Personal information

Biography

I was born in Inner Mongolia, China. I earned a Bachelor of Science Degree in Zoology from Inner Mongolia University and a Master of Science Degree in Hydrobiology from the Chinese Academy of Sciences. Then I worked at the academy for 6 years, including 4 years at the Institute of Hydrobiology (Wuhan) studying parasitic protozoa and 2 years at the Institute of Zoology (Beijing) studying spiders. In 1991, I went to the City University of New York (CUNY) to pursue my doctoral study in biology under the advisor Dr. John J. Lee, a well-known marine microbiologist. Then I continued my academic journey at Harvard University as a postdoctoral research fellow studying cardiac aging in Dr. Jeanne Y. Wei’s Lab(1998-2001). In November 2001, I was recruited by the US Department of Veterans Affairs (VA) as an Associate Investigator working with Dr. Andrzej S. Tarnawski initially and became a Principal Investigator in 2004. Meantime, I was also a faculty at the University of California, School of Medicine in Irvine till 2016. During this period, I established the Laboratory of Gastrointestinal Injury and Cancer at Long Beach VA Healthcare System, studying digestive diseases, particularly esophageal cancer biology. After residing in the United States for a quarter of a century, I decided to move back to my hometown (Baotou, China), and make some scientific contributions to the local people. To date, I have published 8 books and dozens of research articles on various subjects, and mentored dozens of graduate students.

Activities

Employment (3)

Baotou Medical College: Baotou, CN

2016-08-01 to present | Professor
Employment
Source: Self-asserted source
Jianyuan Chai

VA Long Beach Healthcare System: Long Beach, CA, US

2001-11-16 to 2016-07-31 | Principal Investigator
Employment
Source: Self-asserted source
Jianyuan Chai

Chinese Academy of Sciences: Beijing, CN

1985-09-01 to 1991-08-31 | Assistant Research Professor
Employment
Source: Self-asserted source
Jianyuan Chai

Education and qualifications (4)

Harvard University: Cambridge, MA, US

1998-09-01 to 2001-11-15 | Postdoctoral Fellow
Education
Source: Self-asserted source
Jianyuan Chai

City University of New York: NY, NY, US

1991-09-01 to 1998-08-31 | Ph.D.
Education
Source: Self-asserted source
Jianyuan Chai

Chinese Academy of Sciences: Beijing, CN

1982-09-01 to 1985-08-31 | Masters of Science
Education
Source: Self-asserted source
Jianyuan Chai

Inner Mongolia University: Hohhot, CN

1978-09-01 to 1982-08-31 | Bachelors of Science
Education
Source: Self-asserted source
Jianyuan Chai

Works (50 of 63)

Items per page:
Page 1 of 2

CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma

Scientific Reports
2025-01-13 | Journal article | Conceptualization, Data curation, Writing - review & editing
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai

Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma

Journal of Cell Communication and Signaling
2024-07-02 | Journal article | Author
Part of ISSN: 1873-9601
Part of ISSN: 1873-961X
Contributors: Ruize Xu; Zhenyu Jiang; Xianmei Meng; Lingling Xing; Wula Aladan; Baoxing Chi; Tong Dang; Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai

Mouse auditory cortex sub-fields receive neuronal projections from MGB subdivisions independently

Scientific Reports
2024-03-25 | Journal article
Part of ISSN: 2045-2322
Contributors: Chi Wang; Zhen-yu Jiang; Jian-yuan Chai; Hong-suo Chen; Li-xia Liu; Tong Dang; Xian-mei Meng
Source: Self-asserted source
Jianyuan Chai

Gastroesophageal Reflux Disease - A Growing Concern

IntechOpen
2023-05-24 | Edited book
Source: Self-asserted source
Jianyuan Chai

Introductory Chapter: Do We Really Know GERD?

Gastroesophageal Reflux Disease - A Growing Concern
2023-05-24 | Book chapter
Part of ISBN: 9781803559575
Part of ISBN: 9781803559582
Contributors: Xianmei Meng; Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai

The Application of Probe-Based Confocal Laser Endomicroscopy as a Diagnostic Tool in Choledochoscopic Gallbladder-Preserving Surgery.

