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molecular biology, biochemistry, mitochondria, RNA, gene therapy, translation
France

Biography

Curriculum vitæ

Tarassov Ivan

Born in Moscow (USSR) 1961, French
Email : i.tarassov@unistra.fr
Phone: +33 (0) 6 87 33 98 49 / +33 (0) 3 68 85 14 81
Directeur de Recherche CNRS 1Cl

Professional status :
Director of the UMR 7156 GMGM (CNRS-University of Strasbourg) Génétique Moléculaire, Génomique, Microbiologie" (2013-2022), leader of the team "Intracellular traffic of RNA and mitochondrial pathologies" at the UMR7156, Coordinator of the LabEx (Research Cluster) MitoCross, member of the Directory board of the EUR IMCBio Graduate School IMCBio and of the ITI (Interdisciplinary Thematic Institute) IMCBio+, 2023-2024 coordinator of IMCBio+.

Carrier :
2013-2022 - UMR 7156 GMGM Director; 2014 - Directeur de Recherche 1Cl CNRS, UMR7156 CNRS-UNISTRA; 2006 - Directeur de Recherche 2Cl CNRS, UMR7156 CNRS-ULP; 1996-2006 Chargé de Recherche 1Cl CNRS, UPR9005, FRE2735; 1992-1996 Postdoctoral stage (FEBS fellowship), UPR9005 CNRS (Strasbourg) (dir. P. Remy); 1990-1992 Researcher at Moscow University, team leader at the Dep. of Molecular Biology (dir. A. Spirin).

Cursus :
Habilitation à Diriger les Recherches (HDR), Université Louis Pasteur, Strasbourg, 1999; PhD degree,1990 Master degree (mention cum laude), Molecular Bilogy Dep., Moscow State University 1984.

Coordination experience :
Scientific Director of the LabEx MitoCross (National program “Investissements d’Avenir”, 6 teams from 3 institutes; member of the Executive Bord of the EUR IMCBio Graduate School (Strasbourg, 3 LabEx : MitoCross, INRT & NetRNA) and of the ITI (Interdiscipliary Thematic Institute) IMCBio-plus (60 teams form 6 institutes, Idex UNISTRA); HFSP international collaboration grant (4 participants), French responsible (1996-2001); AFM (Association Française contre les Myopathies), coordinator in several grants in 2001-2003, 2005-2007; 2010-2011; PICS (DREI CNRS), coordinator, international collaboration project 2007-2009; ARCUS (Alsace - Russie - Ukraine), responsible for a collaboration, 2006-2009; ANR (Maladies Rares) grant, coordinator (3 participants), 2007-2009; ANR (BLANC) grant, responsible (mono-participant grant), 2009-2012; FRM - grant, associated with the label "Equipe FRM 2008", responsible/laureat, 2009-201; LIA scientific director, "Laboratoire International Associé" ARNmitocure, UMR7156/Moscow University (2011-2018); Team leadership: 1990-1992, at Moscow State University; from 1999 - at UPR9005/FRE2375/UMR7156, Strasbourg; Participation, as organization body member or in advisory boards, of several national and international workshops and meetings. Invited expert in several institutional evaluations by EU-CORDIS, ERC, AERES and HCERES 2011-2018.

Scientific production :
Co-author of >80 papers in peer-reviewed scientific journals, including high-impact ones (Science, Nature, Genes & Dev., Molecular cell, EMBO J., Human Mol. Genet., PNAS, Am. J. Hum. Genet., Biomaterials, Nucleic Acids Res., etc.), the majority (50) as corresponding author; 1 US Patent (2016); >90 presentations at scientific meetings, from which 38 upon invitation. RG Score 37, h-index 33, >3,500 citations.

Teaching :
Conferences in the frame of M1/M2 cursus at the University of Strasbourg (2012-2021); Conferences in the frame of DEA cursus at the Institut Pasteur, Paris (2000); supervision of 12 PhD theses; >17 Invited conferences including those at the University of Newcastle (UK) (2016), University of Meinz (2015), IGM, Montpelliler (2014), IMAGINE (2017), Titisee Boeringer MH annual conference (2017), conferences, selection juries and examinations in the frame of the EUR IMCBio (2018-…), etc.

Personnal distinctions :
Prix Maurice Nicloux de la Société Française de Biochimie et de Biologie Moléculaire (SFBBM), 2002, for outstanding achievements in the research on RNA targeting into mitochondria; Laureate of competition for the label "Equipe FRM 2008", for innovative research in biomedical field.

