Personal information

cardiovascular biology, cell cycle, oxygen, development and evolution, leukocyte and endothelial cel
Japan

Activities

Employment (1)

Kawasaki Medical School: Kurashiki, Okayama, JP

2019-04-01 to present | Associate Professor (First Department of Physiology)
Employment
Source: Self-asserted source
Ken Hashimoto

Funding (27)

運動と循環の起源と進化:新たな指標による地球環境変遷との関連解明

2020-07-30 to 2023-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20K21453
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

軟らかく分裂能の高い心筋細胞による革新的心筋再生戦略の創出

2020-04-01 to 2024-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20H04521
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

心筋細胞の張力伝達ネットワークによる機械受容機構解明と心不全治療への展開

2020-04-01 to 2023-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20H04508
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

哺乳類と異なる戦略で優れた心機能を発揮する鳥類に学ぶ革新的心不全治療の創出

2019-06-28 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 19K22962
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

低酸素環境を起点とした多階層の胎内履歴情報に基づく心筋再生への新たな試み

2018-06-29 to 2021-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 18K19943
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Elucidation of regulating system of fetal cardiovascular development via reassessment of substance transport in fetal circulation

2017-06-30 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 17H06272
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Investigation of regulatory mechanism of cardiac mechanics by molecular-spring connectin and clinical application for heart failure

2017-04-01 to 2021-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 17H00859
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

新規遺伝子Fam64aを用いた心筋再生医療に向けた基礎的検討

2017-04-01 to 2020-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 17H02092
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Elucidation of the mechanosensing function in heart by a muscle elastic protein connectin

2016-04-01 to 2019-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 16K01385
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Information control for a linkage between macro cardiac function and gene expression: physiomic analysis of responses to oxygen environment

2014-04-01 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 26282127
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

The importance of local Ca2+ control beneathe the T-tubule membrane in cardiomyocytes

2014-04-01 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 26702014
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

The role of mechanosensor molecule TRPV2 during monocyte transmigration across vascular endothelium in atherogenesis.

2013-04-01 to 2016-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 25350544
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Physiomic analysis of the regulatory mechanism of cardiomyocyte

2013-04-01 to 2015-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 25560214
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Physiomic analyses of cardiac hypertrophy and ventricular geometry of in cardiac regulation

2011-04-01 to 2014-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 23300171
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Analysis of reverse transmigration of monocytes across endothelium as the anti-atherogenic system.

2011-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 23700546
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Development of visualization of soft tissue morphology and protein concentration by X-ray phase-contrast computed tomography.

2011-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 23650277
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Analysis of trafficking mechanism of endothelial PECAM-1 to the spot of monocyte transmigration in atherogenesis.

2009-01-01 to 2010-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 21700476
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Coronary Circulation-Cardiac Mechanics Coupling

2008-01-01 to 2010-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20300160
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Real time and in situ observation of actin structure in migrating leukocyte

2008-01-01 to 2010-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20500402
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

The effects of exercise on angiogenesis and oxidative stress in the brain after cerebral infarction

2008-01-01 to 2010-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20500474
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Analysis of three-dimensional molecular dynamics of PECAM-1 on monocytes and vascular endothelial cells in the early atherogenesis.

2007-01-01 to 2008-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 19700391
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Physiome analysis on arteriosclerosis appearance and localized mechanism

2006-01-01 to 2008-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 18300156
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

酸化LDLが個々の単球の浸潤及び内皮細胞VE-cadherin動態に及ぼす影響

2005-01-01 to 2006-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 17700411
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

多光子型顕微鏡を用いた独自実験系による個別単球の内皮下浸潤動態の時系列3次元解析

2004-01-01 to 2005-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 16650117
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

高血圧症の発症および進展におけるスーパーオキサイドと一酸化窒素(NO)の役割

2004-01-01 to 2005-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 16650116
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

動脈硬化の予防及び治療を目的とした単球の内皮下侵入メカニズムの解明-内皮細胞本体を通る単球の侵入経路の生細胞における3次元連続解析-

2003-01-01 to 2004-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 15700341
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

細胞表面および細胞内部への応力負荷に対する内皮細胞内情報伝達メカニズムの解析

2002-01-01 to 2004-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 14658297
Source: Self-asserted source
Ken Hashimoto via DimensionsWizard

Works (27)

Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15

iScience
2022-05 | Journal article
Contributors: Ken Hashimoto; Aya Kodama; Momoko Ohira; Misaki Kimoto; Reiko Nakagawa; Yuu Usui; Yoshihiro Ujihara; Akira Hanashima; Satoshi Mohri
Source: check_circle
Crossref

Transient induction of cell cycle promoter Fam64a improves cardiac function through regulating Klf15-dependent cardiomyocyte differentiation in mice

2021-04-03 | Preprint
Contributors: Ken Hashimoto; Aya Kodama; Momoko Ohira; Misaki Kimoto; Reiko Nakagawa; Yuu Usui; Yoshihiro Ujihara; Akira Hanashima; Satoshi Mohri
Source: check_circle
Crossref

Turtle spongious ventricles exhibit more compliant diastolic propertyand possess larger elastic regions of connectin in comparison to ratcompact left ventricles

Kawasaki Medical Journal
2018 | Journal article
Contributors: Satoshi MOHRI
Source: Self-asserted source
Ken Hashimoto via JaLC

Nuclear connectin novex-3 promotes proliferation of hypoxic foetal cardiomyocytes.

Scientific reports
2018-08 | Journal article
Contributors: Hashimoto K; Kodama A; Sugino M; Yobimoto T; Honda T; Hanashima A; Ujihara Y; Mohri S
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.

Scientific reports
2017-06 | Journal article
Contributors: Hashimoto K; Kodama A; Honda T; Hanashima A; Ujihara Y; Murayama T; Nishimatsu SI; Mohri S
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle.

Gene
2016-10 | Journal article
Contributors: Hanashima A; Hashimoto K; Ujihara Y; Honda T; Yobimoto T; Kodama A; Mohri S
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling

Cardiovascular Research
2016-05 | Journal article
Part of ISSN: 0008-6363
Contributors: Yoshihiro Ujihara; Keiichiro Iwasaki; Satomi Takatsu; Ken Hashimoto; Keiji Naruse; Satoshi Mohri; Yuki Katanosaka
Source: Self-asserted source
Ken Hashimoto via Crossref Metadata Search

Left ventricular mechanics and myocardial calcium dynamics in short-term and long-term hyperthyroid mice

2016-03-17 | Dissertation or Thesis
Contributors: Yumi Sasae
Source: Self-asserted source
Ken Hashimoto via JaLC

Increased passive stiffness of cardiomyocytes in the transverse direction and residual actin and myosin cross-bridge formation in hypertrophied rat hearts induced by chronic β-adrenergic stimulation.

Circulation journal : official journal of the Japanese Circulation Society
2012-12 | Journal article
Contributors: Sumita Yoshikawa W; Nakamura K; Miura D; Shimizu J; Hashimoto K; Kataoka N; Toyota H; Okuyama H; Miyoshi T; Morita H et al.
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Calcium influx through the TRPV1 channel of endothelial cells (ECs) correlates with a stronger adhesion between monocytes and ECs.

Advances in Medical Sciences
2012-01 | Journal article
Contributors: Himi N; Hamaguchi A; Hashimoto K; Koga T; Narita K; Miyamoto O
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Live-cell visualization of the trans-cellular mode of monocyte transmigration across the vascular endothelium, and its relationship with endothelial PECAM-1.

The journal of physiological sciences : JPS
2011-11 | Journal article
Contributors: Hashimoto K; Kataoka N; Nakamura E; Hagihara K; Okamoto T; Kanouchi H; Mohri S; Tsujioka K; Kajiya F
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Cadherins in potential link between atherosclerosis and cancer.

International journal of cardiology
2011-04 | Journal article
Contributors: Hashimoto K; Kataoka N; Mohri S; Kajiya F
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

An Experimental Model for Studying Molecular Behavior of Platelet-Endothelial Cell Adhesion Molecule-1 during Mechanical Interactions between Monocytes and Vascular Endothelial Cells

Journal of Biomechanical Science and Engineering
2010 | Journal article
Contributors: Ken HASHIMOTO; Noriyuki KATAOKA; Emi NAKAMURA; Takeaki OKAMOTO; Hiroaki KANOUCHI; Yohsuke MINATOGAWA; Satoshi MOHRI; Katsuhiko TSUJIOKA; Fumihiko KAJIYA
Source: Self-asserted source
Ken Hashimoto via JaLC

Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions.

