Personal information

Other IDs

Scopus Author ID: 56212667200

Biography

My main research interests lie in cancer and Alzheimer’s disease research. I aim to further understand the molecular pathways underlying these diseases and how these pathways can be exploited for the development of therapeutic interventions.

My research to date has focused on apoptosis and apoptotic pathways (cell death pathways) as well as signal transduction pathways and molecular mechanisms of various anti-cancer treatments. During the course of my post-doctorate, I was involved in the development of antibodies and siRNAs directed against and downregulating LRP/LR, respectively, as powerful alternative anti-cancer tools. I have furthermore investigated the effects of the anti-LRP/LR antibody, IgG1-iS18 as a therapeutic agent for the treatment of Alzheimer’s disease in an Alzheimer’s disease transgenic mouse model and have investigated the effect of overexpression of LRP::FLAG on the ageing process as well as age related disorders in C57BL/6J mice. My academic and research career has thus far resulted in 18 publications in international peer reviewed journals as well as 5 patents. I am currently investigating the association between metabolic diseases and Alzheimer’s disease.

Activities

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Employment (5)

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2021-01-01 to present | Lecturer (School of Molecular and Cell Biology)
Employment
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2020-01-02 to 2020-12-31 | Sessional lecturer (School of Molecular and Cell Biology)
Employment
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2014-11-01 to 2019-12-31 | Postdoctoral Fellow (School of Molecular and Cell Biology)
Employment
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2016-06-01 to 2016-12-31 | Lecturer (School of Molecular and Cell Biology)
Employment
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg - Doornfontein Campus: Doornfontein, ZA

2009-07-01 to 2009-12-31 | Lecturer (Biotechnology and Food Technology)
Employment
Source: Self-asserted source
Eloise Ferreira

Education and qualifications (4)

University of Johannesburg: Auckland Park, Gauteng, ZA

2010-01-01 to 2015-04-13 | PhD Biochemistry (Biochemistry)
Education
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2007-01-01 to 2009-03-31 | MSc Biochemistry (cum laude) (Biochemistry)
Education
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2006-01-01 to 2006-12-31 | BSc Hons Biochemistry (cum laude) (Biochemistry)
Education
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2003-01-01 to 2005-12-31 | BSc Biochemistry and Psychology (cum laude) (Faculty of Science)
Education
Source: Self-asserted source
Eloise Ferreira

Professional activities (12)

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2015 to present | Member of the Molecular Biosciences Health for Africa Research Thrust (MBRT) Portfolio: Equipment (School of Molecular and Cell Biology)
Membership
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2015 to present | Member of the Life Sciences Imaging Facility Board (School of Molecular and Cell Biology)
Membership
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg, ZA

2022-12-12 | Friedel Sellschop Award 2023
Distinction
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2018-01-01 to 2019-12-31 | Claude Leon Foundation Postdoctoral Fellowship (School of Molecular and Cell Biology)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of the Witwatersrand: Johannesburg-Braamfontein, Gauteng, ZA

2017 to 2017 | Alzheimer’s Drug Discovery Foundation (ADDF) Young Investigator Scholarship (School of Molecular and Cell Biology)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2010 to 2013 | NRF Innovation scholarship (Biochemistry)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2009 to 2009 | Inqaba Biotec prize for the best biochemistry masters student (Biochemistry)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2007 to 2008 | NRF Prestigious and Equity scholarship (Biochemistry)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2006 to 2006 | NRF Scarce Skills bursary (Biochemistry)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2006 to 2006 | Labhouse prize for the best biochemistry honours student (Biochemistry)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2005 to 2005 | Merck prize for best third year student in biochemistry (Biochemistry)
Distinction
Source: Self-asserted source
Eloise Ferreira

University of Johannesburg: Auckland Park, Gauteng, ZA

2003 to 2003 | Golden key award for academic achievers (Biochemistry )
Distinction
Source: Self-asserted source
Eloise Ferreira

Funding (9)

Metabolic disorders and Alzheimer’s disease: investigating shared pathological pathways and molecular mechanisms for early detection and prevention

2022-01 to 2024-12 | Grant
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Eloise Ferreira

National Equipment Programme (NEP)

2019 to 2019 | Grant
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Eloise Ferreira

An in vivo investigation of the effect of LRP::FLAG overexpression on the ageing process, age related disorders and telomere dynamics in mice.

