Personal information

Genome editing, Molecular endocrinology, Molecular oncology, Novel functional molecules, Natural product research

Activities

Employment (5)

Chinese University of Hong Kong: New Territories, HK

2017 to present | Research Professor (School of Biomedical Sciences)
Employment
Source: Self-asserted source
Christopher H.K. Cheng

Chinese University of Hong Kong Shenzhen Research Institute: Shenzhen, CN

2015-08 to present | Director
Employment
Source: Self-asserted source
Christopher H.K. Cheng

Hong Kong Institute of Biotechnology: Shatin, Hong Kong, CN

2011-01 to present | Managing Director
Employment
Source: Self-asserted source
Christopher H.K. Cheng

Chinese University of Hong Kong: New Territories, HK

2009 to 2017 | Professor (School of Biomedical Sciences)
Employment
Source: Self-asserted source
Christopher H.K. Cheng

Chinese University of Hong Kong: New Territories, HK

1996 to 2009 | Professor (Department of Biochemistry)
Employment
Source: Self-asserted source
Christopher H.K. Cheng

Works (50 of 266)

Items per page:
Page 1 of 6

A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain

Theranostics
2019 | Journal article
Part of ISSN: 1838-7640
Contributors: Idy H.T. Ho; Xiaodong Liu; Yidan Zou; Taian Liu; Wei Hu; Hung Chan; Yuanyuan Tian; Yuchen Zhang; Qing Li; Shanglong Kou et al.
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer

Cancer Prevention Research
2019-08 | Journal article
Part of ISSN: 1940-6207
Contributors: Xiao Sun; Tony T.H. Ng; Kathy W.Y. Sham; Lin Zhang; Matthew T.V. Chan; William K.K. Wu; Christopher H.K. Cheng
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer

BMC Cancer
2019-07-02 | Journal article
Part of ISSN: 1471-2407
Contributors: Tung H. Ng; Kathy W. Y. Sham; Chuan M. Xie; Simon S. M. Ng; Ka F. To; Joanna H. M. Tong; Wing Y. Z. Liu; Lin Zhang; Matthew T. V. Chan; William K. K. Wu et al.
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development

Cell Death & Disease
2019-06 | Journal article
Part of ISSN: 2041-4889
Contributors: Xiaoyu Liu; Peng Zhang; Chuanming Xie; Kathy W. Y. Sham; Simon S. M. Ng; Yangchao Chen; Christopher H. K. Cheng
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Fertility impairment with defective spermatogenesis and steroidogenesis in male zebrafish lacking androgen receptor

Biology of Reproduction
2018 | Journal article
WOSUID:

WOS:000428258400010

Contributors: Tang, Haipei; Chen, Yu; Wang, Le; Yin, Yike; Li, Gaofei; Guo, Yin; Liu, Yun; Lin, Haoran; Cheng, Christopher H. K.; Liu, Xiaochun
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain

Anesthesiology
2018 | Journal article
WOSUID:

WOS:000429408200017

Contributors: Tian, Yuanyuan; Liu, Xiaodong; Jia, Mingzhong; Yu, Hui; Lichtner, Peter; Shi, Yujian; Meng, Zhaoyu; Kou, Shanglong; Ho, Idy H. T.; Jia, Bo et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain (vol 128, pg 587, 2018)

Anesthesiology
2018 | Journal article
WOSUID:

WOS:000435562800037

Contributors: Tian, Y.; Liu, X.; Jia, M.; Yu, H.; Lichtner, P.; Shi, Y.; Meng, Z.; Kou, S.; Ho, I. H. T.; Jia, B. et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Zinc mediates the action of androgen in acting as a downstream effector of luteinizing hormone on oocyte maturation in zebrafish†

Biology of Reproduction
2018-11-06 | Journal article
Part of ISSN: 0006-3363
Contributors: Jianzhen Li; Duo Huang; Xiao Sun; Xuehui Li; Christopher H K Cheng
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish

Translational Psychiatry
2018-10 | Journal article
Part of ISSN: 2158-3188
Contributors: Taian Liu; Yujian Shi; Matthew T. V. Chan; Gang Peng; Quan Zhang; Xiao Sun; Zeyao Zhu; Yuxin Xie; Kathy W. Y. Sham; Jianzhen Li et al.
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Oncogenes expand during evolution to withstand somatic amplification

