Personal information

Angiotensin II, AT1 (AT1a) receptor, Kidney, Hypertension, Proximal tubule, Physiological Genomics, G Protein-coupled receptor, The renin-angiotensin-system
United States

Biography

Dr. Jia Long (Joe) Zhuo, M.D., Ph.D., is the Director of Tulane Hypertension and Renal Center of Excellence (THRCE) and a tenured Professor in the Departments of Physiology at Tulane University School of Medicine, New Orleans, Louisiana. He recently joined Tulane University School of Medicine from the University of Mississippi Medical Center and Henry Ford Health System, where he served as a tenured professor in the Department of Pharmacology and Toxicology, 2010 - 2019, and the Director of Receptor and Signal Transduction Laboratory in the Division of Hypertension and Vascular Research, 2001 - 2010, respectively. Dr. Zhuo received a Doctor of Medicine degree (M.D.) from Guangxi Medical University, Guangxi, China in 1983, and a Ph.D. degree in renal physiology and hypertension from the Department of Physiology at the University of Melbourne, Australia in 1990. He served as a National Health and Medical Research Council of Australia Senior Research Officer (equivalent to Senior Lecturer) at the Austin and Repatriation Medical Center and Howard Florey Institute of Experimental Physiology and Medicine at the University of Melbourne from 1993 to 2000. Dr. Zhuo has more than 30 years’ productive sponsored research investigating the roles of circulating (endocrine), tissue (paracrine), and intracellular (intracrine) angiotensin II and its receptor mapping and signaling in renal physiology and hypertension. His research has been continuously supported by grants from the National Health and Medical Research Council (NHMRC) of Australia, American Heart Association (AHA), American Society of Nephrology (ASN), and National Institute of Health (NIH/NIDDK). As a well-recognized expert in the renin-angiotensin research field, Dr. Zhuo is a regular invited national and international speaker and has published 115 high impact peer-reviewed articles and book chapters. He is an elected Fellow of the American Association for the Advancement of Science, Section on Medical Sciences (FAAAS), Overseas Fellow of Royal Society of Medicine, England (FRSM), and a Fellow of American Heart Association (FAHA) and American Society of Nephrology (FASN), respectively. Dr. Zhuo was the past Chair of the American Physiological Society Physiological Genomics Group, a permanent member for NIH/Center for Scientific Review Hypertension and Microcirculation Study Section (HM), and an Ad Hoc reviewer for numerous special emphasis panels. His current hypertension and kidney research projects are supported by multiple R01 grants from the National Institute of Diabetes and Digestive and Kidney Diseases.

Activities

Employment (6)

Tulane University School of Medicine: New Orleans, LA, US

2020-02-03 to present | Professor and Director (Department of Physiology)
Employment
Source: Self-asserted source
Jia Long Zhuo

University of Mississippi School of Medicine: Jackson, MS, US

2010-09 to 2020-02 | Professor & Director (Department of Pharmacology and Toxicology)
Employment
Source: Self-asserted source
Jia Long Zhuo

Henry Ford Hospital: Detroit, Michigan, US

2001-06 to 2010-08 | Senior Staff Investigator and Director (Division of Hypertension and Vascular Research)
Employment
Source: Self-asserted source
Jia Long Zhuo

The University of Melbourne: Melbourne, Victoria, AU

1997-01 to 2001-05 | NH & MRC Senior Research Officer (Howard Florey Institute of Experimental Physiology and Medicine)
Employment
Source: Self-asserted source
Jia Long Zhuo

Tulane University School of Medicine: New Orleans, LA, US

1999-09 to 2000-03 | Visiting Assistant Professor (Department of Physiology)
Employment
Source: Self-asserted source
Jia Long Zhuo

The University of Melbourne: Melbourne, Victoria, AU

1992-01 to 1996-12 | NH & MRC Research Officer (Austin and Repatriation Medical Center)
Employment
Source: Self-asserted source
Jia Long Zhuo

Education and qualifications (3)

Tulane University School of Medicine: New Orleans, LA, US

1999-09 to 2000-03 | Visiting Professor (Department of Physiology)
Education
Source: Self-asserted source
Jia Long Zhuo

University of Melbourne: Melbourne, VIC, AU

1984-06 to 1989-06 | PhD (Department of Physiology)
Education
Source: Self-asserted source
Jia Long Zhuo

Guangxi Medical University: Nanning, Guangxi, CN

1977-12 to 1983-01 | MD (Faculty of Medicine)
Education
Source: Self-asserted source
Jia Long Zhuo

Funding (6)

Intratubular Angiotensin II and AT1a Receptors in The Proximal Tubules: Roles in Hypertension and Kidney Injury

2020-05-18 to 2024-04-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: R01DK123144
Source: Self-asserted source
Jia Long Zhuo via DimensionsWizard

