Biography

Most recent:
1: Antila S, Chilov D, Nurmi H, Li Z, Näsi A, Gotkiewicz M, Sitnikova V, Jäntti
H, Acosta N, Koivisto H, Ray J, Keuters MH, Sultan I, Scoyni F, Trevisan D,
Wojciechowski S, Kaakinen M, Dvořáková L, Singh A, Jukkola J, Korvenlaita N,
Eklund L, Koistinaho J, Karaman S, Malm T, Tanila H, Alitalo K. Sustained
meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer's
disease-related amyloid pathology. Nat Cardiovasc Res. 2024 Apr;3:474-491. doi:
10.1038/s44161-024-00445-9. Epub 2024 Mar 15. PMID: 39087029; PMCID: PMC7616318.

2: Naumenko N, Koivumäki JT, Lunko O, Tuomainen T, Leigh R, Rabiee M, Laurila J,
Oksanen M, Lehtonen S, Koistinaho J, Tavi P. Presenilin-1 ΔE9 mutation
associated sarcoplasmic reticulum leak alters [Ca²⁺]_i
distribution in human iPSC-derived cardiomyocytes. J Mol Cell Cardiol. 2024
Aug;193:78-87. doi: 10.1016/j.yjmcc.2024.06.003. Epub 2024 Jun 6. PMID:
38851626.

3: Kettunen P, Koistinaho J, Rolova T. Contribution of CNS and extra-CNS
infections to neurodegeneration: a narrative review. J Neuroinflammation. 2024
Jun 6;21(1):152. doi: 10.1186/s12974-024-03139-y. PMID: 38845026; PMCID:
PMC11157808.

4: Keuters MH, Antila S, Immonen R, Plotnikova L, Wojciechowski S, Lehtonen S,
Alitalo K, Koistinaho J, Dhungana H. The Impact of VEGF-C-Induced Dural
Lymphatic Vessel Growth on Ischemic Stroke Pathology. Transl Stroke Res. 2024
Jun 1. doi: 10.1007/s12975-024-01262-9. Epub ahead of print. PMID: 38822994.

5: Räsänen N, Tiihonen J, Koskuvi M, Lehtonen Š, Jalkanen N, Karmila N, Weert I,
Vaurio O, Ojansuu I, Lähteenvuo M, Pietiläinen O, Koistinaho J. Astrocytes
Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species-
and Donor-Specific Manner. Biol Psychiatry Glob Open Sci. 2024 Apr
3;4(4):100313. doi: 10.1016/j.bpsgos.2024.100313. PMID: 38706704; PMCID:
PMC11067005.

6: Spathopoulou A, Sauerwein GA, Marteau V, Podlesnic M, Lindlbauer T, Kipura T,
Hotze M, Gabassi E, Kruszewski K, Koskuvi M, Réthelyi JM, Apáti Á, Conti L, Ku
M, Koal T, Müller U, Talmazan RA, Ojansuu I, Vaurio O, Lähteenvuo M, Lehtonen Š,
Mertens J, Kwiatkowski M, Günther K, Tiihonen J, Koistinaho J, Trajanoski Z,
Edenhofer F. Integrative metabolomics-genomics analysis identifies key networks
in a stem cell-based model of schizophrenia. Mol Psychiatry. 2024 Apr 29. doi:
10.1038/s41380-024-02568-8. Epub ahead of print. PMID: 38684795.

7: Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu YC, Trontti K, McQuade A,
Kalyanaraman S, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S,
Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T,
Lehtonen Š, Tiihonen J, Koistinaho J. Genetic contribution to microglial
activation in schizophrenia. Mol Psychiatry. 2024 Mar 22. doi:
10.1038/s41380-024-02529-1. Epub ahead of print. PMID: 38519640.

8: Räsänen N, Tiihonen J, Koskuvi M, Lehtonen Š, Koistinaho J. The iPSC
perspective on schizophrenia. Trends Neurosci. 2021 Dec 4:S0166-2236(21)00229-0.
doi: 10.1016/j.tins.2021.11.002.

9: Rõlova T, Lehtonen Š, Goldsteins G, Kettunen P, Koistinaho J. Metabolic and
immune dysfunction of glia in neurodegenerative disorders: Focus on iPSC models.
Stem Cells. 2021 Mar;39(3):256-265. doi: 10.1002/stem.3309.

10: Oksanen M, Hyötyläinen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M,
Viitanen M, Levonen AL, Hovatta I, Roybon L, Lehtonen Š, Kanninen KM, Hämäläinen
RH, Koistinaho J. NF-E2-related factor 2 activation boosts antioxidant defenses
and ameliorates inflammatory and amyloid properties in human Presenilin-1
mutated Alzheimer's disease astrocytes. Glia. 2020 Mar;68(3):589-599. doi:
10.1002/glia.23741.

11: Konttinen H, Cabral-da-Silva MEC, Ohtonen S, Wojciechowski S, Shakirzyanova
A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia
MG, Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers
J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz
MP, Pébay A, Koistinaho J, Ooi L, Malm T. PSEN1ΔE9, APPswe, and APOE4 Confer
Disparate Phenotypes in Human iPSC-Derived Microglia. Stem Cell Reports. 2019
Oct 8;13(4):669-683. doi: 10.1016/j.stemcr.2019.08.004.

12: Tiihonen J, Koskuvi M, Storvik M, Hyötyläinen I, Gao Y, Puttonen KA,
Giniatullina R, Poguzhelskaya E, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J,
Therman S, Suvisaari J, Kaprio J, Cheng L, Hill AF, Lähteenvuo M, Tohka J,
Giniatullin R, Lehtonen Š, Koistinaho J. Sex-specific transcriptional and
proteomic signatures in schizophrenia. Nat Commun. 2019 Sep 2;10(1):3933. doi:
10.1038/s41467-019-11797-3. PMID: 31477693; PMCID: PMC6718673.