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Scopus Author ID: 55916025400

Keywords

Cancer Metastasis and Therapeutics, Autophagy, Selective mitochondia phagy (Mitophagy), Cell Death

Countries

Canada

Biography

I'm a driven PhD student investigating lung cancer metastasis with the ultimate aim to increase the survival of these patients.

Lung cancer is the most commonly diagnosed cancer in both men and women around the world and it is the leading cause of cancer-related death in Canada (more than three times the other major types of cancer). As is the case with other cancer types, the main reason for death in patients with lung cancer is metastasis to other organs. EMT is regarded as a prominent prerequisite for cancer cells metastasis, therefore its inhibition can potentially lead to more efficient prevention/inhibition of metastasis in lung cancer patients.

In my doctorate research project, I investigate the modulatory roles of selective mitochondria phagy (i.e. mitophagy) and Extracellular Matrix (ECM) stiffness on the Epithelial to Mesenchymal Transition (EMT) and subsequent metastasis in Non-Small Cell Lung Carcinoma (NSCLC) model. I am interested in elucidating if manipulation of mitophagy can inhibit lung cancer cells to undergo Epithelial to Mesenchymal Transition (EMT) and if so what the playing pathways are. Another focus of my project is to produce a 3-Dimensional (3D) bioprinted model for NSCLC in order to examine how changes in the stiffness of ECM impact EMT and subsequent metastasis in this cancer. This can significantly increase the survival rate of lung cancer patients which is very low (5%) upon metastasis to other organs.

During my M.Sc program, I looked into the involvement of general autophagy pathway in lung cancer metastasis and found promising findings that indicated autophagy inhibition partially reduces the EMT and metastasis of lung cancer cells.

I'm a proud recipient of CIHR-Vanier CGS, the Canadian Lung Association (CLA) PhD Studentship, Ralph A. Mann Memorial Scholarship Award, Manitoba Health Research Council, Children's Hospital Research Institute of Manitoba Studentship, among others.

My extracurricular interests include playing soccer in University of Manitoba Intramural Sports, mentoring summer and research undergraduate students in our lab and volunteering at the Department of Radiology, CancerCare Manitoba.

I'm also Vice-Presisdent Academic (VPA) to the Health Sciences Graduate Student Association (HSGSA) at the University of Manitoba, Canada.

If our interests align, please reach out via email (alizadej@myumanitoba.ca).

Activities

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Employment (3)

University of Vermont: Burlington, VT, US

2017-11-01 to 2018-08-01 | Graduate Research Intern (Medicine)
Employment
Source: Self-asserted source
Javad Alizadeh

GENEOCELL: Tehran, IR

2014-03-01 to 2014-11-01 | Research Technician
Employment
Source: Self-asserted source
Javad Alizadeh

Pasteur Institute of Iran: Tehran, Tehran, IR

2012-03-01 to 2014-03-01 | Research Assistant (Molecular Medicine Department)
Employment
Source: Self-asserted source
Javad Alizadeh

Education and qualifications (5)

University of Manitoba College of Medicine: Winnipeg, MB, CA

2018-09-01 to present | Ph.D (Human Anatomay and Cell Sciences)
Education
Source: Self-asserted source
Javad Alizadeh

University of Manitoba College of Medicine: Winnipeg, MB, CA

2015-01-01 to 2017-05-20 | M.Sc (Human Anatomy and Cell Sciences Department)
Education
Source: Self-asserted source
Javad Alizadeh

Molecular Biology research Center: Tehran, IR

2008-09-01 to 2011-02-01 | M.Sc
Education
Source: Self-asserted source
Javad Alizadeh

Tehran University of Medical Sciences: Tehran, Tehran, IR

2006-08-01 to 2008-07-01 | B.Sc (School of Allied Medicine)
Education
Source: Self-asserted source
Javad Alizadeh

Guilan University of Medical Sciences: Rasht, Gilan, IR

2004-08-01 to 2006-07-01 | Associates (Faculty of Medicine)
Education
Source: Self-asserted source
Javad Alizadeh

Professional activities (7)

