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Employment (3)

CNRS Délégation Paris B: Paris, Île-de-France, FR

2011-10-01 to present | CNRS researcher (CRHC) (UMR144)
Employment
Source: Self-asserted source
Olena Pylypenko

Institute Curie: Paris, FR

2007 to present (UMR 144)
Employment
Source: Self-asserted source
Olena Pylypenko

Max Planck Institute of Molecular Physiology: Dortmund, DE

2003 to 2007 | post-doc (Physical Biochemistry )
Employment
Source: Self-asserted source
Olena Pylypenko

Education and qualifications (2)

PARIS-SACLAY UNIVERSITY: Paris, ile de france, FR

HDR (habilitation à diriger des recherches)
Qualification
Source: Self-asserted source
Olena Pylypenko

Heidelberg University : Heidelberg, DE

2000-01-01 to 2003-07-08 | PhD (Naturwissenschaftlich-Mathematische Gesamtfakultät)
Education
Source: Self-asserted source
Olena Pylypenko

Works (44)

Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution.

Communications biology
2024-07-08 | Journal article | Author
DOI: 10.1038/s42003-024-06458-1
PMID: 38977899
PMC: PMC11231147
Contributors: Martin Kollmar; Welz T; Ravi A; Thomas Kaufmann; Alzahofi N; Klas Hatje; Dr. Asmahan; Kim J; Briggs DA; Samol-Wolf A et al.
Source: Self-asserted source
Olena Pylypenko

Uncovering the Relationship Between Genes and Phenotypes Beyond the Gut in Microvillus Inclusion Disease.

Cellular and molecular gastroenterology and hepatology
2024-02-01 | Journal article
DOI: 10.1016/j.jcmgh.2024.01.015
PMID: 38307491
PMC: PMC11041842
Contributors: Mingyue Sun; Pylypenko O; Zhou Z; Mingqian Xu; Li Q; Houdusse A; van IJzendoorn SCD
Source: Self-asserted source
Olena Pylypenko

MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis.

Developmental cell
2023-10-23 | Journal article
DOI: 10.1016/j.devcel.2023.09.010
PMID: 37875118
Contributors: Serres MP; Shaughnessy R; Sophie Escot; Hammich H; Cuvelier F; Salles A; Rocancourt M; Verdon Q; Gaffuri AL; Sourigues Y et al.
Source: Self-asserted source
Olena Pylypenko

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Oncogene
2021 | Journal article
DOI: 10.1038/s41388-021-01826-1
HAL: hal-03232434
Contributors: Catalina Lodillinsky; Laetitia Fuhrmann; Marie Irondelle; Olena Pylypenko; Xiao-Yan Li; Hélène Bonsang-Kitzis; Fabien Reyal; Sophie Vacher; Claire Calmel; Olivier de Wever et al.
Source: Self-asserted source
Olena Pylypenko via HAL

Force Generation by Myosin Motors: A Structural Perspective

Chemical Reviews
2020-01-08 | Journal article
DOI: 10.1021/acs.chemrev.9b00264
Part of ISSN: 0009-2665
Part of ISSN: 1520-6890
Source: Self-asserted source
Olena Pylypenko

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

Scientific Reports
2019-12 | Journal article
DOI: 10.1038/s41598-019-52537-3
Part of ISSN: 2045-2322
Source: Self-asserted source
Olena Pylypenko

MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update.

Human mutation
2018-01-17 | Journal article
DOI: 10.1002/humu.23386
PMID: 29266534
PMC: PMC5838515
Source: Self-asserted source
Olena Pylypenko

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.

Nature communications
2017-11-01 | Journal article
DOI: 10.1038/s41467-017-01266-0
PMID: 29093437
PMC: PMC5665954
Source: Self-asserted source
Olena Pylypenko

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity.

Small GTPases
2017-07-07 | Journal article
DOI: 10.1080/21541248.2017.1336191
PMID: 28632484
PMC: PMC5902227
Source: Self-asserted source
Olena Pylypenko

Oxidation of F-actin controls the terminal steps of cytokinesis.

Nature communications
2017-02-23 | Journal article
DOI: 10.1038/ncomms14528
PMID: 28230050
PMC: PMC5331220
Source: Self-asserted source
Olena Pylypenko

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.

eLife
2016-09-13 | Journal article
DOI: 10.7554/eLife.17523
PMID: 27623148
PMC: PMC5021521
Source: Self-asserted source
Olena Pylypenko

The myosin X motor is optimized for movement on actin bundles.

