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Activities

Employment (3)

University of Kentucky: Lexington, KY, US

2013-10-01 to present | Scientist II (Cardiovascular Research Center )
Employment
Source: Self-asserted source
Lei Cai

University of Kentucky: Lexington, KY, US

2006-07-01 to 2013-09-30 | Research Assistant Professor (Internal Medicine)
Employment
Source: Self-asserted source
Lei Cai

University of Kentucky: Lexington, KY, US

2001-07-01 to 2006-06-30 | Research associate (Internal Medicine)
Employment
Source: Self-asserted source
Lei Cai

Education and qualifications (3)

Beijing University: Beijing , CN

1995-09-01 to 1998-07-01 | Ph.D (Sports Medicine Institute)
Education
Source: Self-asserted source
Lei Cai

Harbin Medical University: Harbin, Heilongjiang, CN

1992-09-01 to 1995-07-01 | MPH (Nutrition and Food Toxicology)
Education
Source: Self-asserted source
Lei Cai

Norman Bethune medical college, Jilin University : changchun, Jilin, CN

1987-09-01 to 1992-07-01 | Bachlor of Medicine (Medicine)
Education
Source: Self-asserted source
Lei Cai

Works (26)

Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

Arteriosclerosis, Thrombosis, and Vascular Biology
2023-12 | Journal article
Contributors: Sohei Ito; Naofumi Amioka; Michael K. Franklin; Pengjun Wang; Ching-Ling Liang; Yuriko Katsumata; Lei Cai; Ryan E. Temel; Alan Daugherty; Hong S. Lu et al.
Source: check_circle
Crossref

Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates.

Frontiers in medicine
2021-08-26 | Journal article
Contributors: Lang JM; Sedgeman LR; Cai L; Layne JD; Wang Z; Pan C; Lee R; Temel RE; Lusis AJ
Source: Self-asserted source
Lei Cai

Renal Angiotensinogen is Predominantly Liver-Derived in Nonhuman Primates

2021-05-18 | Preprint
Contributors: Masayoshi Kukida; Lei Cai; Dien Ye; Hisashi Sawada; Yuriko Katsumata; Michael K. Franklin; Peter I. Hecker; Kenneth S. Campbell; A.H. Jan Danser; Adam E. Mullick et al.
Source: check_circle
Crossref

Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism.

Hepatology international
2020-10-10 | Journal article
Contributors: Li Y; Luan Y; Li J; Song H; Li Y; Qi H; Sun B; Zhang P; Wu X; Liu X et al.
Source: Self-asserted source
Lei Cai

SR-BI (Scavenger Receptor BI), Not LDL (Low-Density Lipoprotein) Receptor, Mediates Adrenal Stress Response-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology
2020-06-11 | Journal article
Contributors: Ito M; Ye X; Wang Q; Guo L; Hao D; Howatt D; Alan Daugherty; Cai L; Temel R; Xiang-An Li
Source: Self-asserted source
Lei Cai

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism.

American journal of physiology. Heart and circulatory physiology
2020-04-24 | Journal article | Author
Contributors: Pathak P; Robert Helsley; Brown AL; Buffa JA; Choucair I; Ina Nemet; Gogonea CB; Gogonea V; Wang Z; Garcia-Garcia JC et al.
Source: Self-asserted source
Lei Cai

Surface engineered polymersomes for enhanced modulation of dendritic cells during cardiovascular immunotherapy.

Advanced functional materials
2019-08-12 | Journal article
Contributors: Yi S; Zhang X; Sangji H; Liu Y; Allen SD; Baixue Xiao; Bobbala S; Braverman CL; Cai L; Hecker PI et al.
Source: Self-asserted source
Lei Cai

XX sex chromosome complement promotes atherosclerosis in mice.

Nature communications
2019-06-14 | Journal article
Contributors: AlSiraj Y; Chen X; Sean Thatcher; Temel RE; Cai L; Blalock E; Wendy Katz; Ali HM; Petriello M; Pan Deng et al.
Source: Self-asserted source
Lei Cai

Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development.

