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Employment (2)

Shinshu University Hospital: Matsumoto, Nagano, JP

2022-04-01 to present (Department of Pharmacy)
Employment
Source: Self-asserted source
Keita Hirai

Shinshu University: Matsumoto, Nagano, JP

2022-04-01 to present | Associate Professor (Department of Clinical Pharmacology and Therapeutics, Shinshu University Graduate School of Medicine)
Employment
Source: Self-asserted source
Keita Hirai

Education and qualifications (1)

University of Shizuoka, Graduate School of Pharmaceutical Sciences : Shizuoka, JP

2009-10 to 2012-09 | Ph.D. (Pharmaceutical Sciences)
Education
Source: Self-asserted source
Keita Hirai

Funding (8)

喘息・COPD患者の包括的な治療応答性評価に基づくプレシジョンメディスンの構築

2022-04-01 to 2025-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 22K06772
Source: Self-asserted source
Keita Hirai via DimensionsWizard

Clinical pharmacokinetic analysis of antibody drugs by application of innovative measurement techniques directed to personalized medicine

2020-04-01 to 2023-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 20K07157
Source: Self-asserted source
Keita Hirai via DimensionsWizard

Construction of early diagnosis and prognosis prediction system by monitoring of cancer-related antigen CSPG4 specific autoantibodies.

2019-04-01 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 19K07197
Source: Self-asserted source
Keita Hirai via DimensionsWizard

COPD患者におけるプレシジョンメディスンを指向した治療有効性予測マーカーの開発

2019-04-01 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 19K16450
Source: Self-asserted source
Keita Hirai via DimensionsWizard

Construction of a cancer treatment strategy that the extracellular matrix CSPG4 was a molecular target

Source: Self-asserted source
Keita Hirai via DimensionsWizard

Construction of individualized drug therapy based on the new condition classification of bronchial asthma and chronic obstructive pulmonary disease

PK / PD study of oral pulmonary hypertension therapeutic agent in pediatric patients

Source: Self-asserted source
Keita Hirai via DimensionsWizard

Warfarin PK / PD studies in children based on the blood vitamin K concentration and gene polymorphism analysis

Source: Self-asserted source
Keita Hirai via DimensionsWizard

Works (50 of 66)

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Page 1 of 2

PI3K pathway activation in severe asthma is linked to steroid insensitivity and adverse outcomes

Journal of Allergy and Clinical Immunology: Global
2025-05 | Journal article
Contributors: Sekiko Uehara; Keita Hirai; Toshihiro Shirai; Taisuke Akamatsu; Kunihiko Itoh
Source: check_circle
Crossref

Impact of Antibacterials on the Quality of Anticoagulation Control in Patients Initiating Warfarin Therapy

American Journal of Cardiovascular Drugs
2025-03 | Journal article
Contributors: Kyohei Sugiyama; Keita Hirai; Masato Tsutsumi; Shota Furuya; Kunihiko Itoh
Source: check_circle
Crossref

Asthma With Fixed Obstruction Displays a Similar Small Airway Dysfunction to That Observed in Asthma–COPD Overlap

Clinical & Experimental Allergy
2025-02-23 | Journal article
Contributors: Toshihiro Shirai; Keita Hirai; Yasuhiro Gon
Source: check_circle
Crossref

Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction

Allergology International
2025-01 | Journal article
Contributors: Toshihiro Shirai; Keita Hirai; Taisuke Akamatsu; Kenji Mizumura; Hitoshi Sasano; Norihiro Harada; Akihiko Tanaka; Hironori Sagara; Katsunori Masaki; Koichi Fukunaga et al.
Source: check_circle
Crossref

Vitamin D Receptor rs2228570 Gene Polymorphism Is Associated with Asthma Severity and Exacerbations

Biological and Pharmaceutical Bulletin
2025-01-31 | Journal article
Part of ISSN: 0918-6158
Part of ISSN: 1347-5215
Contributors: Sekiko Uehara; Keita Hirai; Toshihiro Shirai; Hinako Otaki; Taisuke Akamatsu; Kunihiko Itoh
Source: Self-asserted source
Keita Hirai

Inflammatory Phenotypes and Potential Bio-markers of ACO: What Is the Specific Feature of ACO?

