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GlaxoSmithKline

Other IDs

Scopus Author ID: 8276922400

Keywords

antibacterial, in vivo, infection, microbiology, model, pharmacodynamic, pharmacokinetic, preclinical, translation

Countries

United States

Activities

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Employment (1)

GlaxoSmithKline USA: Philadelphia, PA, US

1996-08-01 to present | Team Leader/Chief Scientist (Antibacterial Discovery Performance Unit)
Employment
Source: Self-asserted source
Jennifer Hoover

Education and qualifications (2)

West Chester University of Pennsylvania: West Chester, PA, US

1994-09-01 to 1995-06-01 | Bachelors of Science (Biology)
Education
Source: Self-asserted source
Jennifer Hoover

Texas A&M University: College Station, TX, US

1989-09-01 to 1994-06-01 | 104 credits completed (Biochemistry)
Education
Source: Self-asserted source
Jennifer Hoover

Works (50 of 51)

Items per page:
Page 1 of 2

Efficacy of Human Exposures of Gepotidacin (GSK2140944) against Escherichia coli in a Rat Pyelonephritis Model

Antimicrobial Agents and Chemotherapy
2019-05-06 | Journal article
DOI: 10.1128/aac.00086-19
Part of ISSN: 0066-4804
Part of ISSN: 1098-6596
Source: Self-asserted source
Jennifer Hoover

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

Antimicrobial Agents and Chemotherapy
2019-03-04 | Journal article
DOI: 10.1128/aac.02307-18
Part of ISSN: 0066-4804
Part of ISSN: 1098-6596
Source: Self-asserted source
Jennifer Hoover

A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii

Structure
2019-02 | Journal article
DOI: 10.1016/j.str.2018.10.021
Part of ISSN: 0969-2126
Contributors: Satya Prathyusha Bhamidimarri; Michael Zahn; Jigneshkumar Dahyabhai Prajapati; Christian Schleberger; Sandra Söderholm; Jennifer Hoover; Josh West; Ulrich Kleinekathöfer; Dirk Bumann; Mathias Winterhalter et al.
Source: Self-asserted source
Jennifer Hoover via Crossref Metadata Search

Effect of Protein Binding on the Breakpoint for Antibiotics

American Society for Clinical Pharmacology & Therapeutics
2018-03-21 | Conference poster
Source: Self-asserted source
Jennifer Hoover

A robust pneumonia model in immunocompetent rodents to evaluate antibacterial efficacy against S. Pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Journal of Visualized Experiments
2017 | Journal article
DOI: 10.3791/55068
EID:

2-s2.0-85011599340
Contributors: Hoover, J.L.; Lewandowski, T.F.; Mininger, C.L.; Singley, C.M.; Sucoloski, S.; Rittenhouse, S.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Efficacy of cefiderocol against carbapenem-resistant gram-negative bacilli in immunocompetent-rat respiratory tract infection models recreating human plasma pharmacokinetics

Antimicrobial Agents and Chemotherapy
2017 | Journal article
DOI: 10.1128/AAC.00700-17
EID:

2-s2.0-85028329370
Contributors: Matsumoto, S.; Singley, C.M.; Hoover, J.; Nakamura, R.; Echols, R.; Rittenhouse, S.; Tsuji, M.; Yamano, Y.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Pharmacokinetic-pharmacodynamic evaluation of gepotidacin against gram-positive organisms using data from murine infection models

Antimicrobial Agents and Chemotherapy
2017 | Journal article
DOI: 10.1128/AAC.00115-16
EID:

2-s2.0-85010987703
Contributors: Bulik, C.C.; Okusanya, Ó.O.; Lakota, E.A.; Forrest, A.; Bhavnani, S.M.; Hoover, J.L.; Andes, D.R.; Ambrose, P.G.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Reducing antibacterial development risk for GSK1322322 by exploring potential human dose regimens in nonclinical efficacy studies using immunocompetent rats

Antimicrobial Agents and Chemotherapy
2017 | Journal article
DOI: 10.1128/AAC.00959-17
EID:

2-s2.0-85032509341
Contributors: Hoover, J.L.; Singley, C.M.; Elefante, P.; DeMarsh, P.; Zalacain, M.; Rittenhouse, S.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Real time monitoring of drugs in the body with potential for feedback controlled drug delivery

Solutions for Antimicrobial Resistance
2017-08-17 | Other
Source: Self-asserted source
Jennifer Hoover

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
DOI: 10.1016/j.bmcl.2016.03.106
EID:

2-s2.0-84978328258
Contributors: Miles, T.J.; Hennessy, A.J.; Bax, B.; Brooks, G.; Brown, B.S.; Brown, P.; Cailleau, N.; Chen, D.; Dabbs, S.; Davies, D.T. et al.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Pharmacokinetics/pharmacodynamics of peptide deformylase inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in rodent models of infection

Antimicrobial Agents and Chemotherapy
2016 | Journal article
DOI: 10.1128/AAC.01842-15
EID:

