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Penn State PURE

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Employment (7)

Penn State Health Milton S Hershey Medical Center: Hershey, PA, US

2011 to present | Director of Translational Therapeutics Option, Biomedical Sciences Graduate Program,
Employment
Source: Self-asserted source
Jong Yun

Penn State Health Milton S Hershey Medical Center: Hershey, PA, US

2008 to present | Director of Graduate Program, Department of Pharmacology; Director of Molecular Toxicology Graduate Program IBIOS; Member, Penn State Cancer Institute
Employment
Source: Self-asserted source
Jong Yun

Penn State Health Milton S Hershey Medical Center: Hershey, PA, US

2002 to 2008 | Assistant Professor (Tenure-track) (Pharmacology)
Employment
Source: Self-asserted source
Jong Yun

Penn State Health Milton S Hershey Medical Center: Hershey, PA, US

2001 to 2002 | Research Associate/Research Assistant Professor (Non-tenure track) (Pharmacology)
Employment
Source: Self-asserted source
Jong Yun

Penn State Health Milton S Hershey Medical Center: Hershey, PA, US

1999 to 2001 | Research Associate (Pharmacology)
Employment
Source: Self-asserted source
Jong Yun

Case Western Reserve University: Cleveland, OH, US

1998 to 1999 | Research Associate/American Heart Association fellowship (Molecular Cardiovascular Research Center)
Employment
Source: Self-asserted source
Jong Yun

Case Western Reserve University: Cleveland, OH, US

1996 to 1998 | Research Associate/Geriatrics Training fellowship (Molecular Cardiovascular Research Center)
Employment
Source: Self-asserted source
Jong Yun

Education and qualifications (1)

Case Western Reserve University: Cleveland, OH, US

1992 to 1996 | Ph.D. (Pathology)
Education
Source: Self-asserted source
Jong Yun

Professional activities (7)

Society for Neuroscience: Washington, DC, US

2011 to present
Membership
Source: Self-asserted source
Jong Yun

American Society for Pharmacology and Experimental Therapeutics: Bethesda, MD, US

2008 to present
Membership
Source: Self-asserted source
Jong Yun

American Chemical Society: Washington, DC, US

2007 to present
Membership
Source: Self-asserted source
Jong Yun

American Association for Cancer Research: Philadelphia, PA, US

2003 to present
Membership
Source: Self-asserted source
Jong Yun

American Association For The Advancement of Science: Washington D.C., District of Columbia, US

2002 to present
Membership
Source: Self-asserted source
Jong Yun

Penn State College of Medicine: Hershey, PA, US

2004 | Student Association Excellence in Teaching Award
Distinction
Source: Self-asserted source
Jong Yun

American Heart Association: New York, New York, US

1998 | Fellowship Award
Distinction
Source: Self-asserted source
Jong Yun

Funding (1)

Targeting the cysteine rich domain of protein kinase C

2001-07-01 to 2004-06-30 | Grant
National Cancer Institute (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.2603210
GRANT_NUMBER: R21CA091155
Source: Self-asserted source
Jong Yun via DimensionsWizard

Works (50 of 60)

Items per page:
Page 1 of 2

Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor

Cancers
2024-11-27 | Journal article
DOI: 10.3390/cancers16233973
Contributors: Jeremy A. Hengst; Victor J. Ruiz-Velasco; Wesley M. Raup-Konsavage; Kent E. Vrana; Jong K. Yun
Source: check_circle
Crossref
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Preferred source (of 2)‎

Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases

Pharmaceuticals
2023-07-26 | Journal article
DOI: 10.3390/ph16081060
Contributors: Vijay Pralhad Kale; Jeremy A. Hengst; Arati K. Sharma; Upendarrao Golla; Sinisa Dovat; Shantu G. Amin; Jong K. Yun; Dhimant H. Desai
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation

Cancers
2022-10-22 | Journal article
DOI: 10.3390/cancers14215182
Contributors: Jeremy A. Hengst; Asvelt J. Nduwumwami; Jong K. Yun
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

