Personal information

Bioinformatics, Statistics, Next-Generation Sequencing Analyses, Evolutionary Biology
Canada, France

Biography

In eukaryotes, the processes of transcription and maturation of RNAs in the nucleus can result in the expression of different isoforms from the same gene, via the use of alternative splice sites. The architecture of genes (number and size of introns) as well as the degree of complexity of isoform transcripts vary greatly between different taxa. The “raison d’être” for this diversity is still poorly understood. According to some authors, this complexity results from selective pressures to increase the functional repertoire of genomes. But according to others, these isoforms are predominantly non-functional, and result from the accumulation of deleterious mutations by random genetic drift, which would induce errors in the cellular machinery of expression. The objective of my work is to estimate to what extent the effective size of the populations (Ne, which defines the intensity of the genetic drift) influences the evolution of the structure and the complexity of the expression of the genes in metazoa. My research project is based on the comparative analysis of genome and transcriptomes in metazoans. It requires significant bioinformatics developments to ensure the analysis and management of large volumes of data.

Activities

Employment (4)

Centre Hospitalier Universitaire Sainte-Justine: Montreal, CA

2024-09-01 to present | Bioinformaticist (Centre de Recherche)
Employment
Source: Self-asserted source
Florian Bénitière

CNRS Délégation Rhône-Auvergne: Villeurbanne, Auvergne-Rhône-Alpes, FR

2021-12-01 to 2024-08-31 | Ingénieur de Recherche (Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558) (Biology - Bioinformatics)
Employment
Source: Self-asserted source
Florian Bénitière

Université Claude Bernard Lyon 1: Villeurbanne, Auvergne-Rhône-Alpes, FR

2019-12-01 to 2021-11-30 | Ingénieur de Recherche (Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558) (Biology - Bioinformatics)
Employment
Source: Self-asserted source
Florian Bénitière

CNRS Délégation Rhône-Auvergne: Villeurbanne, Auvergne-Rhône-Alpes, FR

2019-03-01 to 2019-09-30 | Ingénieur d'étude de recherche et de formation (Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558) (Biology - Bioinformatics)
Employment
Source: Self-asserted source
Florian Bénitière

Education and qualifications (3)

Claude Bernard University Lyon 1: Villeurbanne, FR

2021-12 to 2024-05 | PhD in Evolutionary Genomics (Evolutionary Genomics, Bioinformatics)
Education
Source: Self-asserted source
Florian Bénitière

École Nationale Supérieure Agronomique de Toulouse: Toulouse, Occitanie, FR

2015-09-01 to 2019-10-01 | Ingénieur (Biology - Bioinformatics - Biostatistics)
Education
Source: Self-asserted source
Florian Bénitière

Université Laval: Québec, CA

2017-09-01 to 2018-05-01 | Baccalauréat (Bioinformatics)
Education
Source: Self-asserted source
Florian Bénitière

Works (9)

Variation in the fitness impact of translationally optimal codons among animals

Genome Research
2025-02-10 | Journal article
Contributors: Florian Bénitière; Tristan Lefébure; Laurent Duret
Source: check_circle
Crossref

Variation in the fitness impact of translationally optimal codons among animals

2024-07-23 | Preprint
Contributors: Florian Bénitìere; Tristan Lefébure; Laurent Duret
Source: check_circle
Crossref

GTDrift: a resource for exploring the interplay between genetic drift, genomic and transcriptomic characteristics in eukaryotes

NAR Genomics and Bioinformatics
2024-04-04 | Journal article
Contributors: Florian Bénitière; Laurent Duret; Anamaria Necsulea
Source: check_circle
Crossref

Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

eLife
2024-03-12 | Journal article
Contributors: Florian Bénitière; Anamaria Necsulea; Laurent Duret
Source: check_circle
Crossref
grade
Preferred source (of 6)‎

GTDrift: A resource for exploring the interplay between genetic drift, genomic and transcriptomic characteristics in eukaryotes

2024-01-25 | Preprint
Contributors: Florian Bénitière; Laurent Duret; Anamaria Necsulea
Source: check_circle
Crossref

Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

SMBE23
2023-07-23 | Conference poster
Contributors: Florian Bénitière; Anamaria Necsulea; Laurent Duret
Source: Self-asserted source
Florian Bénitière

Investigating the impact of random genetic drift on synonymous codon usage in metazoans

ALPHY/AIEM
2023-01-24 | Conference abstract
Contributors: Florian Bénitière; Tristan Lefébure; Laurent Duret
Source: Self-asserted source
Florian Bénitière

Paramecium sonneborni : a promiscuous species ?

ALPHY/AIEM
2021-02-04 | Conference abstract
Contributors: Florian Bénitière; Linda Sperling; Olivier Arnaiz; Emmanuelle Lerat; Eric Meyer; Sandra Duharcourt; Laurent Duret
Source: Self-asserted source
Florian Bénitière

The rate of alternative splicing in metazoans is driven by the mutation-selection-drift balance

ALPHY/AIEM
2020-02-04 | Conference abstract
Contributors: Florian Bénitière; Anamaria Necsulea; Laurent Duret
Source: Self-asserted source
Florian Bénitière