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Scopus Author ID: 26324947700

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Employment (3)

European Molecular Biology Laboratory: Heidelberg, Baden-Württemberg, DE

2017-12-01 to present | Group leader (Genome Biology)
Employment
Source: Self-asserted source
Arnaud Krebs

Friedrich Miescher Institute for Biomedical Research: Basel, Basel-Stadt, CH

2011-01-01 to 2017-12-31 | Post-doc (Epigenetics)
Employment
Source: Self-asserted source
Arnaud Krebs

Université de Strasbourg: Strasbourg, Alsace, FR

2006-06-01 to 2010-12-01 | PhD (IGBMC - Functional genomics)
Employment
Source: Self-asserted source
Arnaud Krebs

Funding (4)

Systematic dissection of Transcription Factor binding cooperativity mechanisms

2020-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.9404359
GRANT_NUMBER: 446603164
Source: Self-asserted source
Arnaud Krebs via DimensionsWizard

Epigenetic control of Transcription Factor activity

2019-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.8102629
GRANT_NUMBER: 418196409
Source: Self-asserted source
Arnaud Krebs via DimensionsWizard

Single molecule footprinting of a mamalian genome

2016-01 to 2018-12 | Grant
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Bern, CH)
Source: Self-asserted source
Arnaud Krebs

Fuctional dissection of CpG islands

2011-01 to 2013-12 | Award
European Molecular Biology Organization (Heidelberg, DE)
Source: Self-asserted source
Arnaud Krebs

Works (32)

Mammalian promoters are characterised by low occupancy and high turnover of RNA polymerase II

2024-09-24 | Preprint
DOI: 10.1101/2024.09.23.614464
Contributors: Kasit Chatsirisupachai; Christina J.I. Moene; Rozemarijn Kleinendorst; Elisa Kreibich; Nacho Molina; Arnaud Krebs
Source: check_circle
Crossref

Relevance of DNA methylation at enhancers for the acquisition of cell identities

FEBS Letters
2023-07 | Journal article
DOI: 10.1002/1873-3468.14686
Contributors: Elisa Kreibich; Arnaud R. Krebs
Source: check_circle
Crossref

Identification of transcription factor co-binding patterns with non-negative matrix factorization

2023-04-29 | Preprint
DOI: 10.1101/2023.04.28.538684
Contributors: Ieva Rauluseviciute; Timothée Launay; Guido Barzaghi; Sarvesh Nikumbh; Boris Lenhard; Arnaud Regis Krebs; Jaime A. Castro-Mondragon; Anthony Mathelier
Source: check_circle
Crossref

Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation.

Molecular cell
2023-02 | Journal article
DOI: 10.1016/j.molcel.2023.01.017
PMID: 36758546
Contributors: Kreibich E; Kleinendorst R; Barzaghi G; Kaspar S; Krebs AR
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.

Nature genetics
2022-11 | Journal article
DOI: 10.1038/s41588-022-01210-z
PMID: 36333500
PMC: PMC9649441
Contributors: Butz S; Schmolka N; Karemaker ID; Villaseñor R; Schwarz I; Domcke S; Uijttewaal ECH; Jude J; Lienert F; Krebs AR et al.
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Cofactors: a new layer of specificity to enhancer regulation.

Trends in biochemical sciences
2022-08 | Journal article
DOI: 10.1016/j.tibs.2022.07.008
PMID: 35970663
Contributors: Kreibich E; Krebs AR
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Single molecule multi-omics reveals context-dependent regulation of enhancers by DNA methylation

2022-05 | Preprint
DOI: 10.1101/2022.05.19.492653
PPR: PPR495576
Contributors: Kreibich E; Kleinendorst R; Barzaghi G; Kaspar S; Krebs AR
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting.

Nature protocols
2021-11 | Journal article
DOI: 10.1038/s41596-021-00630-1
PMID: 34773120
PMC: PMC7613001
Contributors: Kleinendorst RWD; Barzaghi G; Smith ML; Zaugg JB; Krebs AR
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

BANP opens chromatin and activates CpG-island-regulated genes.

Nature
2021-07 | Journal article
DOI: 10.1038/s41586-021-03689-8
PMID: 34234345
Contributors: Grand RS; Burger L; Gräwe C; Michael AK; Isbel L; Hess D; Hoerner L; Iesmantavicius V; Durdu S; Pregnolato M et al.
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central

Studying transcription factor function in the genome at molecular resolution.

Trends in genetics : TIG
2021-04 | Journal article
DOI: 10.1016/j.tig.2021.03.008
PMID: 33892959
Contributors: Krebs AR
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central

McQ – An open-source multiplexed SARS-CoV-2 quantification platform

2020-12 | Preprint
DOI: 10.1101/2020.12.02.20242628
PPR: PPR249234
Contributors: Vonesch SC; Bredikhin D; Dobrev N; Villacorta L; Kleinendorst R; Cacace E; Flock J; Frank M; Jung F; Kornienko J et al.
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central

Single molecule occupancy patterns of transcription factors reveal determinants of cooperative binding in vivo

2020-06 | Preprint
DOI: 10.1101/2020.06.29.167155
PPR: PPR181683
Contributors: Sönmezer C; Kleinendorst R; Imanci D; Villacorta L; Schübeler D; Benes V; Krebs AR
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 4)‎

A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity.

Nature communications
2020-05 | Journal article
DOI: 10.1038/s41467-020-16354-x
PMID: 32471981
PMC: PMC7260214
Contributors: Ginno PA; Gaidatzis D; Feldmann A; Hoerner L; Imanci D; Burger L; Zilbermann F; Peters AHFM; Edenhofer F; Smallwood SA et al.
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans.

