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Employment (2)

University of Oklahoma: Norman, OK, US

2019-01 to present | Assistant Professor (Biology)
Employment
Source: Self-asserted source
Luca Fornelli

Northwestern University: Evanston, IL, US

2014-02-01 to 2018-07-30 | Postdoctoral Fellow (Chemistry of Life Processes)
Employment
Source: Self-asserted source
Luca Fornelli

Education and qualifications (1)

École Polytechnique Fédérale de Lausanne: Lausanne, VD, CH

2009-04-01 to 2014-01-31 | PhD, Chemistry and Chemical Engineering (Chemistry and Chemical Engineering)
Education
Source: Self-asserted source
Luca Fornelli

Works (50 of 77)

Items per page:
Page 1 of 2

Leveraging Ion–Ion and Ion–Photon Activation to Improve the Sequencing of Proteins Carrying Multiple Disulfide Bonds: The Human Serum Albumin Case Study

Journal of the American Society for Mass Spectrometry
2024-12-04 | Journal article
Contributors: Linda B. Lieu; Joshua D. Hinkle; John E. P. Syka; Luca Fornelli
Source: check_circle
Crossref

Enhanced Payload Localization in Antibody–Drug Conjugates Using a Middle-Down Mass Spectrometry Approach with Proton Transfer Charge Reduction

Analytical Chemistry
2024-11-19 | Journal article
Contributors: Linda B. Lieu; Cynthia Nagy; Jingjing Huang; Christopher Mullen; Graeme C. McAlister; Vlad Zabrouskov; Kristina Srzentić; Kenneth R. Durbin; Rafael D. Melani; Luca Fornelli
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Crossref

Top‐down mass spectrometry analysis of capsid proteins of recombinant adeno‐associated virus using multiple ion activations and proton transfer charge reduction

PROTEOMICS
2024-09-05 | Journal article
Contributors: Jake T. Kline; Jingjing Huang; Linda B. Lieu; Kristina Srzentić; David Bergen; Christopher Mullen; Graeme C. McAlister; Kenneth R. Durbin; Rafael D. Melani; Luca Fornelli
Source: check_circle
Crossref

Characterization of a Monoclonal Antibody by Native and Denaturing Top-Down Mass Spectrometry

Journal of the American Society for Mass Spectrometry
2024-09-04 | Journal article
Contributors: Ryan N. Oates; Linda B. Lieu; Kristina Srzentić; Eugen Damoc; Luca Fornelli
Source: check_circle
Crossref

Leveraging ion-ion and ion-photon reactions to improve the sequencing of proteins carrying multiple disulfide bonds: the human serum albumin case study

2024-06-28 | Preprint
Contributors: Linda Lieu; Joshua Hinkle; John Syka; Luca Fornelli
Source: check_circle
Crossref

Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction

2024-06-27 | Preprint
Contributors: Linda Lieu; Cynthia Nagy; Jingjing Huang; Christopher Mullen; Graeme McAlister; Vlad Zabrouskov; Kristina Srzentić; Kenneth Durbin; Rafael Melani; Luca Fornelli
Source: check_circle
Crossref

Top-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction

2024-06-27 | Preprint
Contributors: Jake Kline; Jingjing Huang; Linda Lieu; Kristina Srzentić; David Bergen; Christopher Mullen; Graeme McAlister; Kenneth Durbin; Rafael Melani; Luca Fornelli
Source: check_circle
Crossref

Characterization of a monoclonal antibody by native and denaturing top-down mass spectrometry

2024-05-28 | Preprint
Contributors: Ryan Oates; Linda Lieu; Kristina Srzentić; Eugen Damoc; Luca Fornelli
Source: check_circle
Crossref

Improved label-free quantification of intact proteoforms using field asymmetric ion mobility spectrometry

ChemRxiv
2023 | Other
EID:

2-s2.0-85158031492

Part of ISSN: 25732293
Contributors: Kline, J.T.; Belford, M.W.; Huang, J.; Greer, J.B.; Bergen, D.; Fellers, R.T.; Greer, S.M.; Horn, D.M.; Zabrouskov, V.; Huguet, R. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Improved Label-Free Quantification of Intact Proteoforms Using Field Asymmetric Ion Mobility Spectrometry

Analytical Chemistry
2023 | Journal article
EID:

2-s2.0-85163833785

Part of ISSN: 15206882 00032700
Contributors: Kline, J.T.; Belford, M.W.; Huang, J.; Greer, J.B.; Bergen, D.; Fellers, R.T.; Greer, S.M.; Horn, D.M.; Zabrouskov, V.; Huguet, R. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Orbitrap mass spectrometry and high-field asymmetric waveform ion mobility spectrometry (FAIMS) enable the in-depth analysis of human serum proteoforms

ChemRxiv
2023 | Other
EID:

2-s2.0-85149504888

Part of ISSN: 25732293
Contributors: Kline, J.T.; Belford, M.W.; Boeser, C.L.; Huguet, R.; Fellers, R.T.; Greer, J.B.; Greer, S.M.; Horn, D.M.; Durbin, K.R.; Dunyach, J.-J. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Orbitrap Mass Spectrometry and High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Enable the in-Depth Analysis of Human Serum Proteoforms

Journal of Proteome Research
2023 | Journal article
EID:

2-s2.0-85175486733

Part of ISSN: 15353907 15353893
Contributors: Kline, J.T.; Belford, M.W.; Boeser, C.L.; Huguet, R.; Fellers, R.T.; Greer, J.B.; Greer, S.M.; Horn, D.M.; Durbin, K.R.; Dunyach, J.-J. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Proteomics evaluation of five economical commercial abundant protein depletion kits for enrichment of diseases-specific biomarkers from blood serum

Proteomics
2023 | Journal article
EID:

2-s2.0-85159607420

Part of ISSN: 16159861 16159853
Contributors: Ahsan, N.; Fornelli, L.; Najar, F.Z.; Gamagedara, S.; Hossan, M.R.; Rao, R.S.P.; Punyamurtula, U.; Bauer, A.; Yang, Z.; Foster, S.B. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Targeted Quantification of Proteoforms in Complex Samples by Proteoform Reaction Monitoring

ChemRxiv
2023 | Other
EID:

2-s2.0-85165448613

Part of ISSN: 25732293
Contributors: Huang, C.-F.; Kline, J.T.; Negrão, F.; Robey, M.T.; Toby, T.K.; Durbin, K.R.; Fellers, R.T.; Friedewald, J.J.; Levitsky, J.; Abecassis, M.M.I. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Mass spectrometry characterization of antibodies at the intact and subunit levels: From targeted to large-scale analysis

International Journal of Mass Spectrometry
2023-10 | Journal article
Contributors: Jake T. Kline; Rafael D. Melani; Luca Fornelli
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Characterization of large intact protein ions by mass spectrometry: What directions should we follow?

Biochimica et Biophysica Acta - Proteins and Proteomics
2022 | Journal article
EID:

2-s2.0-85123675530

Part of ISSN: 18781454 15709639
Contributors: Fornelli, L.; Toby, T.K.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications

PLoS Biology
2022 | Journal article
EID:

2-s2.0-85141889194

Part of ISSN: 15457885 15449173
Contributors: Nitika; Zheng, B.; Ruan, L.; Kline, J.T.; Omkar, S.; Sikora, J.; Torres, M.T.; Wang, Y.; Takakuwa, J.E.; Huguet, R. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Structural Analysis of Monoclonal Antibodies with Top-down and Middledown Electron Transfer Dissociation Mass Spectrometry: The First Decade

Chimia
2022 | Journal article
EID:

2-s2.0-85128330147

Part of ISSN: 00094293
Contributors: Fornelli, L.; Ayoub, D.; Srzentić, K.; Nagornov, K.O.; Kozhinov, A.N.; Gasilova, N.; Menine, L.; Beck, A.; Tsybin, Y.O.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na<sub>V</sub>1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