Respiratory Disease Series: Diagnostic Tools and Disease Managements
2024 | Book chapter
Part of ISBN: 9789819602162
Part of ISBN: 9789819602179
Part of ISSN: 2509-5552
Part of ISSN: 2509-5560
Contributors: Keita Hirai
Source: Self-asserted source
Keita Hirai

Association of a CYP3A5 gene polymorphism with exacerbation in adult patients with asthma

The Journal of Allergy and Clinical Immunology: In Practice
2024-08 | Journal article
Contributors: Sekiko Uehara; Keita Hirai; Toshihiro Shirai; Kunihiko Itoh
Source: check_circle
Crossref

Impact of once-daily versus multiple-daily dosing of gentamicin on the incidence of acute kidney injury in patients treated with synergistic combinations of antibiotics

Journal of Pharmaceutical Health Care and Sciences
2024-07-15 | Journal article
Contributors: Kyohei Sugiyama; Keita Hirai; Yukako Suyama; Masato Tsutsumi
Source: check_circle
Crossref

Association of the predicted free blood concentration of teicoplanin with the development of renal dysfunction

European Journal of Clinical Pharmacology
2024-04 | Journal article
Contributors: Kyohei Sugiyama; Keita Hirai; Yukako Suyama; Kento Furuya; Kenta Ito
Source: check_circle
Crossref

Effect of Enoxaparin and Daikenchuto Coadministration on Hepatic Disorder Markers in Gynecological Cancer Patients after Abdominal Surgery

Biological and Pharmaceutical Bulletin
2024-04-02 | Journal article
Part of ISSN: 0918-6158
Part of ISSN: 1347-5215
Contributors: Hiroaki Watanabe; Keita Hirai; Yuka Nakazawa; Ayaka Koike; Hiroyuki Tsuchiya; Takafumi Naito
Source: Self-asserted source
Keita Hirai

Gene Polymorphisms of NLRP3 Associated With Plasma Levels of 4β‐Hydroxycholesterol, an Endogenous Marker of CYP3A Activity, in Patients With Asthma

Clinical Pharmacology & Therapeutics
2024-03-14 | Journal article
Part of ISSN: 0009-9236
Part of ISSN: 1532-6535
Contributors: Keita Hirai; Tomoki Kimura; Yuya Suzuki; Takayuki Shimoshikiryo; Toshihiro Shirai; Kunihiko Itoh
Source: Self-asserted source
Keita Hirai

Combined assessment of respiratory resistance and reactance is helpful in diagnosing cough variant asthma

Allergology International
2023-01 | Journal article
Contributors: Yoshihiro Kitahara; Toshihiro Shirai; Keita Hirai; Taisuke Akamatsu; Hirofumi Watanabe; Hiromasa Nakayasu
Source: check_circle
Crossref

Mucus Plugs and Small Airway Dysfunction in Asthma, COPD, and Asthma-COPD Overlap

Allergy, Asthma & Immunology Research
2022 | Journal article
Contributors: Kanami Tamura; Toshihiro Shirai; Keita Hirai; Hiromasa Nakayasu; Shingo Takahashi; Yutaro Kishimoto; Taisuke Akamatsu; Kazuhiro Asada; Satoshi Kato
Source: check_circle
Crossref

Forced oscillatory parameters as predictors of COPD assessment test improvement in untreated COPD patients

Respiratory Physiology & Neurobiology
2022-02 | Journal article
Contributors: Shingo Takahashi; Toshihiro Shirai; Keita Hirai; Taisuke Akamatsu
Source: check_circle
Crossref

Benralizumab restores gene and microRNA expression involved in steroid sensitivity in severe asthma

Allergy
2021-08 | Journal article
Contributors: Keita Hirai; Sekiko Uehara; Toshihiro Shirai; Yuuka Rachi; Tomoki Kimura; Taisuke Akamatsu; Kunihiko Itoh
Source: check_circle
Crossref

Blood eosinophil count and FeNO to predict benralizumab effectiveness in real-life severe asthma patients.