2018-01 to 2019-12 | Salary award
Claude Leon Foundation (London , GB)
Source: Self-asserted source
Eloise Ferreira

Verification of the therapeutic potential of LRP/LR downregulation and anti-LRP/LR antibody IgG1-iS18 for the prevention of tumour formation and metastasis in BALB/c nude mice

2018 to 2020 | Grant
Cancer Association of South Africa (Johannesburg, ZA)
Source: Self-asserted source
Eloise Ferreira

The validation of antibodies directed against the 37kDa/67kDa Laminin Receptor (LRP/LR) as therapeutics for the treatment of Alzheimer’s Disease in B6SJL-Tg6799 mice

2014-11 to 2017-12 | Salary award
University of the Witwatersrand, Johannesburg (Johannesburg, ZA)
Source: Self-asserted source
Eloise Ferreira

NFkB and apoptosis in MCF-7 cells

2010-01 to 2013-12 | Salary award
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Eloise Ferreira

SALICYLIC ACID AND HSP70: PARTNERS FOR INDUCING APOPTOSIS IN BREAST CANCER CELLS?

2010 to 2012 | Salary award
Cancer Association of South Africa (Johannesburg, ZA)
Source: Self-asserted source
Eloise Ferreira

SALICYLIC ACID AND HSP70: PARTNERS FOR INDUCING APOPTOSIS IN BREAST CANCER CELLS?

2007-01 to 2008-12 | Salary award
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Eloise Ferreira

Metabolic Disorders and Alzheimer’s Disease: Investigating Shared Pathological Pathways and Molecular Mechanisms for Early detection and Prevention

Grant
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Eloise Ferreira

Works (35)

37 kDa LRP::FLAG enhances telomerase activity and reduces ageing markers in vivo

Cellular and Molecular Life Sciences
2025-02-22 | Journal article
DOI: 10.1007/s00018-025-05593-0
Contributors: Tyrone C. Otgaar; Martin Bernert; Gavin Morris; Pavan Baichan; Monique J. Bignoux; Boitelo Letsolo; Stefan F. T. Weiss; Eloise Ferreira
Source: check_circle
Crossref

PLGA nanocapsules as a delivery system for a recombinant LRP‐based therapeutic

FEBS Open Bio
2024-07 | Journal article
DOI: 10.1002/2211-5463.13809
Contributors: Martin Bernert; Monique J. Bignoux; Chandni Madhav; Sichumiso Gqeba; Tyrone C. Otgaar; Gavin Morris; Stefan F. T. Weiss; Eloise Ferreira
Source: check_circle
Crossref

Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells

FEBS Open Bio
2023-02 | Journal article
DOI: 10.1002/2211-5463.13544
Contributors: Monique J. Bignoux; Tyrone C. Otgaar; Martin Bernert; Stefan F. T. Weiss; Eloise Ferreira
Source: check_circle
Crossref

LDLR upregulation: A potential therapeutic strategy in preventing amyloid beta formation and tau hyperphosphorylation in Alzheimer’s Disease.

