Personal information

Emails & domains

Verified email domains

Websites & social links

Research group website

Activities

Collapse all

Employment (3)

Johannes Gutenberg University Mainz: Mainz, Rheinland-Pfalz, DE

2022-05-01 to present | Junior group leader (Medicinal chemistry)
Employment
Source: Self-asserted source
Fabian Barthels

Yale University: New Haven, US

2024-04-01 to 2024-09-30 | Postdoctoral associate (Yale Center for Molecular Discovery)
Employment
Source: Self-asserted source
Fabian Barthels

Johannes Gutenberg University of Mainz: Mainz, Rheinland-Pfalz, DE

2018-11-01 to 2022-04-30 | PhD student (Institute for Pharmacy)
Employment
Source: Self-asserted source
Fabian Barthels

Education and qualifications (2)

University of Tübingen: Tübingen, DE

2016-10-01 to 2018-10-31 | MSc (Biochemistry)
Education
Source: Self-asserted source
Fabian Barthels

University of Tübingen: Tübingen, DE

2013-10-01 to 2016-09-30 | BSc (Biochemistry)
Education
Source: Self-asserted source
Fabian Barthels

Professional activities (4)

Boehringer Ingelheim (Germany): Ingelheim am Rhein, DE

2023-07-01 | Boehringer-Ingelheim foundation dissertation award
Distinction
Source: Self-asserted source
Fabian Barthels

Deutsche Pharmazeutische Gesellschaft (DPhG): Frankfurt, DE

2022-09-27 | Walter-Schunack prize for scientific achievements in medicinal chemistry.
Distinction
Source: Self-asserted source
Fabian Barthels

Phoenix Pharma SE: Mannheim, DE

2022-01-01 | Phoenix Pharmacy award (co-awarded) with Prof. Dr. Tanja Schirmeister
Distinction
Source: Self-asserted source
Fabian Barthels

Bundesministerium für Bildung und Forschung: Berlin, DE

2017-01-01 | Deutschlandstipendium (BMBF), awarded for outstanding academic potential
Distinction
Source: Self-asserted source
Fabian Barthels

Funding (1)

MAINCE: Medical AI combining Natural products and CEllular Imaging

Source: Self-asserted source
Fabian Barthels

Works (23)

A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors

Communications Chemistry
2025-02-03 | Journal article
DOI: 10.1038/s42004-025-01439-9
Contributors: Zarina Nidoieva; Mark O. Sabin; Tristan Dewald; Annabelle C. Weldert; Sabrina N. Hoba; Mark Helm; Fabian Barthels
Source: check_circle
Crossref

Nanomole Scale Screening of Fluorescent RNA‐Methyltransferase Probes Enables the Discovery of METTL1 Inhibitors

Angewandte Chemie International Edition
2024-11-25 | Journal article
DOI: 10.1002/anie.202403792
Contributors: J. Laurenz Meidner; Ariane F. Frey; Robert A. Zimmermann; Mark O. Sabin; Zarina Nidoieva; Annabelle C. Weldert; Sabrina N. Hoba; Mackenzie W. Krone; Fabian Barthels
Source: check_circle
Crossref

Screening fluoreszenter RNA‐Methyltransferase‐Sonden im Nanomolmaßstab ermöglicht die Entdeckung von METTL1‐Inhibitoren

Angewandte Chemie
2024-11-25 | Journal article
DOI: 10.1002/ange.202403792
Contributors: J. Laurenz Meidner; Ariane F. Frey; Robert A. Zimmermann; Mark O. Sabin; Zarina Nidoieva; Annabelle C. Weldert; Sabrina N. Hoba; Mackenzie W. Krone; Fabian Barthels
Source: check_circle
Crossref

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

2024-07-17 | Preprint
DOI: 10.7554/eLife.98310
Contributors: Viviane Kremling; Sven Falke; Yaiza Fernández-García; Christiane Ehrt; Antonia Kiene; Bjarne Klopprogge; Emilie Scheer; Fabian Barthels; Philipp Middendorf; Sebastian Kühn et al.
Source: check_circle
Crossref

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

2024-07-17 | Preprint
DOI: 10.7554/eLife.98310.1
Contributors: Viviane Kremling; Sven Falke; Yaiza Fernández-García; Christiane Ehrt; Antonia Kiene; Bjarne Klopprogge; Emilie Scheer; Fabian Barthels; Philipp Middendorf; Sebastian Kühn et al.
Source: check_circle
Crossref

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

2024-03-13 | Preprint
DOI: 10.1101/2024.03.13.583470
Contributors: Viviane Kremling; Sven Falke; Yaiza Fernández-García; Christiane Ehrt; Antonia Kiene; Bjarne Klopprogge; Emilie Scheer; Fabian Barthels; Philipp Middendorf; Sebastian Kühn et al.
Source: check_circle
Crossref

Designing photoaffinity tool compounds for the investigation of the DENV NS2B–NS3 protease allosteric binding pocket

RSC Medicinal Chemistry
2023 | Journal article
DOI: 10.1039/D3MD00331K
Contributors: Hannah Maus; Andrea Gellert; Olivia R. Englert; Jia-Xuan Chen; Tanja Schirmeister; Fabian Barthels
Source: check_circle
Crossref

Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications

Chemical Science
2023 | Journal article
DOI: 10.1039/D3SC02993J
Contributors: Elisabeth Kallert; Malte Behrendt; Ariane Frey; Christian Kersten; Fabian Barthels
Source: check_circle
Crossref

Next Generation of Fluorometric Protease Assays: 7‐Nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl‐amides (NBD‐Amides) as Class‐Spanning Protease Substrates

