Personal information

No personal information available

Activities

Collapse all

Employment (3)

Keio University: Tkyo, JP

2023-04-01 to present | Sakigake Fellow
Employment
Source: Self-asserted source
Iku Tsutsui-Kimura

Harvard University Harvard Film Archive: Cambridge, MA, US

2019-09-01 to 2023-03-31 | Postdoc (Dept. Molecular and Cellular Biology)
Employment
Source: Self-asserted source
Iku Tsutsui-Kimura

Keio University : Tokyo, JP

2017-04-01 to 2017-07-31 | Postdoc (Dept. Neuropsychiatry)
Employment
Source: Self-asserted source
Iku Tsutsui-Kimura

Professional activities (3)

Japan Society for the Promotion of Science: Tokyo, JP

2017-09-01 to 2019-08-31 | Overseas PD
Invited position
Source: Self-asserted source
Iku Tsutsui-Kimura

Japan Society for the Promotion of Science: Tokyo, JP

2014-04-01 to 2017-03-31 | RPD
Invited position
Source: Self-asserted source
Iku Tsutsui-Kimura

Japan Society for the Promotion of Science: Tokyo, JP

2011-04-01 to 2014-03-31 | DC1
Invited position
Source: Self-asserted source
Iku Tsutsui-Kimura

Works (35)

A hypothalamic circuit underlying the dynamic control of social homeostasis

Nature
2025-02-26 | Journal article
DOI: 10.1038/s41586-025-08617-8
Contributors: Ding Liu; Mostafizur Rahman; Autumn Johnson; Ryunosuke Amo; Iku Tsutsui-Kimura; Zuri A. Sullivan; Nicolai Pena; Mustafa Talay; Brandon L. Logeman; Samantha Finkbeiner et al.
Source: check_circle
Crossref

Dopamine dynamics are dispensable for movement but promote reward responses

Nature
2024-11-14 | Journal article
DOI: 10.1038/s41586-024-08038-z
Contributors: Xintong Cai; Changliang Liu; Iku Tsutsui-Kimura; Joon-Hyuk Lee; Chong Guo; Aditi Banerjee; Jinoh Lee; Ryunosuke Amo; Yudi Xie; Tommaso Patriarchi et al.
Source: check_circle
Crossref

Inhibition of the dorsomedial striatal direct pathway is essential for the execution of action sequences

Neuropsychopharmacology Reports
2023-09 | Journal article
DOI: 10.1002/npr2.12369
Contributors: Anna Kono; Yu Shikano; Kenji F. Tanaka; Katsunori Yamaura; Iku Tsutsui‐Kimura
Source: check_circle
Crossref

Dynamical management of potential threats regulated by dopamine and direct- and indirect-pathway neurons in the tail of the striatum

2022-02-07 | Preprint
DOI: 10.1101/2022.02.05.479267
Contributors: Iku Tsutsui-Kimura; Naoshige Uchida; Mitsuko Watabe-Uchida
Source: check_circle
Crossref

Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

2021-12-21 | Preprint
DOI: 10.1101/2021.12.21.473723
Contributors: Korleki Akiti; Iku Tsutsui-Kimura; Yudi Xie; Alexander Mathis; Jeffrey Markowitz; Rockwell Anyoha; Sandeep Robert Datta; Mackenzie Weygandt Mathis; Naoshige Uchida; Mitsuko Watabe-Uchida
Source: check_circle
Crossref

Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder

Biochemical and Biophysical Research Communications
2021-08 | Journal article
DOI: 10.1016/j.bbrc.2021.06.057
Contributors: Yuichi Hiraoka; Kaori Sugiyama; Daiki Nagaoka; Iku Tsutsui-Kimura; Kenji F. Tanaka; Kohichi Tanaka
Source: check_circle
Crossref

Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task.

eLife
2020-12-21 | Journal article
DOI: 10.7554/elife.62390
PMID: 33345774
Source: Self-asserted source
Iku Tsutsui-Kimura
grade
Preferred source (of 2)‎

A Unified Framework for Dopamine Signals across Timescales.

Cell
2020-11-27 | Journal article
DOI: 10.1016/j.cell.2020.11.013
PMID: 33248024
Source: Self-asserted source
Iku Tsutsui-Kimura

Spatial inference without a cognitive map: the role of higher-order path integration.

Biological reviews of the Cambridge Philosophical Society
2020-09-16 | Journal article
DOI: 10.1111/brv.12645
PMID: 32939978
Source: Self-asserted source
Iku Tsutsui-Kimura

Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.

Cell reports
2020-06-01 | Journal article
DOI: 10.1016/j.celrep.2020.107829
PMID: 32610130
Source: Self-asserted source
Iku Tsutsui-Kimura

Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects.

Neuropharmacology
2019-07-09 | Journal article
DOI: 10.1016/j.neuropharm.2019.107703
PMID: 31299228
Source: Self-asserted source
Iku Tsutsui-Kimura

AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation.

Neurochemistry international
2019-05-16 | Journal article
DOI: 10.1016/j.neuint.2019.104470
PMID: 31102607
Source: Self-asserted source
Iku Tsutsui-Kimura

5-HT3 antagonists decrease discounting rate without affecting sensitivity to reward magnitude in the delay discounting task in mice.

Psychopharmacology
2018-06-28 | Journal article
DOI: 10.1007/s00213-018-4954-0
PMID: 29955899
Source: Self-asserted source
Iku Tsutsui-Kimura

Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.

