Personal information

Computational Biology, Cancer, Bioinformatics, Cancer genomics, Next-generation sequencing data analysis
Brazil, United Kingdom

Biography

Jacqueline is a PhD student at the Wellcome Sanger Institute and the University of Cambridge. Before starting her doctoral studies, she worked as a bioinformatician for a year in Dr. David Adams' Experimental Cancer Genetics group at the Wellcome Sanger Institute. Jacqueline obtained a BSc degree in Molecular Sciences from the University of São Paulo (USP) and carried out undergraduate-level research in the Laboratory of Neurobiology and Stem Cells of the Institute of Biomedical Sciences of USP, under the supervision of Dr. Marilene H. Lopes. As the Sanger Prize 2021 winner, Jacqueline worked as a visiting researcher for 3 months in Dr. Sarah Teichmann's lab.

Activities

Employment (3)

Wellcome Sanger Institute: Cambridge, Cambridgeshire, GB

2022-10-03 to 2023-09-30 | Bioinformatician (Experimental Cancer Genetics Group; Cancer, Ageing and Somatic Mutation Programme)
Employment
Source: Self-asserted source
Jacqueline Marcia Boccacino

Wellcome Sanger Institute: Cambridge, Cambridgeshire, GB

2022-04 to 2022-07 | Visiting Researcher (Teichmann Lab; Cellular Genetics Programme)
Employment
Source: Self-asserted source
Jacqueline Marcia Boccacino

University of São Paulo: São Paulo, São Paulo (SP), BR

2020-01 to 2022-07 | Research Student (Department of Cell and Developmental Biology, Institute of Biomedical Sciences)
Employment
Source: Self-asserted source
Jacqueline Marcia Boccacino

Education and qualifications (2)

University of Cambridge: Cambridge, Cambridgeshire, GB

2023-10-01 to 2027-09-30 | PhD in Biological Science (Wellcome Sanger Institute)
Education
Source: Self-asserted source
Jacqueline Marcia Boccacino

University of São Paulo: São Paulo, São Paulo (SP), BR

2018-08 to 2022-08 | BSc in Molecular Sciences
Education
Source: Self-asserted source
Jacqueline Marcia Boccacino

Professional activities (6)

American Society for Biochemistry and Molecular Biology: Rockville, US

2022-02 to present | Student
Membership
Source: Self-asserted source
Jacqueline Marcia Boccacino

American Society for Cell Biology: Bethesda, Maryland, US

2020-12 to present | Undergraduate member
Membership
Source: Self-asserted source
Jacqueline Marcia Boccacino

Sociedade Brasileira de Biologia Celular: São Paulo, São Paulo, BR

2020-10 to present | Student member
Membership
Source: Self-asserted source
Jacqueline Marcia Boccacino

American Association for Cancer Research: Philadelphia, PA, US

2020-12 to 2022-06 | Student member
Membership
Source: Self-asserted source
Jacqueline Marcia Boccacino

Wellcome Sanger Institute: Hinxton, Cambridgeshire, GB

2021 | Sanger Prize
Distinction
Source: Self-asserted source
Jacqueline Marcia Boccacino

Human Cell Atlas: Cambridge, GB

2021 | Selected for a flash talk presentation at the Developmental and Pediatric Cell Atlas Meeting
Distinction
Source: Self-asserted source
Jacqueline Marcia Boccacino

Funding (2)

Evaluation of transcript levels of PrPC downstream targets and intracellular signaling pathways in glioblastoma stem cells

2020-08 to 2022-07 | Grant
Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo, BR)
GRANT_NUMBER:

2020/07450-5

Part of GRANT_NUMBER:

2018/15557-4

Source: Self-asserted source
Jacqueline Marcia Boccacino

In silico analysis of the expression of cellular prion protein (PrPC) and ligands in samples of patients with glioblastoma in treatment with temozolomide (TMZ)

2020-02 to 2020-07 | Grant
Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasília, BR)
GRANT_NUMBER:

101796/2020-0

Source: Self-asserted source
Jacqueline Marcia Boccacino

Works (12)

Single-cell integration reveals metaplasia in inflammatory gut diseases

Nature
2024-11-21 | Journal article | Author
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Amanda Jane Oliver; Ni Huang; Bartolomé-Casado R.; Ruoyan Li; Simon Koplev; Hogne R. Nilsen; Madelyn Moy; Batuhan Cakir; Krzysztof Polański; Victoria Gudiño et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Exploring the driver events of eccrine poromas and porocarcinomas: A retrospective, cross-institutional study of 54 cases