Annals of Oncology
2018-09-11 | Journal article
Part of ISSN: 0923-7534
Contributors: X Wang; X Li; L Zhang; S H Wong; M H T Wang; G Tse; R Z W Dai; G Nakatsu; O O Coker; Z Chen et al.
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Igf3 serves as a mediator of luteinizing hormone in zebrafish ovulation†

Biology of Reproduction
2018-06 | Journal article
Part of ISSN: 0006-3363
Contributors: Jianzhen Li; Caiyan Niu; Christopher H K Cheng
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Evolution of gonadotropin signaling on gonad development: insights from gene knockout studies in zebrafish†

Biology of Reproduction
2018-04 | Journal article
Part of ISSN: 0006-3363
Contributors: Jianzhen Li; Christopher H K Cheng
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway

Oncotarget
2018-02-11 | Journal article
Part of ISSN: 1949-2553
Contributors: Chuan-Ming Xie; Xiao-Tong Lin; Di Wu; Ye Tan; Christopher H.K. Cheng; Jun Zhang
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Functional expression of G protein-coupled receptor 30 in immature rat epididymal epithelium

Cell Biology International
2017 | Journal article
WOSUID:

WOS:000393312200003

Contributors: Cao, Xiaonian; Huang, Jiehong; Zhang, Geng; Zuo, Wulin; Lan, Chongfeng; Sun, Qing; Yang, Dengliang; Gao, Dongdong; Cheng, Christopher H. K.; Zhou, Wen-Liang
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish

Endocrinology
2017 | Journal article
WOSUID:

WOS:000397104200018

Contributors: Liu, Yun; Tang, Haipei; Xie, Rui; Li, Shuisheng; Liu, Xiaochun; Lin, Haoran; Zhang, Yong; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Genome editing reveals dmrt1 as an essential male sex-determining gene in Chinese tongue sole (Cynoglossus semilaevis)

Scientific Reports
2017 | Journal article
WOSUID:

WOS:000394219400001

Contributors: Cui, Zhongkai; Liu, Yun; Wang, Wenwen; Wang, Qian; Zhang, Ning; Lin, Fan; Wang, Na; Shao, Changwei; Dong, Zhongdian; Li, Yangzhen et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Germline-specific dgcr8 knockout in zebrafish using a BACK approach

Cellular and Molecular Life Sciences
2017 | Journal article
WOSUID:

WOS:000403344300011

Contributors: Liu, Yun; Zhu, Zeyao; Ho, Idy H. T.; Shi, Yujian; Xie, Yuxin; Li, Jianzhen; Zhang, Yong; Chan, Matthew T. V.; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

LH signaling induced ptgs2a expression is required for ovulation in zebrafish

Molecular and Cellular Endocrinology
2017 | Journal article
WOSUID:

WOS:000400719300014

Contributors: Tang, Haipei; Liu, Yun; Li, Jianzhen; Li, Gaofei; Chen, Yu; Yin, Yike; Guo, Yin; Cheng, Christopher H. K.; Liu, Xiaochun; Lin, Haoran
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study

Scientific Reports
2017 | Journal article
WOSUID:

WOS:000414566600012

Contributors: Zheng, Binbin; Li, Shuisheng; Liu, Yun; Li, Yu; Chen, Huapu; Tang, Haipei; Liu, Xiaochun; Lin, Haoran; Zhang, Yong; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

The highly overlapping actions of Lh signaling and Fsh signaling on zebrafish spermatogenesis

Journal of Endocrinology
2017 | Journal article
WOSUID:

WOS:000407888200004

Contributors: Xie, Yuxin; Chu, Lianhe; Liu, Yun; Sham, Kathy W. Y.; Li, Jianzhen; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia

Pflugers Archiv-European Journal of Physiology
2016 | Journal article
WOSUID:

WOS:000380241000015

Contributors: Hao, Yuan; Chow, Alison W.; Yip, Wallace C.; Li, Chi H.; Wan, Tai F.; Tong, Benjamin C.; Cheung, King H.; Chan, Wood Y.; Chen, Yangchao; Cheng, Christopher H. et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish

Scientific Reports
2016 | Journal article
WOSUID:

WOS:000378325300001

Contributors: Tang, Haipei; Liu, Yun; Li, Jianzhen; Yin, Yike; Li, Gaofei; Chen, Yu; Li, Shuisheng; Zhang, Yong; Lin, Haoran; Liu, Xiaochun et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy
2016 | Journal article
WOSUID:

WOS:000373595400001

Contributors: Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Arozena, Abraham Acevedo; Adachi, Hiroaki; Adams, Christopher M.; Adams, Peter D.; Adeli, Khosrow et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Mutagenesis in Xenopus and Zebrafish using TALENs

Talens: Methods and Protocols
2016 | Book chapter
WOSUID:

WOS:000368438100017

Contributors: Liu, Yun; Zhao, Hui; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

What is Missing in STD Screening in Hong Kong?

