Personal information

Asthma, COPD, IPF, Airway Remodeling, Extracellular Matrix, Epithelial cells, Fibroblasts
Canada

Activities

Employment (1)

The University of British Columbia: Vancouver, BC, CA

2013-02-02 to present | Professor (Anesthesiology, Pharmacology & Therapeutics)
Employment
Source: Self-asserted source
Tillie-Louise Hackett

Education and qualifications (1)

University of Southampton: Southampton, Hampshire, GB

2002 to 2006 | Ph.D. (Cellular Sciences)
Qualification
Source: Self-asserted source
Tillie-Louise Hackett

Professional activities (1)

American Thoracic Society: New York, New York, US

2018 | Inaugural ATS Fellow 2018
Distinction
Source: Self-asserted source
Tillie-Louise Hackett

Works (13)

Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair

Matrix Biology
2024-09 | Journal article
Contributors: Kauna Usman; May Fouadi; Kingsley Okechukwu Nwozor; Fatemeh Aminazadeh; Parameswaran Nair; Honglin Luo; Don D. Sin; Emmanuel Twumasi Osei; Tillie-Louise Hackett
Source: check_circle
Crossref

Extracellular Matrix Remodeling in Atopic Dermatitis Harnesses the Onset of an Asthmatic Phenotype and Is a Potential Contributor to the Atopic March

Journal of Investigative Dermatology
2024-05 | Journal article
Contributors: Patrick Graff; Dana Woerz; Jenny Wilzopolski; Anne Voss; Jana Sarrazin; Travis M. Blimkie; January Weiner; Olivia Kershaw; Preety Panwar; Tillie Hackett et al.
Source: check_circle
Crossref

Platelet Activating Factor Receptor and Intercellular Adhesion Molecule–1 Expression Increases in the Small Airway Epithelium and Parenchyma of Patients with Idiopathic Pulmonary Fibrosis: Implications for Microbial Pathogenesis

Journal of Clinical Medicine
2024-04-06 | Journal article
Contributors: Affan Mahmood Shahzad; Wenying Lu; Surajit Dey; Prem Bhattarai; Archana Vijay Gaikwad; Jade Jaffar; Glen Westall; Darren Sutherland; Gurpreet Kaur Singhera; Tillie-Louise Hackett et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

TGF-β1, pSmad-2/3, Smad-7, and β-Catenin Are Augmented in the Pulmonary Arteries from Patients with Idiopathic Pulmonary Fibrosis (IPF): Role in Driving Endothelial-to-Mesenchymal Transition (EndMT)

Journal of Clinical Medicine
2024-02 | Journal article | Author
Contributors: Archana Vijay Gaikwad; Mathew Eapen; Surajit Dey; Prem Bhattarai; Affan Mahmood Shahzad; Collin Chia; Jade Jaffar; Glen Westall; Darren Sutherland; Gurpreet Singhera et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Taking Small Airways in Chronic Obstructive Pulmonary Disease to TASC

American Journal of Respiratory and Critical Care Medicine
2023-05-01 | Journal article
Contributors: Maor Sauler; Tillie-Louise Hackett
Source: check_circle
Crossref

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

Cells
2022-09 | Journal article | Author
Contributors: Anthony Tam; Osei ET; Chung Y. Cheung; Michael R. Hughes; Chen X. Yang; Kelly McNagny; Delbert R. Dorscheid; Gurpreet Singhera; Teal S. Hallstrand; Stephanie Warner et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Reply to Cottin: Small Airways in Pulmonary Fibrosis: Revisiting an Old Question with New Tools

American Journal of Respiratory and Critical Care Medicine
2022-08-15 | Journal article
Contributors: Dragoş M. Vasilescu; Kohei Ikezoe; Christopher J. Ryerson; James C. Hogg; Tillie-Louise Hackett
Source: check_circle
Crossref

Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Peptidase Serine 2 (TMPRSS2), and Furin Expression Increases in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lymphangioleiomyomatosis (LAM): Implications for SARS-CoV-2 (COVID-19) Infections

Journal of Clinical Medicine
2022-01 | Journal article | Author
Contributors: Wenying Lu; Mathew Eapen; Gurpreet Singhera; James Markos; Greg Haug; Collin Chia; Josie Larby; Samuel James Brake; Glen P. Westall; Jade Jaffar et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

The Role of the Dynamic Lung Extracellular Matrix Environment on Fibroblast Morphology and Inflammation

Cells
2022-01-06 | Journal article
Contributors: Tillie-Louise Hackett; Noamie R. T. F. Vriesde; May AL-Fouadi; Leila Mostaco-Guidolin; Delaram Maftoun; Aileen Hsieh; Nicole Coxson; Kauna Usman; Don D. Sin; Steve Booth et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Modeling Extracellular Matrix-Cell Interactions in Lung Repair and Chronic Disease

Cells
2021-08-20 | Journal article
Contributors: Tillie Louise Hackett; Emmanuel Twumasi Osei
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Pulmonary Vascular Remodeling Is an Early Feature of Fatal and Nonfatal Asthma

American Journal of Respiratory Cell and Molecular Biology
2021-07 | Journal article
Contributors: Leila B. Mostaço-Guidolin; Chen Xi Yang; Tillie-Louise Hackett
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Crossref

What Have In Vitro Co-Culture Models Taught Us about the Contribution of Epithelial-Mesenchymal Interactions to Airway Inflammation and Remodeling in Asthma?

Cells
2020-07 | Journal article | Author
Contributors: Osei ET; Steven Booth; Tillie-Louise Hackett
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Reply to Janssen and Wouters: Loss of Alveolar Attachments as a Pathomechanistic Link between Small Airway Disease and Emphysema

American Journal of Respiratory and Critical Care Medicine
2020-04-01 | Journal article
Contributors: Dragoş M. Vasilescu; Tillie-Louise Hackett; Fernando J. Martinez; Jeffrey L. Curtis; James C. Hogg; MeiLan K. Han
Source: check_circle
Crossref

Peer review (1 review for 1 publication/grant)

Review activity for Thorax (1)