Cancer Biology & Therapy
2020-09-01 | Journal article
DOI: 10.1080/15384047.2020.1798696
Contributors: Jeremy A. Hengst; Taryn E. Dick; Charles D. Smith; Jong K. Yun
Source: check_circle
Crossref

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming

Frontiers in Molecular Neuroscience
2018-09-19 | Journal article
DOI: 10.3389/fnmol.2018.00323
Part of ISSN: 1662-5099
Source: Self-asserted source
Jong Yun

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Cancer Translational Medicine
2017 | Journal article
DOI: 10.4103/ctm.ctm_7_17
Part of ISSN: 2395-3977
Source: Self-asserted source
Jong Yun

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Oncotarget
2016-12-13 | Journal article
DOI: 10.18632/oncotarget.13079
Part of ISSN: 1949-2553
Source: Self-asserted source
Jong Yun

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Cell Reports
2016-11 | Journal article
DOI: 10.1016/j.celrep.2016.10.019
Part of ISSN: 2211-1247
Source: Self-asserted source
Jong Yun

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Cancer Biology & Therapy
2015-12-02 | Journal article
DOI: 10.1080/15384047.2015.1078949
Part of ISSN: 1538-4047
Part of ISSN: 1555-8576
Source: Self-asserted source
Jong Yun

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Cancer Letters
2015-06 | Journal article
DOI: 10.1016/j.canlet.2015.03.017
Part of ISSN: 0304-3835
Source: Self-asserted source
Jong Yun

The Apoptotic Mechanism of Action of the Sphingosine Kinase 1 Selective Inhibitor SKI-178 in Human Acute Myeloid Leukemia Cell Lines

Journal of Pharmacology and Experimental Therapeutics
2015-03 | Journal article
DOI: 10.1124/jpet.114.219659
Part of ISSN: 0022-3565
Part of ISSN: 1521-0103
Source: Self-asserted source
Jong Yun

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

Cancer Letters
2014-11 | Journal article
DOI: 10.1016/j.canlet.2014.08.032
Part of ISSN: 0304-3835
Source: Self-asserted source
Jong Yun

Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca2+channel modulation in rat sympathetic neurons

The Journal of Physiology
2012-10 | Journal article
DOI: 10.1113/jphysiol.2012.237644
Part of ISSN: 0022-3751
Source: Self-asserted source
Jong Yun

Sphingosine kinase: a key to solving the ‘French Paradox’?

British Journal of Pharmacology
2012-07 | Journal article
DOI: 10.1111/j.1476-5381.2012.01898.x
Part of ISSN: 0007-1188
Source: Self-asserted source
Jong Yun

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

Journal of Biological Chemistry
2012-04-06 | Journal article
DOI: 10.1074/jbc.m111.309104
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Jong Yun

Targeting sphingosine kinase-1 to inhibit melanoma

Pigment Cell & Melanoma Research
2012-03 | Journal article
DOI: 10.1111/j.1755-148x.2012.00970.x
Part of ISSN: 1755-1471
Source: Self-asserted source
Jong Yun

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

Biochemical and Biophysical Research Communications
2011-10 | Journal article
DOI: 10.1016/j.bbrc.2011.09.038
Part of ISSN: 0006-291X
Source: Self-asserted source
Jong Yun

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

European Journal of Medicinal Chemistry
2011-08 | Journal article
DOI: 10.1016/j.ejmech.2011.04.058
Part of ISSN: 0223-5234
Source: Self-asserted source
Jong Yun

AP-1 binding transcriptionally regulates human neutral ceramidase

Archives of Biochemistry and Biophysics
2011-07 | Journal article
DOI: 10.1016/j.abb.2011.04.009
Part of ISSN: 0003-9861
Source: Self-asserted source
Jong Yun

Transcriptional regulation of the human neutral ceramidase gene

Archives of Biochemistry and Biophysics
2011-07 | Journal article
DOI: 10.1016/j.abb.2011.04.012
Part of ISSN: 0003-9861
Source: Self-asserted source
Jong Yun

