Personal information

Medicinal Chemistry, Drug Discovery, Natural Product Chemistry, Synthetic methodology
India

Biography

Dr. Santosh Kumar Rath is an Assistant Professor in Faculty of Pharmacy, DIT University since 2nd March 2022. Dr. Rath is a medicinal and natural product chemist having over 8 years of experience in research, academia and industry. Dr Rath received his PhD in 2022 from AcSIR under the supervision of Dr Sanjib Das, Principal Scientist, Materials Chemistry Department at CSIR-Institute of Minerals and Materials Technology (CSIR-IMMT), Bhubaneswar, India. Formerly, he worked as an Associate Professor and Research Head at the department of Pharmaceutical Chemistry, Danteswari College of Pharmacy, Jagdalpur, Chhattisgarh. He also worked as Research Associate (CSIR-RA) in School of Chemistry & Biochemistry at Thapar Institute of Engineering & Technology, Patiala, India. He got awarded Senior Research Fellowship (ICMR-SRF) from ICMR, New Delhi India and did research work at CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu, India. Dr. Santosh has published more than 17 research papers in reputed journals and filed 1 Indian patent.
Dr. Rath is well trained in organic synthesis and characterization techniques, including HPLC and 2D-NMR techniques. Dr. Rath is working on isolation & characterization of bioactive molecules from natural sources, performs structural modification on major bioactive isolates and their SAR studies. His research areas involve multistep synthesis of biologically active synthetic and/or natural product based hybrid scaffolds for lead identification in special target to neurological disease, cancer, HIV, Covid-19 and infectious diseases. His research is mainly focussed on the synthesis of novel P-gp and bacterial efflux pump inhibitors, besides synthetic modifications of the bioactive natural products for better activity/less toxicity profiles.
Research Interest:
Medicinal Chemistry and Organic Synthesis
Natural Product Chemistry
Synthetic Methodology
Synthesis of drug conjugates and lipid based multifunctional nanoformulations

Activities

Works (29)

A Glimpse for the subsistence from pandemic SARS-CoV-2 infection

Bioorganic Chemistry
2025-01 | Journal article
Contributors: Santosh K. Rath; Ashutosh K. Dash; Nandan Sarkar; Mitali Panchpuri
Source: check_circle
Crossref

Structural characterization, in-silico studies, and antifungal activity of 5-methylmellein isolated from endophytic Alternaria burnsii

3 Biotech
2025-01 | Journal article
Contributors: Vagish Dwibedi; Gulshan Kumar; Mohammad Khalid Al-Sadoon; Gursharan Kaur; Ashok Kumar; Nancy George; Mahavir Joshi; Rajinder Kaur; Palak Rana; Santosh Kumar Rath
Source: check_circle
Crossref

Nanomaterials and Neurological Disorders Management

2024 | Book chapter
Contributors: Sibasankar Sahu; Debasis Gantayat; Sipu Kumar Sahu; Gursharan Kaur; Vagish Dwibedi; Santosh Kumar Rath
Source: check_circle
Crossref

Computational and in-vitro Investigation of Phytochemicals from Allamanda cathartica as a Potential Candidate for the Treatment of Type 2 Diabetes mellitus

Journal of Computational Biophysics and Chemistry
2024-09 | Journal article
Contributors: Ritu Tomar; Shashank Shekher Mishra; Jagannath Sahoo; Santosh Kumar Rath
Source: check_circle
Crossref

Purification of ursolic acid and β-sitosterol from endophytic Alternaria alternata for their alpha-amylase inhibitory activity

Journal of Biomolecular Structure and Dynamics
2024-09 | Journal article
Contributors: Vagish Dwibedi; Shashank Shekher Mishra; Nancy George; Mahavir Joshi; Gursharan Kaur; Mukul Gupta; Santosh Kumar Rath
Source: check_circle
Crossref

Isolation, chemical characterization, antimicrobial activity, and molecular docking studies of 2,6-dimethoxy benzoquinone isolated from medicinal plant Flacourtia jangomas

3 Biotech
2024-06 | Journal article
Contributors: Ritu Tomar; Shashank Shekher Mishra; Jagannath Sahoo; Santosh Kumar Rath
Source: check_circle
Crossref

Harnessing the action mechanisms of microbial endophytes for enhancing plant performance and stress tolerance: current understanding and future perspectives

Archives of Microbiology
2023-09 | Journal article
Contributors: Gursharan Kaur; Arvind Patel; Vagish Dwibedi; Santosh Kumar Rath
Source: check_circle
Crossref

Hetero Cyclic Compounds in the Treatment of Triple-Negative Breast Cancer

Current Cancer Therapy Reviews
2023-08 | Journal article
Contributors: Santosh Kumar Rath; Sudip Kumar Mandal; Agnidipta Das; Anindya Bose; Vagish Dwibedi; Paramita Ganguly; Sipra Sarkar; Ranjana Prakash; Biplab Kumar Dey; Sanjeet Mandal
Source: check_circle
Crossref

Capsicum annuum L. and its bioactive constituents: A critical review of a traditional culinary spice in terms of its modern pharmacological potentials with toxicological issues

