Xiaowei Wu (0000-0001-7248-9149)

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Biography

Dr. Xiaowei Wu is a Principal Investigator at the Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), and the Zhongshan Institute for Drug Discovery, SIMM, CAS. He earned his Ph.D. in 2017 from SIMM. From 2017 to 2021, he pursued postdoctoral research at the H. Lee Moffitt Cancer Center & Research Institute and Baylor College of Medicine. Dr. Wu's primary research focuses on the development of novel small-molecule therapeutics for the treatment of cancer, viral infections, and neuropsychiatric disorders. Additionally, he is interested in designing green and practical methodologies for the synthesis of drug-like heterocycles.

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Shanghai Institute of Materia Medica: Shanghai, Shanghai, CN

2021-03-24 to present | associate professor (Drug discovery)

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Xiaowei Wu

https://orcid.org/0000-0001-7248-9149

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Employment (3)

Shanghai Institute of Materia Medica: Shanghai, Shanghai, CN

Baylor College of Medicine: Houston, Texas, US

Moffitt Cancer Center: Tampa, Florida, US

Education and qualifications (1)

Shanghai Institute of Materia Medica: Pudong, CN

Works (36)

Enantioselective Synthesis of Indole-Fused Polycycles Bearing Four Consecutive Stereocenters via Rhodium Catalysis

Direct C–H difluoroallylation of α,β-unsaturated amides and aryl amides by rhodium catalysis

Discovery of Imidazo[1,2-<i>a</i>]pyrazine Derivatives as Potent ENPP1 Inhibitors

Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C–H Activation/[4+2] Cyclization

Rhodium-Catalyzed Diastereoselective C–H Activation/[4 + 2] Annulation of α,β-Unsaturated Amides with Bicyclic Alkenes

An unusual four-step cascade reaction for accessing furo[3,4-c]pyridine-1,4-diones via rhodium catalysis

Rhodium-catalyzed regioselective C–H activation/Lossen rearrangement/annulation for the green synthesis of trisubstituted 2-pyridones

The synthesis of spirocyclopropane skeletons enabled by Rh(III)-catalyzed enantioselective C–H activation/[4 + 2] annulation

Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L

Recyclable rhodium-catalyzed C–H activation/[4 + 2] annulation with unconventional regioselectivity at ambient temperature: experimental development and mechanistic insight

Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease

Temperature‐Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2‐ <i>a</i> ]indole Derivatives via Iridium Catalysis

Chemo-, Regio-, and Stereoselective Assembly of Polysubstituted Furan-2(5H)-ones Enabled by Rh(III)-Catalyzed Domino C–H Alkenylation/Directing Group Migration/Lactonization: A Combined Experimental and Computational Study

Chemo‐ and Regioselective Synthesis of Functionalized 1 <i>H</i> ‐imidazo[1,5‐ <i>a</i> ]indol‐3(2 <i>H</i> )‐ones via a Redox‐Neutral Rhodium(III)‐Catalyzed [4+1] Annulation between Indoles and Alkynes

Redox-Neutral Rhodium(III)-Catalyzed Chemospecific and Regiospecific [4+1] Annulation between Indoles and Alkenes for the Synthesis of Functionalized Imidazo[1,5-a]indoles

Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-<i>a</i>]indoles and α,α-Difluoromethylene Tetrasubstituted Alkenes

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors

Synthesis, Structure–Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease

Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo[1,2-a]indol-3-ones via Rhodium Catalysis

Rhodium(III)-Catalyzed C–H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes

Rhodium‐Catalyzed Cascade Reactions of Indoles with 4‐Hydroxy‐2‐Alkynoates for the Synthesis of Indole‐Fused Polyheterocycles

Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design

Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes

Rhodium(iii)-catalyzed C–H allylation of indoles with allyl alcohols via β-hydroxide elimination

Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution

Rhodium-Catalyzed [4 + 1] Cyclization via C–H Activation for the Synthesis of Divergent Heterocycles Bearing a Quaternary Carbon

Ruthenium(II)-Catalyzed Regio- and Stereoselective C–H Allylation of Indoles with Allyl Alcohols

Rh(III)-Catalyzed C–H Cyclization of Arylnitrones with Diazo Compounds: Access to 3-Carboxylate Substituted N-Hydroxyindoles

Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C–H Bond Activation: Accessing a Pyrroloindolone Scaffold

Ruthenium-Catalyzed Redox-Neutral [4 + 1] Annulation of Benzamides and Propargyl Alcohols via C–H Bond Activation

Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C–H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon

Site-specific indolation of proline-based peptides via copper(ii)-catalyzed oxidative coupling of tertiary amine N-oxides

Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors

Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

Peer review (13 reviews for 6 publications/grants)