Frontiers in Pharmacology
2022 | Journal article
EID:

2-s2.0-85131726754

Part of ISSN: 16639812
Contributors: George, K.; Lopez-Mateos, D.; Abd El-Aziz, T.M.; Xiao, Y.; Kline, J.; Bao, H.; Raza, S.; Stockand, J.D.; Cummins, T.R.; Fornelli, L. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

Science
2022 | Journal article
EID:

2-s2.0-85123606688

Part of ISSN: 10959203 00368075
Contributors: Melani, R.D.; Gerbasi, V.R.; Anderson, L.C.; Sikora, J.W.; Toby, T.K.; Hutton, J.E.; Butcher, D.S.; Negrão, F.; Seckler, H.S.; Srzentic, K. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

A novel multifunctional role for Hsp70 in binding post-translational modifications on client proteins

bioRxiv
2021 | Other
EID:

2-s2.0-85115059307

Part of ISSN: 26928205
Contributors: Nitika; Zheng, B.; Ruan, L.; Kline, J.T.; Sikora, J.; Torres, M.T.; Wang, Y.; Takakuwa, J.E.; Huguet, R.; Klemm, C. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Chapter 3: ECD/ETD for Sequencing of Peptides and Denatured Proteins

New Developments in Mass Spectrometry
2021 | Book chapter
EID:

2-s2.0-85098713420

Part of ISSN: 20457553
Contributors: Fornelli, L.; Toby, T.K.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Evolutionary dynamics of indels in SARS-CoV-2 spike glycoprotein

bioRxiv
2021 | Other
EID:

2-s2.0-85115169868

Part of ISSN: 26928205
Contributors: Rao, R.S.P.; Ahsan, N.; Xu, C.; Su, L.; Verburgt, J.; Fornelli, L.; Kihara, D.; Xu, D.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Evolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein

Evolutionary Bioinformatics
2021 | Journal article
EID:

2-s2.0-85120825257

Part of ISSN: 11769343
Contributors: Rao, R.S.P.; Ahsan, N.; Xu, C.; Su, L.; Verburgt, J.; Fornelli, L.; Kihara, D.; Xu, D.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Identification and characterization of novel proteins from Arizona bark scorpion venom that inhibit Nav1.8, a voltage-gated sodium channel regulator of pain signaling

bioRxiv
2021 | Other
EID:

2-s2.0-85111365558

Part of ISSN: 26928205
Contributors: Abd El-Aziz, T.M.; Xiao, Y.; Kline, J.; Gridley, H.; Heaston, A.; Linse, K.D.; Ward, M.J.; Rokyta, D.R.; Stockand, J.D.; Cummins, T.R. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches

Proteomics
2021 | Journal article
EID:

2-s2.0-85105032883

Part of ISSN: 16159861 16159853
Contributors: Ahsan, N.; Rao, R.S.P.; Wilson, R.S.; Punyamurtula, U.; Salvato, F.; Petersen, M.; Ahmed, M.K.; Abid, M.R.; Verburgt, J.C.; Kihara, D. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Sequential ion-ion reactions for enhanced gas-phase sequencing of large intact proteins in a tribrid Orbitrap mass spectrometer

ChemRxiv
2021 | Other
EID:

2-s2.0-85103342310

Part of ISSN: 25732293
Contributors: Kline, J.T.; Mullen, C.; Durbin, K.R.; Oates, R.N.; Huguet, R.; Syka, J.E.P.; Fornelli, L.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells

The FEBS Journal
2021-12 | Journal article
Contributors: Peter F. Doubleday; Luca Fornelli; Ioanna Ntai; Neil L. Kelleher
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Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study

Journal of the American Heart Association
2021-09-07 | Journal article
Contributors: John T. Wilkins; Henrique S. Seckler; Jonathan Rink; Philip D. Compton; Luca Fornelli; C. Shad Thaxton; Rich LeDuc; David Jacobs; Peter F. Doubleday; Allan Sniderman et al.
Source: check_circle
Crossref
grade
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Sequential Ion–Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer

Journal of the American Society for Mass Spectrometry
2021-09-01 | Journal article
Contributors: Jake T. Kline; Christopher Mullen; Kenneth R. Durbin; Ryan N. Oates; Romain Huguet; John E. P. Syka; Luca Fornelli
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Crossref
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Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

Toxins
2021-07 | Journal article | Author
Contributors: Tarek Mohamed Abd El-Aziz; Yucheng Xiao; Jake Kline; Harold Gridley; Alyse Heaston; Klaus D. Linse; Micaiah Ward; Darin Rokyta; James D. Stockand; Theodore R. Cummins et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
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Sequential Ion-Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer

2021-02-17 | Preprint
Contributors: Jake Kline; Christopher Mullen; Kenneth Durbin; Ryan Oates; Romain Huguet; John Syka; Luca Fornelli
Source: check_circle
Crossref

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

Journal of Proteome Research
2020 | Journal article
EID:

2-s2.0-85079084912

Part of ISSN: 15353907 15353893
Contributors: Doubleday, P.F.; Fornelli, L.; Kelleher, N.L.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

Journal of the American Society for Mass Spectrometry
2020 | Journal article
EID:

2-s2.0-85090252615

Part of ISSN: 18791123 10440305
Contributors: Srzentić, K.; Fornelli, L.; Tsybin, Y.O.; Loo, J.A.; Seckler, H.; Agar, J.N.; Anderson, L.C.; Bai, D.L.; Beck, A.; Brodbelt, J.S. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics

Molecular & Cellular Proteomics
2020-02-30 | Journal article
Contributors: Luca Fornelli; Kristina Srzentić; Timothy K. Toby; Peter F. Doubleday; Romain Huguet; Christopher Mullen; Rafael D. Melani; Henrique dos Santos Seckler; Caroline J. DeHart; Chad R. Weisbrod et al.
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A comprehensive pipeline for translational top-down proteomics from a single blood draw

Nature Protocols
2019 | Journal article
EID:

2-s2.0-85058038129

Part of ISSN: 17502799 17542189
Contributors: Toby, T.K.; Fornelli, L.; Srzentić, K.; DeHart, C.J.; Levitsky, J.; Friedewald, J.; Kelleher, N.L.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

Nature Methods
2019 | Journal article
EID:

2-s2.0-85068061823

Part of ISSN: 15487105 15487091
Contributors: Donnelly, D.P.; Rawlins, C.M.; DeHart, C.J.; Fornelli, L.; Schachner, L.F.; Lin, Z.; Lippens, J.L.; Aluri, K.C.; Sarin, R.; Chen, B. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry

Analytical Chemistry
2019 | Journal article
EID:

2-s2.0-85061129259

Part of ISSN: 15206882 00032700
Contributors: Van Der Burgt, Y.E.M.; Kilgour, D.P.A.; Tsybin, Y.O.; Srzentić, K.; Fornelli, L.; Beck, A.; Wuhrer, M.; Nicolardi, S.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms

Analytical Chemistry
2019-12-17 | Journal article
Contributors: Romain Huguet; Christopher Mullen; Kristina Srzentić; Joseph B. Greer; Ryan T. Fellers; Vlad Zabrouskov; John E. P. Syka; Neil L. Kelleher; Luca Fornelli
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Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

mAbs
2019-11-17 | Journal article
Contributors: Rafael D. Melani; Kristina Srzentić; Vincent R. Gerbasi; John P. McGee; Romain Huguet; Luca Fornelli; Neil L. Kelleher
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Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Journal of Biological Chemistry
2019-08 | Journal article
Contributors: Xiaoxiao Huang; Richard D. LeDuc; Luca Fornelli; Alissa J. Schunter; Richard L. Bennett; Neil L. Kelleher; Jonathan D. Licht
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Direct Measurement of Light and Heavy Antibody Chains Using Differential Ion Mobility Spectrometry and Middle-Down Mass Spectrometry