Science (New York, N.Y.)
2018-02-01 | Journal article
DOI: 10.1126/science.aaq1144
PMID: 29439241
Source: Self-asserted source
Iku Tsutsui-Kimura

Distinct Roles of Ventromedial versus Ventrolateral Striatal Medium Spiny Neurons in Reward-Oriented Behavior.

Current biology : CB
2017-09-28 | Journal article
DOI: 10.1016/j.cub.2017.08.061
PMID: 28966085
Source: Self-asserted source
Iku Tsutsui-Kimura

Striatonigral direct pathway activation is sufficient to induce repetitive behaviors.

Neuroscience research
2017-09-20 | Journal article
DOI: 10.1016/j.neures.2017.09.007
PMID: 28939413
Source: Self-asserted source
Iku Tsutsui-Kimura

Yokukansankachimpihange increased body weight but not food-incentive motivation in wild-type mice.

Nagoya journal of medical science
2017-08-01 | Journal article
DOI: 10.18999/nagjms.79.3.351
PMID: 28878440
PMC: PMC5577021
Source: Self-asserted source
Iku Tsutsui-Kimura

A New Paradigm for Evaluating Avoidance/Escape Motivation.

The international journal of neuropsychopharmacology
2017-07-01 | Journal article
DOI: 10.1093/ijnp/pyx031
PMID: 28482015
PMC: PMC5492826
Source: Self-asserted source
Iku Tsutsui-Kimura

Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner.

Journal of pharmacological sciences
2017-06-27 | Journal article
DOI: 10.1016/j.jphs.2017.06.004
PMID: 28694090
Source: Self-asserted source
Iku Tsutsui-Kimura

The data set describing cognitive performance after varenicline administration in a 3-choice serial reaction time task in rats.

Data in brief
2017-03-03 | Journal article
DOI: 10.1016/j.dib.2017.02.050
PMID: 28337467
PMC: PMC5349458
Source: Self-asserted source
Iku Tsutsui-Kimura

Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2017-02-06 | Journal article
DOI: 10.1523/jneurosci.3377-16.2017
PMID: 28167674
PMC: PMC6596637
Source: Self-asserted source
Iku Tsutsui-Kimura

Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation.

Nature communications
2017-02-01 | Journal article
DOI: 10.1038/ncomms14304
PMID: 28145402
PMC: PMC5296642
Source: Self-asserted source
Iku Tsutsui-Kimura

Varenicline provokes impulsive action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner.

Pharmacology, biochemistry, and behavior
2017-01-10 | Journal article
DOI: 10.1016/j.pbb.2017.01.002
PMID: 28087221
Source: Self-asserted source
Iku Tsutsui-Kimura

Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex.

Behavioural brain research
2015-09-02 | Journal article
DOI: 10.1016/j.bbr.2015.08.025
PMID: 26341319
Source: Self-asserted source
Iku Tsutsui-Kimura

Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.

The international journal of neuropsychopharmacology
2014-12-08 | Journal article
DOI: 10.1093/ijnp/pyu083
PMID: 25522418
PMC: PMC4376543
Source: Self-asserted source
Iku Tsutsui-Kimura

[Anti-impulsivity drugs and their mechanisms of action].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology
2014-04-01 | Journal article
PMID: 25080806
Source: Self-asserted source
Iku Tsutsui-Kimura

Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor.

Journal of pharmacological sciences
2013-05-24 | Journal article
DOI: 10.1254/jphs.12264fp
PMID: 23707971
Source: Self-asserted source
Iku Tsutsui-Kimura

Milnacipran enhances the control of impulsive action by activating D₁-like receptors in the infralimbic cortex.

Psychopharmacology
2012-08-15 | Journal article
DOI: 10.1007/s00213-012-2835-5
PMID: 22892727
Source: Self-asserted source
Iku Tsutsui-Kimura

Impulsive behavior and nicotinic acetylcholine receptors.

Journal of pharmacological sciences
2012-03-22 | Journal article
DOI: 10.1254/jphs.11r06cr
PMID: 22447304
Source: Self-asserted source
Iku Tsutsui-Kimura

Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.

Psychopharmacology
2011-09-21 | Journal article
DOI: 10.1007/s00213-011-2496-9
PMID: 21947315
Source: Self-asserted source
Iku Tsutsui-Kimura

Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats.

European journal of pharmacology
2010-06-08 | Journal article
DOI: 10.1016/j.ejphar.2010.05.028
PMID: 20639140
Source: Self-asserted source
Iku Tsutsui-Kimura

Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex.

Psychopharmacology
2010-03-19 | Journal article
DOI: 10.1007/s00213-010-1804-0
PMID: 20238211
Source: Self-asserted source
Iku Tsutsui-Kimura

The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2010-01-13 | Journal article
DOI: 10.1038/npp.2009.229
PMID: 20072117
PMC: PMC3055345
Source: Self-asserted source
Iku Tsutsui-Kimura

Assessment of attentional function and impulsivity using 5-choice serial reaction time task/3-choice serial reaction time task.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
2009-09-01 | Journal article
DOI: 10.1254/fpj.134.137
PMID: 19749485
Source: Self-asserted source
Iku Tsutsui-Kimura

The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task: a simple and valid model of impulsive action using rats.

Behavioural pharmacology
2009-09-01 | Journal article
DOI: 10.1097/fbp.0b013e3283305e65
PMID: 19730368
Source: Self-asserted source
Iku Tsutsui-Kimura
How many people are using ORCID?