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Other IDs

Scopus Author ID: 57195490711
Loop profile: 1480558

Keywords

Tuberculosis , host-pathogen interaction, markers, protection, human

Countries

Tunisia

Biography

We are studying the mechanisms underlying human immune responses to mycobacteria. Major aims: To 1) identify immune markers able to define infection status and outcomes. TB lymphadenitis is a public health problem in Tunisia. Its diagnosis is challenging. We are funded to 2) identify biosignatures for diagnosis of TB lymphadenitis. As a Subawrd-PI of NIH-RO1 grant (Robert Modlin, UCLA) we are proposing to 3) study the cellular and molecular architecture of human TB granuloma. In my NIH international RO1 grant we are interested in determining the cellular and molecular architecture of TB lymphadeinitis granulomas, identifying biomarkers related to antimicrobial responses that correlate with the causative agent,
M. bovis vs. M. tuberculosis. During COVID19 pandemic we were inviloved to 4) study COVID19 seroserveillance and vaccine monitoring.

Activities

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Employment (1)

Institut Pasteur de Tunis: Tunis, TN

2009-10-01 to present | Assistant Professor (Laboratory of Transmission, Control and Immunobiology of Infection, LR11IPT02)
Employment
Source: Self-asserted source
Chaouki Benabdessalem

Education and qualifications (5)

WHO, WHO center, Lausanne and University of Lausanne: Lausanne, CH

2010-10-11 to 2010-10-23 | Diploma of Advanced course on immunology, vaccinology and biotechnology applied to Tuberculosis
Education
Source: Self-asserted source
Chaouki Benabdessalem

University Tunis-Elmanar: Tunis, TN

2004-01-01 to 2008-12-30 | PhD (Immunology & Molecular Biotechnology)
Education
Source: Self-asserted source
Chaouki Benabdessalem

WHO, WHO center, Lausanne and University of Lausanne: Lausanne, CH

2007-05-09 to 2007-06-23 | Diploma of Advanced course on immunology, vaccinology and biotechnology applied to infectious diseases
Education
Source: Self-asserted source
Chaouki Benabdessalem

Institute Pasteur of Paris, Pierre et Marie Curie University (Paris VI) and Denis Diderot University (Paris VII): Paris, FR

2004-09-06 to 2004-10-28 | Diploma of Advanced Immunology
Education
Source: Self-asserted source
Chaouki Benabdessalem

Faculty of Pharmacy, University of Monastir: Monastir, TN

2002-09-23 to 2003-10-28 | Master in Biotechnology and Immunology applied to infectious diseases.
Education
Source: Self-asserted source
Chaouki Benabdessalem

Professional activities (2)

Tunisian Immunological society: Tunis, TN

2022-12-26 to present | Board member (Immunology)
Membership
Source: Self-asserted source
Chaouki Benabdessalem

Society for Leukocyte Biology: Bethesda, Maryland, US

2019-01-12 to 2022-01-31 | Member of the Membership committee
Membership
Source: Self-asserted source
Chaouki Benabdessalem

Funding (2)

Cellular and molecular architecture of granulomas in human tuberculous lymphadenitis

Source: Self-asserted source
Chaouki Benabdessalem

Dynamics of the cellular and molecular architecture of human pulmonary TB granulomas

2022-02-10 to 2027-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.10021014
GRANT_NUMBER: R01AI166313
Source: Self-asserted source
Chaouki Benabdessalem via DimensionsWizard

Works (20)

Snapshot of Anti-SARS-CoV-2 IgG Antibodies in COVID-19 Recovered Patients in Guinea

Journal of Clinical Medicine
2024-05 | Journal article | Author
DOI: 10.3390/jcm13102965
Contributors: Solène Grayo; Houlou Sagno; Oumar Diassy; Jean-Baptiste Zogbelemou; Sia Jeanne Kondabo; Marilyn Houndekon; Koussay Dellagi; VIGAN-WOMAS Ines; Samia Rourou; Wafa Ben Hamouda et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

A Longitudinal Study in Tunisia to Assess the Anti-RBD IgG and IgA Responses Induced by Three Different COVID-19 Vaccine Platforms.

Tropical medicine and infectious disease
2024-03-13 | Journal article
DOI: 10.3390/tropicalmed9030061
PMID: 38535885
PMC: PMC10975151
Contributors: Ben Hamouda W; Hanachi M; Ben Hamouda S; Kammoun Rebai W; Gharbi A; Baccouche A; Bettaieb J; Souiai O; Barbouche MR; Dellagi K et al.
Source: Self-asserted source
Chaouki Benabdessalem

Development of an Optimized Process for Functional Recombinant SARS-CoV-2 Spike S1 Receptor-Binding Domain Protein Produced in the Baculovirus Expression Vector System

Tropical Medicine and Infectious Disease
2023-11 | Journal article | Author
DOI: 10.3390/tropicalmed8110501
Contributors: Mohamed Boumaiza; Ameni Chaabene; Ines Akrouti; Meriem Ben Zakour; Hana Askri; Said Salhi; Wafa Ben Hamouda; SOUMAYA MARZOUKI; Chaouki Benabdessalem; Melika Ben Ahmed et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

HBHA-IGRA and cytotoxic mediators release assays for the diagnosis of cervical tuberculous lymphadenitis.