PloS one
2017-08-09 | Journal article
Contributors: Kim S; Yang L; Kim S; Lee RG; Graham MJ; Berliner JA; Lusis AJ; Cai L; Temel RE; Rateri DL et al.
Source: Self-asserted source
Lei Cai

Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a.

Circulation research
2017-06-21 | Journal article
Contributors: Henry S. Cheng; Besla R; Li A; Chen Z; Shikatani EA; Nazari-Jahantigh M; Adel HAMMOUTENE; Nguyen MA; Geoffrion M; Cai L et al.
Source: Self-asserted source
Lei Cai

The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.

Cell metabolism
2014-11-04 | Journal article
Contributors: Hong C; Marshall SM; McDaniel AL; Graham M; Layne JD; Cai L; Elena Scotti; Boyadjian R; Kim J; Brian Chamberlain et al.
Source: Self-asserted source
Lei Cai

Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation.

Journal of lipid research
2014-06-02 | Journal article
Contributors: Jason Meyer; Ji A; Cai L; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation.

Journal of lipid research
2012-07-25 | Journal article
Contributors: Jason Meyer; Ji A; Cai L; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI.

Journal of lipid research
2011-12-20 | Journal article
Contributors: Ji A; Wroblewski JM; Cai L; de Beer MC; Webb NR; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

Scavenger receptor SR-BI in macrophage lipid metabolism.

Atherosclerosis
2011-04-09 | Journal article
Contributors: Ji A; Jason Meyer; Cai L; Akinmusire A; de Beer MC; Webb NR; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

Accumulation and expression of serum amyloid P component in human atherosclerotic lesions.

Atherosclerosis
2010-02-06 | Journal article
Contributors: Song Z; Cai L; Guo L; Tsukamoto Y; Yutani C; Li XA
Source: Self-asserted source
Lei Cai

Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E.

Biochemistry
2009-12-01 | Journal article
Contributors: Claudine Neyen; Annette Pluddemann; Pietro Roversi; Thomas B; Cai L; van der Westhuyzen DR; Robert Sim; Gordon S
Source: Self-asserted source
Lei Cai

SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance.

The Journal of clinical investigation
2008-01-01 | Journal article
Contributors: Cai L; Ji A; de Beer FC; Tannock LR; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif.

The Journal of biological chemistry
2005-12-19 | Journal article
Contributors: Eckhardt ER; Cai L; Shetty S; Zhao Z; Szanto A; Webb NR; Van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.

The Journal of biological chemistry
2005-08-23 | Journal article
Contributors: van der Westhuyzen DR; Cai L; de Beer MC; de Beer FC
Source: Self-asserted source
Lei Cai

Serum amyloid A is a ligand for scavenger receptor class B type I and inhibits high density lipoprotein binding and selective lipid uptake.

The Journal of biological chemistry
2004-11-23 | Journal article
Contributors: Cai L; de Beer MC; de Beer FC; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

Low-density lipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner.

Arteriosclerosis, thrombosis, and vascular biology
2004-10-28 | Journal article
Contributors: Zhao Z; de Beer MC; Cai L; Asmis R; de Beer FC; de Villiers WJ; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36.

Journal of lipid research
2004-01-16 | Journal article
Contributors: de Beer MC; Castellani LW; Cai L; Stromberg AJ; de Beer FC; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

High density lipoprotein uptake by scavenger receptor SR-BII.

The Journal of biological chemistry
2004-01-15 | Journal article
Contributors: Eckhardt ER; Cai L; Sun B; Webb NR; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

Scavenger receptor class B type I reduces cholesterol absorption in cultured enterocyte CaCo-2 cells.

Journal of lipid research
2003-11-16 | Journal article
Contributors: Cai L; Eckhardt ER; Shi W; Zhao Z; Nasser M; de Villiers WJ; van der Westhuyzen DR
Source: Self-asserted source
Lei Cai

The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake.

Journal of lipid research
2002-11-01 | Journal article
Contributors: Webb NR; Cai L; Ziemba KS; Yu J; Kindy MS; van der Westhuyzen DR; de Beer FC
Source: Self-asserted source
Lei Cai