MBRT Symposium
2022-12-01 | Conference poster | Conceptualization, Funding acquisition, Methodology, Project administration, Supervision
Contributors: Eloise Ferreira; Ester Tshipamba; Monique Bignoux; Tyrone Otgaar
Source: Self-asserted source
Eloise Ferreira

Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells

BMC Cancer
2021 | Journal article
DOI: 10.1186/s12885-021-08081-3
EID:

2-s2.0-85104111501

Part of ISSN: 14712407
Contributors: Vania, L.; Morris, G.; Ferreira, E.; Weiss, S.F.T.
Source: Self-asserted source
Eloise Ferreira via Scopus - Elsevier

LRP: : FLAG reduces phosphorylated tau levels in Alzheimer’s Disease

bioRxiv
2020 | Other
DOI: 10.1101/2020.01.14.905661
EID:

2-s2.0-85095641189

Part of ISSN: 26928205
Contributors: Cuttler, K.; Bignoux, M.J.; Otgaar, T.C.; Chigumba, S.; Ferreira, E.; Weiss, S.F.T.
Source: Self-asserted source
Eloise Ferreira via Scopus - Elsevier

LRP::FLAG Reduces Phosphorylated Tau Levels in Alzheimer's Disease Cell Culture Models

Journal of Alzheimer's Disease
2020 | Journal article
DOI: 10.3233/JAD-200244
EID:

2-s2.0-85088849445

Part of ISSN: 18758908 13872877
Contributors: Cuttler, K.; Bignoux, M.J.; Otgaar, T.C.; Chigumba, S.; Ferreira, E.; Weiss, S.F.T.
Source: Self-asserted source
Eloise Ferreira via Scopus - Elsevier

A method of decreasing concentration of tau (τ) protein and/or phosphorylated tau (τ) protein

2019 | Patent
PAT:

2019/02879
Source: Self-asserted source
Eloise Ferreira

LRP::FLAG Rescues Cells from Amyloid--Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity

Journal of Alzheimer's Disease
2019 | Journal article
Source: Self-asserted source
Eloise Ferreira

LRP::FLAG Rescues Cells from Amyloid-β-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity

Journal of Alzheimer's Disease
2019 | Journal article
DOI: 10.3233/JAD-190075
EID:

2-s2.0-85067116968

Part of ISSN: 18758908 13872877
Contributors: Bignoux, M.J.; Cuttler, K.; Otgaar, T.C.; Ferreira, E.; Letsolo, B.T.; Weiss, S.F.T.
Source: Self-asserted source
Eloise Ferreira via Scopus - Elsevier

Patented therapeutic approaches targeting LRP/LR for cancer treatment

Expert Opinion on Therapeutic Patents
2019 | Journal article
DOI: 10.1080/13543776.2019.1693543
EID:

2-s2.0-85075377413

Part of ISSN: 17447674 13543776
Contributors: Vania, L.; Morris, G.; Otgaar, T.C.; Bignoux, M.J.; Bernert, M.; Burns, J.; Gabathuse, A.; Singh, E.; Ferreira, E.; Weiss, S.F.T.
Source: Self-asserted source
Eloise Ferreira via Scopus - Elsevier

LRP/LR specific antibody IgG1-iS18 enhances mTERT levels and impedes neurodegeneration in Alzheimer's disease transgenic mice

South African Society for Biochemistry and Molecular Biology (SASBMB)- Federation of African Societies of Biochemistry and Molecular Biology (FASBMB)
2018 | Conference abstract
Source: Self-asserted source
Eloise Ferreira

Knock-down of LRP/LR promotes apoptosis in early and late stage colorectal carcinoma cells via caspase activation

2018-12 | Journal article
DOI: 10.1186/s12885-018-4531-2
Part of ISSN: 1471-2407
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

siRNA - Mediated LRP/LR knock-down reduces cellular viability of malignant melanoma cells through the activation of apoptotic caspases

2018-07 | Journal article
DOI: 10.1016/j.yexcr.2018.04.003
Part of ISSN: 0014-4827
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice

2018-06-05 | Journal article
DOI: 10.18632/oncotarget.25473
Part of ISSN: 1949-2553
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Knockdown of LRP/LR induces apoptosis in pancreatic cancer and neuroblastoma cells through activation of caspases

2017-11 | Journal article
DOI: 10.1016/j.yexcr.2017.09.016
Part of ISSN: 0014-4827
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers <i>in vitro</i>

2017-10-17 | Journal article
DOI: 10.18632/oncotarget.21278
Part of ISSN: 1949-2553
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

