Alessandro Castorina (0000-0001-7037-759X)

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Biography

A/Prof. Alessandro Castorina is an academic and neuroscientist.
His teaching experience spans from Gross Anatomy, Visceral Anatomy, Musculoskeletal Anatomy, Neuroanatomy and Neuroscience.
Research is focussed on investigating the pathogenic mechanisms responsible for the development of neurodegenerative diseases and study the mode of action of new/old drugs that can reduce the inflammatory burden.
A/Prof. Castorina is heavily involved in editorial activities for several international reputable journals, including IJMS, Cells, NRR, Journal of Molecular Neuroscience and Frontiers in Endocrine Science and Frontiers in Pharmacology.

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University of Technology Sydney: NSW, NSW, AU

2021-01-08 to present | Associate Professor (School of Life Sciences / Faculty of Science)

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Alessandro Castorina

https://orcid.org/0000-0001-7037-759X

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Employment (7)

University of Technology Sydney: NSW, NSW, AU

University of Technology Sydney: Sydney, NSW, AU

University of Sydney: Sydney, NSW, AU

University of Technology Sydney: Sydney, NSW, AU

University of Technology Sydney: Broadway, NSW, AU

University of Sydney: Sydney, NSW, AU

University of Catania: Catania, Italy, IT

Professional activities (4)

Sydney New Horizon meeting 2019: Sydney, NSW, AU

Australian Society for Medical Research: Sydney, NSW, AU

University of Sydney: Sydney, NSW, AU

University of Sydney: Sydney, NSW, AU

Funding (7)

Targeting the GABA system to promote remyelination

Azetidine-2-carboxylic acid - a plant-derived non-protein amino acid as a novel environmental risk factor for MS

Neuropeptide-based approach to improve myelin repair in Multiple Sclerosis

Profiling inflammation-associated microRNAs in a murine model of Multiple Sclerosis (MS): testing the efficacy of the neuropeptides PACAP, VIP and maxadilan

In vitro identification of microRNA networks regulated by the endogenous bioactive neuropeptide PACAP in neuronal and glial cells exposed to immune and metabolic challenges

Investigating the effects of neonatal lipopolysaccharide treatment on the expression of PACAP family members in an animal model of neuropathic injury

PACAPergic system dysregulation in the affective / emotional disruptions caused by neuropathic pain in nerve injured rats - the devil from within

Works (50 of 77)

Targeting the PAC1 receptor mitigates degradation of myelin and synaptic markers and diminishes locomotor deficits in the cuprizone demyelination model

Exploring body composition and somatotype profiles among youth professional soccer players

Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling

Differential Expression of PACAP/VIP Receptors in the Post-Mortem CNS White Matter of Multiple Sclerosis Donors

Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma

Adapted Physical Activity Programs for Children with Autism Spectrum Disorder and Neurotypical Children: Differences between Online and Face-to-Face Training

Hippocampal neuroinflammation causes sex-specific disruptions in action selection, food approach memories, and neuronal activation

The Neuroanatomy of the Habenular Complex and Its Role in the Regulation of Affective Behaviors

Potential Crosstalk between the PACAP/VIP Neuropeptide System and Endoplasmic Reticulum Stress—Relevance to Multiple Sclerosis Pathophysiology

An Overview of Physical Exercise Program Protocols and Effects on the Physical Function in Multiple Sclerosis: An Umbrella Review

Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury

Altered Hippocampal and Striatal Expression of Endothelial Markers and VIP/PACAP Neuropeptides in a Mouse Model of Systemic Lupus Erythematosus

L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid

Identification of Key Genes and Regulatory Pathways in Multiple Sclerosis Brain Samples: A Meta-Analysis of Micro-Array Datasets

Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review

Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury

Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells

Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells

Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington’s Disease

Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis

The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson’s Disease

Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet

The role of exercise on peripheral nerve regeneration: from animal model to clinical application

PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

PACAP and VIP Modulate LPS-induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

Doxycycline and Minocycline Act as Positive Allosteric Modulators of the PAC1 Receptor and Induce Plasminogen Activators in RT4 Schwann Cells

Doxycycline and Minocycline act as Positive Allosteric Modulators of the PAC1 Receptor and Induce Plasminogen Activators in RT4 Schwann Cells

Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes

Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells

Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients

Robust Dopaminergic Differentiation and Enhanced LPS-Induced Neuroinflammatory Response in Serum-Deprived Human SH-SY5Y Cells: Implication for Parkinson’s Disease

Dopamine: an immune transmitter

Evaluation of a Cell-Free Collagen Type I-Based Scaffold for Articular Cartilage Regeneration in an Orthotopic Rat Model

PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury

Dopaminergic-GABAergic interplay and alcohol binge drinking

A correlation between intestinal microbiota dysbiosis and osteoarthritis

Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key

Identification of Dysregulated microRNA Networks in Schwann Cell-Like Cultures Exposed to Immune Challenge: Potential Crosstalk with the Protective VIP/PACAP Neuropeptide System

Insights into the Role of Neuroinflammation in the Pathogenesis of Multiple Sclerosis

Tackling dipeptidyl peptidase IV in neurological disorders

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Musculoskeletal Disorders

Angiogenesis correlates with macrophage and mast cell infiltration in lung tissue of animals exposed to fluoro-edenite fibers

Increased aquaporin 1 expression in the tunica albuginea of Peyronie’s disease patients: An in vivo pilot study

Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution

Ameliorative effects of PACAP against cartilage degeneration. Morphological, immunohistochemical and biochemical evidence from in vivo and in vitro models of rat osteoarthritis

Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme