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obesity, diabetes, steatosis, gastrointestinal hormones
United States

Activities

Employment (2)

University of Michigan: Ann Arbor, MI, US

2011-09-01 to present | Associate Professor (Surgery)
Employment
Source: Self-asserted source
Weizhen Zhang

Peking University Health Science Centre: Beijing, Beijing, CN

2007-09-01 to present | Professor (Physiology and Pathophysiology)
Employment
Source: Self-asserted source
Weizhen Zhang

Education and qualifications (1)

Peking University Health Science Centre: Beijing, Beijing, CN

1991-09-01 to 1994-07-01 | PhD
Education
Source: Self-asserted source
Weizhen Zhang

Works (50 of 127)

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Page 1 of 3

GPR180 Reduces Adiposity by Inhibiting Lipogenesis and Fatty Acid Uptake in Adipocytes

American Journal of Physiology-Endocrinology and Metabolism
2025-02-10 | Journal article
Contributors: Ziming Zhu; Yaxu Yang; Lijun Sun; Yunhua Zhang; Xue Han; Chao Luo; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

Nuclear Acly protects the liver from ischemia-reperfusion injury

Hepatology
2024-11 | Journal article
Contributors: Wenbin Gao; Liping Zhang; Ziru Li; Tong Wu; Chunhui Lang; Michael W. Mulholland; Weizhen Zhang
Source: check_circle
Crossref

ETS Transcription Factors in Immune Cells and Immune-Related Diseases

International Journal of Molecular Sciences
2024-09-17 | Journal article
Contributors: Yaxu Yang; Xue Han; Lijun Sun; Fangyu Shao; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice

Nature Communications
2024-05-23 | Journal article
Contributors: Yuan Liang; Chao Luo; Lijun Sun; Tiange Feng; Wenzhen Yin; Yunhua Zhang; Michael W. Mulholland; Weizhen Zhang; Yue Yin
Source: check_circle
Crossref

Hepatic LGR4 aggravates cholestasis-induced liver injury in mice

American Journal of Physiology-Gastrointestinal and Liver Physiology
2024-04-01 | Journal article
Contributors: Yuan Gao; Wenbo Zhai; Lijun Sun; Xueqian Du; Xianfeng Wang; Michael W. Mulholland; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

eLife
2024-03-27 | Journal article
Contributors: Hong Chen; Lijun Sun; Lu Feng; Xue Han; Yunhua Zhang; Wenbo Zhai; Zehe Zhang; Michael Mulholland; Weizhen Zhang; Yue Yin
Source: check_circle
Crossref

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

eLife
2024-03-27 | Journal article
Contributors: Hong Chen; Lijun Sun; Lu Feng; Xue Han; Yunhua Zhang; Wenbo Zhai; Zehe Zhang; Michael Mulholland; Weizhen Zhang; Yue Yin
Source: check_circle
Crossref

Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling

The FASEB Journal
2023-04 | Journal article
Contributors: Wenzhen Yin; Lijun Sun; Yuan Liang; Chao Luo; Tiange Feng; Yunhua Zhang; Weizhen Zhang; Yue Yin
Source: check_circle
Crossref

Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway

Nutrients
2023-04-11 | Journal article
Contributors: Yunhua Zhang; Ziming Zhu; Lijun Sun; Wenzhen Yin; Yuan Liang; Hong Chen; Yanghui Bi; Wenbo Zhai; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring

Communications Biology
2023-01-12 | Journal article
Contributors: Yuan Liang; Wenzhen Yin; Chao Luo; Lijun Sun; Tiange Feng; Yunhua Zhang; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

p-Hydroxybenzoic Acid Ameliorates Colitis by Improving the Mucosal Barrier in a Gut Microbiota-Dependent Manner

Nutrients
2022-12-18 | Journal article
Contributors: Xue Han; Miaomiao Li; Lijun Sun; Xinjuan Liu; Yue Yin; Jianyu Hao; Weizhen Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Peptidoglycan inhibits beigeing of adipose tissue

Acta Pharmaceutica Sinica B
2022-02 | Journal article
Contributors: Hong Chen; Lijun Sun; Lu Feng; Michael Mulholland; Weizhen Zhang; Yue Yin
Source: check_circle
Crossref

Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low‐grade inflammation via blockade of Kupffer cell M1 polarization

Journal of Cellular Physiology
2021-07 | Journal article
Contributors: Yue Yin; Qin Wang; Meiyuzhen Qi; Chen Zhang; Ziru Li; Weizhen Zhang
Source: check_circle
Crossref

Rspo1–LGR4 axis in BMSCs protects bone against radiation‐induced injury through the mTOR‐dependent autophagy pathway

Journal of Cellular Physiology
2021-06 | Journal article
Contributors: Xiaodan Chen; Lingling Chen; Jiali Tan; Liping Zhang; Juan Xia; Bin Cheng; Weizhen Zhang
Source: check_circle
Crossref

Ghrelin Based Therapy of Metabolic Diseases

Current Medicinal Chemistry
2021-04 | Journal article
Contributors: Yuan Liang; Wenzhen Yin; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

Maternal Intermittent Fasting Before Mating Alters Hepatic DNA Methylation in Offspring

Epigenomics
2021-03 | Journal article
Contributors: Wenzhen Yin; Yuan Liang; Lijun Sun; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway

Diabetes
2021-01-01 | Journal article
Contributors: Zhuo Mao; Mingji Feng; Zhuoran Li; Minsi Zhou; Langning Xu; Ke Pan; Shaoxiang Wang; Wen Su; Weizhen Zhang
Source: check_circle
Crossref

m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells

Diabetes
2020-08-01 | Journal article
Contributors: Yanqiu Wang; Jiajun Sun; Zhen Lin; Weizhen Zhang; Shu Wang; Weiqing Wang; Qidi Wang; Guang Ning
Source: check_circle
Crossref

Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma

International Journal of Genomics
2020-07-28 | Journal article
Contributors: Yun Ji; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

The Molecular and Mechanistic Insights Based on Gut–Liver Axis: Nutritional Target for Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement

International Journal of Molecular Sciences
2020-04-26 | Journal article
Contributors: Yun Ji; Yue Yin; Lijun Sun; Weizhen Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Anti-Inflammatory and Anti-Oxidative Activity of Indole-3-Acetic Acid Involves Induction of HO-1 and Neutralization of Free Radicals in RAW264.7 Cells

International Journal of Molecular Sciences
2020-02-25 | Journal article
Contributors: Yun Ji; Wenzhen Yin; Yuan Liang; Lijun Sun; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress

Nutrients
2019-09-03 | Journal article
Contributors: Yun Ji; Yuan Gao; Hong Chen; Yue Yin; Weizhen Zhang
Source: check_circle
Crossref

Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)

Nutrients
2019-07-25 | Journal article
Contributors: Yun Ji; Yue Yin; Ziru Li; Weizhen Zhang
Source: check_circle
Crossref

Modulation of Bone and Marrow Niche by Cholesterol

Nutrients
2019-06-21 | Journal article
Contributors: Wenzhen Yin; Ziru Li; Weizhen Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Ghrelin Restores the Disruption of the Circadian Clock in Steatotic Liver

International Journal of Molecular Sciences
2018-10 | Journal article | Author
Contributors: Qin Wang; Yue Yin; Weizhen Zhang
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Ghrelin Stimulates Endothelial Cells Angiogenesis through Extracellular Regulated Protein Kinases (ERK) Signaling Pathway

International Journal of Molecular Sciences
2018-08 | Journal article | Author
Contributors: Jun Wang; Lin He; Bahetiyaer Huwatibieke; Lingchao Liu; He Lan; Jing Zhao; Yin Li; Weizhen Zhang
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Role of mTOR in Glucose and Lipid Metabolism

International Journal of Molecular Sciences
2018-07 | Journal article
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.

Biochemical and biophysical research communications
2018-04 | Journal article
Contributors: Liu S; Yin Y; Yu R; Li Y; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Esophagus-duodenum Gastric Bypass Surgery Improves Glucose and Lipid Metabolism in Mice.

EBioMedicine
2018-02 | Journal article
Contributors: He R; Yin Y; Li Y; Li Z; Zhao J; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells.

