Personal information

retina, computational neuroscience, vision, myopia, diabetic retinopathy
United States

Biography

A concise summary of my career trajectory is that I have uncovered new computations in retinal circuits, and I have revealed new mechanisms that support these computations. These discoveries have impacted both vision science and systems neuroscience more generally. Receiving the New Innovator Award (DP2) in 2015, near the start of my independent career, allowed my lab to branch out into several new areas, including transcriptomics, retina to brain connectivity, neurovascular coupling, and retinal control of myopia development. The core of my research program remains rooted in the investigation of retinal circuits through visual stimulation and electrophysiology.

I am driven by the desire to understand how computations are performed in neural circuits and how they drive perception and behavior. My approach combines molecular genetics, anatomy, physiology, and computation to map the precise connectivity of neural circuits and measure responses to sensory stimuli at multiple locations throughout each circuit. I have chosen the mouse retina as a model system because of its well-characterized complement of distinct cell types and the ability to record from complete circuits ex vivo in the context of natural light stimuli.

Training the next generation of vision scientists and systems neuroscientists is fundamental to my professional goals. In my own lab, my first 3 postdocs were successful in attaining independent funding, and 3 of my first 4 graduate students (all three eligible ones) received individual NRSAs. On the institutional level, I serve as the Director of Admissions for NUIN, the interdepartmental neuroscience graduate program at Northwestern, and on the NUIN advisory board.

Activities

Employment (1)

Northwestern University Feinberg School of Medicine: Chicago, IL, US

2013-10-01 to present | Associate Professor (Ophthalmology)
Employment
Source: Self-asserted source
Greg Schwartz

Education and qualifications (2)

University of Washington: Seattle, WA, US

2008-12-01 to 2013-09-30 | Postdoctoral Fellow (Physiology and Biophysics)
Qualification
Source: Self-asserted source
Greg Schwartz

Princeton University: Princeton, NJ, US

2003-09-01 to 2008-05-20 | PhD (Molecular Biology and Neuroscience)
Education
Source: Self-asserted source
Greg Schwartz

Professional activities (12)

Northwestern University Interdepartmental Neuroscience Program: Chicago, IL, US

2021-01-25 to present | Associate Director
Service
Source: Self-asserted source
Greg Schwartz

Northwestern University: Evanston, IL, US

2018 to present | Member of Steering Committee (NUIN IN-PREP)
Service
Source: Self-asserted source
Greg Schwartz

Northwestern University: Evanston, IL, US

2016 to present | Member, Kellogg Business for Scientists Executive Education Admissions Committee (Kellogg School of Managment)
Service
Source: Self-asserted source
Greg Schwartz

University of Texas Medical School at Houston: Houston, TX, US

2019 | Adrien and Gladys Drouilhet Visiting Professor Lecture (Ruiz Department of Ophthalmology)
Distinction
Source: Self-asserted source
Greg Schwartz

Northwestern University: Evanston, IL, US

2016 to 2019 | Director of Graduate Admissions (NUIN)
Service
Source: Self-asserted source
Greg Schwartz

University of Washington: Seattle, WA, US

2018 | Joan and Gordon Bergy Endowed Lecture (Ophthalmology)
Distinction
Source: Self-asserted source
Greg Schwartz

World Economic Forum: Cologny, GE, CH

2016 | Young Scientist
Distinction
Source: Self-asserted source
Greg Schwartz

NIH Office of the Director: Md., Md., US

2015 | New Innovator Award
Distinction
Source: Self-asserted source
Greg Schwartz

Research to Prevent Blindness: New York, New York, US

2014 | Career Development Award
Distinction
Source: Self-asserted source
Greg Schwartz

Karl Kirchgessner Foundation: Redondo Beach, CA, US

2014 | Vision Research Grant
Distinction
Source: Self-asserted source
Greg Schwartz

Visual Neuroscience: Steamboat Springs, CO, US

2012 | Young Investigator Award
Distinction
Source: Self-asserted source
Greg Schwartz

Helen Hay Whitney Foundation: New York, NY, US

2010 | Fellow
Distinction
Source: Self-asserted source
Greg Schwartz

Funding (6)

Functional consequences of heterotypic retinal ganglion cell coupling

2020-07-01 to 2025-04-30 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R01EY031329
Source: Self-asserted source
Greg Schwartz via DimensionsWizard