Digestive diseases (Basel, Switzerland)
2022-09-05 | Journal article
Contributors: Tang B; Jia Y; Dang T; Chai J; Wang Q; Chang Z; Han W; Li X; Ma Y
Source: Self-asserted source
Jianyuan Chai

Peptic Ulcer Disease - What's New?

IntechOpen
2022-08-25 | Book | Writing - review & editing
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai

TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the “enemy” a friend

Archives of Biochemistry and Biophysics
2022-06 | Journal article
Part of ISSN: 0003-9861
Source: Self-asserted source
Jianyuan Chai

CCN1 suppresses cell proliferation of esophageal squamous cell carcinoma through amyloid precursor protein without DR6 participation.

Cellular signalling
2022-05-30 | Journal article
Contributors: Wang P; Chang Z; Meng J; Cui X; Chai J; Dang T
Source: Self-asserted source
Jianyuan Chai

The role of CCN1 in esophageal adenocarcinoma: What we have learned from the lab

Cancer Control
2022-03-16 | Journal article
Source: Self-asserted source
Jianyuan Chai

TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma

Cytokine
2022-01 | Journal article
Part of ISSN: 1043-4666
Source: Self-asserted source
Jianyuan Chai

Introductory Chapter: Celiac Disease - Now and Then

Celiac Disease
2021-05-12 | Book chapter
Source: Self-asserted source
Jianyuan Chai

Celiac Disease

InTechOpeb
2021-05-01 | Edited book
Source: Self-asserted source
Jianyuan Chai

From Apoptosis to Necroptosis: The Death Wishes to Cancer

Cancer Control
2021-01 | Journal article
Part of ISSN: 1073-2748
Part of ISSN: 1073-2748
Source: Self-asserted source
Jianyuan Chai

Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation

Experimental Cell Research
2020-11 | Journal article
Part of ISSN: 0014-4827
Source: Self-asserted source
Jianyuan Chai

Molecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?

Current Cancer Drug Targets
2020-11-02 | Journal article
Part of ISSN: 1568-0096
Source: Self-asserted source
Jianyuan Chai

Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure

Digestive and Liver Disease
2020-10 | Journal article
Part of ISSN: 1590-8658
Source: Self-asserted source
Jianyuan Chai

Long non-coding RNA HNF1A-AS1 upregulates OTX1 to enhance angiogenesis in colon cancer via the binding of transcription factor PBX3

Experimental Cell Research
2020-08 | Journal article
Part of ISSN: 0014-4827
Source: Self-asserted source
Jianyuan Chai

Acid/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR

The International Journal of Biochemistry & Cell Biology
2020-05 | Journal article
Part of ISSN: 1357-2725
Source: Self-asserted source
Jianyuan Chai

Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFkB activation

Cytokine
2019-01 | Journal article
Source: Self-asserted source
Jianyuan Chai

Esophageal Cancer and Beyond

IntechOpen
2018 | Book
Source: Self-asserted source
Jianyuan Chai

Stomach Disorders

IntechOpen
2018 | Book
Source: Self-asserted source
Jianyuan Chai

CCN1 induces apoptosis in esophageal adenocarcinoma through p53‐dependent downregulation of survivin

Journal of Cellular Biochemistry
2018-12-14 | Journal article
Source: Self-asserted source
Jianyuan Chai

Introductory Chapter: Esophagus and Esophageal Cancer

Esophageal Cancer and Beyond
2018-11-07 | Book chapter
Source: Self-asserted source
Jianyuan Chai

Introductory Chapter: Stomach-Beyond Digestion

Stomach Disorders
2018-01-10 | Book chapter
Source: Self-asserted source
Jianyuan Chai

Effectiveness and Safety of the Combination of the Traditional Chinese Medicine Prescription Jade Screen and Desloratadine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Evidence-Based Complementary and Alternative Medicine
2017 | Journal article
Part of ISSN: 1741-427X
Part of ISSN: 1741-4288
Source: Self-asserted source
Jianyuan Chai

Esophageal Abnormalities

IntechOpen
2017-11 | Book
Source: Self-asserted source
Jianyuan Chai

CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis

Experimental Cell Research
2017-10-18 | Journal article
Source: Self-asserted source
Jianyuan Chai

Validity of Markers for Epithelial Cells and Mesenchymal Cells

Stem Cells and Cancer Stem Cells, Volume 10
2013 | Other
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Research Directions in Tumor Angiogenesis

2013-02-06 | Book
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Roles of SRF in Endothelial Cells During Hypoxia

Research Directions in Tumor Angiogenesis
2013-02-06 | Other
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Esophageal malignancy: A growing concern

World Journal of Gastroenterology
2012 | Journal article
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

S100A4 in esophageal cancer: Is this the one to blame?