Scientific interests :
The IT research pursues the threefold objective. First - to understand the molecular mechanisms involved in the importation of ribonucleic acids into mitochondria, starting with their targeting towards mitochondria, continuing by their passage through the mitochondrial double membrane and ending in their functioning in organelles. Second, - to capitalize on the knowledge of this unique natural pathway of nucleic acid addressing in mitochondria to develop models of gene therapy for mitochondrial diseases caused by mutations in the organelle's own DNA. Finally - to exploit our know-how in the domains of RNA and mitochondria to better understand the sub-adjacent mechanisms of various mitochondrial diseases. Over the years, our team has become one of the internationally recognized leaders in all these fields of research.

Activities

Employment (6)

UMR 7156 GMGM CNRS-Strasbourg University: Strasbourg, FR

2023-01-01 to present | Team leader
Employment
Source: Self-asserted source
Ivan Tarassov

UMR 7156 GMGM CNRS-Strasbourg University: Strasbourg, FR

2013-01-01 to 2022-12-31 | Research Director CNRS (DR1), Head of the Institute
Employment
Source: Self-asserted source
Ivan Tarassov

UMR 7156 GMGM CNRS-Strasbourg University: Strasbourg, FR

2006 to 2012 | Research Director CNRS (DR2), Team Leader
Employment
Source: Self-asserted source
Ivan Tarassov

UPR 9005 / FRE 2375 / UMR 7156 GMGM CNRS-Strasbourg University: Strasbourg, FR

1996 to 2005 | Researcher CNRS (CR1)
Employment
Source: Self-asserted source
Ivan Tarassov

UPR 9005 CNRS: Strasbourg, FR

1992 to 1995 | Postdoc
Employment
Source: Self-asserted source
Ivan Tarassov

Moscow State University: Moscow, RU

1990 to 1991 | Researcher, team leader (Biology)
Employment
Source: Self-asserted source
Ivan Tarassov

Education and qualifications (3)

Université Louis Pasteur: Strasbourg, FR

1996 to present | HDR (Habilitation to Direct Research)
Education
Source: Self-asserted source
Ivan Tarassov

Moscow State University: Moscow, RU

1986 to 1989 | PhD (Biology)
Education
Source: Self-asserted source
Ivan Tarassov

Moscow State University: Moscow, RU

1979 to 1984 | Master (Biology)
Education
Source: Self-asserted source
Ivan Tarassov

Professional activities (3)

Société Française de Biochimie et Biologie Moléculaire: Paris, Île-de-France, FR

Membership
Source: Self-asserted source
Ivan Tarassov

Groupe Français de Bioénérgétique (GFB): Bordeaux, FR

Membership
Source: Self-asserted source
Ivan Tarassov

Societé Française de Biochimie et de Biologie Moleculaie: Paris, FR

2002 | Prix Maurice Nicloux
Distinction
Source: Self-asserted source
Ivan Tarassov

Funding (20)

Institut Thématique Interdisciplinaire (ITI) IMCBio

2020-12 to 2028-12 | Contract
Université de Strasbourg (Strasbourg, -- please choose --, FR)
Source: Self-asserted source
Ivan Tarassov

PRC-CNRS : "New approaches for targeted cellular delivery of RNA molecules capable of modulating the mitochondrial genome expression"

2020-01 to 2022-12 | Grant
Centre National de la Recherche Scientifique (Strasbourg, -- please choose --, FR)
Source: Self-asserted source
Ivan Tarassov

Graduate School IMCBio

2018 to present | Grant
Programme Ivestissement Avenir (PIA) (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

LabEX MitoCross

2011 to 2020 | Grant
Ministère de l'Enseignement Supérieur et de la Recherche (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

LIA ARN-mitocure

2011 to 2018 | Grant
CNRS-DRI (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Mechanisms of RNA targeting and translocation into mitochondria

2009 to 2012 | Grant
Agence Nationale de la Recherche (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Equipe FRM 2008 : Award/subvention for innovative research on mitochondrial functions and diseases

2009 to 2011 | Award
Fondation pour la Recherche Médicale (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Elucidation of autosomal recessive mitochondrial pathologies

2009 to 2010 | Grant
AFM-Téléthon (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Chemistry and Biotechnology

2007 to 2009 | Grant
ARCUS (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Mitochondrial import of RNA and mitochondrial diseases