Nature neuroscience
2019-07 | Journal article
DOI: 10.1038/s41593-019-0431-2
PMID: 31285614
Contributors: Jüttner J; Szabo A; Gross-Scherf B; Morikawa RK; Rompani SB; Hantz P; Szikra T; Esposti F; Cowan CS; Bharioke A et al.
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 3)‎

CG dinucleotides enhance promoter activity independent of DNA methylation.

Genome research
2019-02 | Journal article
DOI: 10.1101/gr.241653.118
PMID: 30709850
PMC: PMC6442381
Contributors: Hartl D; Krebs AR; Grand RS; Baubec T; Isbel L; Wirbelauer C; Burger L; Schübeler D
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central

Genome-wide Single-Molecule Footprinting Reveals High RNA Polymerase II Turnover at Paused Promoters

Molecular Cell
2017 | Journal article
DOI: 10.1016/j.molcel.2017.06.027
EID:

2-s2.0-85025480824
Contributors: Krebs, A.R.; Imanci, D.; Hoerner, L.; Gaidatzis, D.; Burger, L.; Schübeler, D.
Source: Self-asserted source
Arnaud Krebs via Scopus - Elsevier

Cis-regulatory landscapes of four cell types of the retina.

Nucleic acids research
2017-11 | Journal article
DOI: 10.1093/nar/gkx923
PMID: 29059322
PMC: PMC5714137
Contributors: Hartl D; Krebs AR; Jüttner J; Roska B; Schübeler D
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central

Systems biology approaches bring new insights in the understanding of global gene regulatory mechanisms and their deregulation in cancer

Systems Biology of Cancer
2015 | Book
DOI: 10.1017/9780511979811.006
EID:

2-s2.0-84954304854
Contributors: Krebs, A.; Tora, L.
Source: Self-asserted source
Arnaud Krebs via Scopus - Elsevier

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation.

2015-04 | Journal article
DOI: 10.1038/nature14176
PMID: 25607372
Contributors: Baubec T; Colombo DF; Wirbelauer C; Schmidt J; Burger L; Krebs AR; Akalin A; Schübeler D
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions.

2014 | Journal article
DOI: 10.7554/elife.04094
PMID: 25259795
PMC: PMC4381937
Contributors: Krebs AR; Dessus-Babus S; Burger L; Schübeler D
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Interpreting and visualizing ChIP-seq data with the seqMINER software.

2014 | Journal article
DOI: 10.1007/978-1-4939-0512-6_8
PMID: 24743995
Contributors: Ye T; Ravens S; Krebs AR; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells.

2012 | Journal article
DOI: 10.1186/1471-2164-13-424
PMID: 22920947
PMC: PMC3473242
Contributors: Karmodiya K; Krebs AR; Oulad-Abdelghani M; Kimura H; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Tracking the evolution of cancer methylomes.

2012-11 | Journal article
DOI: 10.1038/ng.2451
PMID: 23104061
Contributors: Krebs AR; Schübeler D
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.

2011-11 | Journal article
DOI: 10.1016/j.molcel.2011.08.037
PMID: 22055187
PMC: PMC4641564
Contributors: Krebs AR; Karmodiya K; Lindahl-Allen M; Struhl K; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

seqMINER: an integrated ChIP-seq data interpretation platform.

2011-03 | Journal article
DOI: 10.1093/nar/gkq1287
PMID: 21177645
PMC: PMC3064796
Contributors: Ye T; Krebs AR; Choukrallah MA; Keime C; Plewniak F; Davidson I; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.

2010 | Journal article
DOI: 10.1186/1471-2164-11-530
PMID: 20920259
PMC: PMC3091680
Contributors: Martianov I; Choukrallah MA; Krebs A; Ye T; Legras S; Rijkers E; Van Ijcken W; Jost B; Sassone-Corsi P; Davidson I
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Lessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferases.

2010 | Journal article
DOI: 10.1186/1756-8935-3-18
PMID: 20961410
PMC: PMC2972259
Contributors: Anamika K; Krebs AR; Thompson J; Poch O; Devys D; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

2010-07 | Journal article
DOI: 10.1038/embor.2010.75
PMID: 20508642
PMC: PMC2897115
Contributors: Krebs AR; Demmers J; Karmodiya K; Chang NC; Chang AC; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.

2010-07 | Journal article
DOI: 10.1038/emboj.2010.125
PMID: 20562830
PMC: PMC2910275
Contributors: Orpinell M; Fournier M; Riss A; Nagy Z; Krebs AR; Frontini M; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.

2010-02 | Journal article
DOI: 10.1007/s00018-009-0199-8
PMID: 19936620
Contributors: Nagy Z; Riss A; Fujiyama S; Krebs A; Orpinell M; Jansen P; Cohen A; Stunnenberg HG; Kato S; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Keys to open chromatin for transcription activation: FACT and Asf1.

2009-05 | Journal article
DOI: 10.1016/j.molcel.2009.05.004
PMID: 19481517
Contributors: Krebs A; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

GPAT: retrieval of genomic annotation from large genomic position datasets.

2008 | Journal article
DOI: 10.1186/1471-2105-9-533
PMID: 19077303
PMC: PMC2654044
Contributors: Krebs A; Frontini M; Tora L
Source: Self-asserted source
Arnaud Krebs via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (17 reviews for 12 publications/grants)

Review activity for Cell. (1)
Review activity for EMBO reports. (1)
Review activity for Genome biology. (1)
Review activity for Molecular systems biology. (1)
Review activity for Nature (2)
Review activity for Nature cell biology (1)
Review activity for Nature communications (3)
Review activity for Nature genetics. (1)
Review activity for Nature methods. (1)
Review activity for Nature protocols (2)
Review activity for Nature structural & molecular biology. (2)
Review activity for Science. (1)
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