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Scopus Author ID: 56517881200

Keywords

Structural Systems Biology

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United States

Biography

Center for Structural Biology - National Cancer Institute, NIH

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Employment (2)

Center for Cancer Research: Frederick, Maryland, US

2022-06-06 to present | Stadtman Investigator (Center for Structural Biology)
Employment
Source: Self-asserted source
Francis J O'Reilly

Technical University of Berlin: Berlin, DE

2016-04-01 to 2022-05-31 (Bioanalytics)
Employment
Source: Self-asserted source
Francis J O'Reilly

Education and qualifications (4)

EMBL Heidelberg Genome Biology: Heidelberg, Baden-Württemberg, DE

2011-09-01 to 2015-09-11 | Ph.D student (Structural and Computational Biology)
Qualification
Source: Self-asserted source
Francis J O'Reilly

Universität Heidelberg: Heidelberg, DE

2011-09-10 to 2015-09-01 | Ph.D
Education
Source: Self-asserted source
Francis J O'Reilly

University of Edinburgh: Edinbrugh, Scotland, GB

2010-09-01 to 2011-08-30 | Masters by Research (Biological Sciences)
Education
Source: Self-asserted source
Francis J O'Reilly

The University of Edinburgh Edinburgh Neuroscience: Edinburgh, Edinburgh, GB

2007-09-01 to 2010-06-01 | Batchelor's of Science (Biological Sciences)
Education
Source: Self-asserted source
Francis J O'Reilly

Works (30)

Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates

Nature Communications
2024-09-03 | Journal article
DOI: 10.1038/s41467-024-52076-0
Contributors: Changqing Li; Stefano Moro; Kateryna Shostak; Francis J. O’Reilly; Mariel Donzeau; Andrea Graziadei; Alastair G. McEwen; Dominique Desplancq; Pierre Poussin-Courmontagne; Thomas Bachelart et al.
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Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT

Nature Structural & Molecular Biology
2023-09 | Journal article
DOI: 10.1038/s41594-023-01075-8
Contributors: Eva Absmeier; Viswanathan Chandrasekaran; Francis J. O’Reilly; James A. W. Stowell; Juri Rappsilber; Lori A. Passmore
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Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon

Communications Biology
2023-05-22 | Journal article
DOI: 10.1038/s42003-023-04885-0
Contributors: Ioannis Skalidis; Fotis L. Kyrilis; Christian Tüting; Farzad Hamdi; Toni K. Träger; Jaydeep Belapure; Gerd Hause; Marta Fratini; Francis J. O’Reilly; Ingo Heilmann et al.
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Cross-linking mass spectrometry for mapping protein complex topologies in situ

Essays in Biochemistry
2023-03-29 | Journal article
DOI: 10.1042/EBC20220168
Contributors: Hannah Britt; Rebecca Beveridge; Antonio Calabrese; Kitaik Lee; Francis J. O'Reilly
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Protein complexes in cells by AI-assisted structural proteomics.

Molecular systems biology
2023-02-23 | Journal article
DOI: 10.1101/2022.07.26.501605
DOI: 10.15252/msb.202311544
PMID: 36815589
EID:

2-s2.0-85148580144

Part of ISSN: 17444292
Contributors: O'Reilly FJ; Andrea Graziadei; Christian Forbrig; Rica Bremenkamp; Kristine Charles; Swantje Lenz; Christoph Elfmann; Lutz Fischer; Jörg Stülke; Juri Rappsilber et al.
Source: Self-asserted source
Francis J O'Reilly
grade
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Improved Peptide Backbone Fragmentation Is the Primary Advantage of MS-Cleavable Crosslinkers

Analytical Chemistry
2022 | Journal article
DOI: 10.1021/acs.analchem.1c05266
EID:

2-s2.0-85131897419

Part of ISSN: 15206882 00032700
Contributors: Kolbowski, L.; Lenz, S.; Fischer, L.; Sinn, L.R.; O'Reilly, F.J.; Rappsilber, J.
Source: Self-asserted source
Francis J O'Reilly via Scopus - Elsevier
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Mpe1 senses the binding of pre-mRNA and controls 3′ end processing by CPF

Molecular Cell
2022 | Journal article
DOI: 10.1016/j.molcel.2022.04.021
EID:

2-s2.0-85133276370

Part of ISSN: 10974164 10972765
Contributors: Rodríguez-Molina, J.B.; O'Reilly, F.J.; Fagarasan, H.; Sheekey, E.; Maslen, S.; Skehel, J.M.; Rappsilber, J.; Passmore, L.A.
Source: Self-asserted source
Francis J O'Reilly via Scopus - Elsevier

AI-guided cryo-EM probes a thermophilic cell-free system with succinyl-coA manufacturing capability

2022-10-08 | Preprint
DOI: 10.1101/2022.10.08.511438
Contributors: Ioannis Skalidis; Fotis L. Kyrilis; Christian Tüting; Farzad Hamdi; Toni K. Träger; Jaydeep Belapure; Gerd Hause; Marta Fratini; Francis J. O’Reilly; Ingo Heilmann et al.
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Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses

PLOS Pathogens
2021-08-02 | Journal article
DOI: 10.1371/journal.ppat.1009775
Contributors: Sofia Banchenko; Gilda Tachedjian; Ferdinand Krupp; Christine Gotthold; Jörg Bürger; Andrea Graziadei; Francis J. O’Reilly; Ludwig Sinn; Olga Ruda; Juri Rappsilber et al.
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Coupling proteomics and metabolomics for the unsupervised identification of protein–metabolite interactions in Chaetomium thermophilum

PLOS ONE
2021-07-09 | Journal article
DOI: 10.1371/journal.pone.0254429
Contributors: Yuanyue Li; Qi Wu; Michael Kuhn; Joanna Zukowska-Kasprzyk; Marco L. Hennrich; Panagiotis L. Kastritis; Francis J. O’Reilly; Prasad Phapale; Martin Beck; Anne-Claude Gavin et al.
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Reliable identification of protein-protein interactions by crosslinking mass spectrometry

Nature Communications
2021-06-11 | Journal article
DOI: 10.1038/s41467-021-23666-z
Contributors: Swantje Lenz; Ludwig R. Sinn; Francis J. O’Reilly; Lutz Fischer; Fritz Wegner; Juri Rappsilber
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Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

The EMBO Journal
2021-04-15 | Journal article | Author
DOI: 10.15252/embj.2020106164
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Contributors: Clinton Lau; Francis J O'Reilly; Balaji Santhanam; Samuel Lacey; Juri Rappsilber; Andrew Carter
Source: Self-asserted source
Francis J O'Reilly
grade
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Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts.

Cell reports
2021-02 | Journal article
DOI: 10.1016/j.celrep.2021.108727
PMID: 33567276
Contributors: Kyrilis FL; Semchonok DA; Skalidis I; Tüting C; Hamdi F; O'Reilly FJ; Rappsilber J; Kastritis PL
Source: Self-asserted source
Francis J O'Reilly via Europe PubMed Central
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Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.

Molecular cell
2020-12-09 | Journal article
DOI: 10.1016/j.molcel.2020.11.012
PMID: 33301732
PMC: PMC7758880
Source: Self-asserted source
Francis J O'Reilly
grade
Preferred source (of 2)‎

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism

Nature Structural & Molecular Biology
2020-08-13 | Journal article
DOI: 10.1038/s41594-020-0457-x
Contributors: Byung-Gil Lee; Fabian Merkel; Matteo Allegretti; Markus Hassler; Christopher Cawood; Léa Lecomte; Francis J. O’Reilly; Ludwig R. Sinn; Pilar Gutierrez-Escribano; Marc Kschonsak et al.
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A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.

Molecular cell
2020-07 | Journal article
DOI: 10.1016/j.molcel.2020.07.013
PMID: 32755595
Contributors: Higashi TL; Eickhoff P; Sousa JS; Locke J; Nans A; Flynn HR; Snijders AP; Papageorgiou G; O'Reilly N; Chen ZA et al.
Source: Self-asserted source
Francis J O'Reilly via Europe PubMed Central
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In-cell architecture of an actively transcribing-translating expressome

Science
2020-07-31 | Journal article
DOI: 10.1126/science.abb3758
DOI: 10.1101/2020.02.28.970111
Contributors: Francis J. O’Reilly; Liang Xue; Andrea Graziadei; Ludwig Sinn; Swantje Lenz; Dimitry Tegunov; Cedric Blötz; Neil Singh; Wim J. H. Hagen; Patrick Cramer et al.
Source: Self-asserted source
Francis J O'Reilly
grade
Preferred source (of 4)‎

