Personal information

Verified email addresses

Verified email domains

Parasitology, host-pathogen interactions, microbiome, cell death, plasmodium, malaria, Blastocystis,
Singapore

Biography

Kevin SW TAN is Associate Professor, Head, and Dean’s Chair of the Department of Microbiology and Immunology, National University of Singapore. He is also Vice-Dean, Graduate Studies, at the Yong Loo Lin School of Medicine. His curiosity for parasites originated from his graduate student days at NUS and blossomed during his postdoctoral stint at The Rockefeller University, New York City. He is relieved to be awarded tenure in 2011, and can now spend more time on social issues, such as public science education. Kevin’s research focuses on understanding how parasites commit suicide and exploiting such knowledge to trigger death mechanisms as an anti-parasite strategy. He is also interested in the problem of drug resistance and his team has developed new ways to find drugs that overcome resistance. More recently, his team has embarked on projects focusing on the role of single cell eukaryotes (SCEs) in the host microbiome. He hopes that the research from his team will accelerate the finding of new cures for parasitic diseases.

Activities

Works (17)

Unveiling the hidden ally: Blastocystis links healthier diets and cardiometabolic benefits

Signal Transduction and Targeted Therapy
2025-03-03 | Journal article
Contributors: Lei Deng; Kevin S. W. Tan
Source: check_circle
Crossref

Mechanistic Insights on Microbiota-Mediated Development and Progression of Esophageal Cancer

Cancers
2024-09-27 | Journal article
Contributors: Kyaw Thu Moe; Kevin Shyong-Wei Tan
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Blastocystis: view from atop the gut–brain iceberg

Trends in Parasitology
2024-01 | Journal article
Contributors: Steven Santino Leonardi; Kevin Shyong-Wei Tan
Source: check_circle
Crossref

Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes

npj Biofilms and Microbiomes
2023-04-25 | Journal article
Contributors: Lei Deng; Lukasz Wojciech; Chin Wen Png; Yan Qin Dorinda Kioh; Geok Choo Ng; Eric Chun Yong Chan; Yongliang Zhang; Nicholas R. J. Gascoigne; Kevin Shyong Wei Tan
Source: check_circle
Crossref

Chloroquine induces eryptosis inP. falciparum-infectedred blood cells and the release of extracellular vesicles with a unique protein profile

2023-01-12 | Preprint
Contributors: Claudia Carrera-Bravo; Tianchi Zhou; Jing Wen Hang; Harshvardhan Modh; Fred Huang; Benoit Malleret; Matthias G Wacker; Jiong-Wei Wang; Laurent Renia; Kevin SW Tan
Source: check_circle
Crossref

Changes in Gut Microbiota Composition Associated with the Presence of Enteric Protist Blastocystis in Captive Forest Musk Deer ( Moschus Berezovskii )

Microbiology Spectrum
2022-08-31 | Journal article
Contributors: Lei Deng; Shanyu Chen; Wanyu Meng; Ziyao Zhou; Haifeng Liu; Zhijun Zhong; Hualin Fu; Liuhong Shen; Suizhong Cao; Kevin S. W. Tan et al.
Source: check_circle
Crossref

Interactions between Blastocystis subtype ST4 and gut microbiota in vitro

Parasites & Vectors
2022-03-08 | Journal article
Contributors: Lei Deng; Kevin S. W. Tan
Source: check_circle
Crossref

Characterisation of novel functionality within the Blastocystis tryptophanase gene

PLOS Neglected Tropical Diseases
2021-09-07 | Journal article
Contributors: Steven Santino Leonardi; Kiyoshi Kita; Feng-Jun Li; Melissa Su-Juan Chee; John Anthony Yason; Hui Yi Tay; John Yu-Shen Chen; Eileen Yiling Koh; Cynthia Ying-Xin He; Kevin Shyong-Wei Tan
Source: check_circle
Crossref

New insights into the interactions between Blastocystis, the gut microbiota, and host immunity

PLOS Pathogens
2021-02-25 | Journal article
Contributors: Lei Deng; James B. Lok; Lukasz Wojciech; Nicholas R. J. Gascoigne; Guangneng Peng; Kevin S. W. Tan
Source: check_circle
Crossref

Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies

Microbiome
2019-12 | Journal article
Contributors: John Anthony Yason; Yi Ran Liang; Chin Wen Png; Yongliang Zhang; Kevin Shyong Wei Tan
Source: check_circle
Crossref

Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum

2019-12-02 | Other
Contributors: Renugah Naidu; Trang TT Chu; Jaishree Tripathi; Yang Hu; Gowtham Subramanian; Jie Xin Tong; Pallavi Tripathi; Kong Fang; Kevin SW Tan; Chwee Teck Lim et al.
Source: check_circle
Crossref

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

Nature Communications
2019-08-12 | Journal article
Contributors: Adeline C. Y. Chua; Jessica Jie Ying Ong; Benoit Malleret; Rossarin Suwanarusk; Varakorn Kosaisavee; Anne-Marie Zeeman; Caitlin A. Cooper; Kevin S. W. Tan; Rou Zhang; Bee Huat Tan et al.
Source: check_circle
Crossref

Viability Screen of LOPAC 1280 Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the Plasmodium falciparum Ring Stage

Antimicrobial Agents and Chemotherapy
2019-04 | Journal article
Contributors: Jie Xin Tong; Sarah E. L. Ang; Esther H. N. Tan; Kevin S. W. Tan
Source: check_circle
Crossref

Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes

Scientific Reports
2019-02-28 | Journal article
Contributors: Feng-Jun Li; Anastasios D. Tsaousis; Tracy Purton; Vincent T. K. Chow; Cynthia Y. He; Kevin S. W. Tan
Source: check_circle
Crossref

Viability Screen of LOPAC 1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates

Antimicrobial Agents and Chemotherapy
2018-08 | Journal article
Contributors: John Anthony Yason; Kristine Anne Ru Ping Koh; Kevin Shyong Wei Tan
Source: check_circle
Crossref

High-Content Screening of the Medicines for Malaria Venture Pathogen Box for Plasmodium falciparum Digestive Vacuole-Disrupting Molecules Reveals Valuable Starting Points for Drug Discovery

Antimicrobial Agents and Chemotherapy
2018-03 | Journal article
Contributors: Jie Xin Tong; Rajesh Chandramohanadas; Kevin Shyong-Wei Tan
Source: check_circle
Crossref

Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

mSphere
2018-02-28 | Journal article
Contributors: Gowtham Subramanian; Meenakshi A. Belekar; Anurag Shukla; Jie Xin Tong; Ameya Sinha; Trang T. T. Chu; Akshay S. Kulkarni; Peter R. Preiser; D. Srinivasa Reddy; Kevin S. W. Tan et al.
Source: check_circle
Crossref

Peer review (2 reviews for 2 publications/grants)

Review activity for Parasitology research. (1)
Review activity for The ISME journal (1)