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Biography

As a researcher, one of my key interests has centered on host-pathogen interactions. This has led me to investigate how Borrelia burgdorferi, the causative agent of Lyme Disease, remakes itself when it infects a mammalian host, and how Chlamydia pneumoniae infections can drive asthmatic responses, and also exacerbate atherosclerotic plaque development. More recently, I have become interested in the possibility that infectious agents may play a role in the development and progression of Alzheimer’s Disease. While there is evidence that infections may play a role in AD, few direct studies have been attempted, highlighting the need for new investigations.

Activities

Employment (2)

University of California Los Angeles: Los Angeles, CA, US

2016-01-01 to present | Adjunct Professor (Pediatrics)
Employment
Source: Self-asserted source
Timothy R. Crother

Cedars-Sinai Medical Center: Los Angeles, CA, US

2006 to present | Professor (Pediatrics)
Employment
Source: Self-asserted source
Timothy R. Crother

Education and qualifications (2)

Indiana University Bloomington: Bloomington, IN, US

1992-09 to 1999-03 | Ph.D. (Molecular, Cellular, and Developmental Biology)
Education
Source: Self-asserted source
Timothy R. Crother

University of California Irvine: Irvine, CA, US

1987-09 to 1991-06 | B.S. (Biology)
Education
Source: Self-asserted source
Timothy R. Crother

Professional activities (3)

ISTAART: CHICAGO, IL, US

2022 to present
Membership
Source: Self-asserted source
Timothy R. Crother

American Heart Association: Dallas, Texas, US

2013 to present
Membership
Source: Self-asserted source
Timothy R. Crother

American Society for Microbiology: Washington DC, US

2002 to present
Membership
Source: Self-asserted source
Timothy R. Crother

Funding (4)

The role of Chlamydia pneumoniae infection in Alzheimer's Disease

2021-10 to 2026-06 | Grant
National Institute on Aging (Md., Md., US)
GRANT_NUMBER: R01 AG075998
Source: Self-asserted source
Timothy R. Crother

Chlamydia pneumoniae infection accelerated Alzheimer’s Disease.

2021-10 to 2024-09 | Grant
Alzheimer's Association (IL, IL, US)
GRANT_NUMBER:

AARG-NTF-21-84658

Source: Self-asserted source
Timothy R. Crother

Role of Rip2 in the Generation of Pathogenic Th17/Th1 T-cells and Ileitis

2020-12-07 to 2022-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI156311
Source: Self-asserted source
Timothy R. Crother via DimensionsWizard

The role of the inflammasome in plasmacytoid dendritic cells during bacterial infection

2015-06-15 to 2017-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI112826
Source: Self-asserted source
Timothy R. Crother via DimensionsWizard

Works (50 of 104)

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Page 1 of 3

Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice.

Circulation research
2025-03-03 | Journal article | Author
Contributors: Prasant Kumar Jena; Wakita D; Angela C Gomez; Thacyana Teixeira de Carvalho; Asli Ekin Atici; Emily Aubuchon; Narayanan M; Youngho Lee; Michael Fishbein; Yoshihiro Takasato et al.
Source: Self-asserted source
Timothy R. Crother

The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice

BioRxiv
2024 | Journal article
Contributors: Jena, Prasant K; Wakita, Daiko; Gomez, Angela C; Carvalho, Thacyana T; Atici, Asli E; Narayanan, Meena; Lee, Youngho; Fishbein, Michael C; Cani, Patrice D; de Vos, Willem M et al.
Source: check_circle
Web of Science Researcher Profile Sync

Long-term cardiovascular inflammation and fibrosis in a murine model of vasculitis induced by Lactobacillus casei cell wall extract

Frontiers in Immunology
2024-06-25 | Journal article
Part of ISSN: 1664-3224
Contributors: Ana Paula Lombardi Pereira; Emily Aubuchon; Debbie P. Moreira; Malcolm Lane; Thacyana T. Carvalho; Thassio R. R. Mesquita; Youngho Lee; Timothy R. Crother; Rebecca A. Porritt; Waldiceu A. Verri et al.
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

<i>Chlamydia pneumoniae</i> in Alzheimer's disease pathology.