Cryo-EM reveals the complex architecture of dynactin’s shoulder and pointed end

2020-07-16 | Preprint
DOI: 10.1101/2020.07.16.206359
Contributors: Clinton K. Lau; Francis J. O’Reilly; Balaji Santhanam; Samuel E. Lacey; Juri Rappsilber; Andrew P. Carter
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The structure of human thyroglobulin

Nature
2020-02 | Journal article
DOI: 10.1038/s41586-020-1995-4
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Francis J O'Reilly

In Situ Structural Restraints from Cross-Linking Mass Spectrometry in Human Mitochondria

Journal of Proteome Research
2020-01-03 | Journal article
DOI: 10.1021/acs.jproteome.9b00541
Part of ISSN: 1535-3893
Part of ISSN: 1535-3907
Source: Self-asserted source
Francis J O'Reilly
grade
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Structure of the Fanconi anaemia monoubiquitin ligase complex.

Nature
2019-10-30 | Journal article
DOI: 10.1038/s41586-019-1703-4
PMID: 31666700
Source: Self-asserted source
Francis J O'Reilly

An integrated workflow for crosslinking mass spectrometry

Molecular Systems Biology
2019-09 | Journal article
DOI: 10.15252/msb.20198994
Contributors: Marta L Mendes; Lutz Fischer; Zhuo A Chen; Marta Barbon; Francis J O'Reilly; Sven H Giese; Michael Bohlke‐Schneider; Adam Belsom; Therese Dau; Colin W Combe et al.
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First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

Analytical Chemistry
2019-06-04 | Journal article
DOI: 10.1021/acs.analchem.9b00658
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Source: Self-asserted source
Francis J O'Reilly
grade
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A folded conformation of MukBEF and cohesin

Nature Structural & Molecular Biology
2019-03 | Journal article
DOI: 10.1038/s41594-019-0196-z
DOI: 10.1101/464701
OTHER-ID:

PXD012370

OTHER-ID:

PXD012377

Part of ISSN: 1545-9993
Part of ISSN: 1545-9985
Source: Self-asserted source
Francis J O'Reilly
grade
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Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes

Molecular & Cellular Proteomics
2018-12 | Journal article
DOI: 10.1074/mcp.RA118.000892
Contributors: Nikolina Šoštarić; Francis J. O'Reilly; Piero Giansanti; Albert J.R. Heck; Anne-Claude Gavin; Vera van Noort
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Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology

Nature Structural & Molecular Biology
2018-11 | Journal article
DOI: 10.1038/s41594-018-0147-0
Part of ISSN: 1545-9993
Part of ISSN: 1545-9985
Source: Self-asserted source
Francis J O'Reilly

Capturing protein communities by structural proteomics in a thermophilic eukaryote.

Molecular systems biology
2017-07 | Journal article
DOI: 10.15252/msb.20167412
PMID: 28743795
Source: Self-asserted source
Francis J O'Reilly via Europe PubMed Central
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Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome‐reduced bacterium

Molecular Systems Biology
2015-01 | Journal article
DOI: 10.15252/msb.20145558
Part of ISSN: 1744-4292
Part of ISSN: 1744-4292
Source: Self-asserted source
Francis J O'Reilly
grade
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Organizing a PhD symposium--an inside view. Setting up a scientific meeting is challenging--a PhD symposium offers its own unique opportunities and pitfalls.

2013-10 | Journal article
DOI:

10.1038/embor.2013.147

PMID:

24042316

PMC:

PMC3807234
Contributors: Schröder MS; Harnett D; Minke BA; Nair PS; Committee Member Consortium
Source: Self-asserted source
Francis J O'Reilly via Europe PubMed Central

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

Proceedings of the National Academy of Sciences
2013-04-09 | Journal article
DOI: 10.1073/pnas.1217157110
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Francis J O'Reilly
grade
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Peer review (14 reviews for 9 publications/grants)

Review activity for Communications biology. (1)
Review activity for Current opinion in structural biology. (1)
Review activity for Journal of proteome research. (2)
Review activity for Molecular cell. (1)
Review activity for Nature communications (4)
Review activity for Nature methods. (2)
Review activity for Nature structural & molecular biology. (1)
Review activity for Proceedings of the National Academy of Sciences of the United States of America. (1)
Review activity for Rapid communications in mass spectrometry : (1)
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