Personal information

signaling, Rho GTPases, MAPK signaling, live cell imaging, genetically-encoded biosensors, optogenetic actuators, fate decision signaling, cell morphogenesis signaling, cell migration, neurite outgrowth, oncogenic signaling
Switzerland

Activities

Employment (3)

University of Bern: Bern, BE, CH

2024-02-01 to present | Full Professor (Institute of Cell Biology)
Employment
Source: Self-asserted source
olivier pertz

University of Bern: Bern, BE, CH

2016-02-01 to 2024-01-31 | Associate Prof (Institute of Cell biology)
Employment
Source: Self-asserted source
olivier pertz

University of Basel: Basel, Basel-Stadt, CH

2007-12-01 to 2015-11-30 | Assistant Professor (Dept of Biomedicine)
Employment
Source: Self-asserted source
olivier pertz

Education and qualifications (3)

University of California San Diego: La Jolla, CA, US

2004-01-01 to 2007-11-01 | staff scientist (PAthology)
Education
Source: Self-asserted source
olivier pertz

Scripps Research Institute: La Jolla, CA, US

2000-01-01 to 2003-12-31 | postdoc (Department of Cell Biology)
Education
Source: Self-asserted source
olivier pertz

University of Basel: Basel, Basel-Stadt, CH

1995-06-01 to 1999-12-31 | PhD (Biocenter)
Education
Source: Self-asserted source
olivier pertz

Professional activities (1)

Faculty Opinions: London, GB

2014-08-04 to present | Faculty Member
Invited position
Source: check_circle
Faculty Opinions

Funding (31)

Imaging breast cancer oncogenic signalling and its response to targeted therapy at the single cell level.

2020 to 2022 | Grant
Swiss Cancer League (Bern, CH)
Source: Self-asserted source
olivier pertz

Realtime imaging of epithelial homeostasis signalling in a lung-on-a-chip.

2020 to 2021 | Grant
University of Bern (Bern, CH)
Source: Self-asserted source
olivier pertz

Realtime Control of Fate Decision Signaling to understand and manipulate Epithelial Homeostasis

2020 to 2020 | Grant
Novartis (basel, CH)
Source: Self-asserted source
olivier pertz

Installing a Hyperion CyTOF mass cytometry platform for high-dimensional single cell analysis at the University of Bern

2019-10-01 to 2021-11-30 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 183501
Source: Self-asserted source
olivier pertz via DimensionsWizard

Real time Exploration of GTPase-Cytoskeletal feedback underlying Contractile Actomyosin Systems

2019-09-01 to 2023-08-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 183550
Source: Self-asserted source
olivier pertz via DimensionsWizard

Decoding and Re-Encoding Receptor Tyrosine Kinase/Fate Decision Signaling

2019-06-01 to 2023-05-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 185376
Source: Self-asserted source
olivier pertz via DimensionsWizard

A spatiotemporal map of signalling processes controlling human stem cell renewal and differentiation

2019-05-01 to 2022-04-30 | Grant
International Human Frontier Science Program Organization (Strasbourg, FR)
GRANT_NUMBER:

75bfe94e

Source: Self-asserted source
olivier pertz via DimensionsWizard

A high content confocal microscope for fast 3D imaging of living samples

2018-10-01 to 2020-03-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 177096
Source: Self-asserted source
olivier pertz via DimensionsWizard

Hunting for natural products targeting aberrant proliferative signaling in melanoma

2018-01-01 to 2022-02-28 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 176008
Source: Self-asserted source
olivier pertz via DimensionsWizard

An integrated microscopy/computer vision platform for high content 3D imaging of aberrant proliferative signalling in cancer organoids.

2018 to 2019 | Grant
University of Bern (Bern, CH)
Source: Self-asserted source
olivier pertz

Dissecting a Rho GTPase spatio-temporal signaling network regulating growth cone motility, neurite and axonal outgrowth

2017-11-01 to 2020-12-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 173462
Source: Self-asserted source
olivier pertz via DimensionsWizard

Immunology in context: Analyzing adaptive immunity through advanced microscopy

2017-04-01 to 2021-03-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 172994
Source: Self-asserted source
olivier pertz via DimensionsWizard

Mapping Rho GTPase signaling networks through acute, dynamic stimulation of spatio-temporal signaling fluxes.