World Journal of Gastroenterology
2012 | Journal article
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

253 Integrin α11 Mediates CCN1-Induced -Catenin Translocation in Esophageal Squamous Cell Carcinoma

Gastroenterology
2012-05 | Journal article
Contributors: M. Mazen Jamal; Manith Norng; Jennifer Pham; Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Tu1132 Dynamic Expression of CCN1 During Esophageal Malignancy

Gastroenterology
2012-05 | Journal article
Contributors: M. Mazen Jamal; Yi Ouyang; Manith Norng; Jennifer Pham; Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Gastric Ulcer Healing – Role of Serum Response Factor

Peptic Ulcer Disease
2011-11-04 | Other
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Peptic Ulcer Disease

2011-11-04 | Book
Contributors: Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

Serum response factor: Look into the gut

World Journal of Gastroenterology
2010 | Journal article
Part of ISSN: 1007-9327
Source: Self-asserted source
Jianyuan Chai

W1891 Epithelial or Mesenchymal: Where to Draw the Line?

Gastroenterology
2010-05 | Journal article
Contributors: Cristina Modak; Jennifer Pham; Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells

Laboratory Investigation
2010-05-10 | Journal article
Contributors: Jianyuan Chai; Manith Norng; Cristina Modak; Kevin M Reavis; Wasim Mouazzen; Jennifer Pham
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

CCN1 is critical for acid-induced esophageal epithelial cell transformation

Biochemical and Biophysical Research Communications
2010-02 | Journal article
Part of ISSN: 0006-291X
Source: Self-asserted source
Jianyuan Chai
grade
Preferred source (of 2)‎

Potential of casein kinase I in digestive cancer screening

World Journal of Gastrointestinal Oncology
2009 | Journal article
Part of ISSN: 1948-5204
Source: Self-asserted source
Jianyuan Chai

SRF Protects Brain Endothelial Cells Against Hypoxic Damage

Circulation
2009 | Journal article
Source: Self-asserted source
Jianyuan Chai

Roles of Casein Kinase I η and δ in Gastrointestinal Cancers: Potential New Screening Markers and Drug Targets

Current Cancer Therapy Reviews
2009-08-01 | Journal article
Contributors: Cristina Modak; Jianyuan Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

T1965 Low pH Induces Epithelial-Mesenchymal Transition in Esophageal Squamous Cells - Role of Cyr61

Gastroenterology
2008-04 | Journal article
Contributors: Jianyuan Chai; Manith Norng; Jasmine Chai
Source: Self-asserted source
Jianyuan Chai via Crossref Metadata Search

A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats

Gut
2007-05-01 | Journal article
Part of ISSN: 0017-5749
Source: Self-asserted source
Jianyuan Chai

Novel Roles of Local Insulin-Like Growth Factor-1 Activation in Gastric Ulcer Healing

The American Journal of Pathology
2007-04 | Journal article
Part of ISSN: 0002-9440
Source: Self-asserted source
Jianyuan Chai

TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells—Mechanisms behind a possible new “hot” cancer treatment

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2007-04 | Journal article
Part of ISSN: 0167-4889
Source: Self-asserted source
Jianyuan Chai

Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells

World Journal of Gastroenterology
2006 | Journal article
Part of ISSN: 1007-9327
Source: Self-asserted source
Jianyuan Chai

Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF‐induced angiogenesis

The FASEB Journal
2004-08 | Journal article
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Jianyuan Chai
Items per page:
Page 1 of 2

Peer review (11 reviews for 8 publications/grants)

Review activity for Biochemical pharmacology. (2)
Review activity for Biochimica et biophysica acta. (1)
Review activity for Cytokine. (2)
Review activity for Experimental and molecular pathology. (1)
Review activity for Heliyon. (2)
Review activity for Journal of cell communication and signaling. (1)
Review activity for Journal of inflammation research (1)
Review activity for Life sciences. (1)