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Plant toxins, natural products, immunotherapy, immunoconjugates, ribosome-inactivating proteins, xanthine oxidoreductase, oxidative stress
Italy

Biography

Prof. Letizia Polito - Alma Mater Studiorum University of Bologna
PRESENT POSITION: Associate Professor in General Pathology at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna. EDUCATION: PhD in Experimental Pathology. Degree in Biological Sciences (BiolD). TEACHING: Courses of General Pathology and History of Medicine, School of Medicine, University of Bologna. SCIENTIFIC ACTIVITY: The scientific activity is focused on four main fields, concerning 1) the study of plant toxins, known as ribosome-inactivating proteins (RIPs), 2) the design and the in vitro and in vivo experimentation of immunotoxins, in order to obtain toxic pharmacological molecules specifically towards certain cellular targets responsible for a pathological state; 3) the study of enzymes that can vary the cellular REDOX balance; 4) impact of natural products on human health.
The results obtained in the researches have been published as about 100 papers in international journals.
Citations: - SCOPUS, more than 4500 , h-index = 38; - GOOGLE SCHOLAR, about 6400, h-index = 42, i10-index =75.
The obtained results have been frequently presented to several national and international meetings, with about 60 publications in meeting proceedings. Reviewer for several international journals with Impact Factor.
- ASSOCIATE EDITOR for “Frontiers in Pharmacology” section Experimental Pharmacology and Drug Discovery, ISSN: 1663-9812.
Member of the Editorial Board of the journals:
- Anti-Cancer Agents in Medicinal Chemistry, ISSN: 1875-5992.
- Biomedicines, ISSN 2227-9059.
Member of the jury of the Italian "National Prize for Science Communication" (2014)
GUEST EDITOR OF SPECIAL ISSUE AND RESEARCH TOPIC
2020 - Guest editor for the Special Issue "Antibody Based Delivery of Toxins and Other Active Molecules for Cancer Therapy" - “Biomedicines”. ISSN 2227-9059.
2019 - Guest editor for the Special Issue "Toxin and Immunotoxin Based Therapeutic Approaches"" - “Toxins”. ISSN 2072-6651.
2019 - Frontiers Topic Editor for the Research Topic “Toxic Plant Proteins as Experimental Drugs for Human Pathologies” - “Frontiers Frontiers in Pharmacology (Section Experimental Pharmacology and Drug Discovery)”. ISSN 1663-9812.
2017 - Guest editor for the Special Issue "Immunoconjugates" - “Biomedicines”. ISSN 2227-9059.

Activities

Employment (10)

University of Bologna: Bologna, Emilia-Romagna, IT

2023-01-01 to present | Associate Professor (Department of Medical and Surgical Sciences)
Employment
Source: Self-asserted source
Letizia Polito

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

2023-01-01 to present | Docenti di ruolo di IIa fascia (DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE)
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

2022-04-11 to 2022-12-31 | Docenti di ruolo di IIa fascia (DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE (attivo dal 28/10/2011 al 31/12/2022))
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Università degli Studi di Bologna Dipartimento di Scienze Mediche e Chirurgiche: Bologna, Emilia-Romagna, IT

2022-04-01 to 2022-12-31 | Associate Professor (Department of Experimental, Diagnostic and Specialty Medicine)
Employment
Source: Self-asserted source
Letizia Polito

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

2012-10-16 to 2022-04-11 | Ricercatori (DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE (attivo dal 28/10/2011 al 31/12/2022))
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Alma Mater Studiorum - University of Bologna: BOLOGNA, IT

2010-10-01 to 2022-03-31 | Assistant professor, Academic discipline: MED/04 ( Department of Experimental, Diagnostic and Specialty Medicine - DIMES )
Employment
Source: Self-asserted source
Letizia Polito

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

2010-10-01 to 2012-10-15 | Ricercatori (DIP. DI PATOLOGIA SPERIMENTALE)
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

2001-04-23 to 2010-10-01 | Personale tecnico amm.vo (DIP. DI PATOLOGIA SPERIMENTALE)
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

1999-05-01 to 2001-04-30 | Assegnisti (DIP. DI PATOLOGIA SPERIMENTALE)
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Alma Mater Studiorum Universita' di Bologna: Bologna, Emilia-Romagna, IT

1994-11-01 to 1998-10-31 | Dottorandi (DIP. DI PATOLOGIA SPERIMENTALE)
Employment
Source: check_circle
Alma Mater Studiorum Università di Bologna - IRIS

Peer review (29 reviews for 14 publications/grants)

Review activity for Anti-cancer agents in medicinal chemistry. (1)
Review activity for Antibodies. (1)
Review activity for Biochemical journal. (1)
Review activity for Biotechnology and applied biochemistry. (1)
Review activity for BMC plant biology (3)
Review activity for Future oncology. (2)
Review activity for International journal of cancer. (1)
Review activity for International journal of nanomedicine (1)
Review activity for International Journal of Oncology. (1)
Review activity for Molecules. (2)
Review activity for PloS one. (1)
Review activity for SpringerPlus. (3)
Review activity for Toxicon. (1)
Review activity for Toxins. (10)