Frontiers in neuroscience
2024-05-06 | Journal article
Contributors: Subedi L; Gaire BP; Koronyo Y; Koronyo-Hamaoui M; Crother TR
Source: Self-asserted source
Timothy R. Crother

Il-1 Signaling On Vascular Smooth Muscle Cells Accelerates Atherosclerosis After Murine Kawasaki Disease Vasculitis

Circulation Research
2023 | Journal article
Contributors: Chen, Shuang; Lee, Youngho; Lane, Malcolm; Moreira, Debbie; Aubuchon, Emily; Shimada, Kenichi; Crother, Timothy R.; Rivas, Magali Noval; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

IL-33 promotes cardiovascular lesions development in a mouse model of Kawasaki Disease

The Journal of Immunology
2023 | Journal article
Contributors: De Carvalho, Thacyana Teixeira; Jena, Prasant Kumar; Franklin, Michael Kyle; Fishbein, Michael C.; Crother, Timothy R.; Chen, Shuang; Shimada, Kenichi; Arditi, Moshe; Rivas, Magali Noval
Source: check_circle
Web of Science Researcher Profile Sync

IL-33 Promotes Cardiovascular Lesions Development In A Mouse Model Of Kawasaki Disease

Arteriosclerosis, Thrombosis, and Vascular Biology
2023 | Journal article
Contributors: de Carvalho, Thacyana Teixeira; Jena, Prasant; Franklin, Michael; Fishbein, Michael C.; Chen, Shuang; Shimada, Kenichi; Crother, Timothy R.; Arditi, Moshe; Rivas, Magali Noval
Source: check_circle
Web of Science Researcher Profile Sync

Mitochondrial quality control in health and cardiovascular diseases.

Frontiers in cell and developmental biology
2023-11-06 | Journal article
Contributors: Atici AE; Crother TR; Noval Rivas M
Source: Self-asserted source
Timothy R. Crother

Single-cell and spatial transcriptomics reveal NLRP3 inflammasome-mediated immunestromal interactions during vasculitis and cardiovascular inflammation

2021 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis.

Circulation research
2021-09-14 | Journal article
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.

JCI insight
2021-08-17 | Journal article
Source: Self-asserted source
Timothy R. Crother

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Immunity
2021-07 | Journal article
Contributors: Hongxu Xian; Yuan Liu; Alexandra Rundberg Nilsson; Raphaella Gatchalian; Timothy R. Crother; Warren G. Tourtellotte; Yi Zhang; German R. Aleman-Muench; Gavin Lewis; Weixuan Chen et al.
Source: check_circle
Crossref

Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

Proceedings of the National Academy of Sciences
2021-01-05 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Timothy R. Crother

Autophagy-mitophagy Induction Improves Cardiovascular Inflammation in a Murine Model of Kawasaki Disease Vasculitis

Circulation
2020 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

Induction of autophagy or mitophagy improves the cardiovascular lesions of Kawasaki Disease in a murine model of vasculitis

The Journal of Immunology
2020 | Journal article
Contributors: Marek-Iannucci, Stefanie; Gomez, Angela C.; Moreira, Debbie; Lane, Malcolm; Porritt, Rebecca; Lee, Youngho; Shimada, Kenichi; Crother, Timothy R.; Rivas, Magali Noval; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

Therapeutic hypothermia rescues severe acute lung injury (ALI) by IL-1β-induced neutrophil extracellular traps (NETs) formation through down-regulation of Gasdermin D

The Journal of Immunology
2020 | Journal article
Contributors: Shimada, Kenichi; Nosaka, Nobuyuki; Martinon, Daisy; Crother, Timothy R.; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Frontiers in Immunology
2020-09-24 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

MD-2 as a possible therapeutic target for atherosclerosis

EBioMedicine
2020-05 | Journal article
Part of ISSN: 2352-3964
Source: Self-asserted source
Timothy R. Crother

Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice

JACC: Basic to Translational Science
2020-05 | Journal article
Part of ISSN: 2452-302X
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

Loss of testosterone impairs anti-tumor neutrophil function

Nature Communications
2020-03-31 | Journal article
Contributors: Janet L. Markman; Rebecca A. Porritt; Daiko Wakita; Malcolm E. Lane; Daisy Martinon; Magali Noval Rivas; Michael Luu; Edwin M. Posadas; Timothy R. Crother; Moshe Arditi
Source: check_circle
Crossref
grade
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Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury

Frontiers in Immunology
2020-02-14 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Timothy R. Crother

IL-1R signaling enhances neutrophil extracellular traps (NETs) formation and leads to increase lung permeability and hypoxemia in LPS/mechanical ventilation-induced acute lung injury mouse model

The Journal of Immunology
2019 | Journal article
Contributors: Nosaka, Nobuyuki; Martinon, Daisy; Crother, Timothy R.; Arditi, Moshe; Shimada, Kenichi
Source: check_circle
Web of Science Researcher Profile Sync

Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis

Jci Insight
2019 | Journal article
WOSUID:

WOS:000458037000014

Contributors: Matundan, H. H.; Sin, J.; Rivas, M. N.; Fishbein, M. C.; Lehman, T. J.; Chen, S.; Gottlieb, R. A.; Crother, T. R.; Abe, M.; Arditi, M.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis.