Nature communications
2016-09-01 | Journal article
DOI: 10.1038/ncomms12456
PMID: 27580874
PMC: PMC5025751
Source: Self-asserted source
Olena Pylypenko

Force-producing ADP state of myosin bound to actin.

2016-03 | Journal article
DOI: 10.1073/pnas.1516598113
PMID: 26976594
PMC: PMC4822626
Contributors: Wulf SF; Ropars V; Fujita-Becker S; Oster M; Hofhaus G; Trabuco LG; Pylypenko O; Sweeney HL; Houdusse AM; Schröder RR
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Myosin VI deafness mutation prevents the initiation of processive runs on actin.

2015-03 | Journal article
DOI: 10.1073/pnas.1420989112
PMID: 25751888
PMC: PMC4371908
Contributors: Pylypenko O; Song L; Shima A; Yang Z; Houdusse AM; Sweeney HL
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function and Localization

Ras Superfamily Small G Proteins: Biology and Mechanisms 2
2014 | Book chapter
DOI: 10.1007/978-3-319-07761-1_3
Part of ISBN: 9783319077604
Part of ISBN: 9783319077611
Source: Self-asserted source
Olena Pylypenko

Structural basis of myosin V Rab GTPase-dependent cargo recognition.

2013-12 | Journal article
DOI: 10.1073/pnas.1314329110
PMID: 24248336
PMC: PMC3870677
Contributors: Pylypenko O; Attanda W; Gauquelin C; Lahmani M; Coulibaly D; Baron B; Hoos S; Titus MA; England P; Houdusse AM
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI.

2012-10 | Journal article
DOI: 10.1016/j.molcel.2012.07.034
PMID: 22940248
PMC: PMC3472048
Contributors: Ménétrey J; Isabet T; Ropars V; Mukherjea M; Pylypenko O; Liu X; Perez J; Vachette P; Sweeney HL; Houdusse AM
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.

2012-04 | Journal article
DOI: 10.1038/ng.2218
PMID: 22406640
Contributors: Louis-Dit-Picard H; Barc J; Trujillano D; Miserey-Lenkei S; Bouatia-Naji N; Pylypenko O; Beaurain G; Bonnefond A; Sand O; Simian C et al.
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Posttranslational modifications of Rab GTPases help their insertion into membranes.

2012-04 | Journal article
DOI: 10.1073/pnas.1202494109
PMID: 22451945
PMC: PMC3326495
Contributors: Pylypenko O; Goud B
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

How myosin motors power cellular functions: an exciting journey from structure to function: based on a lecture delivered at the 34th FEBS Congress in Prague, Czech Republic, July 2009.

2012-02 | Journal article
DOI: 10.1111/j.1742-4658.2011.08449.x
PMID: 22171985
PMC: PMC3269445
Contributors: Llinas P; Pylypenko O; Isabet T; Mukherjea M; Sweeney HL; Houdusse AM
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Role of insert-1 of myosin VI in modulating nucleotide affinity.

2011-04 | Journal article
DOI: 10.1074/jbc.M110.200626
PMID: 21278381
PMC: PMC3064223
Contributors: Pylypenko O; Song L; Squires G; Liu X; Zong AB; Houdusse A; Sweeney HL
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Essential "ankle" in the myosin lever arm.

2011-01 | Journal article
DOI: 10.1073/pnas.1017676108
PMID: 21177429
PMC: PMC3017131
Contributors: Pylypenko O; Houdusse AM
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases.

2008-10 | Journal article
DOI: 10.1016/j.ab.2008.06.039
PMID: 18638444
PMC: PMC2633595
Contributors: Schwartz SL; Tessema M; Buranda T; Pylypenko O; Rak A; Simons PC; Surviladze Z; Sklar LA; Wandinger-Ness A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.

2008-09 | Journal article
DOI: 10.1016/j.str.2008.06.008
PMID: 18786395
Contributors: Schulte A; Stolp B; Schönichen A; Pylypenko O; Rak A; Fackler OT; Geyer M
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.

2008-06 | Journal article
DOI: 10.1074/jbc.M709718200
PMID: 18426803
Contributors: Ignatev A; Kravchenko S; Rak A; Goody RS; Pylypenko O
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state.

2008-06 | Journal article
DOI: 10.1016/j.jmb.2008.04.007
PMID: 18471828
Contributors: Wallgren M; Adén J; Pylypenko O; Mikaelsson T; Johansson LB; Rak A; Wolf-Watz M
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9.