The Journal of asthma : official journal of the Association for the Care of Asthma
2021-08 | Journal article
Contributors: Watanabe H; Shirai T; Hirai K; Akamatsu T; Nakayasu H; Tamura K; Masuda T; Takahashi S; Tanaka Y; Kishimoto Y et al.
Source: Self-asserted source
Keita Hirai via Europe PubMed Central

Circulating microRNA‐15b‐5p as a biomarker for asthma‐COPD overlap

Allergy
2021-03 | Journal article
Contributors: Keita Hirai; Toshihiro Shirai; Takayuki Shimoshikiryo; Megumi Ueda; Yasuhiro Gon; Shuichiro Maruoka; Kunihiko Itoh
Source: check_circle
Crossref

High fractional exhaled nitric oxide levels may predict short‐term worsening of respiratory oscillometry in asthma

Allergy
2021-01 | Journal article
Contributors: Yoshinari Endo; Toshihiro Shirai; Keita Hirai; Taisuke Akamatsu; Eishi Kato; Hidehiko Furui; Tetsuo Hiramatsu
Source: check_circle
Crossref

Oscillometry as a Predictor of Exercise Tolerance in COPD.

COPD
2020-11 | Journal article
Contributors: Yamamoto A; Shirai T; Hirai K; Tanaka Y; Watanabe H; Endo Y; Shimoda Y; Suzuki T; Noguchi R; Mochizuki E et al.
Source: Self-asserted source
Keita Hirai via Europe PubMed Central
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Preferred source (of 2)‎

Annual changes in forced oscillation technique parameters correlate with FEV1 decline in patients with asthma, COPD, and asthma-COPD overlap

Allergology International
2020-10 | Journal article
Contributors: Yuko Tanaka; Keita Hirai; Hiromasa Nakayasu; Kanami Tamura; Toshihiro Masuda; Shingo Takahashi; Hirofumi Watanabe; Yutaro Kishimoto; Kyouhei Ohishi; Mika Saigusa et al.
Source: check_circle
Crossref

Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy.

Die Pharmazie
2020-10 | Journal article
Contributors: Nishida S; Hayashi Y; Hirai K; Takekoshi A; Yamada Y; Kobayashi R; Shimizu S; Niwa T; Hayashi H; Shimohata T et al.
Source: Self-asserted source
Keita Hirai via Europe PubMed Central

Oscillometry improves earlier than spirometry after benralizumab initiation in severe asthma

Allergy
2020-10 | Journal article
Contributors: Toshihiro Shirai; Taisuke Akamatsu; Keita Hirai; Hirofumi Watanabe; Kanami Tamura; Yutaro Kishimoto; Mika Saigusa
Source: check_circle
Crossref

Benralizumab restored expression of key molecules involved in steroid-resistance in patients with severe asthma

2020-09-07 | Book chapter
Contributors: Keita Hirai; Toshihiro Shirai; Taisuke Akamatsu; Sekiko Uehara; Yuka Rachi; Kanami Tamura; Yutaro Kishimoto; Mika Saigusa; Kazuhiro Asada; Kunihiko Itoh
Source: check_circle
Dimensions

Combined assessment of serum eosinophil-derived neurotoxin and YKL-40 may identify asthma-COPD overlap

2020-09-07 | Book chapter
Contributors: Toshihiro Shirai; Keita Hirai; Yasuhiro Gon; Shuichiro Maruoka; Kenji Mizumura; Mari Hikichi; Kunihiko Itoh; Shu Hashimoto
Source: check_circle
Dimensions

Role of Type2 Inflammatory Biomarkers in Chronic Obstructive Pulmonary Disease

Journal of Clinical Medicine
2020-08-18 | Journal article
Contributors: Keiji Oishi; Kazuto Matsunaga; Toshihiro Shirai; Keita Hirai; Yasuhiro Gon
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Combined assessment of serum eosinophil-derived neurotoxin and YKL-40 may identify Asthma-COPD overlap.

Allergology international : official journal of the Japanese Society of Allergology
2020-06 | Journal article
Contributors: Shirai T; Hirai K; Gon Y; Maruoka S; Mizumura K; Hikichi M; Itoh K; Hashimoto S
Source: Self-asserted source
Keita Hirai via Europe PubMed Central

Forced Oscillatory Parameters Improved After Benralizumab Treatment in Severe Asthma

B101. NEW BIOLOGICAL TREATMENTS FOR ASTHMA
2020-05 | Conference abstract
Source: Self-asserted source
Keita Hirai

Annual change in forced oscillation technique correlates with FEV1 decline in patients with asthma, COPD, and asthma-COPD overlap

Journal of Allergy and Clinical Immunology
2020-02 | Conference paper
Part of ISSN: 0091-6749
Source: Self-asserted source
Keita Hirai

