Personal information

Emails & domains

Verified email addresses

Verified email domains

Keywords

Radiation Biology, Cancer metabolism, Head and neck cancer, Genetically engineered mouse models

Countries

United States

Biography

I am an Assistant Professor in the Department of Radiation Oncology at Baylor College of Medicine. My area of expertise includes radiation & cancer biology, cancer metabolism, and the development of genetically engineered mouse models (GEMMs) for cancer research. Recently, I developed GEMMs of human papillomavirus (HPV) positive and negative head and neck cancers using the Cre-LoxP and Sleeping Beauty Transposon system to study how HPV status affects the response to cancer therapy. I aim to develop an independent research program to (1) determine how cancer metabolism plays a role in radiation resistance and metastasis, (2) identify potential metabolic targets for pharmacological screening, (3) Investigate metabolites as prognostic markers for radioresistance or recurrence, and (4) study how different types of HPV viruses impact patient survival using GEMMs of head and neck cancers.

Activities

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Employment (4)

Baylor College of Medicine: Houston, Texas, US

2023-11 to present | Assistant Professor (Radiation Oncology)
Employment
Source: Self-asserted source
Rutulkumar Patel

Duke University: Durham, NC, US

2019-05 to 2023-11 | Postdoctoral Associate (Radiation Oncology)
Employment
Source: Self-asserted source
Rutulkumar Patel

Case Western Reserve University School of Medicine: Cleveland, OH, US

2012-07 to 2014-08 | Research Assistant - 2 (Radiation Oncology)
Employment
Source: Self-asserted source
Rutulkumar Patel

IIT Research Institute: Chicago, Illinois, US

2010-06 to 2012-06 | Biologist-1 (Cancer Biology)
Employment
Source: Self-asserted source
Rutulkumar Patel

Education and qualifications (3)

Case Western Reserve University School of Medicine: Cleveland, OH, US

2014-08 to 2019-01 | PhD in Pharmacology (Pharmacology)
Education
Source: Self-asserted source
Rutulkumar Patel

Illinois Institute of Technology: Chicago, IL, US

2007-08 to 2009-12 | MS in Molecular Biochemistry and Biophysics (Biology)
Education
Source: Self-asserted source
Rutulkumar Patel

AR College of Pharmacy and GH Patel Institute of Pharmacy: Vallabh Vidyanagar, Gujarat, IN

2003-10 to 2007-05 | Bachelor of Pharmacy
Education
Source: Self-asserted source
Rutulkumar Patel

Professional activities (11)

American Society for Radiation Oncology: Arlington, VA, US

2020 to present | Postdoctoral Fellow
Membership
Source: Self-asserted source
Rutulkumar Patel

American Association for Cancer Research: Philadelphia, PA, US

2017-10 to present | Associate Membership
Membership
Source: Self-asserted source
Rutulkumar Patel

Radiation Research Society: Bozeman, MT, US

2015-08 to present | Senior Scholar-In-Training (SIT)
Membership
Source: Self-asserted source
Rutulkumar Patel

Radiation Research Society: Bozeman, MT, US

2021-10 | Scholar-In-Training (SIT) travel award to attend the 2021 annual meeting
Distinction
Source: Self-asserted source
Rutulkumar Patel

Radiation Research Society: Bozeman, MT, US

2021-10 | Invited speaker for 67th Annual International Meeting of the Radiation Research Society 2021
Distinction
Source: Self-asserted source
Rutulkumar Patel

Radiation Research Society: Bozeman, MT, US

2020-10 | 2020 Marie Curie Award
Distinction
Source: Self-asserted source
Rutulkumar Patel

Radiation Research Society: Bozeman, MT, US

2018-10 | Scholar-In-Training (SIT) travel award to attend the 2018 annual meeting
Distinction
Source: Self-asserted source
Rutulkumar Patel

Case Western Reserve University School of Medicine: Cleveland, OH, US

2018-10 | Department of Pharmacology Student of the year 2018
Distinction
Source: Self-asserted source
Rutulkumar Patel

National Cancer Institute: Bethesda, Maryland, US

2018-05 | NCI Graduate Student Recruiting Program
Distinction
Source: Self-asserted source
Rutulkumar Patel

Radiation Research Society: Bozeman, MT, US

2017 | Scholar-In-Training (SIT) travel award to attend the 2017 Annual meeting
Distinction
Source: Self-asserted source
Rutulkumar Patel

NASA Johnson Space Center: Houston, TX, US

2015 | Certificate of outstanding achievement in the 2015 NASA Space Radiation Summer School (NASA Space Radiation School)
Distinction
Source: Self-asserted source
Rutulkumar Patel

Funding (1)

Radiosensitizing rhabdomyosarcoma by targeting metabolic vulnerabilities

Source: Self-asserted source
Rutulkumar Patel

Works (16)

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

Communications Biology
2024-05-20 | Journal article
DOI: 10.1038/s42003-024-06262-x
Contributors: Rutulkumar Patel; Daniel E. Cooper; Kushal T. Kadakia; Annamarie Allen; Likun Duan; Lixia Luo; Nerissa T. Williams; Xiaojing Liu; Jason W. Locasale; David G. Kirsch
Source: check_circle
Crossref

Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus

Journal of Clinical Investigation
2023-07-03 | Journal article
DOI: 10.1172/JCI149310
Contributors: Warren Floyd; Matthew Pierpoint; Chang Su; Rutulkumar Patel; Lixia Luo; Katherine Deland; Amy J. Wisdom; Daniel Zhu; Yan Ma; Suzanne Bartholf DeWitt et al.
Source: check_circle
Crossref

Data from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

2023-04-03 | Preprint
DOI: 10.1158/1535-7163.c.6543630
Contributors: Rutulkumar Patel; Yvonne M. Mowery; Yi Qi; Alex M. Bassil; Matt Holbrook; Eric S. Xu; Cierra S. Hong; Jonathon E. Himes; Nerissa T. Williams; Jeffrey Everitt et al.
Source: check_circle
Crossref

Data from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

2023-04-03 | Preprint
DOI: 10.1158/1535-7163.c.6543630.v1
Contributors: Rutulkumar Patel; Yvonne M. Mowery; Yi Qi; Alex M. Bassil; Matt Holbrook; Eric S. Xu; Cierra S. Hong; Jonathon E. Himes; Nerissa T. Williams; Jeffrey Everitt et al.
Source: check_circle
Crossref

Neoadjuvant radiation therapy and surgery improves metastasis-free survival over surgery alone in a primary mouse model of soft-tissue sarcoma.

Molecular cancer therapeutics
2022-09-26 | Journal article | Author
DOI: 10.1158/1535-7163.mct-21-0991
PMID: 36162051
Contributors: Rutulkumar Patel; Yvonne Mowery; Yi Qi; Alex Bassil; Matthew Holbrook; Eric Xu; Cierra S. Hong; Jonathon Himes; Nerissa Williams; Jeffrey Everitt et al.
Source: Self-asserted source
Rutulkumar Patel
grade
Preferred source (of 2)‎

Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning

Tomography
2021-08 | Journal article | Author
DOI: 10.3390/tomography7030032
Contributors: Matthew Holbrook; Darin P. Clark; Rutulkumar Patel; Yi Qi; Alex M. Bassil; Yvonne M. Mowery; Cristian T. Badea
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Metabolomics in cancer research and emerging applications in clinical oncology.

CA: a cancer journal for clinicians
2021-05-13 | Journal article
DOI: 10.3322/caac.21670
PMID: 33982817
Source: Self-asserted source
Rutulkumar Patel

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance.

Cancer discovery
2021-03-23 | Journal article
DOI: 10.1158/2159-8290.cd-20-1453
PMID: 33757970
Source: Self-asserted source
Rutulkumar Patel

Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.

Nature communications
2020-12-17 | Journal article
DOI: 10.1038/s41467-020-19917-0
PMID: 33335088
PMC: PMC7746723
Source: Self-asserted source
Rutulkumar Patel

Protons and High-Linear Energy Transfer Radiation Induce Genetically Similar Lymphomas With High Penetrance in a Mouse Model of the Aging Human Hematopoietic System.

International journal of radiation oncology, biology, physics
2020-07-04 | Journal article
DOI: 10.1016/j.ijrobp.2020.06.070
PMID: 32629081
Source: Self-asserted source
Rutulkumar Patel

Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure.

Leukemia
2018-10-01 | Journal article
DOI: 10.1038/s41375-018-0269-8
PMID: 30275527
PMC: PMC6443507
Source: Self-asserted source
Rutulkumar Patel

MMR Deficiency Does Not Sensitize or Compromise the Function of Hematopoietic Stem Cells to Low and High LET Radiation.

Stem cells translational medicine
2018-04-14 | Journal article
DOI: 10.1002/sctm.17-0295
PMID: 29656536
PMC: PMC6052615
Source: Self-asserted source
Rutulkumar Patel

Long-Term Deficits in Behavior Performances Caused by Low- and High-Linear Energy Transfer Radiation.

Radiation research
2017-09-29 | Journal article
DOI: 10.1667/rr14795.1
PMID: 28961076
Source: Self-asserted source
Rutulkumar Patel

Radiosensitization of non-small-cell lung cancer cells and xenografts by the interactive effects of pemetrexed and methoxyamine.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2016-11-09 | Journal article
DOI: 10.1016/j.radonc.2016.10.007
PMID: 27838149
Source: Self-asserted source
Rutulkumar Patel

Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.

PloS one
2013-06-10 | Journal article
DOI: 10.1371/journal.pone.0065113
PMID: 23762292
PMC: PMC3677900
Source: Self-asserted source
Rutulkumar Patel

Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.

Clinical & experimental metastasis
2013-05-05 | Journal article
DOI: 10.1007/s10585-013-9585-6
PMID: 23645347
PMC: PMC3796171
Source: Self-asserted source
Rutulkumar Patel

Peer review (5 reviews for 3 publications/grants)

Review activity for Communications medicine. (1)
Review activity for International journal of radiation oncology, biology, physics. (3)
Review activity for The Journal of experimental medicine. (1)
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