI: 10.1101/2024.11.26.625361
Contributors: Wei Song; Yichen Zhao; Annamaria Ruggiano; Christina Redfield; Joseph A Newman; Xiaosheng Zhu; Abimael Cruz-Migoni; Rebecca Roddan; Peter McHugh; Paul Elliott et al.
Source: check_circle
Crossref

SNM1A is crucial for efficient repair of complex DNA breaks in human cells

Nature Communications
2024-06-25 | Journal article
DOI: 10.1038/s41467-024-49583-5
Contributors: Lonnie P. Swift; B. Christoffer Lagerholm; Lucy R. Henderson; Malitha Ratnaweera; Hannah T. Baddock; Blanka Sengerova; Sook Lee; Abimael Cruz-Migoni; Dominic Waithe; Christian Renz et al.
Source: check_circle
Crossref

SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells

2022-07-21 | Preprint
DOI: 10.1101/2022.07.21.500940
Contributors: Lonnie P. Swift; B. Christoffer Lagerholm; Hannah T. Baddock; Lucy R. Henderson; Malitha Ratnaweera; Blanka Sengerova; Sook Lee; Abimael Cruz-Migoni; Dominic Waithe; Christian Renz et al.
Source: check_circle
Crossref

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

Nature
2020-09-30 | Journal article
DOI: 10.1038/s41586-020-2769-8
PMID: 32999459
Source: Self-asserted source
Abimael Cruz Migoni

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

2020-08-13 | Preprint
DOI: 10.1101/2020.08.13.248211
Contributors: Hannah T. Baddock; Sanja Brolih; Yuliana Yosaatmadja; Malitha Ratnaweera; Marcin Bielinski; Lonnie P. Swift; Abimael Cruz-Migoni; Garrett M. Morris; Christopher J. Schofield; Opher Gileadi et al.
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Crossref

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

2020-08-13 | Other
DOI: 10.21203/rs.3.rs-56596/v1
Contributors: Hannah Baddock; Sanja Brolih; Yuliana Yosaatmadja; Malitha Rantnaweera; Marcin Bielinski; Lonnie Swift; Abimael Cruz-Migoni; Garrett Morris; Christopher Schofield; Opher Gileadi et al.
Source: check_circle
Crossref

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

Proceedings of the National Academy of Sciences of the United States of America
2019-01 | Journal article
DOI: 10.1073/pnas.1811360116
PMID: 30683716
Contributors: Cruz-Migoni A; Canning P; Quevedo CE; Bataille CJR; Bery N; Miller A; Russell AJ; Phillips SEV; Carr SB; Rabbitts TH
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.

2018-08 | Other
DOI: 10.2210/pdb5ocg/pdb
Contributors: A. Cruz-Migoni; M.T. Ehebauer; S.E.V. Phillips; C.E. Quevedo; T.H. Rabbitts
Source: Self-asserted source
Abimael Cruz Migoni via Crossref Metadata Search

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Nature Communications
2018-08-09 | Journal article
DOI: 10.1038/s41467-018-05707-2
Contributors: Camilo E. Quevedo; Abimael Cruz-Migoni; Nicolas Bery; Ami Miller; Tomoyuki Tanaka; Donna Petch; Carole J. R. Bataille; Lydia Y. W. Lee; Phillip S. Fallon; Hanna Tulmin et al.
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Crossref

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.

eLife
2018-07 | Journal article
DOI: 10.7554/elife.37122
PMID: 29989546
PMC: PMC6039175
Contributors: Bery N; Cruz-Migoni A; Bataille CJ; Quevedo CE; Tulmin H; Miller A; Russell A; Phillips SE; Carr SB; Rabbitts TH
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor.

Acta crystallographica. Section F, Structural biology communications
2018-02 | Journal article
DOI: 10.1107/s2053230x18001553
PMID: 29497017
PMC: PMC5947699
Contributors: Hannon C; Cruz-Migoni A; Platonova O; Owen RL; Nettleship JE; Miller A; Carr SB; Harris G; Rabbitts TH; Phillips SEV
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.

Scientific reports
2017-12 | Journal article
DOI: 10.1038/s41598-017-16742-2
PMID: 29203900
PMC: PMC5715112
Contributors: Bao L; Hannon C; Cruz-Mignoni A; Ptchelkine D; Sun MY; Miller A; Bunjobpol W; Quevedo CE; Derveni M; Chambers J et al.
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

From intracellular antibody fragments to small molecule inhibitors of mutant KRAS

2017-04-01 | Journal article
Source: Self-asserted source
Abimael Cruz Migoni

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.

Scientific reports
2014-01 | Journal article
DOI: 10.1038/srep03643
PMID: 24407558
PMC: PMC3887373
Contributors: Sewell H; Tanaka T; El Omari K; Mancini EJ; Cruz A; Fernandez-Fuentes N; Chambers J; Rabbitts TH
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

Peptides: minimal drug surrogates to interrogate and interfere with protein function

Medicinal Chemistry Communications, MedChemComm
2013-07-19 | Journal article
Source: Self-asserted source
Abimael Cruz Migoni

A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.

Science (New York, N.Y.)
2011-11 | Journal article
DOI: 10.1126/science.1211915
PMID: 22076380
PMC: PMC3364511
Contributors: Cruz-Migoni A; Hautbergue GM; Artymiuk PJ; Baker PJ; Bokori-Brown M; Chang CT; Dickman MJ; Essex-Lopresti A; Harding SV; Mahadi NM et al.
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

Cloning, purification and crystallographic analysis of a hypothetical protein, BPSL1549, from Burkholderia pseudomallei.

Acta crystallographica. Section F, Structural biology and crystallization communications
2011-11 | Journal article
DOI: 10.1107/s1744309111028995
PMID: 22139182
PMC: PMC3232155
Contributors: Cruz-Migoni A; Ruzheinikov SN; Sedelnikova SE; Obeng B; Chieng S; Mohamed R; Nathan S; Baker PJ; Rice DW
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central

One-step purification and immobilization in cellulose of the GroEL apical domain fused to a carbohydrate-binding module and its use in protein refolding.

Biotechnology letters.
2006-03 | Journal article
DOI: 10.1007/s10529-005-5714-x
PMID: 16614916
Contributors: Ramón-Luing LA; Cruz-Migoni A; Ruíz-Medrano R; Xoconostle-Cázares B; Ortega-Lopez J
Source: Self-asserted source
Abimael Cruz Migoni via Europe PubMed Central
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