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Works (15)

A deep learning approach to perform defect classification of freeze-dried product

International Journal of Pharmaceutics
2025-02 | Journal article
DOI: 10.1016/j.ijpharm.2024.125127
Contributors: Quentin Herve; Nusret Ipek; Jan Verwaeren; Thomas De Beer
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Automated particle inspection of continuously freeze-dried products using computer vision

International Journal of Pharmaceutics
2024-10 | Journal article
DOI: 10.1016/j.ijpharm.2024.124629
Contributors: Quentin Herve; Nusret Ipek; Jan Verwaeren; Thomas De Beer
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Optimizing the secondary drying phase of a continuous Spin-Freeze Drying process: A semi-mechanistic modelling approach

International Journal of Pharmaceutics
2024-10 | Journal article
DOI: 10.1016/j.ijpharm.2024.124597
Contributors: Laurens Leys; Thomas De Beer
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A framework for the in silico assessment of the robustness of an MPC in a CDC line in function of process variability

International Journal of Pharmaceutics
2024-06 | Journal article
DOI: 10.1016/j.ijpharm.2024.124137
Contributors: Ruben Waeytens; Daan Van Hauwermeiren; Wouter Grymonpré; Ingmar Nopens; Thomas De Beer
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Cracking the code: Spatial heterogeneity as the missing piece for modeling granular fluidized bed drying

International Journal of Pharmaceutics
2024-05 | Journal article
DOI: 10.1016/j.ijpharm.2024.124135
Contributors: Tuur Vandeputte; Michael Ghijs; Thomas De Beer; Ingmar Nopens
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Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics

International Journal of Pharmaceutics
2023-11 | Journal article
DOI: 10.1016/j.ijpharm.2023.123447
Contributors: Tuur Vandeputte; Michael Ghijs; Daan Van Hauwermeiren; Eduardo Dos Santos Schultz; Elisabeth Schäfer; Fanny Stauffer; Thomas De Beer; Ingmar Nopens
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T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information

International Journal of Pharmaceutics
2023-11 | Journal article
DOI: 10.1016/j.ijpharm.2023.123481
Contributors: Kensaku Matsunami; Jonathan Meyer; Martin Rowland; Neil Dawson; Thomas De Beer; Daan Van Hauwermeiren
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Validation of model-based design of experiments for continuous wet granulation and drying

International Journal of Pharmaceutics
2023-11 | Journal article
DOI: 10.1016/j.ijpharm.2023.123493
Contributors: Kensaku Matsunami; Tuur Vandeputte; Ana Alejandra Barrera Jiménez; Michiel Peeters; Michael Ghijs; Daan Van Hauwermeiren; Fanny Stauffer; Eduardo dos Santos Schultz; Ingmar Nopens; Thomas De Beer
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Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process

International Journal of Pharmaceutics
2023-06 | Journal article
DOI: 10.1016/j.ijpharm.2023.123062
Contributors: Laurens Leys; Gust Nuytten; Pieter-Jan Van Bockstal; Thomas De Beer
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Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation

International Journal of Pharmaceutics
2023-06 | Journal article
DOI: 10.1016/j.ijpharm.2023.123040
Contributors: Ana Alejandra Barrera Jiménez; Kensaku Matsunami; Daan Van Hauwermeiren; Michiel Peeters; Fanny Stauffer; Eduardo dos Santos Schultz; Ashish Kumar; Thomas De Beer; Ingmar Nopens
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An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes

International Journal of Pharmaceutics
2022-11 | Journal article
DOI: 10.1016/j.ijpharm.2022.122154
Contributors: Ruben Waeytens; Lisa De Souter; Wouter Grymonpré; Daan Van Hauwermeiren; Ingmar Nopens; Thomas De Beer
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Development of liposomal drug delivery system as a strategy for improving bioavailability and therapeutic efficacy, by Design of Experiments

2021 | Conference paper
DOI: 10.14232/syrptbrs.2021.op24
Contributors: Lucia Ruxandra Tefas; Cătălina Bogdan; Alina Porfire; Tryfon Digkas; Thomas De Beer; Ioan Tomuță
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Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation

Pharmaceutics
2021-06-22 | Journal article
DOI: 10.3390/pharmaceutics13070928
Contributors: Ashish Kumar; Stefan Radl; Krist V. Gernaey; Thomas De Beer; Ingmar Nopens
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Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis

Pharmaceutics
2021-05-11 | Journal article
DOI: 10.3390/pharmaceutics13050692
Contributors: Ana Alejandra Barrera Jiménez; Daan Van Hauwermeiren; Michiel Peeters; Thomas De Beer; Ingmar Nopens
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Predicting Pharmaceutical Particle Size Distributions Using Kernel Mean Embedding

Pharmaceutics
2020-03-16 | Journal article
DOI: 10.3390/pharmaceutics12030271
Contributors: Daan Van Hauwermeiren; Michiel Stock; Thomas De Beer; Ingmar Nopens
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