2019-07-05 | Other
Contributors: Rafael D Melani; Kristina Srzentić; Vincent R Gerbasi; John P McGee; Romain Huguet; Luca Fornelli; Neil L Kelleher
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Crossref
grade
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A multi-modal proteomics strategy for characterizing posttranslational modifications of tumor suppressor p53 reveals many sites but few modified forms

bioRxiv
2018 | Other
EID:

2-s2.0-85095635396

Part of ISSN: 26928205
Contributors: DeHart, C.J.; Fornelli, L.; Anderson, L.C.; Fellers, R.T.; Lu, D.; Hendrickson, C.L.; Lahav, G.; Gunawardena, J.; Kelleher, N.L.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

Journal of Proteome Research
2018 | Journal article
EID:

2-s2.0-85047979376

Part of ISSN: 15353907 15353893
Contributors: Seckler, H.D.S.; Fornelli, L.; Mutharasan, R.K.; Thaxton, C.S.; Fellers, R.; Daviglus, M.; Sniderman, A.; Rader, D.; Kelleher, N.L.; Lloyd-Jones, D.M. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Analytical Chemistry
2018 | Journal article
EID:

2-s2.0-85048709940

Part of ISSN: 15206882 00032700
Contributors: Fornelli, L.; Srzentić, K.; Huguet, R.; Mullen, C.; Sharma, S.; Zabrouskov, V.; Fellers, R.T.; Durbin, K.R.; Compton, P.D.; Kelleher, N.L.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Chemical-Mediated Digestion: An Alternative Realm for Middle-down Proteomics?

Journal of Proteome Research
2018 | Journal article
EID:

2-s2.0-85046654789

Part of ISSN: 15353907 15353893
Contributors: Srzentić, K.; Zhurov, K.O.; Lobas, A.A.; Nikitin, G.; Fornelli, L.; Gorshkov, M.V.; Tsybin, Y.O.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody

Analytical Chemistry
2018 | Journal article
EID:

2-s2.0-85054955162

Part of ISSN: 15206882 00032700
Contributors: Srzentić, K.; Nagornov, K.O.; Fornelli, L.; Lobas, A.A.; Ayoub, D.; Kozhinov, A.N.; Gasilova, N.; Menin, L.; Beck, A.; Gorshkov, M.V. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85045511496

Part of ISSN: 10916490 00278424
Contributors: Ntai, I.; Fornelli, L.; DeHart, C.J.; Hutton, J.E.; Doubleday, P.F.; LeDuc, R.D.; van Nispen, A.J.; Fellers, R.T.; Whiteley, G.; Boja, E.S. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics

Journal of the American Society for Mass Spectrometry
2018 | Journal article
EID:

2-s2.0-85040980186

Part of ISSN: 18791123 10440305
Contributors: Lyon, Y.A.; Riggs, D.; Fornelli, L.; Compton, P.D.; Julian, R.R.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier

Top-down characterization of endogenous protein complexes with native proteomics

Nature Chemical Biology
2018 | Journal article
EID:

2-s2.0-85037724019

Part of ISSN: 15524469 15524450
Contributors: Skinner, O.S.; Haverland, N.A.; Fornelli, L.; Melani, R.D.; Do Vale, L.H.F.; Seckler, H.S.; Doubleday, P.F.; Schachner, L.F.; Srzentić, K.; Kelleher, N.L. et al.
Source: Self-asserted source
Luca Fornelli via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (35 reviews for 7 publications/grants)

Review activity for ACS infectious diseases. (3)
Review activity for Analytical chemistry. (12)
Review activity for Cell reports. (2)
Review activity for Chemical research in toxicology. (1)
Review activity for Journal of proteome research. (3)
Review activity for Journal of the American Society for Mass Spectrometry. (13)
Review activity for Nature protocols (1)