2007 to 2009 | Grant
CNRS-DRI (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Modelling gene therapy of mitochondrial diseases

2007 to 2009 | Grant
Agence Nationale de la Recherche (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Mitochondrial RNA import as a therapeutic tool

2007 to 2008 | Grant
AFM-Téléthon (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Mitochondrial translation diseases

2005 to 2007 | Grant
AFM-Téléthon (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Mitochondrial RNA and mitochondrial translation

2004 to 2005 | Grant
GIS-Institut des Maladies Rares (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

RNA mitochondrial import as a tool for biomedicine

2003 to 2005 | Grant
CNRS-DRI (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

MitEURO

2001 to 2005 | Grant
European Commission (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

RNA mitochondrial import and mitochondrial function

2001 to 2005 | Grant
Human Frontier Science Program (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Mitochondrial RNA and mitochondrial diseases

2001 to 2003 | Grant
AFM-Téléthon (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Addressing Mitochondrial diseases

1999 to 2001 | Grant
AFM-Téléthon (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

INTAS

1997 to 2000 | Grant
European Commission (Strasbourg, FR)
Source: Self-asserted source
Ivan Tarassov

Works (50 of 70)

Items per page:
Page 1 of 2

Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA <sup>Thr</sup> production

Proceedings of the National Academy of Sciences
2025-01-07 | Journal article | Author
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Xihui Xu; Rozhin Penjweini; Lóránt Székvölgyi; Zsolt Karányi; Anne-Marie Heckel; Devikala Gurusamy; Dora Varga; Shutong Yang; Alexandra L Brown; Wenqi Cui et al.
Source: Self-asserted source
Ivan Tarassov

Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma

Nature Cell Biology
2024-06-07 | Journal article | Author
Part of ISSN: 1465-7392
Part of ISSN: 1476-4679
Contributors: Najla El-Hachem; Marine Leclercq; Miguel Susaeta Ruiz; Raphaël Vanleyssem; Kateryna Shostak; Pierre-René Körner; Coralie Capron; Lorena Martin-Morales; Patrick Roncarati; Arnaud Lavergne et al.
Source: Self-asserted source
Ivan Tarassov

Targeting of CRISPR-Cas12a crRNAs into human mitochondria

Biochimie
2023-09 | Journal article
Part of ISSN: 0300-9084
Contributors: Natalia Nikitchina; Egor Ulashchik; Vadim Shmanai; Anne-Marie Heckel; Ivan Tarassov; Ilya Mazunin; Nina Entelis
Source: Self-asserted source
Ivan Tarassov

CoLoC-seq probes the global topology of organelle transcriptomes

Nucleic Acids Research
2022-12-20 | Journal article | Author
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Damien Jeandard; Anna Smirnova; Akinyemi Mandela Fasemore; Léna Coudray; Nina Entelis; Konrad U. Förstner; Ivan Tarassov; Alexandre Smirnov
Source: Self-asserted source
Ivan Tarassov

Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable into Human Mitochondria

Methods in Molecular Biology
2021 | Book chapter
Part of ISBN: 9781071612699
Part of ISBN: 9781071612705
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Ivan Tarassov

Suborganellar Localization of Mitochondrial Proteins and Transcripts in Human Cells

Methods in Molecular Biology
2021 | Book chapter
Part of ISBN: 9781071612699
Part of ISBN: 9781071612705
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Ivan Tarassov

Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA

Nucleic Acids Research
2021-12-24 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Ivan Tarassov

Staphylococcus aureus Panton‐Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria

The FASEB Journal
2020-11-25 | Journal article
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Ivan Tarassov

Homoplasmic mitochondrial tRNAPro mutation causing exercise-induced muscle swelling and fatigue

Neurology Genetics
2020-08 | Journal article
Part of ISSN: 2376-7839
Source: Self-asserted source
Ivan Tarassov

YBEY is an essential biogenesis factor for mitochondrial ribosomes

Nucleic Acids Research
2020-03-17 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Ivan Tarassov

Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches

Cells
2019 | Journal article
Source: Self-asserted source
Ivan Tarassov

40 Years of Studying RNA Import into Mitochondria: From Basic Mechanisms to Gene Therapy Strategies

Molecular Biology
2019-11 | Journal article
Part of ISSN: 0026-8933
Part of ISSN: 1608-3245
Source: Self-asserted source
Ivan Tarassov

Can Mitochondrial DNA be CRISPRized: Pro and Contra

IUBMB Life
2018 | Journal article
Source: Self-asserted source
Ivan Tarassov

Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner

PLOS ONE
2018-06 | Journal article
Source: Self-asserted source
Ivan Tarassov

Factors Beyond Enolase 2 and Mitochondrial Lysyl-tRNA Synthetase Precursor Are Required for tRNA Import into Yeast Mitochondria.