The Na+/H+ Exchanger 3, Pressure Natriuresis, and Hypertension

2016-09-15 to 2018-08-31 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
GRANT_NUMBER: R56HL130988
Source: Self-asserted source
Jia Long Zhuo via DimensionsWizard

Role of Proximal Tubule NHE3 in Angiotensin II-induced Hypertension

2014-09-12 to 2022-05-31 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: R01DK102429
Source: Self-asserted source
Jia Long Zhuo via DimensionsWizard

Novel Roles of Mitochondrial Angiotensin II in The Proximal Tubule of The Kidney

2004-03-01 to 2022-08-31 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: R01DK067299
Source: Self-asserted source
Jia Long Zhuo via DimensionsWizard

Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells

2004-03-01 to 2010-09-29 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: R56DK067299
Source: Self-asserted source
Jia Long Zhuo via DimensionsWizard

Autocoids in Hypertension: Pathogenesis and End Organ Damage

1982-09-01 to 2019-01-31 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
GRANT_NUMBER: P01HL028982
Source: Self-asserted source
Jia Long Zhuo via DimensionsWizard

Works (10)

Deletion of AT1a receptors selectively in the proximal tubules of the kidney alters the hypotensive and natriuretic response to atrial natriuretic peptide via NPRA/cGMP/NO signaling

American Journal of Physiology-Renal Physiology
2024-12-01 | Journal article
Contributors: Xiao Chun Li; Chih-Hong Wang; Rumana Hassan; Akemi Katsurada; Ryosuke Sato; Jia Long Zhuo
Source: check_circle
Crossref

Intracellular Angiotensin II Stimulation of Sodium Transporter Expression in Proximal Tubule Cells via AT1 (AT1a) Receptor-Mediated, MAP Kinases ERK1/2- and NF-кB-Dependent Signaling Pathways

Cells
2023-05-28 | Journal article
Contributors: Xiaochun Li; Jialong Zhuo
Source: check_circle
Crossref
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Preferred source (of 2)‎

Chronic Kidney Disease Transdifferentiates Veins into a Specialized Immune–Endocrine Organ with Increased MYCN-AP1 Signaling

Cells
2023-05-26 | Journal article
Contributors: Fatma Saaoud; Laisel Martinez; Yifan Lu; Keman Xu; Ying Shao; Jia L Zhuo; Avrum Gillespie; Hong Wang; Marwan Tabbara; Alghidak Salama et al.
Source: check_circle
Crossref
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The Renin-Angiotensin-Aldosterone System in Metabolic Diseases and Other Pathologies

International Journal of Molecular Sciences
2023-04-18 | Journal article
Contributors: Rudy M. Ortiz; Ryousuke Satou; Jia L. Zhuo; Akira Nishiyama
Source: check_circle
Crossref
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Genetic Deletion of AT1a Receptor or Na+/H+ Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice

International Journal of Molecular Sciences
2022-12-13 | Journal article
Contributors: Xiao Chun Li; Rumana Hassan; Ana Paula O. Leite; Akemi Katsurada; Courtney Dugas; Ryosuke Sato; Jia Long Zhuo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Angiotensin II and AT1a Receptors in the Proximal Tubules of the Kidney: New Roles in Blood Pressure Control and Hypertension

International Journal of Molecular Sciences
2022-02-22 | Journal article
Contributors: Ana Paula de Oliveira Leite; Xiao C. Li; Sarah M. Nwia; Rumana Hassan; Jia L. Zhuo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney

Clinical Science
2021-08-13 | Journal article
Contributors: Ana Paula Oliveira Leite; Xiao C. Li; Rumana Hassan; Xiaowen Zheng; Barbara Alexander; Dulce Elena Casarini; Jia L. Zhuo
Source: check_circle
Crossref

New Insights into the Critical Importance of Intratubular Na+/H+ Exchanger 3 and Its Potential Therapeutic Implications in Hypertension

Current Hypertension Reports
2021-06 | Journal article
Contributors: Jia Long Zhuo; Manoocher Soleimani; Xiao Chun Li
Source: check_circle
Crossref

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II–Induced Hypertension in PT- Agtr1a −/− Mice

Hypertension
2021-04 | Journal article
Contributors: Xiao Chun Li; Ana Paula Oliveira Leite; Xiaowen Zheng; Chunling Zhao; Xu Chen; Liang Zhang; Xinchun Zhou; Isabelle Rubera; Michel Tauc; Jia Long Zhuo
Source: check_circle
Crossref

Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules

Hypertension
2020-07 | Journal article
Contributors: Xiao Chun Li; Xinchun Zhou; Jia Long Zhuo
Source: check_circle
Crossref

Peer review (2 reviews for 2 publications/grants)

Review activity for Advanced science. (1)
Review activity for Biomedicines. (1)