Personal information

pulmonary, critical care, nanomedicine, medical devices
United States

Activities

Employment (1)

University of Pennsylvania: Philadelphia, PA, US

Sponsor
Employment
Source: check_circle
University of Pennsylvania via ORCID Member Portal

Works (21)

Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting

Nano Letters
2024-04-10 | Journal article
Contributors: Marco E. Zamora; Serena Omo-Lamai; Manthan N. Patel; Jichuan Wu; Evguenia Arguiri; Vladmir R. Muzykantov; Jacob W. Myerson; Oscar A. Marcos-Contreras; Jacob S. Brenner
Source: check_circle
Crossref

A combination of physicochemical tropism and affinity moiety targeting of lipid nanoparticles enhances organ targeting

2023-11-21 | Preprint
Contributors: Marco E. Zamora; Serena Omo-Lamai; Manthan N. Patel; Jichuan Wu; Evguenia Arguiri; Vladmir Muzykantov; Jacob Myerson; Oscar Marcos-Contreras; Jacob S. Brenner
Source: check_circle
Crossref

Effective Prevention of Arterial Thrombosis with Albumin-Thrombin Inhibitor Conjugates

Molecular Pharmaceutics
2023-11-06 | Journal article
Contributors: Oscar A. Marcos-Contreras; Jacob W. Myerson; Jia Nong; Jacob Samuel Brenner; Vladimir R. Muzykantov; Patrick M. Glassman
Source: check_circle
Crossref

Automated measurement of distance-walked as a “sixth vital sign” for detecting infusion reactions during preclinical testing

International Journal of Pharmaceutics
2023-10 | Journal article
Contributors: Liam S. Chase; Michael H. Zaleski; Lianne J. Morrell; Jacob S. Brenner
Source: check_circle
Crossref

DOVE: Shoulder-based Opioid Overdose Detection and Reversal Device

2023-06-21 | Conference paper
Contributors: Anush Lingamoorthy; Amanda Watson; David Gordon; Ayan Mandal; Korey Henderson; Xiaonan Ma; James Weimer; Jacob Brenner; Nagarajan Kandasamy
Source: check_circle
Crossref

Targeted In Vivo Loading of Red Blood Cells Markedly Prolongs Nanocarrier Circulation

Bioconjugate Chemistry
2022-07-20 | Journal article
Contributors: Patrick M. Glassman; Carlos H. Villa; Oscar A. Marcos-Contreras; Elizabeth D. Hood; Landis R. Walsh; Colin F. Greineder; Jacob W. Myerson; Tea Shuvaeva; Laura Puentes; Jacob S. Brenner et al.
Source: check_circle
Crossref

Nanoparticle-induced augmentation of neutrophils’ phagocytosis of bacteria

2022-05-14 | Preprint
Contributors: Kathryn M. Rubey; Alexander R. Mukhitov; Jia Nong; Jichuan Wu; Vera P. Krymskaya; Jacob W. Myerson; G. Scott Worthen; Jacob S. Brenner
Source: check_circle
Crossref

Nanomedicine to fight infectious disease

Advanced Drug Delivery Reviews
2021-12 | Journal article
Contributors: Kathryn M. Rubey; Jacob S. Brenner
Source: check_circle
Crossref

Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers

Advanced Drug Delivery Reviews
2021-11 | Journal article
Contributors: Patrick M. Glassman; Elizabeth D. Hood; Laura T. Ferguson; Zongmin Zhao; Don L. Siegel; Samir Mitragotri; Jacob S. Brenner; Vladimir R. Muzykantov
Source: check_circle
Crossref

Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics

Pharmaceutics
2020-05-09 | Journal article
Contributors: Patrick M. Glassman; Carlos H. Villa; Anvay Ukidve; Zongmin Zhao; Paige Smith; Samir Mitragotri; Alan J. Russell; Jacob S. Brenner; Vladimir R. Muzykantov
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain.

Journal of controlled release : official journal of the Controlled Release Society
2019-03-11 | Journal article
Source: Self-asserted source
Jacob Brenner

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake.

Journal of controlled release : official journal of the Controlled Release Society
2018-10-15 | Journal article
Source: Self-asserted source
Jacob Brenner

Vascular Immunotargeting: Take the Highway to the First Exit.

Hepatology (Baltimore, Md.)
2018-10-13 | Journal article
Source: Self-asserted source
Jacob Brenner

Using selective lung injury to improve murine models of spatially heterogeneous lung diseases

2018-08-06 | Other
Contributors: Andrew J. Paris; Lei Guo; Ning Dai; Jeremy B. Katzen; Pryal N. Patel; G. Scott Worthen; Jacob S. Brenner
Source: check_circle
Crossref

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Nature Communications
2018-07-11 | Journal article
Contributors: Jacob S. Brenner; Daniel C. Pan; Jacob W. Myerson; Oscar A. Marcos-Contreras; Carlos H. Villa; Priyal Patel; Hugh Hekierski; Shampa Chatterjee; Jian-Qin Tao; Hamideh Parhiz et al.
Source: check_circle
Crossref

Unintended effects of drug carriers: Big issues of small particles.

Advanced drug delivery reviews
2018-05-01 | Journal article
Source: Self-asserted source
Jacob Brenner

Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9.

Scientific reports
2018-01-29 | Journal article
Source: Self-asserted source
Jacob Brenner

The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series).

Pulmonary circulation
2017-12-20 | Journal article
Source: Self-asserted source
Jacob Brenner

Nanomedicine for the Treatment of Acute Respiratory Distress Syndrome. The 2016 ATS Bear Cage Award–winning Proposal

Annals of the American Thoracic Society
2017-04 | Journal article
Contributors: Jacob S. Brenner
Source: check_circle
Crossref

Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions.

Nanomedicine : nanotechnology, biology, and medicine
2017-01-05 | Journal article
Source: Self-asserted source
Jacob Brenner

Endothelial nanomedicine for the treatment of pulmonary disease.

Expert opinion on drug delivery
2014-11-14 | Journal article
Source: Self-asserted source
Jacob Brenner

Peer review (8 reviews for 6 publications/grants)

Review activity for ACS biomaterials science & engineering. (1)
Review activity for ACS nano. (2)
Review activity for Advanced materials. (1)
Review activity for Journal of controlled release. (2)
Review activity for Nature biotechnology. (1)
Review activity for Nature nanotechnology (1)