Biochemistry (Moscow)
2017 | Journal article
Source: Self-asserted source
Ivan Tarassov

The prospects of gene therapy of for mitochondrial diseases: can’t we do without CRISPR/Cas9?

Bulletin of RSMU
2017 | Journal article
Source: Self-asserted source
Ivan Tarassov

Vector for therapy of mitochondrial disease

Source: Self-asserted source
Ivan Tarassov

Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: Lipophilic conjugates with cleavable bonds

Biomaterials
2016 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Modifications in Therapeutic Oligonucleotides Improving the Delivery

Modified Nucleic Acids in Biology and Medicine
2016 | Book chapter
Part of ISBN: 9783319341736
Part of ISBN: 9783319341750
Part of ISSN: 2197-9731
Part of ISSN: 2197-9758
Source: Self-asserted source
Ivan Tarassov

Procedure for Purification of Recombinant preMsk1p from E. coli Determines Its Properties as a Factor of tRNA Import into Yeast Mitochondria

Biochemistry (Mosc)
2016 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA

Int J Mol Sci
2015 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Mitochondrial targeting of recombinant RNA

Methods Mol Biol
2015 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Characterization of chemically modified oligonucleotides targeting a pathogenic mutation in human mitochondrial DNA

Biochimie
2014 | Journal article
Source: Self-asserted source
Ivan Tarassov

Mitochondria: an organelle for life

Biochimie
2014 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA

J Biol Chem
2014 | Journal article
Source: Self-asserted source
Ivan Tarassov

Induced tRNA import into human mitochondria: implication of a host aminoacyl-tRNA-synthetase

PLoS One
2013 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome

Nucleic Acids Res
2013 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit

PLoS One
2012 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency

Am J Hum Genet
2012 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Noncanonical functions of aminoacyl-tRNA synthetases

Biochemistry (Mosc)
2012 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18

Genes Dev
2011 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria

Nucleic Acids Res
2011 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40

Sci Rep
2011 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria

J Biol Chem
2010 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Selection of RNA aptamers imported into yeast and human mitochondria

RNA
2010 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

tRNA mitochondrial import in yeast: Mapping of the import determinants in the carrier protein, the precursor of mitochondrial lysyl-tRNA synthetase

Mitochondrion
2010 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Acute infantile liver failure due to mutations in the TRMU gene

Am J Hum Genet
2009 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Specific features of 5S rRNA structure - its interactions with macromolecules and possible functions

Biochemistry (Mosc)
2008 | Journal article
Source: Self-asserted source
Ivan Tarassov

Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria

RNA
2008 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

[Targeting allotopic material to the mitochondrial compartment: new tools for better understanding mitochondrial physiology and prospect for therapy]

Med Sci (Paris)
2007 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Deleterious mutation in the mitochondrial arginyl-transfer RNA synthetase gene is associated with pontocerebellar hypoplasia

Am J Hum Genet
2007 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Evidence for an adaptation mechanism of mitochondrial translation via tRNA import from the cytosol

Mol Cell
2007 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Import of nuclear DNA-encoded RNAs into mitochondria and mitochondrial translation

Cell Cycle
2007 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

The analysis of tRNA import into mammalian mitochondria

Methods Mol Biol
2007 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system

FEBS Lett
2007 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae

Genes Dev
2006 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Enolase takes part in a macromolecular complex associated to mitochondria in yeast

Biochim Biophys Acta
2006 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells

Hum Mol Genet
2004 | Journal article
Source: Self-asserted source
Ivan Tarassov
grade
Preferred source (of 2)‎

Import of nuclear encoded RNAs into yeast and human mitochondria: experimental approaches and possible biomedical applications

Genet Eng (N Y)
2002 | Journal article
Source: Self-asserted source
Ivan Tarassov

Targeting of tRNA into yeast and human mitochondria: the role of anticodon nucleotides

Mitochondrion
2002 | Journal article
Source: Self-asserted source
Ivan Tarassov
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