Personal information

Activities

Employment (3)

AstraZeneca FoU Göteborg: Molndal, SE

2017 to present | Director (CPSS - Clinical Pharmacology and Safety Science)
Employment
Source: Self-asserted source
roberto nitsch

AstraZeneca FoU Göteborg: Goteborg, SE

2014 to 2017 | Associate Director (Clinical Pharmacology and Safety Sciences )
Employment
Source: Self-asserted source
roberto nitsch

IMBA - Institute of Molecular Biotechnology: Vienna, AT

2007 to 2014 | Postdoc
Employment
Source: Self-asserted source
roberto nitsch

Education and qualifications (2)

Università degli Studi di Napoli Federico II: Napoli, Campania, IT

2003 to 2007 | PhD in Genetics and Molecular Medicine
Education
Source: Self-asserted source
roberto nitsch

Università degli Studi di Napoli Federico II: Napoli, Campania, IT

1997 to 2003 | Master
Education
Source: Self-asserted source
roberto nitsch

Works (18)

In vivo CRISPR editing with no detectable genome-wide off-target mutations

Nature
2018 | Journal article
EID:

2-s2.0-85053496364

Contributors: Akcakaya, P.; Bobbin, M.L.; Guo, J.A.; Malagon-Lopez, J.; Clement, K.; Garcia, S.P.; Fellows, M.D.; Porritt, M.J.; Firth, M.A.; Carreras, A. et al.
Source: Self-asserted source
roberto nitsch via Scopus - Elsevier

Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype

EBioMedicine
2018 | Journal article
EID:

2-s2.0-85042616653

Contributors: Bjursell, M.; Porritt, M.J.; Ericson, E.; Taheri-Ghahfarokhi, A.; Clausen, M.; Magnusson, L.; Admyre, T.; Nitsch, R.; Mayr, L.; Aasehaug, L. et al.
Source: Self-asserted source
roberto nitsch via Scopus - Elsevier

CRISPR-UMI: Single-cell lineage tracing of pooled CRISPR-Cas9 screens

Nature Methods
2017 | Journal article
EID:

2-s2.0-85036605875

Contributors: Michlits, G.; Hubmann, M.; Wu, S.-H.; Vainorius, G.; Budusan, E.; Zhuk, S.; Burkard, T.R.; Novatchkova, M.; Aichinger, M.; Lu, Y. et al.
Source: Self-asserted source
roberto nitsch via Scopus - Elsevier

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer

Genes and Development
2017 | Journal article
EID:

2-s2.0-85035354896

Contributors: Rao, S.; Sigl, V.; Wimmer, R.A.; Novatchkova, M.; Jais, A.; Wagner, G.; Handschuh, S.; Uribesalgo, I.; Hagelkruys, A.; Kozieradzki, I. et al.
Source: Self-asserted source
roberto nitsch via Scopus - Elsevier

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

2016-09 | Journal article
Contributors: Tortola L; Nitsch R; Bertrand MJ; Kogler M; Redouane Y; Kozieradzki I; Uribesalgo I; Fennell LM; Daugaard M; Klug H et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

TNF-driven cell fate: till HACE do us part.

2016-07 | Journal article
Contributors: Tortola L; Nitsch R; Penninger JM
Source: Self-asserted source
roberto nitsch via Europe PubMed Central

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

2016-05 | Journal article
Contributors: Tortola L; Nitsch R; Bertrand MJ; Kogler M; Redouane Y; Kozieradzki I; Uribesalgo I; Fennell LM; Daugaard M; Klug H et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

A dual role for autophagy in a murine model of lung cancer.

2014 | Journal article
Contributors: Rao S; Tortola L; Perlot T; Wirnsberger G; Novatchkova M; Nitsch R; Sykacek P; Frank L; Schramek D; Komnenovic V et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

2014-03 | Journal article
Contributors: Paolino M; Choidas A; Wallner S; Pranjic B; Uribesalgo I; Loeser S; Jamieson AM; Langdon WY; Ikeda F; Fededa JP et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

2014-02 | Journal article
Contributors: Rotblat B; Southwell AL; Ehrnhoefer DE; Skotte NH; Metzler M; Franciosi S; Leprivier G; Somasekharan SP; Barokas A; Deng Y et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.

2013 | Journal article
Contributors: Daugaard M; Nitsch R; Razaghi B; McDonald L; Jarrar A; Torrino S; Castillo-Lluva S; Rotblat B; Li L; Malliri A et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas.

2012-01 | Journal article
Contributors: Calì G; Gentile F; Mogavero S; Pallante P; Nitsch R; Ciancia G; Ferraro A; Fusco A; Nitsch L
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene.

2010-05 | Journal article
Contributors: Nitsch R; Di Dato V; di Gennaro A; de Cristofaro T; Abbondante S; De Felice M; Zannini M; Di Lauro R
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction.

2006-08 | Journal article
Contributors: D'Andrea B; Iacone R; Di Palma T; Nitsch R; Baratta MG; Nitsch L; Di Lauro R; Zannini M
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells.

2005-11 | Journal article
Contributors: Dentice M; Luongo C; Elefante A; Ambrosio R; Salzano S; Zannini M; Nitsch R; Di Lauro R; Rossi G; Fenzi G et al.
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8

Biochemical Journal
2004 | Journal article
EID:

2-s2.0-1242292284

Contributors: Nitsch, R.; Di Palma, T.; Mascia, A.; Zannini, M.
Source: Self-asserted source
roberto nitsch via Scopus - Elsevier

WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8.

2004-02 | Journal article
Contributors: Nitsch R; Di Palma T; Mascia A; Zannini M
Source: Self-asserted source
roberto nitsch via Europe PubMed Central

The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription.

2003-01 | Journal article
Contributors: Di Palma T; Nitsch R; Mascia A; Nitsch L; Di Lauro R; Zannini M
Source: Self-asserted source
roberto nitsch via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (4 reviews for 2 publications/grants)

Review activity for Molecular therapy (3)
Review activity for Molecular therapy. (1)