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Scopus Author ID: 35466219800
Scopus Author ID: 55510546700

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Employment (3)

University of Cincinnati: Cincinnati, US

2023-09-01 to present | Associate Professor (Cancer Biology)
Employment
Source: Self-asserted source
John Cunningham

University of Cincinnati: Cincinnati, OH, US

2016-02-22 to 2023-08-31 | Assistant Professor (Cancer Biology)
Employment
Source: Self-asserted source
John Cunningham

University of California San Francisco: San Francisco, CA, US

2009-08 to 2016-02-10 | Postdoctoral Fellow (Urology)
Employment
Source: Self-asserted source
John Cunningham

Education and qualifications (2)

Johns Hopkins University: Baltimore, MD, US

2002-09 to 2009-08 | PhD (Cell Biology)
Education
Source: Self-asserted source
John Cunningham

Western Kentucky University: Bowling Green, KY, US

1998-08 to 2002-05 | BS (Biology and Chemistry)
Education
Source: Self-asserted source
John Cunningham

Funding (5)

Investigating Mechanisms of Deregulated Nucleotide Metabolism in Cancer

2019-08 to 2024-07 | Award
National Cancer Institute (Md., Md., US)
GRANT_NUMBER:

R01CA230904
Source: Self-asserted source
John Cunningham

Defining the biological roles of PRPS isozymes in normal and diseased settings

2019-07 to 2024-04 | Award
National Institute of General Medical Sciences (Md., Md., US)
GRANT_NUMBER:

R35GM133561
Source: Self-asserted source
John Cunningham

Selective Targeting of PRPS Isoforms to Inhibit Nucleotide Synthesis in MYC-driven Lymphoma

2017-07 to 2019-07 | Award
V Foundation for Cancer Research (NC, NC, US)
GRANT_NUMBER:

V2017-020
Source: Self-asserted source
John Cunningham

Deciphering the role of Myc-induced cell competition in tumorigenesis

2011-07 to 2014-07 | Award
American Cancer Society (GA, GA, US)
GRANT_NUMBER:

121364-PF-11-184-01-TBG
Source: Self-asserted source
John Cunningham

Targeting 4EBP Downstream of Oncogenic Myc and PI3K/mTOR in Multiple Myeloma

2010 to 2011 | Award
Graduate Education in Medical Sciences/Clinical & Translational Science Institute (San Francisco, US)
Source: Self-asserted source
John Cunningham

Works (18)

PRPS activity tunes redox homeostasis in Myc-driven lymphoma

2025-01-13 | Preprint
DOI: 10.1101/2025.01.08.632009
Contributors: Austin C. MacMillan; Bibek Karki; Juechen Yang; Karmela R. Gertz; Samantha Zumwalde; Jay G. Patel; Maria F. Czyzyk-Krzeska; Jarek Meller; John T. Cunningham
Source: check_circle
Crossref

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma.

Cancer discovery
2024-10-31 | Journal article | Author
DOI: 10.1158/2159-8290.cd-24-0187
PMID: 39476412
Contributors: Megan Bischoff; Behrouz Shamsaei; Juechen Yang; Dina Secic; Bhargav Vemuri; Julie Reisz; Angelo D'Alessandro; Caterina Bartolacci; Rafał Adamczak; Lucas Schmidt et al.
Source: Self-asserted source
John Cunningham

Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex

2024-10-01 | Preprint
DOI: 10.1101/2024.10.01.616059
Contributors: Bibek R. Karki; Austin C. Macmillan; Sara Vicente-Muñoz; Kenneth D. Greis; Lindsey E. Romick; J. Tom Cunningham
Source: check_circle
Crossref

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma

2024-01-20 | Preprint | Author
DOI: 10.1101/2024.01.16.575895
Contributors: Megan Bischoff; Behrouz Shamsaei; Juechen Yang; Dina Secic; Bhargav Vemuri; Julie Reisz; Angelo D'Alessandro; Caterina Bartolacci; Rafał Adamczak; Lucas Schmidt et al.
Source: Self-asserted source
John Cunningham

Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma

Genes
2021-03-09 | Journal article
DOI: 10.3390/genes12030388
Contributors: Maria F. Czyzyk-Krzeska; Julio A. Landero Figueroa; Shuchi Gulati; John T. Cunningham; Jarek Meller; Behrouz ShamsaeI; Bhargav Vemuri; David R. Plas
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.