Synapses as Independent Computational Units in the Excitatory Pathways of the Retina

2020-02-01 to 2024-01-31 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R01EY031029
Source: Self-asserted source
Greg Schwartz via DimensionsWizard

Establishing a comprehensive typology of retinal ganglion cells

2017-02 to 2019-01 | Award
Chicago Biomedical Consortium (Chicago, IL, US)
Source: Self-asserted source
Greg Schwartz

Novel circuit mapping strategies to reverse engineer the retina

2015-09-30 to 2020-09-29 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: DP2EY026770
Source: Self-asserted source
Greg Schwartz via DimensionsWizard

Circuit connectivity and function in the retina

2015-02 to 2016-01 | Award
Karl Kirchgessner Foundation (CA, CA, US)
Source: Self-asserted source
Greg Schwartz

Mapping the circuits of the retina

2014-07 to 2018-06 | Award
Research to Prevent Blindness (NY, NY, US)
Source: Self-asserted source
Greg Schwartz

Works (32)

Retinal Computation

Source: Self-asserted source
Greg Schwartz

An offset ON-OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells.

Nature neuroscience
2020-11-23 | Journal article
Source: Self-asserted source
Greg Schwartz

Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.

The Journal of comparative neurology
2020-11-02 | Journal article
Source: Self-asserted source
Greg Schwartz

Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy.

Journal of clinical medicine
2020-10-31 | Journal article
Source: Self-asserted source
Greg Schwartz

Hemodynamic response of the three macular capillary plexuses in dark adaptation and flicker stimulation using optical coherence tomography angiography

Investigative Ophthalmology and Visual Science
2019 | Journal article
EID:

2-s2.0-85061966466

Contributors: Nesper, P.L.; Lee, H.E.; Fayed, A.E.; Schwartz, G.W.; Yu, F.; Fawzi, A.A.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina

Neuron
2018 | Journal article
EID:

2-s2.0-85055084504

Contributors: Jacoby, J.; Nath, A.; Jessen, Z.F.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Receptive field center-surround interactions mediate context-dependent spatial contrast encoding in the retina

eLife
2018 | Journal article
EID:

2-s2.0-85054722673

Contributors: Turner, M.H.; Schwartz, G.W.; Rieke, F.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

The dynamic receptive fields of retinal ganglion cells

Progress in Retinal and Eye Research
2018 | Journal article
EID:

2-s2.0-85049318640

Contributors: Wienbar, S.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Typology and circuitry of suppressed-by-contrast retinal Ganglion cells

Frontiers in Cellular Neuroscience
2018 | Journal article
EID:

2-s2.0-85053373048

Contributors: Jacoby, J.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites

Current Biology
2017 | Journal article
EID:

2-s2.0-85010911742

Contributors: Mani, A.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Electrical synapses convey orientation selectivity in the mouse retina

Nature communications
2017 | Journal article
EID:

2-s2.0-85043600784

Contributors: Nath, A.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Three small-receptive-field ganglion cells in the mouse retina are distinctly tuned to size, speed, and object motion

Journal of Neuroscience
2017 | Journal article
EID:

2-s2.0-85010301070

Contributors: Jacoby, J.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Cardinal orientation selectivity is represented by two distinct ganglion cell types in mouse retina

Journal of Neuroscience
2016 | Journal article
EID:

2-s2.0-84961279534

Contributors: Nath, A.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina

Neuron
2016 | Journal article
EID:

2-s2.0-84962629310

Contributors: Kuo, S.P.; Schwartz, G.W.; Rieke, F.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina

Cell Reports
2015 | Journal article
EID:

2-s2.0-84961279022

Contributors: Jacoby, J.; Zhu, Y.; DeVries, S.H.; Schwartz, G.W.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Interplay of cell-autonomous and nonautonomous mechanisms tailors synaptic connectivity of converging axons in vivo

Neuron
2014 | Journal article
EID:

2-s2.0-84897401453

Contributors: Okawa, H.; Della Santina, L.; Schwartz, G.W.; Rieke, F.; Wong, R.O.L.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

The neural circuit mechanisms underlying the retinal response to motion reversal

Journal of Neuroscience
2014 | Journal article
EID:

2-s2.0-84911440759

Contributors: Chen, E.Y.; Chou, J.; Park, J.; Schwartz, G.; Berry, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

The synaptic and circuit mechanisms underlying a change in spatial encoding in the retina

Neuron
2014 | Journal article
EID:

2-s2.0-84898685402

Contributors: Grimes, W.N.; Schwartz, G.W.; Rieke, F.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types

Current Biology
2014 | Journal article
EID:

2-s2.0-84895067305

Contributors: Bleckert, A.; Schwartz, G.W.; Turner, M.H.; Rieke, F.; Wong, R.O.L.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Alert response to motion onset in the retina

Journal of Neuroscience
2013 | Journal article
EID:

2-s2.0-84871751047

Contributors: Chen, E.Y.; Marre, O.; Fisher, C.; Schwartz, G.; Levy, J.; da Silviera, R.A.; Berry II, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Controlling gain one photon at a time

eLife
2013 | Journal article
EID:

2-s2.0-84879040106

Contributors: Schwartz, G.W.; Rieke, F.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Low error discrimination using a correlated population code

Journal of Neurophysiology
2012 | Journal article
EID:

2-s2.0-84865065436

Contributors: Schwartz, G.; Macke, J.; Amodei, D.; Tang, H.; Berry II, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

The spatial structure of a nonlinear receptive field

Nature Neuroscience
2012 | Journal article
EID:

2-s2.0-84868215185

Contributors: Schwartz, G.W.; Okawa, H.; Dunn, F.A.; Morgan, J.L.; Kerschensteiner, D.; Wong, R.O.; Rieke, F.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

An expanding view of dynamic electrical coupling in the mammalian retina

Journal of Physiology
2011 | Journal article
EID:

2-s2.0-79955404734

Contributors: Cafaro, J.; Schwartz, G.W.; Grimes, W.N.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Fine spatial information represented in a population of retinal ganglion cells

Journal of Neuroscience
2011 | Journal article
EID:

2-s2.0-79951519137

Contributors: Soo, F.S.; Schwartz, G.W.; Sadeghi, K.; Berry II, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Nonlinear spatial encoding by retinal ganglion cells: When 1 + 1 ≠ 2

Journal of General Physiology
2011 | Journal article
EID:

2-s2.0-80053985482

Contributors: Schwartz, G.; Rieke, F.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

The Retina as Embodying Predictions about the Visual World

Predictions in the Brain: Using Our Past to Generate a Future
2011 | Book
EID:

2-s2.0-84922761246

Contributors: Berry, M.J.; Schwartz, G.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns

Network: Computation in Neural Systems
2009 | Journal article
EID:

2-s2.0-70649102201

Contributors: Gao, J.; Schwartz, G.; Berry II, M.J.; Holmes, P.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Sophisticated temporal pattern recognition in retinal ganglion cells

Journal of Neurophysiology
2008 | Journal article
EID:

2-s2.0-42249092528

Contributors: Schwartz, G.; Berry II, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Detection and prediction of periodic patterns by the retina

Nature Neuroscience
2007 | Journal article
EID:

2-s2.0-34247547976

Contributors: Schwartz, G.; Harris, R.; Shrom, D.; Berry II, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Synchronized Firing among Retinal Ganglion Cells Signals Motion Reversal

Neuron
2007 | Journal article
EID:

2-s2.0-34548555640

Contributors: Schwartz, G.; Taylor, S.; Fisher, C.; Harris, R.; Berry II, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Shadows of the past: Temporal retrieval effects in recognition memory

Psychological Science
2005 | Journal article
EID:

2-s2.0-28944447960

Contributors: Schwartz, G.; Howard, M.W.; Jing, B.; Kahana, M.J.
Source: Self-asserted source
Greg Schwartz via Scopus - Elsevier

Peer review (28 reviews for 12 publications/grants)

Review activity for Cell reports. (4)
Review activity for Cognitive neurodynamics. (1)
Review activity for Communications biology. (1)
Review activity for Current biology. (5)
Review activity for eLife (1)
Review activity for iScience. (1)
Review activity for Nature (1)
Review activity for Nature communications (8)
Review activity for Nature neuroscience. (2)
Review activity for Neuron. (2)
Review activity for PLoS biology. (1)
Review activity for PloS one. (1)