Effectiveness of benralizumab in patients with severe asthma

Journal of Allergy and Clinical Immunology
2020-02 | Conference paper
Part of ISSN: 0091-6749
Source: Self-asserted source
Keita Hirai

Comparison of the association between circulating vitamin D<sub>3</sub> levels and clinical outcomes in patients with asthma and chronic obstructive pulmonary disease: a prospective observational study

Biological and Pharmaceutical Bulletin
2019 | Journal article
Contributors: Keita Hirai; Toshihiro Shirai; Yuya Suzuki; Tatsuki Shimomura; Kunihiko Itoh
Source: check_circle
Dimensions

Impact of gene expression associated with glucocorticoid-induced transcript 1 (GLCCI1) on severe asthma and future exacerbation

Biological and Pharmaceutical Bulletin
2019 | Journal article
Contributors: Keita Hirai; Toshihiro Shirai; Yuuka Rachi; Sekiko Uehara; Megumi Ueda; Eiji Nakatani; Kunihiko Itoh
Source: check_circle
Dimensions

CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis.

The pharmacogenomics journal
2019-11 | Journal article
Contributors: Takeuchi M; Kobayashi T; Biss T; Kamali F; Vear SI; Ho RH; Bajolle F; Loriot MA; Shaw K; Carleton BC et al.
Source: Self-asserted source
Keita Hirai via Europe PubMed Central

DIFFERENTIATION OF ASTHMA, COPD, AND ASTHMA-COPD OVERLAP VIA A SIMPLIFIED SPUTUM CELL COUNT METHOD

Chest
2019-10 | Conference abstract
Part of ISSN: 0012-3692
Source: Self-asserted source
Keita Hirai

FORCED OSCILLATORY PARAMETERS AS PREDICTORS OF COPD ASSESSMENT TEST IMPROVEMENT IN UNTREATED COPD PATIENTS

Chest
2019-10 | Conference abstract
Part of ISSN: 0012-3692
Source: Self-asserted source
Keita Hirai

Forced Oscillation Technique May Identify Severe Asthma

The Journal of Allergy and Clinical Immunology In Practice
2019-06 | Journal article
Contributors: Toshihiro Shirai; Keita Hirai; Yasuhiro Gon; Shuichiro Maruoka; Kenji Mizumura; Mari Hikichi; Kunihiko Itoh; Shu Hashimoto
Source: check_circle
Dimensions
grade
Preferred source (of 3)‎

Improved cough- and sputum-related quality of life after initiation of treatment in pulmonary tuberculosis

Respiratory Investigation
2019-05 | Journal article
Contributors: Takahito Suzuki; Toshihiro Shirai; Keita Hirai; Yuko Tanaka; Hirofumi Watanabe; Yoshinari Endo; Yukiko Shimoda; Mika Saigusa; Taisuke Akamatsu; Akito Yamamoto et al.
Source: check_circle
Crossref

Forced oscillatory parameters in reversibility testing as predictors for chronic cough responsive to inhaled corticosteroid/long-acting β2 agonist

Annals of Allergy, Asthma & Immunology
2019-03 | Journal article
Contributors: Hirofumi Watanabe; Toshihiro Shirai; Taisuke Akamatsu; Kazuhiro Asada; Keita Hirai
Source: check_circle
Crossref

Forced oscillation technique may identify asthma-COPD overlap

Allergology International
2019-02 | Journal article
Contributors: Toshihiro Shirai; Keita Hirai; Yasuhiro Gon; Shuichiro Maruoka; Kenji Mizumura; Mari Hikichi; Kunihiko Itoh; Shu Hashimoto
Source: check_circle
Dimensions
grade
Preferred source (of 2)‎

[BIOMARKERS FOR PREDICTING FUTURE EXACERBATIONS IN ADULT PATIENTS WITH ASTHMA].