Clinical and experimental immunology
2019-12-09 | Journal article
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation.

Immunity
2019-08-21 | Journal article
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

IL-1 Receptor Antagonist, Anakinra, Prevents Myocardial Dysfunction in a Mouse Model of Kawasaki Disease Vasculitis and Myocarditis.

Clinical and experimental immunology
2019-05-17 | Journal article
Source: Self-asserted source
Timothy R. Crother

Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection

2019-04-12 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Timothy R. Crother
grade
Preferred source (of 2)‎

Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis

Journal of the American College of Cardiology
2018 | Journal article
Contributors: Chen, Shuang; Shimada, Kenichi; Crother, Timothy R.; Erbay, Ebru; Shah, Prediman K.; Arditi, Moshe
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis

Cell Metabolism
2018 | Journal article
Contributors: Tumurkhuu, Gantsetseg; Dagvadorj, Jargalsaikhan; Porritt, Rebecca A.; Crother, Timothy R.; Shimada, Kenichi; Tarling, Elizabeth J.; Erbay, Ebru; Arditi, Moshe; Chen, Shuang
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells

Cancer Medicine
2018 | Journal article
Contributors: Cavassani, Karen A.; Meza, Rebecca J.; Habiel, David M.; Chen, Jie-Fu; Montes, Alexander; Tripathi, Manisha; Martins, Gislaine A.; Crother, Timothy R.; You, Sungyong; Hogaboam, Cory M. et al.
Source: check_circle
Web of Science Researcher Profile Sync

Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice

PLoS Pathogens
2018 | Journal article
Contributors: Skalski, Joseph H.; Limon, Jose J.; Sharma, Purnima; Gargus, Matthew D.; Nguyen, Christopher; Tang, Jie; Coelho, Ana Lucia; Hogaboam, Cory M.; Crother, Timothy R.; Underhill, David M.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Monocyte-produced Chitinase-3-like 1 is a driver of metastatic behavior in prostate cancer patients

Cancer Research
2018 | Journal article
Contributors: Cavassani, Karen A.; Meza, Rebecca J.; Habiel, David M.; Chen, Jie-Fu; Montes, Alexander; Tripathi, Manisha; Martins, Gislaine A.; Crother, Timothy R.; You, Sungyong; Hogaboam, Cory M. et al.
Source: check_circle
Web of Science Researcher Profile Sync

Monocytes-produced Chitinase-3-like 1 is a driver of metastatic behavior in advanced prostate cancer patients

Cancer Research
2018 | Journal article
WOSUID:

WOS:000441803800198

Contributors: Cavassani, K. A.; Meza, R.; Habiel, D.; Chen, J. F.; Montes, A.; Tripathi, M.; Martins, G.; Crother, T. R.; Hogaboam, C. M.; You, S. et al.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Optimal tube length of orotracheal intubation for mice

Laboratory animals
2018 | Journal article
Contributors: Nosaka, Nobuyuki; Crother, Timothy R.; Chen, Shuang; Arditi, Moshe; Shimada, Kenichi
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Role of Autophagy in Macrophages During Acute Myocardial Infraction

Arteriosclerosis, Thrombosis, and Vascular Biology
2018 | Journal article
Contributors: Chen, Shuang; Shimada, Kenichi; Crother, Timothy R.; Yamashita, Michifumi; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

T Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation

Immunity
2018 | Journal article
Contributors: Shimada, Kenichi; Porritt, Rebecca A.; Markman, Janet L.; O’Rourke, Jacqueline Gire; Wakita, Daiko; Noval Rivas, Magali; Ogawa, Chihiro; Kozhaya, Lina; Martins, Gislâine A.; Unutmaz, Derya et al.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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T-cell intrinsic RIP2 regulates pathogenic Th17 differentiation in chronic lung and vascular inflammation

The Journal of Immunology
2018 | Journal article
Contributors: Porritt, Rebecca A.; Shimada, Kenichi; Crother, Timothy R.; Rivas, Magali Noval; Chen, Shuang; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

The impact of androgens on neutrophils and melanoma tumor burden

The Journal of Immunology
2018 | Journal article
Contributors: Markman, Janet; Wakita, Daiko; Crother, Timothy R.; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

NLRP3 Inflammasome Inhibits Cholesterol Efflux in Macrophages by Down-Regulating Gpr109a Expression: A Novel Pro-Atherogenic Mechanism

Circulation
2017 | Journal article
Contributors: Chen, Shuang; Tumurkhuu, Gantsetseg; Dagvadorj, Jargalsaikhan; Porritt, Rebecca A.; Crother, Timothy R.; Shimada, Kenichi; Erbay, Ebru; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

Nlrp3 Inflammasome Inhibits Cholesterol Efflux in Macrophages by Downregulating Gpr109a Expression. A Novel Proatherogenic Mechanism

