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United Kingdom

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Employment (2)

University of St Andrews: St Andrews, GB

Employment
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University of St Andrews CRIS

University of St Andrews: St Andrews, Fife, GB

2013-06-15 to present | Postdoctoral Research Fellow (School of Biology)
Employment
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Laura Aitken

Education and qualifications (2)

University of St Andrews: St Andrews, GB

Education
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University of St Andrews CRIS

University of St Andrews: St Andrews, Fife, GB

2008-09 to 2012-12 | Doctor of Philosophy (School of Biology)
Education
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Laura Aitken

Works (19)

Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation

European Journal Of Medicinal Chemistry
2023-10-05 | Journal article | Author
SOURCE-WORK-ID:

a91346d6-6015-41e7-8bf7-7b2841477b6f

EID:

2-s2.0-85163144943

Contributors: Ondrej Benek; Michaela Vaskova; Marketa Miskerikova; Monika Schmidt; Rudolf Andrys; Aneta Rotterova; Adam Skarka; Jana Hatlapatkova; Jana Zdarova Karasova; Matej Medvecky et al.
Source: check_circle
University of St Andrews CRIS

Willin/FRMD6 Mediates Mitochondrial Dysfunction Relevant to Neuronal Aβ Toxicity

Cells
2022-10-06 | Journal article
Contributors: Doris Chen; Wanjia Yu; Laura Aitken; Frank Gunn-Moore
Source: check_circle
Crossref
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Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease

Cells
2021-11-04 | Journal article
Contributors: Doris Chen; Wanjia Yu; Laura Aitken; Frank Gunn-Moore
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Crossref
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Tacrine – benzothiazoles

Bioorganic Chemistry
2020-12-28 | Journal article | Author
SOURCE-WORK-ID:

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EID:

2-s2.0-85099004986

WOSUID:

000618104800008

Contributors: Eugenie Nepovimova; Lucie Svobodova; Rafael Dolezal; Vendula Hepnarova; Lucie Junova; Daniel Jun; Jan Korabecny; Tomas Kucera; Zuzana Gazova; Katarina Motykova et al.
Source: check_circle
University of St Andrews CRIS

Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function

Journal of Neurochemistry
2020-10-13 | Journal article | Author
SOURCE-WORK-ID:

6e1e06df-cd5f-45dc-ad87-fedbb699edd9

EID:

2-s2.0-85082929284

WOSUID:

000559593600001

Contributors: Ying Cheng; Matthew Buchan; Karina Vitanova; Laura Aitken; Francis James Gunn-Moore; Rona R. Ramsay; Gayle Doherty
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University of St Andrews CRIS

Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment

International Journal of Molecular Sciences
2020-03-17 | Journal article | Author
SOURCE-WORK-ID:

fe3e8a12-af8f-43dc-8cc7-8264132d98af

EID:

2-s2.0-85082088815

WOSUID:

000529890200155

Contributors: Monika Schmidt; Ondrej Benek; Lucie Vinklarova; Martina Hrabinova; Lucie Zemanova; Matej Chribek; Vendula Kralova; Lukas Hroch; Rafael Dolezal; Antonin Lycka et al.
Source: check_circle
University of St Andrews CRIS

Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential Alzheimer’s disease treatment

Molecules
2019-07-29 | Journal article | Author
SOURCE-WORK-ID:

d4b2522b-c8b3-4f58-8d49-afda62a22d5a

WOSUID:

000482441100080

EID:

2-s2.0-85070791027

Contributors: Laura Aitken; Ondrej Benek; Brogan McKelvie; Rebecca E. Hughes; Lukas Hroch; Monika Schmidt; Louise Major; Lucie Vinklarova; Kamil Kuca; TERRY SMITH et al.
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University of St Andrews CRIS
grade
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1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Journal of Enzyme Inhibition and Medicinal Chemistry
2018-01-01 | Journal article
Contributors: Ondrej Benek; Lukas Hroch; Laura Aitken; Frank Gunn-Moore; Lucie Vinklarova; Kamil Kuca; Daniel I. Perez; Concepcion Perez; Ana Martinez; Zdenek Fisar et al.
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Crossref
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In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease

SLAS Discovery
2017-07 | Journal article | Author
SOURCE-WORK-ID:

f45fb1de-6b41-4946-a0c2-881c536f6648

EID:

2-s2.0-85021171552

WOSUID:

000403909600003

Contributors: Laura Aitken; Gemma Baillie; Andrew Pannifer; Angus Morrison; Philip S. Jones; TERRY SMITH; Stuart P. McElroy; Francis James Gunn-Moore
Source: check_circle
University of St Andrews CRIS

6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment

Medicinal Chemistry
2017-06 | Journal article | Author
SOURCE-WORK-ID:

ba669064-60f3-400e-aa79-ef0a25199a19

EID:

2-s2.0-85020833089

WOSUID:

000402479000004

Contributors: Ondrej Benek; Lukas Hroch; Laura Aitken; Rafael Dolezal; Patrick Guest; Marketa Benkova; Ondrej Soukup; Karel Musil; Rebecca Hughes; Kamil Kuca et al.
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University of St Andrews CRIS

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

Bioorganic & Medicinal Chemistry
2017-02-01 | Journal article | Author
SOURCE-WORK-ID:

5e51b928-c712-4e9e-b7e8-8d62bd7d0834

EID:

2-s2.0-85010904474

WOSUID:

000394201900031

Contributors: Lukas Hroch; Patrick Guest; Ondrej Benek; Ondrej Soukup; Jana Janockova; Rafael Dolezal; Kamil Kuca; Laura Aitken; TERRY SMITH; Francis James Gunn-Moore et al.
Source: check_circle
University of St Andrews CRIS

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment

Bioorganic and Medicinal Chemistry Letters
2016-08-01 | Journal article | Author
SOURCE-WORK-ID:

13411b13-1dd3-495c-8f6f-8b0f59d234fd

EID:

2-s2.0-84973563591

WOSUID:

000380574100058

Contributors: Lukas Hroch; Ondrej Benek; Patrick Guest; Laura Aitken; Ondrej Soukup; Jana Janockova; Karel Musil; Vlastimil Dohnal; Rafael Dolezal; Kamil Kuca et al.
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University of St Andrews CRIS
grade
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Morphology-specific inhibition of β-amyloid aggregates by 17β-hydroxysteroid dehydrogenase type 10

ChemBioChem
2016-06-02 | Journal article | Author
SOURCE-WORK-ID:

5e1d5332-d28d-45e6-99ff-980ad826120b

EID:

2-s2.0-84964381104

WOSUID:

000379156100011

Contributors: Laura Aitken; Steven David Quinn; D. Cibran Perez-Gonzalez; Ifor Samuel; Carlos Penedo; Francis James Gunn-Moore
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University of St Andrews CRIS
grade
Preferred source (of 3)‎

A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the development and treatment of Alzheimer’s disease

Current Medicinal Chemistry
2015 | Journal article | Author
SOURCE-WORK-ID:

fc508e88-d248-450b-9321-6fcacbaa7443

EID:

2-s2.0-84931268553

WOSUID:

000350477600002

Contributors: Ondrej Benek; Laura Aitken; Lukas Hroch; Kamil Kuca; Francis James Gunn-Moore; Kamil Musilek
Source: check_circle
University of St Andrews CRIS

Benzothiazoles - Scaffold of interest for CNS targeted drugs

Current Medicinal Chemistry
2015 | Journal article | Author
SOURCE-WORK-ID:

23c90dc6-cfc8-43d7-85c4-a831addc3a09

WOSUID:

000349388600006

EID:

2-s2.0-84931265913

Contributors: Lukas Hroch; Laura Aitken; Ondrej Benek; Martin Dolezal; Kamil Kuca; Francis James Gunn-Moore; Kamil Musilek
Source: check_circle
University of St Andrews CRIS
grade
Preferred source (of 2)‎

ABAD or a good approach to Alzheimer's disease drug discovery?

Biotech International Drug Discovery
2012-12 | Journal article | Author
SOURCE-WORK-ID:

146e2429-a6fc-4b89-9a1d-78a5ab66d23b

Contributors: Laura Aitken; Francis James Gunn-Moore
Source: check_circle
University of St Andrews CRIS

Is Amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease?

Current Alzheimer's Research
2012-12 | Journal article | Author
SOURCE-WORK-ID:

a40ecad0-ada3-470c-a087-506cba063b30

EID:

2-s2.0-84882445921

Contributors: Eva Borger; Laura Aitken; H Du; W Zhang; Francis James Gunn-Moore; SS Yan
Source: check_circle
University of St Andrews CRIS

Mitochondrial β-amyloid in Alzheimer's disease

Biochemical Society Transactions
2011-08 | Journal article | Author
SOURCE-WORK-ID:

c85fa05f-b1a0-4624-9cef-b370dc8cc897

EID:

2-s2.0-79960868236

Contributors: Eva Borger; Laura Aitken; Kirsty Elizabeth Adair Muirhead; Zoe Eleanor Allen; James Ainge; Stuart Conway; Francis James Gunn-Moore
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University of St Andrews CRIS
grade
Preferred source (of 2)‎

The consequences of mitochondrial amyloid beta peptide in Alzheimer’s disease

Biochemical Journal
2010-03-15 | Journal article | Author
SOURCE-WORK-ID:

7ffc66a2-9b93-4e02-b7b9-95759c47ac42

EID:

2-s2.0-77951931900

Contributors: Kirsty Elizabeth Adair Muirhead; Eva Borger; Laura Aitken; SJ Conway; Francis James Gunn-Moore
Source: check_circle
University of St Andrews CRIS
grade
Preferred source (of 2)‎