Microbiology spectrum
2023-11-01 | Journal article | Author
DOI: 10.1128/spectrum.01638-23
PMID: 37909771
Contributors: Soumaya Bchiri; Asma Bouzekri; Ouni R; Lahiani R; Romdhane E; Dekhil N; Ben Hamouda S; Mardassi H; Asma Ferjani; Petit E et al.
Source: Self-asserted source
Chaouki Benabdessalem

Culture filtrate protein 32 as a potential target to attenuate the heterogeneous antibody response against <i>Mycobacterium tuberculosis</i> Antigens in different endemic settings.

International journal of mycobacteriology
2022-10-01 | Journal article
DOI: 10.4103/ijmy.ijmy_127_22
PMID: 36510921
Contributors: Benabdessalem C; Ouni R; Hamouda WB; Bettaieb J; Fathallah DM; Barbouche MR
Source: Self-asserted source
Chaouki Benabdessalem

COVID-19 in Tunisia (North Africa): Seroprevalence of SARS-CoV-2 in the General Population of the Capital City Tunis.

Diagnostics (Basel, Switzerland)
2022-04-13 | Journal article
DOI: 10.3390/diagnostics12040971
PMID: 35454019
PMC: PMC9031774
Contributors: Ines Cherif; Kharroubi G; Chaabane S; Yazidi R; Dellagi M; Snoussi MA; Salem S; SOUMAYA MARZOUKI; Kammoun Rebai W; Rourou S et al.
Source: Self-asserted source
Chaouki Benabdessalem

Performance of GeneXpert ultra in the diagnosis of Tuberculous Cervical lymphadenitis in formalin fixed paraffin embedded tissues

Tuberculosis
2020-12 | Journal article
DOI: 10.1016/j.tube.2020.102012
Part of ISSN: 1472-9792
Source: Self-asserted source
Chaouki Benabdessalem

Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus

JCI Insight
2020-12-03 | Journal article
DOI: 10.1172/jci.insight.123861
Part of ISSN: 2379-3708
Source: Self-asserted source
Chaouki Benabdessalem

N-glycosylation and homodimeric folding significantly enhance the immunoreactivity of Mycobacterium tuberculosis virulence factor CFP32 when produced in the yeast Pichia pastoris

Biochemical and Biophysical Research Communications
2019-08 | Journal article
DOI: 10.1016/j.bbrc.2019.06.140
Part of ISSN: 0006-291X
Source: Self-asserted source
Chaouki Benabdessalem

Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients.

J Allergy Clin Immunol.
2018-12-19 | Journal article
Source: Self-asserted source
Chaouki Benabdessalem

Granzyme B induced by Rv0140 antigen discriminates latently infected from active tuberculosis individuals.

Journal of Leukocyte Biology
2018-09-13 | Journal article
PMID: 30211958
Source: Self-asserted source
Chaouki Benabdessalem

PPM, a novel Mycobacterium tuberculosis (Mtb) antigen: a candidate for vaccine development to prevent progression to tuberculosis

5th Global Forum on TB vaccine
2018-02-20 | Conference poster
Source: Self-asserted source
Chaouki Benabdessalem

Specific immune responses in mice following subchronic exposure to acetamiprid

Life Sciences
2017 | Journal article
DOI: 10.1016/j.lfs.2017.08.022
EID:

2-s2.0-85028469414
Contributors: Marzouki, S.; Bini Dhouib, I.; Benabdessalem, C.; Rekik, R.; Doghri, R.; Maroueni, A.; Bellasfar, Z.; Fazaa, S.; Bettaieb, J.; Barbouche, M.R. et al.
Source: Self-asserted source
Chaouki Benabdessalem via Scopus - Elsevier

RV0140-Specific granzyme B as an alternative biomarker to discriminate different phases of Mycobacterium tuberculosis infection

10th African Congress of Immunology
2017-12-03 | Conference abstract
Source: Self-asserted source
Chaouki Benabdessalem

Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia.

The Journal of allergy and clinical immunology
2017-10 | Journal article
DOI: 10.1016/j.jaci.2017.04.037
PMID: 28532655
Contributors: Ben-Ali M; Yang J; Chan KW; Ben-Mustapha I; Mekki N; Benabdesselem C; Mellouli F; Bejaoui M; Yang W; Aissaoui L et al.
Source: Self-asserted source
Chaouki Benabdessalem via Europe PubMed Central

Diagnostic potential of HBHA-induced IFN-g release assay for detection of latent tuberculosis in African populations with different levels of exposure

Institut Pasteur international Network Symposium on Biomarkers
2016-11-25 | Conference abstract
Source: Self-asserted source
Chaouki Benabdessalem

Salivary antigen SP32 is the immunodominant target of the antibody response to Phlebotomus papatasi bites in humans

PLoS Neglected Tropical Diseases
2012-11-29 | Journal article
Source: Self-asserted source
Chaouki Benabdessalem

High level expression of recombinant Mycobacterium tuberculosis culture filtrate protein CFP32 in Pichia pastoris

Molecular Biotechnology
2007-01 | Journal article
Source: Self-asserted source
Chaouki Benabdessalem

Enhanced patient serum immunoreactivity to recombinant Mycobacterium tuberculosis CFP32 produced in the yeast Pichia pastoris compared to Escherichia coli and its potential for serodiagnosis of tuberculosis

Journal of Clinical Microbiology
2006-09 | Journal article
Source: Self-asserted source
Chaouki Benabdessalem

Development of an Optimized Process for Functional Recombinant SARS-CoV-2 Spike S1 Receptor-Binding Domain Protein Produced in the Baculovirus Expression Vector System
Source: check_circle
Multidisciplinary Digital Publishing Institute

Peer review (1 review for 1 publication/grant)

Review activity for Virology journal (1)
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