Personal information

Websites & social links

Personal Website
LinkedIn
University of Minnesota profile page
ResearchGate

Other IDs

ResearcherID: K-8600-2017
SciProfiles: 278949
Scopus Author ID: 35751885500

Keywords

Synthetic Biology, Natural products, Drug discovery

Countries

United States

Biography

I obtained my BSc and MSc in Biochemistry and Molecular Biology at the University of Strasbourg (France) and completed my PhD at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (Luxembourg) in the framework of the European RedCat Project. As Marie Curie Fellow, my research project focused on the discovery and the elucidation of the mode of action of several natural and natural-based products as anticancer drugs. After acquisition of new skills in natural products isolation and structure elucidation at the Fundacíon MEDINA (Granada, Spain), I joined the Schmidt-Dannert Lab as Postdoctoral Research Associate. My research project aims to screen a Field-to Lab Basidiomycota strains biobank by biological and bioinformatic approach for isolation of bioactive molecules, biocatalysts, and also biosynthesis of known and new valuable compounds for biotechnological applications and next-generation therapeutics.

Activities

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Employment (7)

University of Minnesota: Minneapolis, Minnesota, US

2024-11-04 to present | Researchers, Research Professional 6 (Biotechnology Institute)
Employment
Source: check_circle
Experts@Minnesota

University of Minnesota: Saint Paul, Minnesota, US

2022-06-10 to present | Research Associate & Laboratory Manager (BioTechnology Institute)
Employment
Source: Self-asserted source
Francois Gaascht

University of Minnesota: Minneapolis, Minnesota, US

2022-06-10 to 2024-11-04 | Researchers, Researcher (Biotechnology Institute)
Employment
Source: check_circle
Experts@Minnesota

University of Minnesota: Minneapolis, Minnesota, US

2016-09-28 to 2021-08-31 | Professionals-in-Training, Post-Doctoral Associate (Biotechnology Institute)
Employment
Source: check_circle
Experts@Minnesota

University of Minnesota: Minneapolis, Minnesota, US

2016-09-01 to 2016-09-28 | Professionals-in-Training, Post-Doctoral Associate (Biotechnology Institute)
Employment
Source: check_circle
Experts@Minnesota

Fundación MEDINA: Granada, ES

2014-11-03 to 2015-01-30 (Chemistry department)
Employment
Source: Self-asserted source
Francois Gaascht

Laboratoire de Biologie Moleculaire et Cellulaire du Cancer: Luxembourg, LU

2009-09-01 to 2013-12-20 | PhD Student (Natural Compounds and Cell Death)
Employment
Source: Self-asserted source
Francois Gaascht

Education and qualifications (3)

Universite de Lorraine Ecole Doctorale BioSE: Vandoeuvre-les-Nancy, Lorraine, FR

2009-09-01 to 2013-12-20 | PhD
Education
Source: Self-asserted source
Francois Gaascht

Université de Strasbourg: Strasbourg, FR

2007-09-01 to 2009-06-30 | MSc in Molecular and Structural Biology
Education
Source: Self-asserted source
Francois Gaascht

Université Louis Pasteur: Strasbourg, FR

2005-09 to 2007-06 | BSc in Biochemistry - Molecular Biology
Education
Source: Self-asserted source
Francois Gaascht

Funding (2)

RedCat Training Network, Initial Training Network

2009-09 to 2012-11 | Grant
Research Executive Agency (Brussels, BE)
GRANT_NUMBER:

215009
Source: Self-asserted source
Francois Gaascht

MSc thesis

2007-09 to 2009-08 | Grant
Lions Club Luxembourg – Action “Vaincre le Cancer” (Luxembourg, LU)
Source: Self-asserted source
Francois Gaascht

Works (17)

Design of a Genetically Programmable and Customizable Protein Scaffolding System for the Hierarchical Assembly of Robust, Functional Macroscale Materials

ACS Synthetic Biology
2024-11-15 | Journal article
DOI: 10.1021/acssynbio.4c00587
Contributors: Ruijie Zhang; Sun-Young Kang; François Gaascht; Eliana L. Peña; Claudia Schmidt-Dannert
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Design of a genetically programmable and customizable protein scaffolding system for the hierarchical assembly of robust, functional macroscale materials

2024-05-03 | Preprint
DOI: 10.1101/2024.05.02.592261
Contributors: Ruijie Zhang; Sun-Young Kang; Francois Gaascht; Eliana L. Pena; Claudia Schmidt- Dannert
Source: check_circle
Crossref

Molecular Identification and Antimicrobial Activity of Foliar Endophytic Fungi on the Brazilian Pepper Tree (Schinus terebinthifolius) Reveal New Species of Diaporthe.