2016-04-01 to 2019-05-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 163061
Source: Self-asserted source
olivier pertz via DimensionsWizard

Understanding single cell-level MAPK activation dynamics for manipulation of neuronal stem cell self-renewal and differentiation fates

2016-03-01 to 2019-02-28 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 162195
Source: Self-asserted source
olivier pertz via DimensionsWizard

A tumor on a chip approach to understand signaling networks mediating melanoma drug resistance at the single cell level.

2016 to 2018 | Grant
Swiss Cancer League (Bern, CH)
Source: Self-asserted source
olivier pertz

Single cell ERK dynamics regulating cell proliferation fate

2016 to 2016 | Grant
Novartis Foundation (basel, CH)
Source: Self-asserted source
olivier pertz

Optogenetic control of receptor tyrosine kinase signaling to manipulate cell fate

2014-02-01 to 2016-01-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 149923
Source: Self-asserted source
olivier pertz via DimensionsWizard

Understanding spatio-temporal dynamics of Rho GTPase signaling at the glial scar interface.

2014 to 2015 | Grant
International Foundation for Research in Paraplegia (zurich, CH)
Source: Self-asserted source
olivier pertz

Rapid, multi-mode, live imaging and photo-manipulation of protein and activation dynamics at the plasma membrane

2012-01-01 to 2012-12-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 139260
Source: Self-asserted source
olivier pertz via DimensionsWizard

Spatio-temporal Rho GTPase signaling mechanisms during cell migration

2011-12-01 to 2013-11-30 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 139201
Source: Self-asserted source
olivier pertz via DimensionsWizard

A slit/robo signaling pathway regulating contact mediated repulsion during cell migration: implications of its deregulation for the acquisition of an invasive phenotype during breast cancer.

2011 to 2013 | Grant
Swiss Cancer Research Foundation (bern, CH)
Source: Self-asserted source
olivier pertz

High Content and High Throughput Microscopy to Decipher Signaling Networks

2010-12-01 to 2011-11-30 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 133860
Source: Self-asserted source
olivier pertz via DimensionsWizard

Spatio-temporal Rho GTPase signaling to the cytoskeleton during neuronal development and repair

2010-05-01 to 2013-04-30 | Grant
International Human Frontier Science Program Organization (Strasbourg, FR)
GRANT_NUMBER:

98714d1b

Source: Self-asserted source
olivier pertz via DimensionsWizard

Understanding Brain morphogenesis: Computer Vision Morphological Feature Extraction and

2009-10-01 to 2012-12-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 127456
Source: Self-asserted source
olivier pertz via DimensionsWizard

Spatio-temporal Rho GTPase signaling to the cytoskeleton during neuronal development

2009-07-01 to 2009-08-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 126305
Source: Self-asserted source
olivier pertz via DimensionsWizard

A system’s level analysis of the spatio-temporal regulation of signaling during polarized cell migration.

2009 to 2011 | Grant
systems x (zurich, CH)
Source: Self-asserted source
olivier pertz

Regulation of neurite outgrowth through spatial control of mRNA translation.

2008 to 2009 | Grant
International Foundation for Research in Paraplegia (zurich, CH)
Source: Self-asserted source
olivier pertz

The role of RhoC in cancer metastasis.

2008 to 2009 | Grant
Krebsliga Beider Basel (Basel, CH)
Source: Self-asserted source
olivier pertz

Spatio-temporal Rho GTPase signaling mechanisms during directed cell migration

2007-12-01 to 2011-11-30 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 114853
Source: Self-asserted source
olivier pertz via DimensionsWizard

Spatio-temporalen Aktivierung von RhoA in lebenden Zellen.