2008-05 | Journal article
DOI: 10.1016/j.jsb.2007.10.011
PMID: 18065239
Contributors: Pylypenko O; Ignatev A; Lundmark R; Rasmuson E; Carlsson SR; Rak A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.

2008-04 | Journal article
DOI: 10.1016/j.jmb.2008.01.099
PMID: 18329045
Contributors: Pylypenko O; Schönichen A; Ludwig D; Ungermann C; Goody RS; Rak A; Geyer M
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Rab GTPases at a glance.

2007-11 | Journal article
DOI: 10.1242/jcs.015909
PMID: 17989088
Contributors: Schwartz SL; Cao C; Pylypenko O; Rak A; Wandinger-Ness A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

The PX-BAR membrane-remodeling unit of sorting nexin 9.

2007-11 | Journal article
DOI: 10.1038/sj.emboj.7601889
PMID: 17948057
PMC: PMC2080800
Contributors: Pylypenko O; Lundmark R; Rasmuson E; Carlsson SR; Rak A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

2007-10 | Journal article
DOI: 10.1107/S1744309107043400
PMID: 17909294
PMC: PMC2339718
Contributors: Schulte A; Rak A; Pylypenko O; Ludwig D; Geyer M
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

A size filtration approach to purify low affinity complexes for crystallization.

2007-07 | Journal article
DOI: 10.1016/j.jsb.2007.02.005
PMID: 17408969
Contributors: Ignatev A; Piatkov K; Pylypenko O; Rak A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

2006-04 | Journal article
DOI: 10.1038/sj.emboj.7601044
PMID: 16541104
PMC: PMC1440319
Contributors: Itzen A; Pylypenko O; Goody RS; Alexandrov K; Rak A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex.

2006-02 | Journal article
DOI: 10.1107/S1744309105042995
PMID: 16511278
PMC: PMC2150963
Contributors: Itzen A; Bleimling N; Ignatev A; Pylypenko O; Rak A
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.

2006-01 | Journal article
DOI: 10.1038/sj.emboj.7600921
PMID: 16395334
PMC: PMC1356364
Contributors: Pylypenko O; Rak A; Durek T; Kushnir S; Dursina BE; Thomae NH; Constantinescu AT; Brunsveld L; Watzke A; Waldmann H et al.
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution.

2005-12 | Journal article
DOI: 10.1016/j.jsb.2005.10.001
PMID: 16332443
Contributors: Bergbrede T; Pylypenko O; Rak A; Alexandrov K
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s.

2004 | Journal article
DOI: 10.1146/annurev.biochem.73.011303.073711
PMID: 15189165
Contributors: Pylypenko O; Schlichting I
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.

2004-06 | Journal article
DOI: 10.1016/j.cell.2004.05.017
PMID: 15186776
Contributors: Rak A; Pylypenko O; Niculae A; Pyatkov K; Goody RS; Alexandrov K
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis.

2003-11 | Journal article
DOI: 10.1074/jbc.M306486200
PMID: 12888556
Contributors: Pylypenko O; Vitali F; Zerbe K; Robinson JA; Schlichting I
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase.

2003-10 | Journal article
DOI: 10.1126/science.1087761
PMID: 14576435
Contributors: Rak A; Pylypenko O; Durek T; Watzke A; Kushnir S; Brunsveld L; Waldmann H; Goody RS; Alexandrov K
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

2003-02 | Journal article
DOI: 10.1016/S1097-2765(03)00044-3
PMID: 12620235
Contributors: Pylypenko O; Rak A; Reents R; Niculae A; Sidorovitch V; Cioaca MD; Bessolitsyna E; Thomä NH; Waldmann H; Schlichting I et al.
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1.

2003-01 | Journal article
DOI: 10.1016/S1047-8477(02)00634-2
PMID: 12576024
Contributors: Rak A; Pylypenko O; Niculae A; Goody RS; Alexandrov K
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Crystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis.

2002-12 | Journal article
DOI: 10.1074/jbc.M206342200
PMID: 12207020
Contributors: Zerbe K; Pylypenko O; Vitali F; Zhang W; Rouset S; Heck M; Vrijbloed JW; Bischoff D; Bister B; Süssmuth RD et al.
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central

Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

2001-11 | Journal article
DOI: 10.1006/jsbi.2001.4433
PMID: 11886217
Contributors: Rak A; Reents R; Pylypenko O; Niculae A; Sidorovitch V; Thomä NH; Waldmann H; Schlichting I; Goody RS; Alexandrov K
Source: Self-asserted source
Olena Pylypenko via Europe PubMed Central
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