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Biography

Professor Sir Magdi Yacoub is Professor of Cardiothoracic Surgery at the National Heart and Lung Institute, Imperial College London, Founder and Director of Research at the Magdi Yacoub Institute at Harefield Heart Science Centre, Founder and President of the Chain of Hope and Founder and Director of the Magdi Yacoub Heart Foundation which created the Aswan Heart Centre.

Born in Egypt and graduated from Cairo University Medical School in 1957 he trained in London and held an Assistant Professorship at the University of Chicago. A former British Heart Foundation Professor of Cardiothoracic Surgery for over 20 years and Consultant Cardiothoracic Surgeon at Harefield Hospital from 1969-2001 and Royal Brompton Hospital from 1986-2001, Professor Yacoub established the largest heart and lung transplantation programme in the world at Harefield Hospital where more than 2,500 transplant operations have been performed. He has developed novel operations for several complex congenital heart anomalies.

Research led by Professor Sir Magdi Yacoub include tissue engineering heart valves, myocardial regeneration, novel left ventricular assist devices and wireless sensors with collaborations within Imperial College, nationally and internationally. He has also supervised over 20 higher degree (PhD/MD) students and authored or co-authored more than 1,400 published papers and numerous book chapters on topics including Transplantation, Paediatric Cardiac Surgery, Aortic valve surgery.

He has a passion for readdressing inequalities in global healthcare delivery with a focus on developing cardiac services in many countries including Egypt, The Gulf region, Jamaica, Ethiopia, Mozambique Rwanda and Uganda. Here his teams at Chain of Hope link experts together around the world to bring life-saving treatments to children in developing and war-torn countries.

Continuing his desire to make healthcare accessible to all, his Centre in Aswan, offers state-of-the art medical services, free of charge to all patients regardless of colour, religion, or gender and trains a generation of young Egyptian doctors, nurses, scientists, and technicians at the highest international standards. Advancing basic science and applied research is an integral component of the program and he oversees over 60 scientists and students in the areas of Heart Valve Biology and Tissue Engineering, Myocardial Regeneration, Stem Cell Biology, Mechanisms and treatment of Heart Failure and Pulmonary Hypertension in his Centres.

Among his honours he was awarded a Knighthood for his services to medicine and surgery in 1992 and awarded the Order of Merit by Her Majesty Queen Elizabeth II in the 2014 New Year’s Honours list. He was awarded Fellowship of the Academy of Medical Sciences in 1998 and Fellowship of The Royal Society in 1999. A lifetime outstanding achievement award in recognition of his contribution to medicine was presented to Professor Yacoub by the Secretary of State for Health in the same year. In 2011 was awarded the Order of the Nile for Science and Humanity and the prestigious Lister Medal in 2015 in recognition of his contribution to surgical science.

Activities

Employment (6)

Magdi Yacoub Heart Foundation: Cairo, Cairo, EG

2009 to present | Founder
Employment
Source: Self-asserted source
Magdi Yacoub

Aswan Heart Centre: Aswan, Aswan, EG

2009 to present | Founder & Director of Research
Employment
Source: Self-asserted source
Magdi Yacoub

National Heart & Lung Institute at Imperial College: London, GB

1986 to present | Professor of Cardiothoracic Surgery
Employment
Source: Self-asserted source
Magdi Yacoub

The Magdi Yacoub Institute: Harefield Hospital, Middlesex, GB

1980 to present | Founder & Director of Research
Employment
Source: Self-asserted source
Magdi Yacoub

Qatar Cardiovascular Research Center: Doha, QA

2010 to 2016 | Executive Director
Employment
Source: Self-asserted source
Magdi Yacoub

Royal Brompton and Harefield NHS Foundation Trust: London, London, GB

1986 to 2001 | Consultant Cardiothoracic Surgeon
Employment
Source: Self-asserted source
Magdi Yacoub

Works (12)