American Medical Journal
2016-02-01 | Journal article
Part of ISSN: 1949-0070
Contributors: Clement Leung-Kwok Chan; Wai Yee Chan; Christopher Hon Ki Cheng; Ping Xia
Source: Self-asserted source
Christopher H.K. Cheng via Crossref Metadata Search

Direct production of XYDMY- sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs

Scientific Reports
2015 | Journal article
WOSUID:

WOS:000361149600001

Contributors: Luo, Daji; Liu, Yun; Chen, Ji; Xia, Xiaoqin; Cao, Mengxi; Cheng, Bin; Wang, Xuejuan; Gong, Wuming; Qiu, Chao; Zhang, Yunsheng et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Evaluation of biocompatible alginate- and deferoxamine-coated ternary composites for magnetic resonance imaging and gene delivery into glioblastoma cells

Quantitative Imaging in Medicine and Surgery
2015 | Journal article
WOSUID:

WOS:000214948400009

Contributors: Leung, Ken Cham-Fai; Sham, Kathy W. Y.; Chak, Chun-Pong; Lai, Josie M. Y.; Lee, Siu-Fung; Wang, Yi-Xiang J.; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Gonadotropin Signaling in Zebrafish Ovary and Testis Development: Insights From Gene Knockout Study

Molecular Endocrinology
2015 | Journal article
WOSUID:

WOS:000366511400008

Contributors: Chu, Lianhe; Li, Jianzhen; Liu, Yun; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

IGFs Mediate the Action of LH on Oocyte Maturation in Zebrafish

Molecular Endocrinology
2015 | Journal article
WOSUID:

WOS:000353291900005

Contributors: Li, Jianzhen; Chu, Lianhe; Sun, Xiao; Liu, Yun; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies

Endocrinology
2015 | Journal article
WOSUID:

WOS:000353131800019

Contributors: Tang, Haipei; Liu, Yun; Luo, Daji; Ogawa, Satoshi; Yin, Yike; Li, Shuisheng; Zhang, Yong; Hu, Wei; Parhar, Ishwar S.; Lin, Haoran et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain

Anesthesiology
2015 | Journal article
WOSUID:

WOS:000368734600014

Contributors: Liu, Xiaodong; Tian, Yuanyuan; Meng, Zhaoyu; Chen, Yan; Ho, Idy H. T.; Choy, Kwong Wai; Lichtner, Peter; Wong, Sunny H.; Yu, Jun; Gin, Tony et al.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Transcription activator-like effector nucleases (TALENs)

U.S. Patent No. 9,181,535
2015-11-10 | Patent
Source: Self-asserted source
Christopher H.K. Cheng

A highly effective TALEN-mediated approach for targeted gene disruption in Xenopus tropicalis and zebrafish

Methods
2014 | Journal article
WOSUID:

WOS:000341803500009

Contributors: Liu, Yun; Luo, Daji; Lei, Yong; Hu, Wei; Zhao, Hui; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma

Cancer Research
2014 | Journal article
WOSUID:

WOS:000344756800029

Contributors: Xiao, Zhangang; Li, Chi Han; Chan, Stephen L.; Xu, Feiyue; Feng, Lu; Wang, Yan; Jiang, Jian-Dong; Sung, Joseph J. Y.; Cheng, Christopher H. K.; Chen, Yangchao
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Cellular uptake behaviour, photothermal therapy performance, and cytotoxicity of gold nanorods with various coatings

Nanoscale
2014 | Journal article
WOSUID:

WOS:000345450300048

Contributors: Zhu, Xiao-Ming; Fang, Caihong; Jia, Henglei; Huang, Yu; Cheng, Christopher H. K.; Ko, Chun-Hay; Chen, Zhiyi; Wang, Jianfang; Wang, Yi-Xiang J.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes

Neuropharmacology
2014 | Journal article
WOSUID:

WOS:000340853600024

Contributors: Chu, John M. T.; Lee, Dicky K. M.; Wong, Daniella P. K.; Wong, Ricky N. S.; Yung, Ken K. L.; Cheng, Christopher H. K.; Yue, Kevin K. M.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

Angewandte Chemie-International Edition
2014 | Journal article
WOSUID:

WOS:000335202700007

Contributors: Wang, Yi-Xiang J.; Zhu, Xiao-Ming; Liang, Qi; Cheng, Christopher H. K.; Wang, Wei; Leung, Ken Cham-Fai
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice

Neurochemistry International
2014 | Journal article
WOSUID:

WOS:000342477600005

Contributors: Xian, Yan-Fang; Su, Zi-Ren; Chen, Jian-Nan; Lai, Xiao-Ping; Mao, Qing-Qiu; Cheng, Christopher H. K.; Ip, Siu-Po; Lin, Zhi-Xiu
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Mechanistic Studies of Anti-Hyperpigmentary Compounds: Elucidating Their Inhibitory and Regulatory Actions

International Journal of Molecular Sciences
2014 | Journal article
WOSUID:

WOS:000341519600090

Contributors: Lam, Rosanna Y. Y.; Lin, Zhi-Xiu; Sviderskaya, Elena V.; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells

Autophagy
2014 | Journal article
WOSUID:

WOS:000341647200003

Contributors: Xie, Chuan-Ming; Liu, Xiao-Yu; Sham, Kathy W. Y.; Lai, Josie M. Y.; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Targeted Gene Disruption in Zebrafish Reveals Noncanonical Functions of LH Signaling in Reproduction

Molecular Endocrinology
2014 | Journal article
WOSUID:

WOS:000346837100004

Contributors: Chu, Lianhe; Li, Jianzhen; Liu, Yun; Hu, Wei; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Temporal and spatial expression of the four Igf ligands and two Igf type 1 receptors in zebrafish during early embryonic development

Gene Expression Patterns
2014 | Journal article
WOSUID:

WOS:000340993600005

Contributors: Li, Jianzhen; Wu, Peng; Liu, Yun; Wang, Deshou; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Cathepsin G - A Novel Protease in the Regulation of Chronic Pain

42nd Annual Meeting of the Society for Neuroscience in Anesthesiology and Critical Care
2014-10 | Conference abstract
Source: Self-asserted source
Christopher H.K. Cheng

1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte: Potential Application for Psoriasis Treatment

Evidence-Based Complementary and Alternative Medicine
2013 | Journal article
WOSUID:

WOS:000317764500001

Contributors: Mok, Chong-Fai; Xie, Chuan-Ming; Sham, Kathy Wai-Yan; Lin, Zhi-Xiu; Cheng, Christopher Hon-Ki
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus

Molecular and Cellular Endocrinology
2013 | Journal article
WOSUID:

WOS:000321170000007

Contributors: Liu, Yun; Li, Shuisheng; Qi, Xing; Zhou, Wenyi; Liu, Xiaochun; Lin, Haoran; Zhang, Yong; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Cardiac glycosides block cancer growth through HIF-1-and NF-B-mediated Plk1

Carcinogenesis
2013 | Journal article
WOSUID:

WOS:000322666800021

Contributors: Xie, Chuan-Ming; Liu, Xiao-Yu; Yu, Sidney; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Chemical Communications
2013 | Journal article
WOSUID:

WOS:000312194000002

Contributors: Leung, Ken Cham-Fai; Chak, Chun-Pong; Lee, Siu-Fung; Lai, Josie M. Y.; Zhu, Xiao-Ming; Wang, Yi-Xiang J.; Sham, Kathy W. Y.; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy

Journal of Materials Chemistry B
2013 | Journal article
WOSUID:

WOS:000319273100006

Contributors: Wang, Da-Wei; Zhu, Xiao-Ming; Lee, Siu-Fung; Chan, Ho-Man; Li, Hung-Wing; Kong, Siu Kai; Yu, Jimmy C.; Cheng, Christopher H. K.; Wang, Yi-Xiang J.; Leung, Ken Cham-Fai
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis

Biochemical and Biophysical Research Communications
2013 | Journal article
WOSUID:

WOS:000320012900004

Contributors: Shi, Yanan; Liu, Xiaochun; Zhu, Pei; Li, Jianzhen; Sham, Kathy W. Y.; Cheng, Shuk Han; Li, Shuisheng; Zhang, Yong; Cheng, Christopher H. K.; Lin, Haoran
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID

GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion

General and Comparative Endocrinology
2013 | Journal article
WOSUID:

WOS:000326427200003

Contributors: Zhu, Pei; Yuen, Jacky M. L.; Sham, Kathy W. Y.; Cheng, Christopher H. K.
Source: Self-asserted source
Christopher H.K. Cheng via ResearcherID
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