Personal information

Immunology, immunomodulation, immunometabolism, cell physiology

Activities

Employment (2)

Ludwig Institute for Cancer Research Lausanne Branch of Immunology: Epalinges, VD, CH

2016-07-01 to present | Postdoctoral fellow
Employment
Source: Self-asserted source
Romain Vuillefroy de Silly

University of Geneva: Geneva, CH

2012-05-01 to 2016-05-31 | Postdoc (Centre of Oncology - Immunobiology of brain tumors)
Employment
Source: Self-asserted source
Romain Vuillefroy de Silly

Education and qualifications (1)

INSERM U1064: Nantes, FR

2008-09-01 to 2011-10-23 | PhD Student (Center of Research in Transplantation & Immunology)
Education
Source: Self-asserted source
Romain Vuillefroy de Silly

Works (26)

Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling

The EMBO Journal
2024-09-16 | Journal article
Contributors: Romain Vuillefroy de Silly; Laetitia Pericou; Bili Seijo; Isaac Crespo; Melita Irving
Source: check_circle
Crossref

Acidity-induced dysfunction of CD8+T cells is characterized by impaired IL-2 responsiveness and perturbations to mTORC1 signaling and c-Myc levels

2023-12-16 | Preprint
Contributors: Romain Vuillefroy de Silly; Laetitia Pericou; Bili Seijo; Isaac Crespo; George Coukos; Melita Irving
Source: check_circle
Crossref

Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells

2023-05-24 | Preprint
Contributors: Yaquelin Ortiz-Miranda; Maria Masid; Cristina Jiménez-Luna; Galia Magela Montalvo Bereau; Tania Muller; Nicolas Rayroux; Elisabetta Cribioli; Jesús Corría-Osorio; Helen Carrasco Hope; Romain Vuillefroy de Silly et al.
Source: check_circle
Crossref

A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor

Nature Biomedical Engineering
2023-04-17 | Journal article
Contributors: Patrick Reichenbach; Greta Maria Paola Giordano Attianese; Khaoula Ouchen; Elisabetta Cribioli; Melanie Triboulet; Sarah Ash; Margaux Saillard; Romain Vuillefroy de Silly; George Coukos; Melita Irving
Source: check_circle
Crossref

Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy

OncoImmunology
2021-01 | Journal article
Contributors: Gaël Boivin; Pierre-Benoit Ancey; Romain Vuillefroy de Silly; Pradeep Kalambaden; Caroline Contat; Benoit Petit; Jonathan Ollivier; Jean Bourhis; Etienne Meylan; Marie-Catherine Vozenin
Source: check_circle
Crossref

Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.

2017 | Journal article
Contributors: Irving M; Vuillefroy de Silly R; Scholten K; Dilek N; Coukos G
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central

Decitabine Treatment of Glioma-Initiating Cells Enhances Immune Recognition and Killing.

2016 | Journal article
Contributors: Riccadonna C; Yacoub Maroun C; Vuillefroy de Silly R; Boehler M; Calvo Tardón M; Jueliger S; Taverna P; Barba L; Marinari E; Pellegatta S et al.
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central

Hypoxia and antitumor CD8+ T cells: An incompatible alliance?

OncoImmunology
2016-09-09 | Journal article
Contributors: Romain Vuillefroy de Silly; Pierre-Yves Dietrich; Paul R. Walker
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

Phenotypic switch of CD8(+) T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells.

2015-08 | Journal article
Contributors: Vuillefroy de Silly R; Ducimetière L; Yacoub Maroun C; Dietrich PY; Derouazi M; Walker PR
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central
grade
Preferred source (of 2)‎

Faculty of 1000 evaluation for Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

F1000 - Post-publication peer review of the biomedical literature
2015-03 | Dataset
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

Faculty of 1000 evaluation for Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.

F1000 - Post-publication peer review of the biomedical literature
2014-10 | Dataset
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

THE IMPACT OF OXYGEN TENSION ON CD8+ T CELL FUNCTION AND INTERACTION WITH GLIOMA CELLS.

2014-07 | Journal article
Contributors: Walker PR; de Silly RV; Derouazi M
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central

Faculty of 1000 evaluation for Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation.

F1000 - Post-publication peer review of the biomedical literature
2014-03 | Dataset
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

F1000Prime Recommendation

2013-10-28 | Book review | Author
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: check_circle
F1000

F1000Prime Recommendation

2013-07-16 | Book review | Author
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: check_circle
F1000

F1000Prime Recommendation

2013-04-19 | Book review | Author
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: check_circle
F1000

Inhibition of cystathionine-γ-lyase controls interleukin-12 production by dendritic cells, delayed-type hypersensitivity and transplant rejection.

2012 | Journal article
Contributors: Vuillefroy de Silly R; Coulon F; Poirier N; Jovanovic V; Brouard S; Ferchaud-Roucher V; Blancho G; Vanhove B
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central

F1000Prime Recommendation

2012-12-19 | Book review | Author
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: check_circle
F1000

F1000Prime Recommendation

2012-10-25 | Book review | Author
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: check_circle
F1000

Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.

2012-03 | Journal article
Contributors: Vuillefroy de Silly R; Coulon F; Poirier N; Jovanovic V; Brouard S; Ferchaud-Roucher V; Blancho G; Vanhove B
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central
grade
Preferred source (of 2)‎

Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance.

2012 | Journal article
Contributors: Dilek N; Vuillefroy de Silly R; Blancho G; Vanhove B
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central
grade
Preferred source (of 2)‎

Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3+)-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates

Clinical and Experimental Immunology
2011 | Journal article
EID:

2-s2.0-79953768104

Contributors: Poirier, N.; Haudebourg, T.; Brignone, C.; Dilek, N.; Hervouet, J.; Minault, D.; Coulon, F.; de Silly, R.V.; Triebel, F.; Blancho, G. et al.
Source: Self-asserted source
Romain Vuillefroy de Silly via Scopus - Elsevier

Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion.

2008-06 | Journal article
Contributors: Dugast AS; Haudebourg T; Coulon F; Heslan M; Haspot F; Poirier N; Vuillefroy de Silly R; Usal C; Smit H; Martinet B et al.
Source: Self-asserted source
Romain Vuillefroy de Silly via Europe PubMed Central

Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion

The Journal of Immunology
2008-06-03 | Journal article
Contributors: A.-S. Dugast; T. Haudebourg; F. Coulon; M. Heslan; F. Haspot; N. Poirier; R. Vuillefroy de Silly; C. Usal; H. Smit; B. Martinet et al.
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

Faculty of 1000 evaluation for Ionic immune suppression within the tumour microenvironment limits T cell effector function.

F1000 - Post-publication peer review of the biomedical literature
Dataset
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

Faculty of 1000 evaluation for Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

F1000 - Post-publication peer review of the biomedical literature
Dataset
Contributors: Paul R Walker; Romain Vuillefroy de Silly
Source: Self-asserted source
Romain Vuillefroy de Silly via Crossref Metadata Search

Peer review (33 reviews for 11 publications/grants)

Review activity for Acta neuropathologica. (1)
Review activity for Biology. (5)
Review activity for Brain sciences. (2)
Review activity for Cells. (3)
Review activity for EMBO reports. (1)
Review activity for FEBS letters. (1)
Review activity for International journal of molecular sciences. (6)
Review activity for Journal of neuroimmunology. (4)
Review activity for Pathobiology (1)
Review activity for Vaccines. (7)
Review activity for Viruses. (2)