2002-08-01 to 2004-07-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 67655
Source: Self-asserted source
olivier pertz via DimensionsWizard

Proteine der extrazellulären Matrix: Wechselwirkungen, supramolekulare Organisation und Einfluss auf Zellen

1992-04-01 to 1997-03-31 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 32251
Source: Self-asserted source
olivier pertz via DimensionsWizard

Works (50 of 77)

Items per page:
Page 1 of 2

Automatic detection of spatio-temporal signalling patterns in cell collectives

bioRxiv
2022 | Journal article
Source: Self-asserted source
olivier pertz

Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma

Journal of natural products
2022 | Journal article
Source: Self-asserted source
olivier pertz

Dimerosesquiterpene and sesquiterpene lactones from Artemisia argyi inhibiting oncogenic PI3K/AKT signaling in melanoma cells

2022 | Journal article
Source: Self-asserted source
olivier pertz

High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma

Journal of natural products
2022 | Journal article
Source: Self-asserted source
olivier pertz

Mining of Single-Cell Signaling Time-Series for Dynamic Phenotypes with Clustering

TGF-Beta Signaling
2022 | Book chapter
Source: Self-asserted source
olivier pertz

Optogenetic actuator--ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Molecular systems biology
2022 | Journal article
Source: Self-asserted source
olivier pertz

The rate of information transmission through the MAPK/ERK signaling pathway stimulated in a pulsatile manner

bioRxiv
2022 | Journal article
Source: Self-asserted source
olivier pertz

Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis

Dev. Cell
2022-09 | Journal article
Source: Self-asserted source
olivier pertz

Chemical-biology-derived in vivo sensors: Past, present, and future

CHIMIA International Journal for Chemistry
2021 | Journal article
Source: Self-asserted source
olivier pertz

CODEX, a neural network approach to explore signaling dynamics landscapes

Molecular systems biology
2021 | Journal article
Source: Self-asserted source
olivier pertz

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

Developmental cell
2021 | Journal article
Source: Self-asserted source
olivier pertz

Exploring Signaling Mechanisms regulating genetic and non-genetic Drug Resistance in Melanoma

2021 | Dissertation or Thesis
Source: Self-asserted source
olivier pertz

Spontaneous rotations in epithelia as an interplay between cell polarity and RhoA activity at boundaries

bioRxiv
2021 | Journal article
Source: Self-asserted source
olivier pertz

CODEX: a Neural Network Approach to reveal Signaling Dynamics Landscapes

Cell Bio Virtual 2020
2020 | Journal article
Source: Self-asserted source
olivier pertz

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Nature cell biology
2020 | Journal article
Source: Self-asserted source
olivier pertz

Automated profiling of growth cone heterogeneity defines relations between morphology and motility

Journal of cell biology
2019 | Journal article
Source: Self-asserted source
olivier pertz

Developmental Erk Signaling Illuminated

Developmental cell
2019 | Journal article
Source: Self-asserted source
olivier pertz

Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Molecular systems biology
2019 | Journal article
Source: Self-asserted source
olivier pertz

Integrated platform for monitoring single-cell MAPK kinetics in computer-controlled temporal stimulations

Scientific reports
2018 | Journal article
Source: Self-asserted source
olivier pertz

Microfluidic platform for single cell analysis under dynamic spatial and temporal stimulation

Biosensors and Bioelectronics
2018 | Journal article
Source: Self-asserted source
olivier pertz

Control of cell shape, neurite outgrowth, and migration by a Nogo-A/HSPG interaction

Developmental cell
2017 | Journal article
Source: Self-asserted source
olivier pertz

Developmental ERK Signaling Goes Digital

Developmental cell
2017 | Journal article
Source: Self-asserted source
olivier pertz

Looking for specific natural inhibitors targeting aberrant proliferation signaling in melanoma

Planta Medica International Open
2017 | Journal article
Source: Self-asserted source
olivier pertz

Machine learning-based tools to model and to remove the off-target effect

Pattern Analysis and Applications
2017 | Journal article
Source: Self-asserted source
olivier pertz

Measuring ERK activity dynamics in single living cells using FRET biosensors

ERK Signaling
2017 | Book chapter
Source: Self-asserted source
olivier pertz

Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling

Journal of cell biology
2016 | Journal article
Source: Self-asserted source
olivier pertz

Frequency modulation of ERK activation dynamics rewires cell fate

Molecular systems biology
2016 | Journal article
Source: Self-asserted source
olivier pertz

Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT)