International journal of cardiology
2010-12 | Journal article
Contributors: Hashimoto K; Kataoka N; Nakamura E; Hagihara K; Hatano M; Okamoto T; Kanouchi H; Minatogawa Y; Mohri S; Tsujioka K et al.
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Evaluation of coronary endothelial function by catheter-type NO sensor in high-fat-diet-induced obese dogs.

Circulation journal : official journal of the Japanese Circulation Society
2009-02 | Journal article
Contributors: Kume T; Kawamoto T; Okura H; Neishi Y; Hashimoto K; Hayashida A; Watanabe N; Kanda Y; Mochizuki S; Goto M et al.
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Intracellular Ca2+ Responses in Cultured Endothelial Cells to Mechanical Stimulation by Laser Tweezers

Journal of Biomechanical Science and Engineering
2008 | Journal article
Contributors: Noriyuki KATAOKA; Ken HASHIMOTO; Susumu KUDO; Ryuhei YAMAGUCHI; Katsuhiko TSUJIOKA; Fumihiko KAJIYA
Source: Self-asserted source
Ken Hashimoto via JaLC

血球細胞の移動現象(<小特集>マイクロナノバイオエンジニアリングにおける輸送現象)

日本機械学会誌
2008 | Journal article
Contributors: 則之 片岡; 謙 橋本
Source: Self-asserted source
Ken Hashimoto via JaLC

Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

International journal of cardiology
2008-12 | Journal article
Contributors: Nakamura K; Shimizu J; Kataoka N; Hashimoto K; Ikeda T; Fujio H; Ohta-Ogo K; Ogawa A; Miura A; Mohri S et al.
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Measurement and finite element modeling of the force balance in the vertical section of adhering vascular endothelial cells.

Journal of the mechanical behavior of biomedical materials
2008-07 | Journal article
Contributors: Deguchi S; Fukamachi H; Hashimoto K; Iio K; Tsujioka K
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes.

Bone
2008-03 | Journal article
Contributors: Sugawara Y; Ando R; Kamioka H; Ishihara Y; Murshid SA; Hashimoto K; Kataoka N; Tsujioka K; Kajiya F; Yamashiro T et al.
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Assessment of the mechanical properties of the nucleus inside a spherical endothelial cell based on microtensile testing.

Journal of Mechanics of Materials and Structures
2007 | Journal article
Source: Self-asserted source
Ken Hashimoto

[Confocal microscopy].

Nihon rinsho. Japanese journal of clinical medicine
2007-02 | Journal article
Contributors: Hashimoto K; Kataoka N; Kajiya F
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Oxidized LDL specifically promotes the initiation of monocyte invasion during transendothelial migration with upregulated PECAM-1 and downregulated VE-cadherin on endothelial junctions.

Atherosclerosis
2006-12 | Journal article
Contributors: Hashimoto K; Kataoka N; Nakamura E; Tsujioka K; Kajiya F
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability.

Hypertension (Dallas, Tex. : 1979)
2005-02 | Journal article
Contributors: Nishiyama A; Yao L; Fan Y; Kyaw M; Kataoka N; Hashimoto K; Nagai Y; Nakamura E; Yoshizumi M; Shokoji T et al.
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

動脈硬化発生に関わる血管内皮細胞のナノ/マイクロメカニクス解析

岡山医学会雑誌
2004 | Journal article
Contributors: 則之 片岡; 謙 橋本; 文彦 梶谷
Source: Self-asserted source
Ken Hashimoto via JaLC

Direct observation and quantitative analysis of spatiotemporal dynamics of individual living monocytes during transendothelial migration.

Atherosclerosis
2004-11 | Journal article
Contributors: Hashimoto K; Kataoka N; Nakamura E; Asahara H; Ogasawara Y; Tsujioka K; Kajiya F
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central

Measurements of endothelial cell-to-cell and cell-to-substrate gaps and micromechanical properties of endothelial cells during monocyte adhesion.

Proceedings of the National Academy of Sciences of the United States of America
2002-11 | Journal article
Contributors: Kataoka N; Iwaki K; Hashimoto K; Mochizuki S; Ogasawara Y; Sato M; Tsujioka K; Kajiya F
Source: Self-asserted source
Ken Hashimoto via Europe PubMed Central