Chemistry – A European Journal
2023-09-06 | Journal article
DOI: 10.1002/chem.202301855
Contributors: Hannah Maus; Patrick Müller; Mergim Meta; Sabrina N. Hoba; Stefan J. Hammerschmidt; Robert A. Zimmermann; Collin Zimmer; Natalie Fuchs; Tanja Schirmeister; Fabian Barthels
Source: check_circle
Crossref

Investigation of the influence of chirality and halogen atoms on the anticancer activity of enantiopure palladium(<scp>ii</scp>) complexes derived from chiral amino-alcohol Schiff bases and 2-picolylamine

New Journal of Chemistry
2022 | Journal article
DOI: 10.1039/d2nj00321j
Part of ISSN: 1144-0546
Part of ISSN: 1369-9261
Contributors: Hadi Amiri Rudbari; Nazanin Kordestani; José Vicente Cuevas-Vicario; Min Zhou; Thomas Efferth; Isabel Correia; Tanja Schirmeister; Fabian Barthels; Mohammed Enamullah; Alexandra Fernandes et al.
Source: Self-asserted source
Fabian Barthels

Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening.

The Journal of antibiotics
2022-04 | Journal article
DOI: 10.1038/s41429-022-00524-8
PMID: 35440771
PMC: PMC9016125
Contributors: Volynets GP; Barthels F; Hammerschmidt SJ; Moshynets OV; Lukashov SS; Starosyla SA; Vyshniakova HV; Iungin OS; Bdzhola VG; Prykhod'ko AO et al.
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments.

HardwareX
2022-01 | Journal article
DOI: 10.1016/j.ohx.2022.e00256
PMID: 35509940
PMC: PMC9058602
Contributors: Barthels F; Hammerschmidt SJ; Fischer TR; Zimmer C; Kallert E; Helm M; Kersten C; Schirmeister T
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases.

Bioorganic & medicinal chemistry
2021-09 | Journal article
DOI: 10.1016/j.bmc.2021.116392
PMID: 34509861
Contributors: Maus H; Barthels F; Hammerschmidt SJ; Kopp K; Millies B; Gellert A; Ruggieri A; Schirmeister T
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.

Journal of medicinal chemistry
2021-08 | Journal article
DOI: 10.1021/acs.jmedchem.1c01002
PMID: 34378914
Contributors: Jung S; Fuchs N; Johe P; Wagner A; Diehl E; Yuliani T; Zimmer C; Barthels F; Zimmermann RA; Klein P et al.
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

2-Sulfonylpyrimidines as Privileged Warheads for the Development of <i>S. aureus</i> Sortase A Inhibitors.

Frontiers in molecular biosciences
2021-01 | Journal article
DOI: 10.3389/fmolb.2021.804970
PMID: 35047562
PMC: PMC8763382
Contributors: Barthels F; Meyr J; Hammerschmidt SJ; Marciniak T; Räder HJ; Ziebuhr W; Engels B; Schirmeister T
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

BANΔIT: B’‐Factor Analysis for Drug Design and Structural Biology

Molecular Informatics
2021-01 | Journal article
DOI: 10.1002/minf.202000144
Contributors: Fabian Barthels; Tanja Schirmeister; Christian Kersten
Source: check_circle
Crossref

Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A

ChemMedChem
2020-05-19 | Journal article
DOI: 10.1002/cmdc.201900687
Contributors: Fabian Barthels; Gabriella Marincola; Tessa Marciniak; Matthias Konhäuser; Stefan Hammerschmidt; Jan Bierlmeier; Ute Distler; Peter R. Wich; Stefan Tenzer; Dirk Schwarzer et al.
Source: check_circle
Crossref

FINDUS: An Open-Source 3D Printable Liquid-Handling Workstation for Laboratory Automation in Life Sciences

SLAS Technology
2020-04 | Journal article
DOI: 10.1177/2472630319877374
Contributors: Fabian Barthels; Ulrich Barthels; Marvin Schwickert; Tanja Schirmeister
Source: check_circle
Crossref

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics.

Molecules (Basel, Switzerland)
2020-04 | Journal article
DOI: 10.3390/molecules25092064
PMID: 32354191
PMC: PMC7248907
Contributors: Klein P; Barthels F; Johe P; Wagner A; Tenzer S; Distler U; Le TA; Schmid P; Engel V; Engels B et al.
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives.

Organic letters
2020-03 | Journal article
DOI: 10.1021/acs.orglett.0c00723
PMID: 32212714
Contributors: Roman D; Raguž L; Keiff F; Meyer F; Barthels F; Schirmeister T; Kloss F; Beemelmanns C
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain.

Molecules (Basel, Switzerland)
2020-03 | Journal article
DOI: 10.3390/molecules25061451
PMID: 32210166
PMC: PMC7145299
Contributors: Klein P; Johe P; Wagner A; Jung S; Kühlborn J; Barthels F; Tenzer S; Distler U; Waigel W; Engels B et al.
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases.

Journal of medicinal chemistry
2019-12 | Journal article
DOI: 10.1021/acs.jmedchem.9b01697
PMID: 31769670
Contributors: Millies B; von Hammerstein F; Gellert A; Hammerschmidt S; Barthels F; Göppel U; Immerheiser M; Elgner F; Jung N; Basic M et al.
Source: Self-asserted source
Fabian Barthels via Europe PubMed Central

Identification of sortase substrates by specificity profiling

Bioorganic & Medicinal Chemistry
2017-09 | Journal article
DOI: 10.1016/j.bmc.2017.06.033
Part of ISSN: 0968-0896
Source: Self-asserted source
Fabian Barthels

Peer review (6 reviews for 4 publications/grants)

Review activity for Analytical biochemistry. (2)
Review activity for Communications chemistry. (1)
Review activity for Nature communications (1)
Review activity for Pharmacological research. (2)
How many people are using ORCID?