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work

Other IDs

Scopus Author ID: 6602391153
ResearcherID: A-1679-2012
Loop profile: 111832

Keywords

ESCRT, coiled coils, protein design

Countries

United Kingdom

Activities

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Employment (3)

University of Sheffield Department of Chemistry: Sheffield, Sheffield, GB

2008-10-01 to present | Lecturer in Biophysical Chemistry (Chemistry)
Employment
Source: Self-asserted source
Barbara Ciani

University of Manchester Faculty of Life Sciences: Manchester, Manchester, GB

2004-05 to 2008-09 | Wellcome PDRA (Wellcome Trust Centre for Matrix Biology)
Employment
Source: Self-asserted source
Barbara Ciani

University of Nottingham School of Chemistry: Nottingham, Nottingham, GB

2001-02 to 2003-12 | PDRA (Chemistry)
Employment
Source: Self-asserted source
Barbara Ciani

Education and qualifications (2)

University of Sussex: Brighton, Brighton and Hove, GB

1998-01-05 to 2002-07-18 | DPhil Biochemistry (School of Biological Sciences)
Education
Source: Self-asserted source
Barbara Ciani

Universita degli Studi di Roma La Sapienza Dipartimento di Chimica: Roma, Lazio, IT

1991-10 to 1997-05 | Laurea in Chemistry (Chemistry)
Education
Source: Self-asserted source
Barbara Ciani

Professional activities (5)

Royal Society of Chemistry: London, London, GB

Member of the Biophysical Chemistry interest group committee (Biophysical Chemistry)
Membership
Source: Self-asserted source
Barbara Ciani

Engineering and Physical Sciences Research Council: London, GB

Full member of the review college
Invited position
Source: Self-asserted source
Barbara Ciani

British Society for Cell Biology: Oxford, Oxfordshire, GB

Membership
Source: Self-asserted source
Barbara Ciani

British Biophysical Society: Norwich, GB

Membership
Source: Self-asserted source
Barbara Ciani

Biochemical Society: London, GB

Membership
Source: Self-asserted source
Barbara Ciani

Funding (6)

BEACON - A multi-user and multi-project facility for biological macromolecules and nanoparticles characterization in solution

2021-07-31 to 2022-07-30 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.9727084
GRANT_NUMBER: BB/V019341/1
Source: Self-asserted source
Barbara Ciani via DimensionsWizard

Harnessing Nature's ability to create membrane compartmentalisation through redesign of a protein machinery.

Source: Self-asserted source
Barbara Ciani via DimensionsWizard

Designing recyclable self-assembled fibrous biomaterials

2015-12 to 2018-11 | Grant
Leverhulme Trust (London, GB)
Source: Self-asserted source
Barbara Ciani

Designing recyclable self-assembled fibrous biomaterials

2015-04-01 to present | Grant
Leverhulme Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.9749605
GRANT_NUMBER: leverhulme_9b3b0639a2
Source: Self-asserted source
Barbara Ciani via DimensionsWizard

Control of self-assembly and functionalisation of coordination cages

2013-02-01 to 2016-01-31 | Grant
Engineering and Physical Sciences Research Council (Swindon, GB)
URL: https://grants.uberresearch.com/501100000266/FF529C99-C610-4AF8-A100-8F86D9E8122B/Control-of-self-assembly-and-functionalisation-of-coordination-cages
GRANT_NUMBER: EP/K003224/1
Source: Self-asserted source
Barbara Ciani via DimensionsWizard
grade
Preferred source (of 2)‎

Masters in Mechanistic Biology

2011-09-30 to 2013-09-29 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.3499912
GRANT_NUMBER: BB/H020543/1
Source: Self-asserted source
Barbara Ciani via DimensionsWizard

Works (33)

CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

mBio
2023-07-24 | Journal article
DOI: 10.1128/mbio.01482-23
Part of ISSN: 2150-7511
Contributors: Luke Green; Rahaf Issa; Fawzyah Albaldi; Lucy Urwin; Ruth Thompson; Henna Khalid; Claire Turner; Barbara Ciani; Lynda J. Partridge; Peter N. Monk
Source: Self-asserted source
Barbara Ciani

CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

2023-01-18 | Preprint
DOI: 10.1101/2023.01.17.524294
Contributors: Luke R. Green; Rahaf Issa; Fawzyah Albaldi; Lucy Urwin; Henna Khalid; Claire E. Turner; Barbara Ciani; Lynda J. Partridge; Peter N. Monk
Source: check_circle
Crossref

Progesterone receptor expression contributes to gemcitabine resistance at higher ECM stiffness in breast cancer cell lines.

PloS one
2022-05-26 | Journal article | Funding acquisition, Writing - review & editing, Supervision
DOI: 10.1371/journal.pone.0268300
PMID: 35617163
PMC: PMC9135204
Contributors: Grant E; Bucklain FA; Lucy Ginn; Laity P; Ciani B; helen bryant; Barbara Ciani
Source: Self-asserted source
Barbara Ciani

The influence of phosphatidylserine localisation and lipid phase on membrane remodelling by the ESCRT-II/ESCRT-III complex

Faraday Discussions
2021 | Journal article
DOI: 10.1039/D0FD00042F
Contributors: Andrew Booth; Christopher J. Marklew; Barbara Ciani; Paul A. Beales
Source: check_circle
Crossref

Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations

Journal of Cell Biology
2021-03-01 | Journal article
DOI: 10.1083/jcb.202004222
Contributors: David J. Thaller; Danqing Tong; Christopher J. Marklew; Nicholas R. Ader; Philip J. Mannino; Sapan Borah; Megan C. King; Barbara Ciani; C. Patrick Lusk
Source: check_circle
Crossref

Direct PA-binding by Chm7 is required for nuclear envelope surveillance at herniations

2020-05-04 | Preprint
DOI: 10.1101/2020.05.04.074880
Contributors: David J. Thaller; Danqing Tong; Christopher J. Marklew; Sapan Borah; Barbara Ciani; C. Patrick Lusk
Source: check_circle
Crossref

The influence of phosphatidylserine localisation and lipid phase on membrane remodelling by the ESCRT-II/ESCRT-III complex

2020-04-22 | Preprint
DOI: 10.1101/2020.04.21.053389
Contributors: Andrew Booth; Christopher J. Marklew; Barbara Ciani; Paul A. Beales
Source: check_circle
Crossref

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

Oncogenesis
2019-04-15 | Journal article
DOI: 10.1038/s41389-019-0136-0
Contributors: Jessica Willan; Alexa J. Cleasby; Neftali Flores-Rodriguez; Flavia Stefani; Cinzia Rinaldo; Alessandra Pisciottani; Emma Grant; Philip Woodman; Helen E. Bryant; Barbara Ciani
Source: check_circle
Crossref

ESCRT-III accumulates in micronuclei with ruptured nuclear envelopes

2018-12-01 | Other
DOI: 10.1101/476630
Contributors: Jessica Willan; Alexa Cleasby; Neftali Flores-Rodriguez; Flavia Stefani; Cinzia Rinaldo; Alessandra Pisciottani; Emma Grant; Philip Woodman; Helen Bryant; Barbara Ciani
Source: check_circle
Crossref

Membrane remodelling by a lipidated endosomal sorting complex required for transport-III chimera, in vitro

Interface Focus
2018-10-06 | Journal article
DOI: 10.1098/rsfs.2018.0035
Contributors: C. J. Marklew; A. Booth; P. A. Beales; B. Ciani
Source: check_circle
Crossref

The artificial cell: biology-inspired compartmentalization of chemical function

Interface Focus
2018-10-06 | Journal article
DOI: 10.1098/rsfs.2018.0046
Contributors: Paul A. Beales; Barbara Ciani; Stephen Mann
Source: check_circle
Crossref