Development of a sphingosine kinase 1 specific small-molecule inhibitor

Bioorganic & Medicinal Chemistry Letters
2010-12 | Journal article
DOI: 10.1016/j.bmcl.2010.10.005
Part of ISSN: 0960-894X
Source: Self-asserted source
Jong Yun

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

Bioorganic & Medicinal Chemistry Letters
2010-11 | Journal article
DOI: 10.1016/j.bmcl.2010.08.113
Part of ISSN: 0960-894X
Source: Self-asserted source
Jong Yun

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

European Journal of Medicinal Chemistry
2010-09 | Journal article
DOI: 10.1016/j.ejmech.2010.06.005
Part of ISSN: 0223-5234
Source: Self-asserted source
Jong Yun

Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

Archives of Biochemistry and Biophysics
2010-02 | Journal article
DOI: 10.1016/j.abb.2009.11.006
Part of ISSN: 0003-9861
Source: Self-asserted source
Jong Yun

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

Archives of Biochemistry and Biophysics
2009-12 | Journal article
DOI: 10.1016/j.abb.2009.09.013
Part of ISSN: 0003-9861
Source: Self-asserted source
Jong Yun

Encapsulation of Organic Molecules in Calcium Phosphate Nanocomposite Particles for Intracellular Imaging and Drug Delivery

Nano Letters
2008-12-10 | Journal article
DOI: 10.1021/nl8019888
Part of ISSN: 1530-6984
Part of ISSN: 1530-6992
Source: Self-asserted source
Jong Yun

Network model of survival signaling in large granular lymphocyte leukemia

Proceedings of the National Academy of Sciences
2008-10-21 | Journal article
DOI: 10.1073/pnas.0806447105
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Jong Yun

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

Leukemia & Lymphoma
2008-01 | Journal article
DOI: 10.1080/10428190801911654
Part of ISSN: 1042-8194
Part of ISSN: 1029-2403
Source: Self-asserted source
Jong Yun

Gene Therapy

xPharm: The Comprehensive Pharmacology Reference
2007 | Book chapter
DOI: 10.1016/b978-008055232-3.60064-9
Part of ISBN: 9780080552323
Source: Self-asserted source
Jong Yun

Sphingosine 1-Phosphate Has Dual Functions in the Regulation of Endothelial Cell Permeability and Ca2+ Metabolism

Journal of Pharmacology and Experimental Therapeutics
2007-10 | Journal article
DOI: 10.1124/jpet.107.121210
Part of ISSN: 0022-3565
Part of ISSN: 1521-0103
Source: Self-asserted source
Jong Yun

Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
2007-04 | Journal article
DOI: 10.1016/j.bbaexp.2007.03.005
Part of ISSN: 0167-4781
Source: Self-asserted source
Jong Yun

Ceramide Recruits and Activates Protein Kinase C ζ (PKCζ) within Structured Membrane Microdomains

Journal of Biological Chemistry
2007-04-27 | Journal article
DOI: 10.1074/jbc.m700082200
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Jong Yun

Antitumor Activity of Sphingosine Kinase Inhibitors

Journal of Pharmacology and Experimental Therapeutics
2006-08 | Journal article
DOI: 10.1124/jpet.106.101345
Part of ISSN: 0022-3565
Part of ISSN: 1521-0103
Source: Self-asserted source
Jong Yun

Functional and structural properties of stannin: Roles in cellular growth, selective toxicity, and mitochondrial responses to injury

Journal of Cellular Biochemistry
2006-05-15 | Journal article
DOI: 10.1002/jcb.20809
Part of ISSN: 0730-2312
Part of ISSN: 1097-4644
Source: Self-asserted source
Jong Yun

Elucidation of Stannin Function Using Microarray Analysis: Implications for Cell Cycle Control

Gene Expression
2006-01-01 | Journal article
DOI: 10.3727/000000006783991944
Part of ISSN: 1052-2166
Source: Self-asserted source
Jong Yun

The protein stannin binds 14-3-3ζ and modulates mitogen-activated protein kinase signaling

Molecular Brain Research
2005-08 | Journal article
DOI: 10.1016/j.molbrainres.2005.04.018
Part of ISSN: 0169-328X
Source: Self-asserted source
Jong Yun