Arerugi = [Allergy]
2019-01 | Journal article
Contributors: Hirai K; Shirai T; Itoh K
Source: Self-asserted source
Keita Hirai via Europe PubMed Central

[Development of Stratified and Personalized Medicine Based on Pharmacogenomic and Pharmacokinetic Analyses].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
2019-01 | Journal article
Contributors: Hirai K
Source: Self-asserted source
Keita Hirai via Europe PubMed Central

Combined assessment of serum periostin and YKL-40 may identify asthma-COPD overlap

The Journal of Allergy and Clinical Immunology: In Practice
2018 | Journal article
Contributors: Shirai, Toshihiro; Hirai, Keita; Gon, Yasuhiro; Maruoka, Shuichiro; Mizumura, Kenji; Hikichi, Mari; Holweg, Cecile; Itoh, Kunihiko; Inoue, Hiromasa; Hashimoto, Shu
Source: Self-asserted source
Keita Hirai via ResearcherID

The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals

Clinical Pharmacology & Therapeutics
2018 | Journal article
Contributors: Danese, Elisa; Raimondi, Sara; Montagnana, Martina; Tagetti, Angela; Langaee, Taimour; Borgiani, Paola; Ciccacci, Cinzia; Carcas, Antonio J.; Borobia, Alberto M.; Tong, Hoi Y. et al.
Source: Self-asserted source
Keita Hirai via ResearcherID

Time-Dependent Decline in Serum Phenytoin Concentration with Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study

Therapeutic Drug Monitoring
2018 | Journal article
Contributors: Ohno, Yuta; Niwa, Takashi; Hirai, Keita; Suzuki, Keiko; Yamada, Yuto; Hayashi, Yuichi; Hayashi, Hideki; Suzuki, Akio; Itoh, Yoshinori
Source: Self-asserted source
Keita Hirai via ResearcherID

Validation of A Nomogram for Achieving Target Trough Concentration of Vancomycin: Accuracy in Patients with Augmented Renal Function

Therapeutic Drug Monitoring
2018 | Journal article
Contributors: Ishii, Hidetoshi; Hirai, Keita; Sugiyama, Kyohei; Nakatani, Eiji; Kimura, Midori; Itoh, Kunihiko
Source: Self-asserted source
Keita Hirai via ResearcherID
grade
Preferred source (of 2)‎

Association between (CCTTT)n repeat polymorphism in NOS2 promoter and asthma exacerbations

Journal of Allergy and Clinical Immunology
2018-08 | Journal article
Contributors: Keita Hirai; Toshihiro Shirai; Masayuki Suzuki; Tatsuki Shimomura; Kunihiko Itoh
Source: check_circle
Crossref

Chemotherapy-induced neutropenia as a prognostic factor in patients with metastatic pancreatic cancer treated with gemcitabine

European Journal of Clinical Pharmacology
2017 | Journal article
Contributors: Otake, Aki; Tsuji, Daiki; Taku, Keisei; Kawasaki, Yohei; Yokoi, Mari; Nakamori, Harumi; Osada, Marika; Matsumoto, Megumi; Inoue, Kazuyuki; Hirai, Keita et al.
Source: Self-asserted source
Keita Hirai via ResearcherID

Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy

Supportive Care in Cancer
2017 | Journal article
Contributors: Yokoi, Mari; Tsuji, Daiki; Suzuki, Kenichi; Kawasaki, Yohei; Nakao, Masahiko; Ayuhara, Hideaki; Kogure, Yuuki; Shibata, Kazuhiko; Hayashi, Toshinobu; Hirai, Keita et al.
Source: Self-asserted source
Keita Hirai via ResearcherID

ドキソルビシン/シクロホスファミド併用療法施行乳がん患者における化学療法誘発性悪心・嘔吐に対するアプレピタントの効果の検討

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
2017 | Journal article
Contributors: Ryo Makuta; Daiki Tsuji; Yong-Il Kim; Keisuke Yamamoto; Aki Otake; Mari Yokoi; Harumi Nakamori; Kazuyuki Inoue; Keita Hirai; Hidenori Nakamichi et al.
Source: check_circle
Dimensions

A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype

Clinical & Experimental Allergy
2017-11 | Journal article
Contributors: K. Hirai; T. Shirai; M. Suzuki; T. Akamatsu; T. Suzuki; I. Hayashi; A. Yamamoto; T. Akita; S. Morita; K. Asada et al.
Source: check_circle
Crossref

Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study

The Pharmacogenomics Journal
2017-10 | Journal article
Contributors: D Tsuji; M Yokoi; K Suzuki; T Daimon; M Nakao; H Ayuhara; Y Kogure; K Shibata; T Hayashi; K Hirai et al.
Source: check_circle
Crossref
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