International journal of molecular medicine
2018-01 | Journal article
Contributors: Jin M; Park SY; Shen Q; Lai Y; Ou X; Mao Z; Lin D; Yu Y; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

mTOR activation protects liver from ischemia/reperfusion-induced injury through NF-κB pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2017-07 | Journal article
Contributors: Li Z; Zhang J; Mulholland M; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

TSC1-mTOR signaling determines the differentiation of islet cells.

The Journal of endocrinology
2017-01 | Journal article
Contributors: Ding L; Yin Y; Han L; Li Y; Zhao J; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

The Role of Ghrelin in Senescence: A Mini-Review.

Gerontology
2016 | Journal article
Contributors: Yin Y; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Exendin-4 decreases ghrelin levels through mTOR signaling.

Molecular and cellular endocrinology
2016-12 | Journal article
Contributors: Hong X; Zhang H; Liang H; Li D; Huang J; Li Z; Jiang S; Zhang W; Xu G
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Nesfatin-1 promotes brown adipocyte phenotype.

Scientific reports
2016-11 | Journal article
Contributors: Wang Y; Li Z; Zhang X; Xiang X; Li Y; Mulholland MW; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

The 2016 Albert Lasker Basic Medical Research Award: Oxygen sensing-a mysterious process essential for survival.

Science China. Life sciences
2016-11 | Journal article
Contributors: Li Z; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

AMPK-dependent regulation of GLP1 expression in L-like cells.

Journal of molecular endocrinology
2016-10 | Journal article
Contributors: Jiang S; Zhai H; Li D; Huang J; Zhang H; Li Z; Zhang W; Xu G
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

GHSR deficiency suppresses neointimal formation in injured mouse arteries.

Biochemical and biophysical research communications
2016-10 | Journal article
Contributors: Li J; Zhang M; Wang M; Wang Z; Liu Y; Zhang W; Wang N
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells.

Integrative biology : quantitative biosciences from nano to macro
2016-09 | Journal article
Contributors: Jin M; Yu B; Zhang W; Zhang W; Xiao Z; Mao Z; Lai Y; Lin D; Ma Q; Pan E et al.
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Can irisin be a linker between physical activity and brain function?

Biomolecular concepts
2016-08 | Journal article
Contributors: Zhang J; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

A Systemic Inflammatory Endotype of Asthma With More Severe Disease Identified by Unbiased Clustering of the Serum Cytokine Profile.

Medicine
2016-06 | Journal article
Contributors: Liang Z; Liu L; Zhao H; Xia Y; Zhang W; Ye Y; Jiang M; Cai S
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central

Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells.

European journal of pharmacology
2016-06 | Journal article
Contributors: Yu Y; Huang Z; Mao Z; Zhang Y; Jin M; Chen W; Zhang W; Yu B; Zhang W; Alaster Lau HY
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Inhibition of rhotekin exhibits antitumor effects in lung cancer cells.

Oncology reports
2016-05 | Journal article
Contributors: Zhang W; Liang Z; Li J
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling.

EBioMedicine
2016-04 | Journal article
Contributors: Tang H; Yu R; Liu S; Huwatibieke B; Li Z; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Ghrelin O-acyltransferase (GOAT) and energy metabolism.

Science China. Life sciences
2016-03 | Journal article
Contributors: Li Z; Mulholland M; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Ghrelin inhibits the differentiation of T helper 17 cells through mTOR/STAT3 signaling pathway.

PloS one
2015 | Journal article
Contributors: Xu Y; Li Z; Yin Y; Lan H; Wang J; Zhao J; Feng J; Li Y; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

LGR4 and Its Role in Intestinal Protection and Energy Metabolism.

Frontiers in endocrinology
2015 | Journal article
Contributors: Li Z; Zhang W; Mulholland MW
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1.

Molecular and cellular endocrinology
2015-12 | Journal article
Contributors: Yin Y; Li Z; Gao L; Li Y; Zhao J; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
grade
Preferred source (of 2)‎

Angiotensin receptor blockers use and the risk of lung cancer: A meta-analysis.

Journal of the renin-angiotensin-aldosterone system : JRAAS
2015-12 | Journal article
Contributors: Zhang W; Liang Z; Li J; Cai S
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central

[A case of Lowe syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2015-11 | Journal article
Contributors: Chen Q; Chen Y; Zhang W
Source: Self-asserted source
Weizhen Zhang via Europe PubMed Central
Items per page:
Page 1 of 3

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)