Proceedings of the National Academy of Sciences
2016 | Journal article
Source: Self-asserted source
olivier pertz

Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics

Scientific Reports
2016 | Journal article
Source: Self-asserted source
olivier pertz

The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns

F1000Research
2016 | Journal article
Source: Self-asserted source
olivier pertz

BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition

Cancer Research
2015 | Journal article
Source: Self-asserted source
olivier pertz

Frequency modulation of ERK activation dynamics rewires cell fate

Molecular systems biology
2015 | Journal article
Source: Self-asserted source
olivier pertz

Growth cone localization of the mRNA encoding the chromatin regulator HMGN5 modulates neurite outgrowth

Molecular and cellular biology
2015 | Journal article
Source: Self-asserted source
olivier pertz

Network-based identification of feedback modules that control RhoA activity and cell migration

Journal of molecular cell biology
2015 | Journal article
Source: Self-asserted source
olivier pertz

Serotonin transporter inhibition prevents Rac1-dependent cytoskeletal remodeling and reduces pancreatic acinar-to-ductal metaplasia formation.

Pancreatology
2015 | Journal article
Source: Self-asserted source
olivier pertz

SrGAP2-dependent integration of membrane geometry and slit-robo-repulsive cues regulates fibroblast contact inhibition of locomotion

Developmental cell
2015 | Journal article
Source: Self-asserted source
olivier pertz

A growth factor-induced, spatially organizing cytoskeletal module enables rapid and persistent fibroblast migration

Developmental cell
2014 | Journal article
Source: Self-asserted source
olivier pertz

Meeting report: 3rd Meeting of the Biosensor Workgroup of the GDR2588

Biotechnology Journal
2014 | Other
Source: Self-asserted source
olivier pertz

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1

Nature communications
2014 | Journal article
Source: Self-asserted source
olivier pertz

Spatial proteomic and phospho-proteomic organization in three prototypical cell migration modes

Proteome science
2014 | Journal article
Source: Self-asserted source
olivier pertz

A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space

Science signaling
2013 | Journal article
Source: Self-asserted source
olivier pertz

Automated quantification of morphodynamics for high-throughput live cell time-lapse datasets

2013 IEEE 10th International Symposium on Biomedical Imaging
2013 | Conference paper
Source: Self-asserted source
olivier pertz

Analysis of a Rho GTPase centered interactome reveals complex regulation of neurite outgrowth.

MOLECULAR BIOLOGY OF THE CELL
2012 | Conference paper
Source: Self-asserted source
olivier pertz

Assessment of Rho GTPase signaling during neurite outgrowth

Rho GTPases
2012 | Book chapter
Source: Self-asserted source
olivier pertz

Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation

PLoS biology
2012 | Journal article
Source: Self-asserted source
olivier pertz

Regulation of Filopodia Dynamics in Outgrowing Neurites by Rho GTPase Signaling Programs.

MOLECULAR BIOLOGY OF THE CELL
2012 | Conference paper
Source: Self-asserted source
olivier pertz

Automated Quantification of Morphodynamics for High-Throughput Live Cell Imaging Datasets

1st International SystemsX. ch Conference on Systems Biology
2011 | Conference paper
Source: Self-asserted source
olivier pertz

Filopodia: Nanodevices that sense nanotopographic ECM cues to orient neurite outgrowth

Communicative & integrative biology
2011 | Journal article
Source: Self-asserted source
olivier pertz

Machine learning techniques to analyse complex, computer vision-extracted, dynamic cellular phenotypes

1st International SystemsX. ch Conference on Systems Biology
2011 | Conference paper
Source: Self-asserted source
olivier pertz

Protein kinase A governs a RhoA--RhoGDI protrusion--retraction pacemaker in migrating cells

Nature cell biology
2011 | Journal article
Source: Self-asserted source
olivier pertz
Items per page:
Page 1 of 2

Peer review (11 reviews for 7 publications/grants)

Review activity for Biophysical reviews. (1)
Review activity for Current opinion in cell biology. (1)
Review activity for EMBO journal. (1)
Review activity for Faculty Opinions (2)
Review activity for Nature cancer. (1)
Review activity for Nature communications (3)
Review activity for PLoS biology. (2)