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Employment (3)

Merck & Co., Inc., Rahway, NJ, USA (United States): Rahway, US

2020-12 to present (Chemical Biotechnologies (Protein Engineering))
Employment
Source: Self-asserted source
Jackson Cahn

ETH Zurich: Zurich, CH

2016-03-29 to 2020-12 | Postdoctoral Scholar (Microbiology)
Employment
Source: Self-asserted source
Jackson Cahn

Whitman College: Walla Walla, WA, US

2010-05 to 2011-08 | Crystallography research assistant (Phyiscs)
Employment
Source: Self-asserted source
Jackson Cahn

Education and qualifications (2)

California Institute of Technology: Pasadena, CA, US

2011-09 to 2016-01-19 | Ph.D. Candidate (Chemistry)
Qualification
Source: Self-asserted source
Jackson Cahn

Whitman College: Walla Walla, WA, US

2006-09 to 2010-05 | B.A. with Honors (Biochemistry, Biophysics, and Molecular Biology)
Qualification
Source: Self-asserted source
Jackson Cahn

Works (20)

Characterization of an Orphan Type III Polyketide Synthase Conserved in Uncultivated “Entotheonella” Sponge Symbionts

ChemBioChem
2019-10-22 | Journal article
DOI: 10.1002/cbic.201900352
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Source: Self-asserted source
Jackson Cahn

Opening up the Single-Cell Toolbox for Microbial Natural Products Research

Angewandte Chemie International Edition
2019-02-12 | Journal article
DOI: 10.1002/anie.201900532
Part of ISSN: 1433-7851
Source: Self-asserted source
Jackson Cahn

Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design

Methods in Molecular Biology
2018 | Book chapter
DOI: 10.1007/978-1-4939-7295-1_2
Part of ISBN: 9781493972944
Part of ISBN: 9781493972951
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Jackson Cahn

The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order

Acta Crystallographica Section D Structural Biology
2018-09-01 | Journal article
DOI: 10.1107/s2059798318008793
Part of ISSN: 2059-7983
Source: Self-asserted source
Jackson Cahn

Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble

Journal of the American Chemical Society
2018-06-13 | Journal article
DOI: 10.1021/jacs.8b03490
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Jackson Cahn

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts

Proceedings of the National Academy of Sciences
2018-02-20 | Journal article
DOI: 10.1073/pnas.1715496115
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Jackson Cahn

4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation

Journal of the American Chemical Society
2017-06-28 | Journal article
DOI: 10.1021/jacs.7b00794
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Jackson Cahn

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore

Cell Chemical Biology
2017-03 | Journal article
DOI: 10.1016/j.chembiol.2017.02.008
Part of ISSN: 2451-9456
Source: Self-asserted source
Jackson Cahn

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases

ACS Synthetic Biology
2017-02-17 | Journal article
DOI: 10.1021/acssynbio.6b00188
Part of ISSN: 2161-5063
Part of ISSN: 2161-5063
Source: Self-asserted source
Jackson Cahn

Engineering, Predicting, and Understanding Nicotinamide Cofactor Specificity

2016 | Dissertation or Thesis
DOI: 10.7907/Z9QV3JJ8
Source: Self-asserted source
Jackson Cahn

Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases

Protein Science
2016-07 | Journal article
DOI: 10.1002/pro.2852
Part of ISSN: 0961-8368
Source: Self-asserted source
Jackson Cahn

Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models

Nature Chemistry
2016-05 | Journal article
DOI: 10.1038/nchem.2474
Part of ISSN: 1755-4330
Part of ISSN: 1755-4349
Source: Self-asserted source
Jackson Cahn

Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes

Protein Engineering Design and Selection
2015-10-27 | Journal article
DOI: 10.1093/protein/gzv057
Part of ISSN: 1741-0126
Part of ISSN: 1741-0134
Source: Self-asserted source
Jackson Cahn

Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases

Biochemical Journal
2015-06-15 | Journal article
DOI: 10.1042/bj20150183
Part of ISSN: 0264-6021
Part of ISSN: 1470-8728
Source: Self-asserted source
Jackson Cahn

Uncovering rare NADH-preferring ketol-acid reductoisomerases

Metabolic Engineering
2014-11 | Journal article
DOI: 10.1016/j.ymben.2014.08.003
Part of ISSN: 1096-7176
Source: Self-asserted source
Jackson Cahn

Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE

ChemBioChem
2014-10-13 | Journal article
DOI: 10.1002/cbic.201402241
Part of ISSN: 1439-4227
Source: Self-asserted source
Jackson Cahn

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH

Proceedings of the National Academy of Sciences
2013-07-02 | Journal article
DOI: 10.1073/pnas.1306073110
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Jackson Cahn

The use of trimethylamineN-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography

Acta Crystallographica Section D Biological Crystallography
2012-01-01 | Journal article
DOI: 10.1107/s0907444911050360
Part of ISSN: 0907-4449
Part of ISSN: 1399-0047
Source: Self-asserted source
Jackson Cahn

Cell adhesion to borate glasses by colloidal probe microscopy

Acta Biomaterialia
2011-05 | Journal article
DOI: 10.1016/j.actbio.2011.01.014
Part of ISSN: 1742-7061
Source: Self-asserted source
Jackson Cahn

Pretreatment with serum-free media enhances short-term adhesion of osteoblasts to borosilicate glass

2010 | Dissertation or Thesis
Source: Self-asserted source
Jackson Cahn

Peer review (3 reviews for 2 publications/grants)

Review activity for ACS synthetic biology. (2)
Review activity for Journal of the American Chemical Society. (1)
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