Endomyocardial fibrosis: recent advances and future therapeutic targets

Nature Reviews Cardiology
2025-02-26 | Journal article
Contributors: Ana O. Mocumbi; Viviane Tiemi Hotta; Gene Bukhman; Ntobeko Ntusi; Magdi H. Yacoub; Paulo Correia-de-Sá
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Multiscale structure and function of the aortic valve apparatus

Physiological Reviews
2024-10-01 | Journal article
Contributors: Hussam El-Nashar; Malak Sabry; Yuan-Tsan Tseng; Nadine Francis; Najma Latif; Kim H. Parker; James E. Moore, Jr; Magdi H. Yacoub
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Physiological basis for xenotransplantation from genetically modified pigs to humans

Physiological Reviews
2024-07-01 | Journal article
Contributors: Leigh Peterson; Magdi H. Yacoub; David Ayares; Kazuhiko Yamada; Daniel Eisenson; Bartley P. Griffith; Muhammad M. Mohiuddin; Willard Eyestone; J. Craig Venter; Ryszard T. Smolenski et al.
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Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community

Arteriosclerosis, Thrombosis, and Vascular Biology
2024-04 | Journal article
Contributors: Elena Aikawa; Mark C. Blaser; Sasha A. Singh; Robert A. Levine; Magdi H. Yacoub
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Hydrogel advancements in vascular tissue regeneration: a comprehensive review and future prospects

Emergent Materials
2024-04-07 | Journal article
Contributors: Hend A. Elshabrawy; Hagar A. Moustafa; Magdi H. Yacoub; Ibrahim M. El-Sherbiny
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Thioredoxin‐1 and its mimetic peptide improve systolic cardiac function and remodeling after myocardial infarction

The FASEB Journal
2024-01 | Journal article
Contributors: Tania Medali; Dominique Couchie; Nathalie Mougenot; Maria Mihoc; Olaf Bergmann; Wouter Derks; Luke I. Szweda; Magdi Yacoub; Saif Soliman; Yasmine Aguib et al.
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Structural aortic wall abnormalities following the Nikaidoh operation, which could be reversible and include a healing process

Global Cardiology Science and Practice
2023-12-07 | Journal article
Contributors: Magdi Yacoub; Ahmed Afifi; Hatem Hosny; Ahmed Nahgoub; Mohamed Nagy; Sanida Vaz; Padmini Sarathchandra; Najma Latif
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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold

Communications Biology
2023-10-07 | Journal article
Contributors: Magdi H. Yacoub; Yuan-Tsan Tseng; Jolanda Kluin; Annemijn Vis; Ulrich Stock; Hassiba Smail; Padmini Sarathchandra; Elena Aikawa; Hussam El-Nashar; Adrian H. Chester et al.
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Asymmetry of flow in aortic root and its application in hypertrophic obstructive cardiomyopathy

Journal of Applied Physiology
2023-10-01 | Journal article
Contributors: Nadine Francis; Mohammed Hosny; Magdi H. Yacoub; Kim H. Parker
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Ethnicity, consanguinity, and genetic architecture of hypertrophic cardiomyopathy

2023-06-02 | Other
Contributors: Mona Allouba; Rachel Buchan; Roddy Walsh; Shehab Anwer; Magdi Yacoub
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Valvulogenesis of A “Living”, Innervated Pulmonary Root Induced By An Acellular Scaffold

2023-01-16 | Preprint
Contributors: Magdi Yacoub; Yuan-Tsan Tseng; Jolanda Kluin; Annemijn Vis; Ulrich Stock; Hassiba Smail; Padmini Sarathchandra; Elena Aikawa; Hussam El-Nashar; Adrian Chester et al.
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Genetic evaluation of cardiomyopathies in Qatar identifies enrichment of pathogenic sarcomere gene variants and possible founder disease mutations in the Arabs

Molecular Genetics & Genomic Medicine
2021-07 | Journal article
Contributors: Kholoud N. Al‐Shafai; Mohammed Al‐Hashemi; Chidambaram Manickam; Rania Musa; Senthil Selvaraj; Najeeb Syed; Fazulur Vempalli; Muneera Ali; Magdi Yacoub; Xavier Estivill
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