Phytotherapy Research
2023-03 | Journal article
Contributors: Sudip Kumar Mandal; Santosh Kumar Rath; Rajan Logesh; Siddhartha Kumar Mishra; Hari Prasad Devkota; Niranjan Das
Source: check_circle
Crossref

Key insights into secondary metabolites from various Chaetomium species

Applied Microbiology and Biotechnology
2023-02 | Journal article
Contributors: Vagish Dwibedi; Santosh Kumar Rath; Sahil Jain; Nayeli Martínez-Argueta; Ranjana Prakash; Sanjai Saxena; Leonardo Rios-Solis
Source: check_circle
Crossref

Antimicrobial Resistance: Meaning and Developing Realization

Emerging Modalities in Mitigation of Antimicrobial Resistance
2022 | Book chapter
Part of ISBN: 9783030841256
Part of ISBN: 9783030841263
Contributors: SANTOSH KUMAR RATH
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

New Insights into and Updates on Antimicrobial Agents

Emerging Modalities in Mitigation of Antimicrobial Resistance
2022 | Book chapter
Part of ISBN: 9783030841256
Part of ISBN: 9783030841263
Contributors: SANTOSH KUMAR RATH
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Microbial endophytes: application towards sustainable agriculture and food security

Applied Microbiology and Biotechnology
2022-07-29 | Journal article
Part of ISSN: 0175-7598
Part of ISSN: 1432-0614
Contributors: SANTOSH KUMAR RATH
Source: Self-asserted source
SANTOSH KUMAR RATH

Theories and Mechanism of Aging and Longevity Through Evolutionary Lens: a Coalition of Plant Anti-oxidants

Revista Brasileira de Farmacognosia
2022-06 | Journal article
Part of ISSN: 1981-528X
Contributors: SANTOSH KUMAR RATH
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Inhibitory activities of grape bioactive compounds against enzymes linked with human diseases

Applied Microbiology and Biotechnology
2022-02 | Journal article
Part of ISSN: 0175-7598
Part of ISSN: 1432-0614
Contributors: SANTOSH KUMAR RATH
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Formulation, Development and Physicochemical Characterization of Diclofenac Topical Emulgel

Egyptian Journal of Chemistry
2021-03 | Journal article
EID:

2-s2.0-85102634333

Part of ISSN: 23570245 04492285
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Response surface statistical optimization of fermentation parameters for resveratrol production by the endophytic fungus Arcopilus aureus and its tyrosinase inhibitory activity

Biotechnology Letters
2020-11-06 | Journal article
Part of ISSN: 0141-5492
Part of ISSN: 1573-6776
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Effect of IS01957, a para‐coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy

Drug Development Research
2019-11 | Journal article
Part of ISSN: 0272-4391
Part of ISSN: 1098-2299
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus

Bioorganic & Medicinal Chemistry
2019-01 | Journal article
Part of ISSN: 0968-0896
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC–ESI–MS/MS method in mice plasma

Journal of Pharmaceutical Investigation
2018-09 | Journal article
Part of ISSN: 2093-5552
Part of ISSN: 2093-6214
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception

Regulatory Toxicology and Pharmacology
2017-12 | Journal article
Part of ISSN: 0273-2300
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Isolation of isoxanthanol and synthesis of novel derivatives as potential cytotoxic agents

Medicinal Chemistry Research
2017-10 | Journal article
Part of ISSN: 1054-2523
Part of ISSN: 1554-8120
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

A convergent synthesis of novel alkyne–azide cycloaddition congeners of betulinic acid as potent cytotoxic agent

Steroids
2017-07 | Journal article
Part of ISSN: 0039-128X
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Synthesis of novel benzylidene analogues of betulinic acid as potent cytotoxic agents

European Journal of Medicinal Chemistry
2017-07 | Journal article
Part of ISSN: 0223-5234
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Cu(i)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

RSC Advances
2016 | Journal article
Part of ISSN: 2046-2069
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

A novel triazole derivative of betulinic acid induces extrinsic and intrinsic apoptosis in human leukemia HL-60 cells

European Journal of Medicinal Chemistry
2016-01 | Journal article
Part of ISSN: 0223-5234
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Isolation, cytotoxic evaluation, and simultaneous quantification of eight bioactive secondary metabolites fromCicer microphyllumby high-performance thin-layer chromatography

Journal of Separation Science
2015-12 | Journal article
Part of ISSN: 1615-9306
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin

Cell Death & Disease
2014-10 | Journal article
Part of ISSN: 2041-4889
Source: Self-asserted source
SANTOSH KUMAR RATH
grade
Preferred source (of 2)‎

DEVELOPMENT AND VALIDATION OF NEW ANALYTICAL METHOD FOR THE ESTIMATION OF ATORVASTATIN CALCIUM HYDRATE RESIDUE BY USING UV SPECTROPHOTOMETER

International journal of pharmaceutical sciences and research
2013-09-01 | Journal issue or edition
Part of ISSN: 2320-5148
Part of ISSN: 0975-8232
Source: Self-asserted source
SANTOSH KUMAR RATH

Peer review (1 review for 1 publication/grant)

Review activity for Chemické zvesti. (1)