Current microbiology
2021-07-02 | Journal article
DOI: 10.1007/s00284-021-02582-x
PMID: 34213615
Source: Self-asserted source
Francois Gaascht
grade
Preferred source (of 2)‎

Discovery of Antifungal and Biofilm Preventative Compounds from Mycelial Cultures of a Unique <i>North American Hericium </i>sp. Fungus

Molecules
2020-02 | Journal article | Author
DOI: 10.3390/molecules25040963
Contributors: Xun Song; Francois Gaascht; Claudia Schmidt-Dannert; Christine E. Salomon
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer.

2015-11 | Journal article
DOI: 10.1007/s12263-015-0501-3
PMID: 26577824
PMC: PMC4648805
Contributors: Gaascht F; Dicato M; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Plumbagin modulates leukemia cell redox status.

2014 | Journal article
DOI: 10.3390/molecules190710011
PMID: 25014531
Contributors: Gaascht F; Teiten MH; Cerella C; Dicato M; Bagrel D; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.

2014-08 | Journal article
DOI: 10.1016/j.bmcl.2014.06.067
PMID: 25042254
Contributors: Seidel C; Schnekenburger M; Zwergel C; Gaascht F; Mai A; Dicato M; Kirsch G; Valente S; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer.

2013 | Journal article
DOI: 10.3389/fonc.2013.00202
PMID: 23971004
PMC: PMC3747514
Contributors: Gaascht F; Dicato M; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central

Découverte, identification et caractérisation de molécules d'origine naturelle capables de cibler les voies de transduction, de prolifération, d'inflammation et de mort cellulaire dans des cellules cancéreuses

2013-12-20 | Other | Author
SOURCE-WORK-ID:

d7477cfb-abe2-47b2-935d-2d7d2bc6361c
Contributors: Francois Gaascht
Source: check_circle
Experts@Minnesota

Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions.

2013-11 | Journal article
DOI: 10.1016/j.bcp.2013.08.007
PMID: 23973807
Contributors: Teiten MH; Gaascht F; Dicato M; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Embellicines A and B: absolute configuration and NF-κB transcriptional inhibitory activity.

2013-04 | Journal article
DOI: 10.1021/jm400034b
PMID: 23484593
Contributors: Ebrahim W; Aly AH; Wray V; Mándi A; Teiten MH; Gaascht F; Orlikova B; Kassack MU; Lin W; Diederich M et al.
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Aurones: interesting natural and synthetic compounds with emerging biological potential.

2012-03 | Journal article
PMID: 22545415
Contributors: Zwergel C; Gaascht F; Valente S; Diederich M; Bagrel D; Kirsch G
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Targeting the wingless signaling pathway with natural compounds as chemopreventive or chemotherapeutic agents.

2012-01 | Journal article
DOI: 10.2174/138920112798868593
PMID: 21466435
Contributors: Teiten MH; Gaascht F; Dicato M; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Natural compounds as inflammation inhibitors.

2011-05 | Journal article
DOI: 10.1007/s12263-011-0231-0
PMID: 21537905
PMC: PMC3092910
Contributors: Schumacher M; Juncker T; Schnekenburger M; Gaascht F; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway.

2011-03 | Journal article
DOI: 10.3892/ijo.2011.905
PMID: 21240460
Contributors: Teiten MH; Gaascht F; Cronauer M; Henry E; Dicato M; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells.

2011-01 | Journal article
DOI: 10.1016/j.bcp.2010.08.025
PMID: 20849830
Contributors: Juncker T; Cerella C; Teiten MH; Morceau F; Schumacher M; Ghelfi J; Gaascht F; Schnekenburger M; Henry E; Dicato M et al.
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Chemopreventive potential of curcumin in prostate cancer.

2010-03 | Journal article
DOI: 10.1007/s12263-009-0152-3
PMID: 19806380
PMC: PMC2820199
Contributors: Teiten MH; Gaascht F; Eifes S; Dicato M; Diederich M
Source: Self-asserted source
Francois Gaascht via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (3 reviews for 1 publication/grant)

Review activity for Applied microbiology and biotechnology (3)
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