University of Vermont Cancer Center: Burlington, VT, US

2018-08-12 to present
Membership
Source: Self-asserted source
Javad Alizadeh

Canadian Thoracic Society: Ottawa, Ontario, CA

2018-07-15 to present
Membership
Source: Self-asserted source
Javad Alizadeh

CancerCare Manitoba: Winnipeg, MB, CA

2015-12-24 to present
Membership
Source: Self-asserted source
Javad Alizadeh

American Cancer Society: Atlanta, GA, US

2015-11-11 to present
Membership
Source: Self-asserted source
Javad Alizadeh

Canadian Cancer Society: Toronto, Ontario, CA

2015-10-07 to present
Membership
Source: Self-asserted source
Javad Alizadeh

Canadian Lung Association: Ottawa, Ontario, CA

2015-08-14 to present
Membership
Source: Self-asserted source
Javad Alizadeh

Iraniain Biotechnology Society : Tehran, IR

2010-09-13 to present
Membership
Source: Self-asserted source
Javad Alizadeh

Funding (4)

The Effect of Matrix Stiffness on Regulation of Autophagy/EMT Cross talk and its Signaling in 3D Culture Model of Non-small Cell Lung Cancer Model

2018-09 to present | Award
University of Manitoba, University of Manitoba Graduate Fellowship (UMGF) (MB, MB, CA)
Source: Self-asserted source
Javad Alizadeh

Stiff substrates enhance mitophagy/EMT crosstalk.

2018-09 to 2019-09 | Salary award
Canadian Lung Association Research Studentship (Ottawa , CA)
Source: Self-asserted source
Javad Alizadeh

Autophagy and Epithelial Mesenchymal Transition in Non-Small Lung Cancer.

2016-09-01 to 2017-08-31 | Grant
Research Manitoba (Winnipeg, CA)
URL: https://app.dimensions.ai/details/grant/grant.7069758
GRANT_NUMBER:

2016-Alizadeh
Source: Self-asserted source
Javad Alizadeh via DimensionsWizard

Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells

2016-05 to present | Award
University of Manitoba, Ralph A. Mann Memorial Scholarship Award (MB, MB, CA)
Source: Self-asserted source
Javad Alizadeh

Works (24)

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Cancers
2023-04-07 | Journal article
DOI: 10.3390/cancers15082195
Contributors: Javad Alizadeh; Mahboubeh Kavoosi; Navjit Singh; Shahrokh Lorzadeh; Amir Ravandi; Biniam Kidane; Naseer Ahmed; Fatima Mraiche; Michael R. Mowat; Saeid Ghavami
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Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy

2023-01-16 | Preprint
DOI: 10.20944/preprints202301.0264.v1
Contributors: Javad Alizadeh; Simone C. Da Silva Rosa; Xiaohui Weng; Joadi Jacobs; Shahrokh Lorzadeh; Amir Ravandi; Rui Vitorino; Stevan Pecic; Shahla Shojaei; Saeid Ghavami
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Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

2023-01-10 | Preprint
DOI: 10.20944/preprints202301.0183.v1
Contributors: Javad Alizadeh; Mahboubeh Kavoosi; Navjit Singh; Shahrokh Lorzadeh; Amir Ravandi; Biniam Kidane; Naseer Ahmed; Fatima Mraiche; Michael R Mowat; Saeid Ghavami
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A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

2022-12-08 | Preprint
DOI: 10.21203/rs.3.rs-2326674/v1
Contributors: Shahla Shojaei; João Basso; Meitham Amereh; Javad Alizadeh; Tania Dehesh; Simone da Silva Rosa; Courtney Clark; Misha Hasan; Mateusz Tomczyk; Laura Cole et al.
Source: check_circle
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Inhibition of Autophagy Flux Promotes Secretion of Chondroitin Sulfate Proteoglycans in Primary Rat Astrocytes

Molecular Neurobiology
2021-12 | Journal article
DOI: 10.1007/s12035-021-02533-4
Contributors: Javad Alizadeh; Matthew M. Kochan; Vanessa D. Stewart; Dennis A. Drewnik; Sari S. Hannila; Saeid Ghavami
Source: check_circle
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Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis

Cells
2021-06-30 | Journal article
DOI: 10.3390/cells10071642
Contributors: Pawan Sharma; Javad Alizadeh; Maya Juarez; Afshin Samali; Andrew J. Halayko; Nicholas J. Kenyon; Saeid Ghavami; Amir A. Zeki
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The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

Life
2020-12-22 | Journal article
DOI: 10.3390/life11010001
Contributors: Mahmoud Aghaei; Sanaz Dastghaib; Sajjad Aftabi; Mohamad-Reza Aghanoori; Javad Alizadeh; Pooneh Mokarram; Parvaneh Mehrbod; Milad Ashrafizadeh; Ali Zarrabi; Kielan Darcy McAlinden et al.
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The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

Virulence
2019-01-01 | Journal article
DOI: 10.1080/21505594.2019.1605803
Contributors: Parvaneh Mehrbod; Sudharsana R. Ande; Javad Alizadeh; Shahrzad Rahimizadeh; Aryana Shariati; Hadis Malek; Mohammad Hashemi; Kathleen K. M. Glover; Affan A. Sher; Kevin M. Coombs et al.
Source: check_circle
Crossref

Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2018-05 | Journal article
DOI: 10.1016/j.bbamcr.2018.02.007
Part of ISSN: 0167-4889
Contributors: Javad Alizadeh; Aleksandra Glogowska; James Thliveris; Forouh Kalantari; Shahla Shojaei; Sabine Hombach-Klonisch; Thomas Klonisch; Saeid Ghavami
Source: Self-asserted source
Javad Alizadeh via Crossref Metadata Search

Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development

Development of the Cerebellum from Molecular Aspects to Diseases
2017 | Other
DOI: 10.1007/978-3-319-59749-2_8
Part of ISBN: 9783319597485
Contributors: Mohammad Amin Moosavi; Marveh Rahmati; Niloufar Ashtari; Javad Alizadeh; Mohammad Hashemi; Seyedeh Zahra Bathaei; Saeid Ghavami
Source: Self-asserted source
Javad Alizadeh via Crossref Metadata Search

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

Scientific Reports
2017 | Journal article
DOI: 10.1038/srep44841
EID:

2-s2.0-85016143851
Contributors: Alizadeh, J.; Zeki, A.A.; Mirzaei, N.; Tewary, S.; Rezaei Moghadam, A.; Glogowska, A.; Nagakannan, P.; Eftekharpour, E.; Wiechec, E.; Gordon, J.W. et al.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Simultaneous Detection of Autophagy and Epithelial to Mesenchymal Transition in the Non-small Cell Lung Cancer Cells

Methods in Molecular Biology
2017 | Other
DOI: 10.1007/7651_2017_84
Part of ISSN: 1064-3745
Contributors: Javad Alizadeh; Shahla Shojaei; Adel Sepanjnia; Mohammad Hashemi; Eftekhar Eftekharpour; Saeid Ghavami
Source: Self-asserted source
Javad Alizadeh via Crossref Metadata Search

Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development. Development of the Cerebellum from Molecular Aspects to Diseases

SPRINGER
2017-08-08 | Book chapter
Source: Self-asserted source
Javad Alizadeh

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

Autophagy
2017-05-04 | Journal article
DOI: 10.1080/15548627.2017.1290751
Contributors: Pooneh Mokarram; Mohammed Albokashy; Maryam Zarghooni; Mohammad Amin Moosavi; Zahra Sepehri; Qi Min Chen; Andrzej Hudecki; Aliyeh Sargazi; Javad Alizadeh; Adel Rezaei Moghadam et al.
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Apoptosis, autophagy and unfolded protein response pathways in arbovirus replication and pathogenesis

Expert Reviews in Molecular Medicine
2016 | Journal article
DOI: 10.1017/erm.2015.19
EID:

2-s2.0-84954501980
Contributors: Iranpour, M.; Moghadam, A.R.; Yazdi, M.; Ande, S.R.; Alizadeh, J.; Wiechec, E.; Lindsay, R.; Drebot, M.; Coombs, K.M.; Ghavami, S.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Evaluation of umbilical cord blood CD34+ hematopoietic stem cells expansion with inhibition of TGF-β receptorII in co-culture with bone marrow mesenchymal stromal cells

Tissue and Cell
2016 | Journal article
DOI: 10.1016/j.tice.2016.06.003
EID:

2-s2.0-84991255820
Contributors: Sohrabi Akhkand, S.; Amirizadeh, N.; Nikougoftar, M.; Alizadeh, J.; Zaker, F.; Sarveazad, A.; Joghataei, M.T.; Faramarzi, M.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Interconnection of estrogen/testosterone metabolism and mevalonate pathway in breast and prostate cancers

Current Molecular Pharmacology
2016 | Journal article
DOI: 10.2174/1874467209666160112125631
EID:

2-s2.0-84994782665
Contributors: Mokarram, P.; Alizadeh, J.; Razban, V.; Barazeh, M.; Solomon, C.; Kavousipour, S.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

The siRNA-mediated down-regulation of vascular endothelial growth factor receptor1

Iranian Red Crescent Medical Journal
2016 | Journal article
DOI: 10.5812/ircmj.23418
EID:

2-s2.0-84964746528
Contributors: Sani, M.J.; Yazdi, F.; Karimi, M.M.; Alizadeh, J.; Rahmati, M.; Mahmudabadi, A.Z.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Cellular commitment in the developing cerebellum

Frontiers in Cellular Neuroscience
2015 | Journal article
DOI: 10.3389/fncel.2014.00450
EID:

2-s2.0-84920997616
Contributors: Marzban, H.; Del Bigio, M.R.; Alizadeh, J.; Ghavami, S.; Zachariah, R.M.; Rastegar, M.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

World Journal of Gastroenterology
2015 | Journal article
DOI: 10.3748/wjg.v21.i47.13225
EID:

2-s2.0-84951842042
Contributors: Yeganeh, B.; Rezaei Moghadam, A.; Alizadeh, J.; Wiechec, E.; Alavian, S.M.; Hashemi, M.; Geramizadeh, B.; Samali, A.; Bagheri Lankarani, K.; Post, M. et al.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Expression of miRNAs in non-small-cell lung carcinomas and their association with clinicopathological features

Tumor Biology
2014 | Journal article
DOI: 10.1007/s13277-014-2755-6
EID:

2-s2.0-84930028390
Contributors: Tafsiri, E.; Darbouy, M.; Shadmehr, M.B.; Zagryazhskaya, A.; Alizadeh, J.; Karimipoor, M.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Expression profile of MAGI2 gene as a novel biomarker in combination with major deregulated genes in prostate cancer

Molecular Biology Reports
2014 | Journal article
DOI: 10.1007/s11033-014-3491-0
EID:

2-s2.0-84906939828
Contributors: Mahdian, R.; Nodouzi, V.; Asgari, M.; Rezaie, M.; Alizadeh, J.; Yousefi, B.; Shahrokh, H.; Abolhasani, M.; Nowroozi, M.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Perillyl Alcohol (Monoterpene Alcohol), Limonene

Enzymes
2014 | Book
DOI: 10.1016/B978-0-12-802215-3.00002-1
EID:

2-s2.0-84919416589
Contributors: Shojaei, S.; Kiumarsi, A.; Moghadam, A.R.; Alizadeh, J.; Marzban, H.; Ghavami, S.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Cloning of Vibrio cholerae outer membrane protein W in Pichia pastoris

Iranian Journal of Microbiology
2013 | Journal article
EID:

2-s2.0-84887036494
Contributors: Alizadeh, J.; Ranjbar, R.; Kamali, M.; Farhadi, N.; Davari, A.; Sadeghifard, N.
Source: Self-asserted source
Javad Alizadeh via Scopus - Elsevier

Peer review (3 reviews for 2 publications/grants)

Review activity for Bioengineered. (2)
Review activity for PloS one. (1)
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