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Biography

I am a physician/scientist with considerable surgical and research experience. My work as a trauma surgeon at Abu Salim Trauma Hospital affiliated with University of Tripoli honed my surgical skills. My research experience began in the laboratory of Dr. Fanburg at Tufts Medical Center, Boston, where I developed proficiency in several biomedical research techniques. My research interests have evolved to focus on understanding and limiting the complications associated with medical devices used to support children with heart or lung failure, including cardiopulmonary bypass (CPB), extracorporeal membrane oxygenation (ECMO), and central venous catheters (CVC). I’ve been collaborating with Drs. James Tweddell, David Morales, Farhan Zafar and Joseph Palumbo on projects related to ECMO and CPB. This work includes developing a variety of clinically relevant animal models to help further our understanding of the hemostasis/thrombosis and inflammatory related complications associated with ECMO and CPB, and to test novel therapeutic targets for mitigation of ECMO/CPB-induced pathologies. To this end, I have developed clinically relevant murine, rat and rabbit models of complete veno-arterial ECMO, and rat and rabbit models of CPB. The proposed studies build upon my research experience and surgical skills to define interventions to decrease life-threatening coagulation associated with extracorporeal life support.

Activities

Employment (1)

Cincinnati Children's Hospital Medical Center: Cincinnati, OH, US

2019-09-30 to present | Research Fellow (Heart Institute. Cardio-Thoracic Surgery)
Employment
Source: Self-asserted source
Mousa Kharnaf

Education and qualifications (1)

University of Tripoli: Tripoli, Libya, LY

MBBS
Education
Source: Self-asserted source
Mousa Kharnaf

Works (6)

Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation

The Journal of Thoracic and Cardiovascular Surgery
2024-08 | Journal article
Contributors: Mousa Kharnaf; Farhan Zafar; Spencer Hogue; Leah Rosenfeldt; Rachel L. Cantrell; Bal Krishan Sharma; Amelia Pearson; Cassandra Sprague; Daniel Leino; William A. Abplanalp et al.
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Crossref

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation

Blood Advances
2023-04-25 | Journal article
Contributors: James S. Tweddell; Mousa Kharnaf; Farhan Zafar; Kyle W. Riggs; James A. Reagor; Brett P. Monia; Alexey Revenko; Daniel G. Leino; A. Phillip Owens, III; Janine K. Martin et al.
Source: check_circle
Crossref

A Murine Model of Veno-Arterial Extracorporeal Membrane Oxygenation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)
2022-10-11 | Journal article | Author
Contributors: Mousa Kharnaf; Hogue S; Wilkes Z; Reagor JA; Leino DG; Gourley B; Rosenfeldt L; Ma Q; Devarajan P; Palumbo JS et al.
Source: Self-asserted source
Mousa Kharnaf
grade
Preferred source (of 2)‎

Contact factors as a potential therapeutic target in the management of Extracorporeal membrane oxygenation: Results from In vitro and In vivo experiments

101st Annual Meeting Featuring Aortic Symposium and Mitral Conclave
2021-04-30 | Conference abstract
Source: Self-asserted source
Mousa Kharnaf

Transglutaminase 2 in Pulmonary and Cardiac Tissue Remodeling in Experimental Pulmonary Hypertension

American Journal of Respiratory Cell and Molecular Biology.
2017-08-01 | Journal article
Source: Self-asserted source
Mousa Kharnaf

Glycolysis-Induced Transglutaminase 2 Regulates Tissue Fibrosis in Pulmonary Hypertension

American Thoracic Society-FROM TARGETS TO THERAPIES IN FIBROSIS
2017-05-01 | Conference abstract
Source: Self-asserted source
Mousa Kharnaf