The Journal of clinical investigation
2021-01-01 | Journal article
DOI: 10.1172/jci140522
PMID: 32970633
Source: Self-asserted source
John Cunningham

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Nature medicine
2019-01-14 | Journal article
DOI: 10.1038/s41591-018-0321-2
PMID: 30643286
PMC: PMC6613562
Source: Self-asserted source
John Cunningham

Development of a stress response therapy targeting aggressive prostate cancer

Science Translational Medicine
2018-05-02 | Journal article
DOI: 10.1126/scitranslmed.aar2036
Contributors: Hao G. Nguyen; Crystal S. Conn; Yae Kye; Lingru Xue; Craig M. Forester; Janet E. Cowan; Andrew C. Hsieh; John T. Cunningham; Charles Truillet; Feven Tameire et al.
Source: check_circle
Crossref

Non-invasive measurement of mTORC1 signaling with 89Zr-transferrin

Clinical Cancer Research
2016 | Journal article
DOI: 10.1158/1078-0432.ccr-16-2448
Contributors: C. Truillet; J. T. Cunningham; M. F. L. Parker; L. T. Huynh; C. S. Conn; D. Ruggero; J. S. Lewis; M. J. Evans
Source: Self-asserted source
John Cunningham via Crossref Metadata Search

Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms

2014 | Journal article
DOI:

10.1210/me.2013-1173

EID:

2-s2.0-84896826173
Contributors: Verdeguer, F.; Blättler, S.M.; Cunningham, J.T.; Hall, J.A.; Chim, H.; Puigserver, P.
Source: Self-asserted source
John Cunningham via Scopus - Elsevier

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

Cell
2014-05-22 | Journal article
DOI:

http://dx.doi.org/10.1016/j.cell.2014.03.052
Contributors: John Cunningham
Source: Self-asserted source
John Cunningham

Investigating Myc-dependent translational regulation in normal and cancer cells

2013 | Book
DOI:

10.1007/978-1-62703-429-6-13

EID:

2-s2.0-84884165107
Contributors: Cunningham, J.T.; Pourdehnad, M.; Stumpf, C.R.; Ruggero, D.
Source: Self-asserted source
John Cunningham via Scopus - Elsevier

New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization

2013 | Journal article
DOI:

10.1158/2159-8290.CD-13-0581

EID:

2-s2.0-84885678178
Contributors: Cunningham, J.T.; Ruggero, D.
Source: Self-asserted source
John Cunningham via Scopus - Elsevier

Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle

2012 | Journal article
DOI:

10.1128/MCB.00337-12

EID:

2-s2.0-84865117354
Contributors: Blättler, S.M.; Verdeguer, F.; Liesa, M.; Cunningham, J.T.; Vogel, R.O.; Chim, H.; Liu, H.; Romanino, K.; Shirihai, O.S.; Vazquez, F. et al.
Source: Self-asserted source
John Cunningham via Scopus - Elsevier

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

2012 | Journal article
DOI:

10.1172/JCI62973

EID:

2-s2.0-84870546460
Contributors: Hart, L.S.; Cunningham, J.T.; Datta, T.; Dey, S.; Tameire, F.; Lehman, S.L.; Qiu, B.; Zhang, H.; Cerniglia, G.; Bi, M. et al.
Source: Self-asserted source
John Cunningham via Scopus - Elsevier

Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling

2012 | Journal article
DOI:

10.1016/j.cmet.2012.03.008

EID:

2-s2.0-84859452677
Contributors: Blättler, S.M.; Cunningham, J.T.; Verdeguer, F.; Chim, H.; Haas, W.; Liu, H.; Romanino, K.; Rüegg, M.A.; Gygi, S.P.; Shi, Y. et al.
Source: Self-asserted source
John Cunningham via Scopus - Elsevier

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Nature
2007-11-29 | Journal article
DOI:

http://dx.doi.org/10.1038/nature06322
Contributors: John Cunningham
Source: Self-asserted source
John Cunningham

Population genetics of resurgence: white-tailed deer in Kentucky.

The Journal of Wildlife Management
2005-01 | Journal article
DOI:

http://dx.doi.org/10.2193/0022-541X(2005)069<0345:PGORWD>2.0.CO;2
Contributors: John Cunningham
Source: Self-asserted source
John Cunningham
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