2-s2.0-84957877148
Contributors: Hoover, J.; Lewandowski, T.; Straub, R.J.; Novick, S.J.; DeMarsh, P.; Aubart, K.; Rittenhouse, S.; Zalacain, M.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Predicting Clinical Doses Based on Exposure-Response Modeling of Static Time-Kill Data

American Conference of Pharmacometrics
2016 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Evaluation of the Pharmacokinetics-Pharmacodynamics (PK-PD) of GSK2140944 (‘944) Against Staphylococcus aureus (SA) and Streptococcus pneumoniae (SP) in a Murine Thigh-Infection Model

54th Interscience Conference of Antimicrobial Agents and Chemotherapy
2014 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Efficacy of GSK2140944 against Streptococcus pneumoniae in a Non-Neutropenic Mouse Lung Infection Model

53rd Interscience Conference of Antimicrobial Agents and Chemotherapy
2013 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Bioorganic and Medicinal Chemistry Letters
2013 | Journal article
DOI: 10.1016/j.bmcl.2013.07.013
EID:

2-s2.0-84883487976
Contributors: Miles, T.J.; Hennessy, A.J.; Bax, B.; Brooks, G.; Brown, B.S.; Brown, P.; Cailleau, N.; Chen, D.; Dabbs, S.; Davies, D.T. et al.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Pharmacokinetics/Pharmacodynamics (PK/PD) of Peptide Deformylase (PDF) Inhibitor GSK1322322 (GSK322) against Staphylococcus aureus in a Rat Abscess Model

23rd European Congress of Clinical Microbiology and Infectious Diseases
2013 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Evaluation of the Pharmacokinetics-Pharmacodynamics of GSK2251052 Against Gram-Negative Bacilli in a Murine-Thigh Infection Model

52nd Interscience Conference of Antimicrobial Agents and Chemotherapy
2012 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Evaluation of the Pharmacokinetics-Pharmacodynamics of GSK2251052 Against Gram-Negative Bacilli Using Data from a Neutropenic Murine-Pneumonia Infection Model

52nd Interscience Conference of Antimicrobial Agents and Chemotherapy
2012 | Conference poster
Source: Self-asserted source
Jennifer Hoover

GSK2251052, a novel LeuRS inhibitor, is effective against multi-drug resistant Pseudomonas aeruginosa in a mouse pneumonia model

52nd Interscience Conference of Antimicrobial Agents and Chemotherapy
2012 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Pharmacokinetics/Pharmacodynamics (PK/PD) of peptide deformylase (PDF) inhibitor GSK1322322 (GSK322) against Streptococcus pneumoniae in a mouse pneumonia model

52nd Interscience Conference of Antimicrobial Agents and Chemotherapy
2012 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Dose Ranging Studies with the LeuRS Inhibitor GSK2251052 against Escherichia coli in a Mouse Thigh Suture Infection Model

51st Interscience Conference of Antimicrobial Agents and Chemotherapy
2011 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Efficacy of a LeuRS Inhibitor GSK2251052 Against Enterobacteriaceae Isolates Using a Computer-Controlled Infusion System to Recreate Human PK Profiles in Rats

21st European Congress of Clinical Microbiology and Infectious Diseases
2011 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Efficacy of a LeuRS Inhibitor GSK2251052 against Pseudomonas aeruginosa using a computer-controlled infusion system to recreate human exposure profiles in rats

51st Interscience Conference of Antimicrobial Agents and Chemotherapy
2011 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

Bioorganic and Medicinal Chemistry Letters
2011 | Journal article
DOI: 10.1016/j.bmcl.2011.09.117
EID:

2-s2.0-81255208413
Contributors: Miles, T.J.; Axten, J.M.; Barfoot, C.; Brooks, G.; Brown, P.; Chen, D.; Dabbs, S.; Davies, D.T.; Downie, D.L.; Eyrisch, S. et al.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

Bioorganic and Medicinal Chemistry Letters
2011 | Journal article
DOI: 10.1016/j.bmcl.2011.09.114
EID:

2-s2.0-81255157631
Contributors: Miles, T.J.; Barfoot, C.; Brooks, G.; Brown, P.; Chen, D.; Dabbs, S.; Davies, D.T.; Downie, D.L.; Eyrisch, S.; Giordano, I. et al.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Antibacterial drug discovery in the age of resistance

Microbe
2010 | Journal article
EID:

2-s2.0-79952950158
Contributors: Benowitz, A.B.; Hoover, J.L.; Payne, D.J.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Efficacy of PDF inhibitor GSK1322322 against abscess infections caused by MRSA using a computer-controlled infusion system to recreate human PK profiles in rats

50th Interscience Conference of Antimicrobial Agents and Chemotherapy
2010 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Selection of a lung infection model to predict efficacy in community-acquired pneumonia (CAP) caused by S. pneumoniae (SP).

