Cristian Follmer (0000-0001-6178-0432)

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Cristian Follmer has B.S. in Chemistry, PhD in Molecular and Cellular Biology at the Federal University of Rio Grande do Sul and Postdoctoral at Weill Cornell Medical College, Cornell University, USA. Prof. Follmer was awarded with the Young Scientist (2013) and Scientist (2019) Scholarship of the State of Rio de Janeiro - Foundation for Support of Research in the State of Rio de Janeiro (FAPERJ). Currently, Prof. Follmer is Research Fellow II of the National Council for Scientific and Technological Development (CNPq), and Associate Professor at the UFRJ, where he is the leader of a research group focusing on the mechanisms of neurodegeneration associated with protein misfolding and aggregation.

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Universidade Federal do Rio de Janeiro: Rio de Janeiro, RJ, BR

2006-04-13 to present | Associate Professor (Physical Chemistry, Institute of Chemistry)

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Cristian Follmer

https://orcid.org/0000-0001-6178-0432

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Employment (1)

Universidade Federal do Rio de Janeiro: Rio de Janeiro, RJ, BR

Education and qualifications (5)

Weill Cornell Medical College: NY, NY, US

Universidade Federal do Rio de Janeiro: Rio de Janeiro, RJ, BR

Universidade Federal do Rio Grande do Sul: Porto Alegre, RS, BR

Universidade Federal do Rio Grande do Sul: Porto Alegre, RS, BR

Universidade Federal do Rio Grande: Rio Grande, RS, BR

Funding (14)

Proteotoxicidade amiloide e neurodegeneração: papel da proteína alfa-sinucleína e de endotoxinas bacterianas na degeneração dos neurônios dopaminérgicos na doença de Parkinson

Metabólitos de dopamina como moduladores da agregação e toxicidade da alfa-sinucleína na doença de Parkinson (Dopamine metabolites as modulators of alpha-synuclein aggregation and toxicity in Parkinson’s disease )

Entendendo o aumento da vulnerabilidade dos neurônios dopaminérgicos da substantia nigra na doença de Parkinson

Mau-enovelamento e agregação de proteínas na etiologia de doenças neurodegenerativas e câncer: uma abordagem multidisciplinar

Mecanismos Moleculares Associados à Degeneração Seletiva de Neurônios Dopaminérgicos na Doença de Parkinson

Mecanismos Moleculares Associados à Degeneração Seletiva de Neurônios Dopaminérgicos na Doença de Parkinson

Modulação cinética e estrutural da formação de fibras da α-sinucleína por toxinas agrícolas: implicações na neuropatogênese da Doença de Parkinson

Binding of the herbicide paraquat to alpha-synuclein and its implications in the stability of protein aggregates

Busca de novos fármacos para doenças neurodegenerativas: aspectos moleculares e farmacológicos de inibidores de monoamino oxidase isolados de plantas brasileiras

Institutos Nacionais de Ciência e Tecnologia INCT- INOMAT

Imobilização de enzimas em nanopartículas sólidas: aplicações clínicas e industriais

Strategies in the biocontrol of agriculture pests – Investigation of the mechanism of action of the insecticidal peptide – jaburetox

Investigação do mecanismo de ação de uma nova classe de peptídeos inseticidas proveniente da hidrólise de ureases vegetais - PepURE´s: uma abordagem físico-química

Investigação do mecanismo de ação de uma nova classe de peptídeos inseticidas provenientes da hidrólise de ureases vegetais

Works (36)

Could the Urease of the Gut Bacterium <i>Proteus mirabilis</i> Play a Role in the Altered Gut–Brain Talk Associated with Parkinson’s Disease?

The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking

Formation of large oligomers of DOPAL-modified α-synuclein is modulated by the oxidation of methionine residues located at C-terminal domain

Conjugation with polyamines enhances the antitumor activity of naphthoquinones against human glioblastoma cells

In vitro neurotoxicity of salsolinol is attenuated by the presynaptic protein α-synuclein

Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein

Role of Parkinson’s Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde

A Medical Approach to the Monoamine Oxidase Inhibition by Using 7H-benzo[e] perimidin-7-one Derivatives

Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)

Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro

Beyond Topoisomerase Inhibition: Antitumor 1,4-Naphthoquinones as Potential Inhibitors of Human Monoamine Oxidase

Monoamine oxidase and alpha-synuclein as targets in Parkinson's disease therapy

UV-induced selective oxidation of Met5 to Met-sulfoxide leads to the formation of neurotoxic fibril-incompetent alpha-synuclein oligomers

Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity

Structure–function studies on jaburetox, a recombinant insecticidal peptide derived from jack bean (Canavalia ensiformis) urease

alpha-Synuclein as an intrinsically disordered monomer - fact or artefact?

Catalytic Properties of Lipases Immobilized onto Ultrasound-treated Chitosan Supports

MULTIFUNCTIONAL DRUGS: MONOAMINE OXIDASE AND alpha-SYNUCLEIN AS TARGETS FOR THE TREATMENT OF PARKINSON'S DISEASE

Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein

Echinococcus granulosus Antigen B Structure: Subunit Composition and Oligomeric States

162. Membrane-disturbing Properties of Urease and Derived Recombinant Peptides

Measuring the Strength of Interaction between the Ebola Fusion Peptide and Lipid Rafts: Implications for Membrane Fusion and Virus Infection

Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: Evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO

The Anti-Parkinsonian Drug Selegiline Delays the Nucleation Phase of α-Synuclein Aggregation Leading to the Formation of Nontoxic Species

Ureases as a target for the treatment of gastric and urinary infections

Membrane-disruptive properties of the bioinsecticide Jaburetox-2Ec: Implications to the mechanism of the action of insecticidal peptides derived from ureases

Insights into the role and structure of plant ureases

Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein

Germa-γ-lactones as novel inhibitors of bacterial urease activity

Cysteine based novel noncompetitive inhibitors of urease(s)—Distinctive inhibition susceptibility of microbial and plant ureases

Effect of chemical modification of histidines on the copper-induced oligomerization of jack bean urease (EC 3.5.1.5)

Jack bean urease (EC 3.5.1.5) aggregation monitored by dynamic and static light scattering

Jackbean, soybean and Bacillus pasteurii ureases - Biological effects unrelated to ureolytic activity

Separation of jack bean (Canavalia ensiformis) urease isoforms by immobilized metal affinity chromatography and characterization of insecticidal properties unrelated to ureolytic activity

PIXE analysis of urease isoenzymes isolated from Canavalia ensiformis (jack bean) seeds

Canatoxin, a toxic protein from jack beans (Canavalia ensiformis), is a variant form of urease (EC 3.5.1.5): biological effects of urease independent of its ureolytic activity

Peer review (5 reviews for 3 publications/grants)