Protein Kinase Cϵ Regulates Tumor Necrosis Factor-α-Induced Stannin Gene Expression

Journal of Pharmacology and Experimental Therapeutics
2005-07 | Journal article
DOI: 10.1124/jpet.105.084236
Part of ISSN: 0022-3565
Part of ISSN: 1521-0103
Source: Self-asserted source
Jong Yun

Attenuation of Shock-Induced Acute Lung Injury by Sphingosine Kinase Inhibition

The Journal of Trauma: Injury, Infection, and Critical Care
2004-11 | Journal article
DOI: 10.1097/01.ta.0000149495.44582.76
Part of ISSN: 0022-5282
Source: Self-asserted source
Jong Yun

Stannin, A Protein That Localizes to the Mitochondria and Sensitizes NIH-3T3 Cells to Trimethyltin and Dimethyltin Toxicity

Molecular Pharmacology
2004-10 | Journal article
DOI: 10.1124/mol.104.001719
Part of ISSN: 0026-895X
Part of ISSN: 1521-0111
Source: Self-asserted source
Jong Yun

Discovery and evaluation of inhibitors of human sphingosine kinase

Journal of Cancer Research
2003-09 | Journal article
Source: Self-asserted source
Jong Yun

Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation

Archives of Biochemistry and Biophysics
2002-12 | Journal article
DOI: 10.1016/s0003-9861(02)00526-x
Part of ISSN: 0003-9861
Source: Self-asserted source
Jong Yun

Inhibitory actions of ceramide upon PKC-e/ERK interactions

American Journal of Physiology - Cell Physiology
2001-07 | Journal article
Source: Self-asserted source
Jong Yun

Ceramide Directly Activates Protein Kinase C ζ to Regulate a Stress-activated Protein Kinase Signaling Complex

Journal of Biological Chemistry
2000-11-10 | Journal article
DOI: 10.1074/jbc.m007346200
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Jong Yun

Ceramide-Coated Balloon Catheters Limit Neointimal Hyperplasia After Stretch Injury in Carotid Arteries

Circulation Research
2000-08-18 | Journal article
DOI: 10.1161/01.res.87.4.282
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Source: Self-asserted source
Jong Yun

Correlation of cytokine elaboration with mononuclear cell adhesion to platelet storage bag plastic polymers: A pilot study

Clinical and Vaccine Immunology
1999-07 | Journal article
Source: Self-asserted source
Jong Yun

Cyclic Strain Effects on Human Monocyte Interactions with Endothelial Cells and Extracellular Matrix Proteins

Tissue Engineering
1999-02 | Journal article
DOI: 10.1089/ten.1999.5.67
Part of ISSN: 1076-3279
Part of ISSN: 1557-8690
Source: Self-asserted source
Jong Yun

Cyclic-strain-induced endothelial cell expression of adhesion molecules and their roles in monocyte-endothelial interaction

Journal of Biomedical Materials Research
1999-01 | Journal article
DOI: 10.1002/(sici)1097-4636(199901)44:1<87::aid-jbm10>3.0.co;2-w
Part of ISSN: 0021-9304
Part of ISSN: 1097-4636
Source: Self-asserted source
Jong Yun

Propensity for Macrophage Apoptosis Is Related to the Pattern of Expression and Function of Integrin Extracellular Matrix Receptors

Biochemical and Biophysical Research Communications
1998-05 | Journal article
DOI: 10.1006/bbrc.1998.8650
Part of ISSN: 0006-291X
Source: Self-asserted source
Jong Yun

[]

Neurochemical Research
1997 | Journal article
DOI: 10.1023/a:1027328314968
Part of ISSN: 0364-3190
Source: Self-asserted source
Jong Yun

Inflammatory mediators are perpetuated in macrophages resistant to apoptosis induced by hypoxia

Proceedings of the National Academy of Sciences
1997-12-09 | Journal article
DOI: 10.1073/pnas.94.25.13903
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Jong Yun
Items per page:
Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for Biochemical pharmacology. (1)
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