47th Interscience Conference of Antimicrobial Agents and Chemotherapy
2007 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Construction of an isogenic pair of CA-MRSA strains containing and lacking the Panton-Valentine leukocidin and their assessment in a rabbit suture wound infection model

106th ASM General Meeting
2006 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic

Antimicrobial Agents and Chemotherapy
2006 | Journal article
DOI: 10.1128/AAC.00183-06
EID:

2-s2.0-33750584520
Contributors: Rittenhouse, S.; Singley, C.; Hoover, J.; Page, R.; Payne, D.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Comparative bacteriological efficacy of pharmacokinetically enhanced amoxicillin-clavulanate against Streptococcus pneumoniae with elevated amoxicillin MICs and Haemophilus influenzae

Antimicrobial Agents and Chemotherapy
2005 | Journal article
DOI: 10.1128/AAC.49.3.908-915.2005
EID:

2-s2.0-14744279816
Contributors: Berry, V.; Hoover, J.; Singley, C.; Woodnutt, G.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Efficacy of retapamulin administered topically against methicillin, mupirocin and multi-drug resistant strains of S. aureus in a murine wound infection model

45th Interscience Conference of Antimicrobial Agents and Chemotherapy
2005 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Efficacy of a pharmacokinetically-enhanced formulation of amoxicillin/clavulanate against experimental respiratory tract infection in rats caused by Haemophilus influenzae

12th European Congress of Clinical Microbiology and Infectious Diseases
2002 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Efficacy of a pharmacokinetically-enhanced formulation of amoxicillin/clavulanate against experimental respiratory tract infection (RTI) in rats caused by Streptococcus pneumoniae (Sp).

41st Interscience Conference of Antimicrobial Agents and Chemotherapy
2001 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin (SB-265805) against experimental gram negative pyelonephritis infection in rats

3rd European Congress of Chemotherapy
2000 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin (SB-265805) against experimental respiratory tract infections in rats caused by strains of S. pneumoniae resistant to major classes of antibiotics

3rd European Congress of Chemotherapy
2000 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin against experimental respiratory tract infection (RTI) in rats caused by Streptococcus pneumoniae

40th Interscience Conference of Antimicrobial Agents and Chemotherapy
2000 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin in experimental models of pyelonephritis and wound infection

Journal of Antimicrobial Chemotherapy
2000 | Journal article
EID:

2-s2.0-0034128350
Contributors: Berry, V.; Page, R.; Satterfield, J.; Singley, C.; Straub, R.; Woodnutt, G.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Comparative in vivo activity of gemifloxacin in a rat model of respiratory tract infection

Journal of Antimicrobial Chemotherapy
2000 | Journal article
EID:

2-s2.0-0034043739
Contributors: Berry, V.; Page, R.; Satterfield, J.; Singley, C.; Straub, R.; Woodnutt, G.
Source: Self-asserted source
Jennifer Hoover via Scopus - Elsevier

Evaluation of the pharmacodynamics of amoxicillin/clavulanate (AMX/CA) against H. influenzae

10th European Congress of Clinical Microbiology and Infectious Diseases
2000 | Conference poster
Source: Self-asserted source
Jennifer Hoover

In vivo efficacy of the novel oral pleuromutilin, SB-264128

40th Interscience Conference on Antimicrobial Agents and Chemotherapy
2000 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Mutilin 14-sulfanylacetates – Derivatives of pleuromutilin for the treatment of respiratory tract and skin and soft tissue infections

Royal Society of Chemistry – Recent advances in the medicinal chemistry of anti-infective agents
2000 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin (SB-265805) against experimental respiratory tract infection in rats caused by ciprofloxacin resistant strains of Streptococcus pneumoniae and Haemophilus influenzae

39th Interscience Conference of Antimicrobial Agents & Chemotherapy
1999 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin against experimental respiratory tract infections in rats caused by Haemophilus influenzae

21st International Congress of Chemotherapy
1999 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin against experimental respiratory tract infections in rats caused by Haemophilus influenzae

European Respiratory Society
1999 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Comparative efficacy of gemifloxacin against experimental respiratory tract infections in rats caused by Streptococcus pneumoniae

21st International Congress of Chemotherapy
1999 | Conference poster
Source: Self-asserted source
Jennifer Hoover

In vivo efficacy of the novel topical pleuromutilins, SB-247386 and SB-268091

39th Interscience Conference of Antimicrobial Agents & Chemotherapy
1999 | Conference poster
Source: Self-asserted source
Jennifer Hoover

The use of genetic approaches to identify novel antibacterial targets from the P. aeruginosa genome

Pseudomonas '99 – Biotechnology and Pathogenesis
1999 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Evaluation of a reduced dosing schedule of amoxicillin/clavulanate against H. influenzae

38th Interscience Conference of Antimicrobial Agents & Chemotherapy
1998 | Conference poster
Source: Self-asserted source
Jennifer Hoover

Isolation of Pseudomonas aeruginosa mutants with attenuated virulence by signature-tagged mutagenesis (STM).

98th ASM General Meeting
1998 | Conference poster
Source: Self-asserted source
Jennifer Hoover
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