British Journal of Dermatology
2024-11-15 | Journal article
Part of ISSN: 0007-0963
Part of ISSN: 1365-2133
Contributors: Mark J Arends; Martin Del Castillo Velasco-Herrera; Saamin Cheema; Kim Wong; Jacqueline M Boccacino; Ian Vermes; Kirsty Roberts; Elizabeth Anderson; Michiel P J van der Horst; Nicolas de Saint Aubain et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Exploration of the mutational landscape of cutaneous leiomyoma confirms <i>FH</i> as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy

British Journal of Dermatology
2024-11-07 | Journal article
Part of ISSN: 0007-0963
Part of ISSN: 1365-2133
Contributors: Louise van der Weyden; Martin Del Castillo Velasco-Herrera; Saamin Cheema; Kim Wong; Jacqueline M Boccacino; Ian Vermes; Victoria Offord; Alastair Droop; David R A Jones; Elizabeth Anderson et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Activation of Wnt/β-catenin signalling by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary gland basal cell adenoma

2024-10-24 | Preprint
Contributors: Kim Wong; Justin A. Bishop; Ilan Weinreb; Marialetizia Motta; Martin Del Castillo Velasco-Herrera; Emanuele Bellacchio; Ingrid Ferreira; Louise van der Weyden; Jacqueline M. Boccacino; Giovannina Rotundo et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma

British Journal of Dermatology
2024-10-11 | Journal article
Part of ISSN: 0007-0963
Part of ISSN: 1365-2133
Contributors: Louise van der Weyden; Martin Del Castillo Velasco-Herrera; Saamin Cheema; Kim Wong; Jacqueline M Boccacino; Victoria Offord; Alastair Droop; David R A Jones; Ian Vermes; Elizabeth Anderson et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

Nature
2024-06-19 | Journal article | Author
Contributors: Rik G.H. Lindeboom; Kaylee Worlock; Lisa M. Dratva; Masahiro Yoshida; David Scobie; Helen Wagstaffe; Laura Richardson; Anna Wilbrey; Josephine L Barnes; Krzysztof Polański et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas

BMC Cancer
2024-02-13 | Journal article
Part of ISSN: 1471-2407
Contributors: Jacqueline Marcia Boccacino; Rafael dos Santos Peixoto; Camila Felix de Lima Fernandes; Giovanni Cangiano; Paula Rodrigues Sola; Bárbara Paranhos Coelho; Mariana Brandão Prado; Maria Isabel Melo-Escobar; Breno Pereira de Sousa; Shamini Ayyadhury et al.
Source: Self-asserted source
Jacqueline Marcia Boccacino

Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression

Frontiers in Cell and Developmental Biology
2022-06-15 | Journal article
Source: Self-asserted source
Jacqueline Marcia Boccacino

Extracellular vesicles throughout development: a potential roadmap for emerging glioblastoma therapies

Seminars in Cell &amp; Developmental Biology
2022-06-10 | Journal article
Source: Self-asserted source
Jacqueline Marcia Boccacino

Multifaceted WNT signaling at the crossroads between epithelial-mesenchymal transition and autophagy in glioblastoma

Frontiers in Oncology
2020-11-12 | Journal article
Source: Self-asserted source
Jacqueline Marcia Boccacino

A New Take on Prion Protein Dynamics in Cellular Trafficking

International Journal of Molecular Sciences
2020-10-20 | Journal article
Contributors: Rodrigo Nunes Alves; Rebeca Piatniczka Iglesia; Mariana Brandão Prado; Maria Isabel Melo Escobar; Jacqueline Marcia Boccacino; Camila Felix de Lima Fernandes; Bárbara Paranhos Coelho; Ailine Cibele Fortes; Marilene Hohmuth Lopes
Source: check_circle
Crossref
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Prion Protein at the Leading Edge: Its Role in Cell Motility

International Journal of Molecular Sciences
2020-09-12 | Journal article
Contributors: Mariana Brandão Prado; Maria Isabel Melo Escobar; Rodrigo Nunes Alves; Bárbara Paranhos Coelho; Camila Felix de Lima Fernandes; Jacqueline Marcia Boccacino; Rebeca Piatniczka Iglesia; Marilene Hohmuth Lopes
Source: check_circle
Crossref
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Preferred source (of 3)‎