C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1501947112
WOSUID:

WOS:000361393700057
Contributors: Muthana, Munitta; Hawtree, Sarah; Wilshaw, Adam; Linehan, Eimear; Roberts, Hannah; Khetan, Sachin; Adeleke, Gbadebo; Wright, Fiona; Akil, Mohammed; Fearon, Ursula et al.
Source: Self-asserted source
Barbara Ciani via ResearcherID

Chemical compartmentalisation by membranes: from biological mechanism to biomimetic applications

Physical Chemistry Chemical Physics
2015 | Journal article
DOI: 10.1039/c5cp90089a
WOSUID:

WOS:000356056000001
Contributors: Beales, Paul A.; Ciani, Barbara
Source: Self-asserted source
Barbara Ciani via ResearcherID

Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments

Physical Chemistry Chemical Physics
2015 | Journal article
DOI: 10.1039/c5cp00480b
WOSUID:

WOS:000356056000002
Contributors: Beales, Paul A.; Ciani, Barbara; Cleasby, Alexa J.
Source: Self-asserted source
Barbara Ciani via ResearcherID

No Evidence for Cardiac Dysfunction in Kif6 Mutant Mice

2013 | Journal article
DOI: 10.1371/journal.pone.0054636
EID:

2-s2.0-84872780038
Contributors: Hameed, A.; Bennett, E.; Ciani, B.; Hoebers, L.P.C.; Milner, R.; Lawrie, A.; Francis, S.E.; Grierson, A.J.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing

2013 | Journal article
DOI: 10.1074/jbc.M113.509489
EID:

2-s2.0-84888367466
Contributors: Patel, N.; Exell, J.C.; Jardine, E.; Ombler, B.; Finger, L.D.; Ciani, B.; Grasby, J.A.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Molecular basis of coiled-coil oligomerization-state specificity

2010 | Journal article
DOI: 10.1073/pnas.1008502107
EID:

2-s2.0-78650537944
Contributors: Ciani, B.; Bjelić, S.; Honnappa, S.; Jawhari, H.; Jaussi, R.; Payapilly, A.; Jowitt, T.; Steinmetz, M.O.; Kammerer, R.A.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Atomic Models of De Novo Designed ccβ-Met Amyloid-Like Fibrils

2008 | Journal article
DOI: 10.1016/j.jmb.2007.11.100
EID:

2-s2.0-38649143194
Contributors: Steinmetz, M.O.; Gattin, Z.; Verel, R.; Ciani, B.; Stromer, T.; Green, J.M.; Tittmann, P.; Schulze-Briese, C.; Gross, H.; van Gunsteren, W.F. et al.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Electrostatic Contributions to the Stability of the GCN4 Leucine Zipper Structure

2007 | Journal article
DOI: 10.1016/j.jmb.2007.09.007
EID:

2-s2.0-35349003263
Contributors: Matousek, W.M.; Ciani, B.; Fitch, C.A.; Garcia-Moreno E., B.; Kammerer, R.A.; Alexandrescu, A.T.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone

2006 | Journal article
DOI: 10.1007/s00223-005-1299-6
EID:

2-s2.0-33646597289
Contributors: Cavey, J.R.; Ralston, S.H.; Sheppard, P.W.; Ciani, B.; Gallagher, T.R.A.; Long, J.E.; Searle, M.S.; Layfield, R.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structure of the extracellular domain of tie receptor tyrosine kinases and localization of the angiopoietin-binding epitope

2006 | Journal article
DOI: 10.1074/jbc.M605219200
EID:

2-s2.0-33748784848
Contributors: Macdonald, P.R.; Progias, P.; Ciani, B.; Patel, S.; Mayer, U.; Steinmetz, M.O.; Kammerer, R.A.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations

2005 | Journal article
DOI: 10.1359/JBMR.041205
EID:

2-s2.0-15344339092
Contributors: Cavey, J.R.; Ralston, S.H.; Hocking, L.J.; Sheppard, P.W.; Ciani, B.; Searle, M.S.; Layfield, R.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Design of β-sheet systems for understanding the thermodynamics and kinetics of protein folding

2004 | Journal article
DOI: 10.1016/j.sbi.2004.06.001
EID:

2-s2.0-4143070403
Contributors: Searle, M.S.; Ciani, B.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Incremental contribution to protein stability from a β hairpin " finger": Limits on the stability of designed β hairpin peptides

2004 | Journal article
DOI: 10.1002/anie.200352955
EID:

2-s2.0-3042737819
Contributors: Searle, M.S.; Platt, G.W.; Bofill, R.; Simpson, S.A.; Ciani, B.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: Genotype phenotype correlation, functional analysis, and structural consequences

2004 | Journal article
DOI: 10.1359/JBMR.0403015
EID:

2-s2.0-4544371010
Contributors: Hocking, L.J.; Lucas, G.J.A.; Daroszewska, A.; Cundy, T.; Nicholson, G.C.; Donath, J.; Walsh, J.P.; Finlayson, C.; Cavey, J.R.; Ciani, B. et al.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone

2004 | Journal article
DOI: 10.1042/BST0320728
EID:

2-s2.0-8744223568
Contributors: Layfield, R.; Ciani, B.; Ralston, S.H.; Hocking, L.J.; Sheppard, P.W.; Searle, M.S.; Cavey, J.R.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Stabilization of β-hairpin peptides by salt bridges: Role of preorganization in the energetic contribution of weak interactions

2003 | Journal article
DOI: 10.1021/ja030074l
EID:

2-s2.0-0041866611
Contributors: Ciani, B.; Jourdan, M.; Searle, M.S.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone

2003 | Journal article
DOI: 10.1074/jbc.M307416200
EID:

2-s2.0-0141844580
Contributors: Ciani, B.; Layfield, R.; Cavey, J.R.; Sheppard, P.W.; Searle, M.S.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

A designed system for assessing how sequence affects α to β conformational transitions in proteins

2002 | Journal article
DOI: 10.1074/jbc.M107663200
EID:

2-s2.0-0037155826
Contributors: Ciani, B.; Gail Hutchinson, E.; Sessions, R.B.; Woolfson, D.N.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein

Cell Death and Differentiation
1999 | Journal article
DOI: 10.1038/sj.cdd.4400568
WOSUID:

WOS:000082959200013
Contributors: Steinert, P.M.; Candi, E.; Tarcsa, E.; Marekov, L.N.; Sette, M.; Paci, M.; Ciani, B.; Guerrieri, P.; Melino, G.
Source: Self-asserted source
Barbara Ciani via ResearcherID

The cornified envelope: a model of cell death in the skin.

1998 | Journal article
EID:

2-s2.0-0032234628
Contributors: Melino, G.; De Laurenzi, V.; Catani, M.V.; Terrinoni, A.; Ciani, B.; Candi, E.; Marekov, L.; Steinert, P.M.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier

Transglutaminase 1 mutations in lamellar ichthyosis: Loss of activity due to failure of activation by proteolytic processing

1998 | Journal article
DOI: 10.1074/jbc.273.22.13693
EID:

2-s2.0-0032577601
Contributors: Candi, E.; Melino, G.; Lahm, A.; Ceci, R.; Rossi, A.; Kim, I.G.; Ciani, B.; Steinert, P.M.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Iodoenolcyclization. III. A general approach to tetrasubstituted furans from 2-alkenyl-1,3-dicarbonyl compounds

1995 | Journal article
DOI: 10.1016/0040-4039(95)01901-S
EID:

2-s2.0-0028864034
Contributors: Antonioletti, R.; Cecchini, C.; Ciani, B.; Magnanti, S.
Source: Self-asserted source
Barbara Ciani via Scopus - Elsevier
grade
Preferred source (of 2)‎
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