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Works (18)

Four-component protein nanocages designed by programmed symmetry breaking

Nature
2025-02-13 | Journal article
Contributors: Sangmin Lee; Ryan D. Kibler; Green Ahn; Yang Hsia; Andrew J. Borst; Annika Philomin; Madison A. Kennedy; Buwei Huang; Barry Stoddard; David Baker
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Hierarchical design of pseudosymmetric protein nanocages

Nature
2025-02-13 | Journal article
Contributors: Quinton M. Dowling; Young-Jun Park; Chelsea N. Fries; Neil C. Gerstenmaier; Sebastian Ols; Erin C. Yang; Adam J. Wargacki; Annie Dosey; Yang Hsia; Rashmi Ravichandran et al.
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Bond-centric modular design of protein assemblies

2024-10-12 | Preprint
Contributors: Shunzhi Wang; Andrew Favor; Ryan Daniel Kibler; Joshua Morris Lubner; Andrew J Borst; Nicolas Coudray; Rachel Redler; Huat Thart Chiang; William Sheffler; Yang Hsia et al.
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Blueprinting extendable nanomaterials with standardized protein blocks

Nature
2024-03-28 | Journal article
Contributors: Timothy F. Huddy; Yang Hsia; Ryan D. Kibler; Jinwei Xu; Neville Bethel; Deepesh Nagarajan; Rachel Redler; Philip J. Y. Leung; Connor Weidle; Alexis Courbet et al.
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De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity

Proceedings of the National Academy of Sciences
2024-02-06 | Journal article
Contributors: Rubul Mout; Ross C. Bretherton; Justin Decarreau; Sangmin Lee; Nicole Gregorio; Natasha I. Edman; Maggie Ahlrichs; Yang Hsia; Danny D. Sahtoe; George Ueda et al.
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Hierarchical design of pseudosymmetric protein nanoparticles

2023-07-10 | Preprint
Contributors: David Baker; Quinton Dowling; Young-Jun Park; Neil Gerstenmaier; Erin Yang; Adam Wargacki; Yang Hsia; Chelsea Fries; Rashmi Ravichandran; Carl Walkey et al.
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Design of four component T=4 tetrahedral, octahedral, and icosahedral protein nanocages through programmed symmetry breaking

2023-06-17 | Preprint
Contributors: Sangmin Lee; Ryan D. Kibler; Yang Hsia; Andrew J. Borst; Annika Philomin; Madison A. Kennedy; Barry Stoddard; David Baker
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De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity

2023-06-03 | Preprint
Contributors: Rubul Mout; Ross C. Bretherton; Justin Decarreau; Sangmin Lee; Natasha I. Edman; Maggie Ahlrichs; Yang Hsia; Danny D. Sahtoe; George Ueda; Nicole Gregorio et al.
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Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

Proceedings of the National Academy of Sciences
2023-03-14 | Journal article
Contributors: Jing Yang (John) Wang; Alena Khmelinskaia; William Sheffler; Marcos C. Miranda; Aleksandar Antanasijevic; Andrew J. Borst; Susana V. Torres; Chelsea Shu; Yang Hsia; Una Nattermann et al.
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De novo design of obligate ABC-type heterotrimeric proteins

Nature Structural & Molecular Biology
2022-12 | Journal article
Contributors: Sherry Bermeo; Andrew Favor; Ya-Ting Chang; Andrew Norris; Scott E. Boyken; Yang Hsia; Hugh K. Haddox; Chunfu Xu; T. J. Brunette; Vicki H. Wysocki et al.
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Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock

2022-10-26 | Preprint
Contributors: William Sheffler; Erin C. Yang; Quinton Dowling; Yang Hsia; Chelsea N. Fries; Jenna Stanislaw; Mark Langowski; Marisa Brandys; Alena Khmelinskaia; Neil P. King et al.
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Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

2022-08-05 | Preprint
Contributors: Jing Yang (John) Wang; Alena Khmelinskaia; William Sheffler; Marcos C. Miranda; Aleksandar Antanasijevic; Andrew J. Borst; Susana Vazquez Torres; Chelsea Shu; Yang Hsia; Una Nattermann et al.
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Computational design of mechanically coupled axle-rotor protein assemblies

Science
2022-04-22 | Journal article
Contributors: A. Courbet; J. Hansen; Y. Hsia; N. Bethel; Y.-J. Park; C. Xu; A. Moyer; S. E. Boyken; G. Ueda; U. Nattermann et al.
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Reconfigurable asymmetric protein assemblies through implicit negative design

Science
2022-01-21 | Journal article
Contributors: Danny D. Sahtoe; Florian Praetorius; Alexis Courbet; Yang Hsia; Basile I. M. Wicky; Natasha I. Edman; Lauren M. Miller; Bart J. R. Timmermans; Justin Decarreau; Hana M. Morris et al.
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Computational design of nanoscale rotational mechanics in de novo protein assemblies

2021-11-12 | Other
Contributors: A. Courbet; J. Hansen; Y. Hsia; N. Bethel; YJ. Park; C. Xu; A. Moyer; S.E. Boyken; G. Ueda; U. Nattermann et al.
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Reconfigurable asymmetric protein assemblies through implicit negative design

2021-08-15 | Other
Contributors: Danny D. Sahtoe; Florian Praetorius; Alexis Courbet; Yang Hsia; Basile I.M. Wicky; Natasha I. Edman; Lauren M. Miller; Bart J. R. Timmermans; Hana M. Morris; Alex Kang et al.
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Design of multi-scale protein complexes by hierarchical building block fusion

Nature Communications
2021-04-16 | Journal article
Contributors: Yang Hsia; Rubul Mout; William Sheffler; Natasha I. Edman; Ivan Vulovic; Young-Jun Park; Rachel L. Redler; Matthew J. Bick; Asim K. Bera; Alexis Courbet et al.
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Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

2020-07-28 | Preprint
Contributors: Yang Hsia; Rubul Mout; William Sheffler; Natasha I. Edman; Ivan Vulovic; Young-Jun Park; Rachel L. Redler; Matthew J. Bick; Asim K. Bera; Alexis Courbet et al.
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