Arteriosclerosis, Thrombosis, and Vascular Biology
2017 | Journal article
Contributors: Tumurkhuu, Gantsetseg; Dagvadorj, Jargalsaikhan; Zhang, Wenxuan; Crother, Timothy; Shimada, Kenichi; Arditi, Moshe; Chen, Shuang
Source: check_circle
Web of Science Researcher Profile Sync

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

Sci Rep
2017 | Journal article
Contributors: Domiciano, T. P.; Wakita, D.; Jones, H. D.; Crother, T. R.; Verri, W. A.; Arditi, M.; Shimada, K.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Role of Intestinal Permeability and Secretory Iga in the Development of Cardiovascular Pathology in a Murine Model of Kawasaki Disease

Circulation
2017 | Journal article
Contributors: Rivas, Magali Noval; Wakita, Daiko; Abe, Masanori; Franklin, Michael K.; Chen, Shuang; Shimada, Kenichi; Crother, Timothy R.; Arditi, Moshe
Source: check_circle
Web of Science Researcher Profile Sync

CD8(+) T cells contribute to the development of coronary arteritis in the Lactobacillus casei extract-induced murine model of Kawasaki Disease.

Arthritis &amp; rheumatology (Hoboken, N.J.)
2016 | Journal article
WOSUID:

MEDLINE:27696768

Contributors: Rivas, Magali Noval; Lee, Youngho; Wakita, Daiko; Chiba, Norika; Dagvadorj, Jargalsaikhan; Shimada, Kenichi; Chen, Shuang; Fishbein, Michael C; Lehman, Thomas J A; Crother, Timothy R et al.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
Preferred source (of 2)‎

Chlamydia pneumoniae Infection and Inflammatory Diseases

Forum on Immunopathological Diseases and Therapeutics
2016 | Journal article
Contributors: Porritt, Rebecca A.; Crother, Timothy R.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Immunological Consequences of Intestinal Fungal Dysbiosis

Cell Host &amp; Microbe
2016 | Journal article
WOSUID:

WOS:000377447000016

Contributors: Wheeler, Matthew L.; Limon, Jose J.; Bar, Agnieszka S.; Leal, Christian A.; Gargus, Matthew; Tang, Jie; Brown, Jordan; Funari, Vincent A.; Wang, Hanlin L.; Crother, Timothy R. et al.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

Circulation Research
2016 | Journal article
WOSUID:

WOS:000383327400001

Contributors: Tumurkhuu, Gantsetseg; Shimada, Kenichi; Dagvadorj, Jargalsaikhan; Crother, Timothy R.; Zhang, Wenxuan; Luthringer, Daniel; Gottlieb, Roberta A.; Chen, Shuang; Arditi, Moshe
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
Preferred source (of 2)‎

Revealing the underlying causes of the gender disparity in melanoma: Role of testosterone

Cancer Research
2016 | Journal article
Contributors: Markman, Janet; Wakita, Daiko; Crother, Timothy; Arditi, Moshe
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Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm

Arteriosclerosis Thrombosis and Vascular Biology
2016 | Journal article
WOSUID:

WOS:000375230000019

Contributors: Wakita, Daiko; Kurashima, Yosuke; Crother, Timothy R.; Rivas, Magali Noval; Lee, Youngho; Chen, Shuang; Fury, Wen; Bai, Yu; Wagner, Shawn; Li, Debiao et al.
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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The microbiome in asthma.

Current opinion in pediatrics
2016 | Journal article
WOSUID:

MEDLINE:27606957

Contributors: Noval Rivas, Magali; Crother, Timothy R; Arditi, Moshe
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice

Cellular Immunology
2015 | Journal article
WOSUID:

WOS:000350188000005

Contributors: Sorrentino, Rosalinda; Yilmaz, Atilla; Schubert, Katja; Crother, Timothy R.; Pinto, Aldo; Shimada, Kenichi; Arditi, Moshe; Chen, Shuang
Source: Self-asserted source
Timothy R. Crother via ResearcherID
grade
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Items per page:
Page 1 of 3

Peer review (18 reviews for 12 publications/grants)

Review activity for American journal of respiratory cell and molecular biology. (2)
Review activity for Cellular & molecular immunology (1)
Review activity for EBioMedicine. (2)
Review activity for Free radical biology & medicine. (2)
Review activity for Frontiers in cellular and infection microbiology. (1)
Review activity for Frontiers in immunology. (1)
Review activity for Journal of Cellular and Molecular Medicine. (4)
Review activity for Journal of inflammation research (1)
Review activity for MBio. (1)
Review activity for Molecular medicine. (1)
Review activity for Molecular neurobiology. (1)
Review activity for Scientifica. (1)