LRP/LR Specific Antibody IgG1-iS18 Enhances mTERT Levels and Impedes Neurodegeneration in B6SJL-Tg6799 Alzheimer's Disease Transgenic Mice

18th International Conference on Alzheimer’s Drug Discovery, September 11-12, 2017, Jersey City, New Jersey, USA.
2017-09 | Conference poster
Source: Self-asserted source
Eloise Ferreira

IgG1-iS18 impedes the adhesive and invasive potential of early and late stage malignant melanoma cells

2017-02 | Journal article
DOI: 10.1016/j.yexcr.2017.01.009
Part of ISSN: 0014-4827
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

The validation of antibodies directed against the 37kDa/67kDa laminin receptor (LRP/LR) as therapeutics for the treatment of Alzheimer’s disease in B6SJL-Tg6799 mice

SASBMB
2016 | Conference abstract
Source: Self-asserted source
Eloise Ferreira

Anti-LRP/LR-specific antibody IgG1-iS18 impedes adhesion and invasion of pancreatic cancer and neuroblastoma cells

2016-12 | Journal article
DOI: 10.1186/s12885-016-2953-2
Part of ISSN: 1471-2407
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Anti-LRP/LR-Specific Antibody IgG1-iS18 Significantly Impedes Adhesion and Invasion in Early- and Late-Stage Colorectal Carcinoma Cells

2016-01 | Journal article
DOI: 10.2119/molmed.2016.00169
Part of ISSN: 1076-1551
Part of ISSN: 1528-3658
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity

2015-11-06 | Journal article
DOI: 10.1371/journal.pone.0141618
Part of ISSN: 1932-6203
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer’s Disease

2015-10-17 | Journal article
DOI: 10.3233/JAD-150482
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Knockdown of LRP/LR Induces Apoptosis in Breast and Oesophageal Cancer Cells

2015-10-01 | Journal article
DOI: 10.1371/journal.pone.0139584
Part of ISSN: 1932-6203
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

2015-08 | Journal article
DOI: 10.1007/s10534-015-9865-5
Part of ISSN: 0966-0844
Part of ISSN: 1572-8773
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer’s disease

2015-05-04 | Journal article
DOI: 10.1517/13543776.2015.1014802
Part of ISSN: 1354-3776
Part of ISSN: 1744-7674
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Selection of Suitable Reference Genes for Quantitative Real-Time PCR in Apoptosis-Induced MCF-7 Breast Cancer Cells

2012-02 | Journal article
DOI: 10.1007/s12033-011-9425-3
Part of ISSN: 1073-6085
Part of ISSN: 1559-0305
Source: Self-asserted source
Eloise Ferreira
grade
Preferred source (of 2)‎

Bisphosphine silverthiocyanate complexes induce cell death in MCF-7 breast cancer cells

The South African Cell Death Society Conference: Cell Death in Diseases
2011 | Conference poster
Source: Self-asserted source
Eloise Ferreira

Effects of salicylic acid and heat shock on apoptosis in MCF-7 breast cancer cells

CANSA Biennial Research Conference
2010 | Conference poster
Source: Self-asserted source
Eloise Ferreira

Salicylic acid and Hsp70: Partners for inducing apoptosis in breast cancer cells

SASBMB
2010 | Conference poster
Source: Self-asserted source
Eloise Ferreira

Salicylic acid and HSP70: Partners for inducing apoptosis in breast cancer cells

International Cell Death Conference
2009 | Conference poster
Source: Self-asserted source
Eloise Ferreira

Biopharmaceutical agents for use in reducing lipid content in cells

Patent
PAT:

2018/04509
Source: Self-asserted source
Eloise Ferreira

Compounds for the use in the treatment of Parkinson’s Disease

Patent
PAT:

2018/08025
Source: Self-asserted source
Eloise Ferreira

Pharmaceutical composition for the site specific delivery of a biopharmaceutical agent

Patent
PAT:

2018/04507
Source: Self-asserted source
Eloise Ferreira
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