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Employment (3)

Australian National University: Canberra, ACT, AU

2016-01-04 to present | Emeritus Professor (John Curtin School of Medical Research)
Employment
Source: Self-asserted source
Angela Dulhunty

Australian National University: Canberra, ACT, AU

1984-04-01 to 2015-12-31 | Fellow/Senior Fellow/Professor (John Curtin School of Medical Research)
Employment
Source: Self-asserted source
Angela Dulhunty

University of Sydney: Sydney, NSW, AU

1976-06-06 to 1984-03-30 | lecturer/Senior lecturer (Anatomy)
Employment
Source: Self-asserted source
Angela Dulhunty

Education and qualifications (3)

University of New South Wales: Sydney, NSW, AU

1989-06 to present | DSc (Physiology)
Education
Source: Self-asserted source
Angela Dulhunty

University of New South Wales: Sydney, NSW, AU

1969-01-05 to 1973-05-15 | PhD (Physiology)
Education
Source: Self-asserted source
Angela Dulhunty

University of Sydney: Sydney, NSW, AU

1965-01-01 to 1968-11-30 | BSc Hons (Physiology)
Education
Source: Self-asserted source
Angela Dulhunty

Funding (2)

Decrypting the excitation contraction coupling machinery in skeletal muscle

2017-01 to 2020-12 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

APP1126201

Source: Self-asserted source
Angela Dulhunty

Interaction between alpha and beta subunits of the DHPR, a missing link in skeletal muscle excitation-contraction coupling

2012-01 to 2016-06 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

APP 1020589

Source: Self-asserted source
Angela Dulhunty

Works (50 of 197)

Items per page:
Page 1 of 4

Complex Actions of FKBP12 on RyR1 Ion Channel Activity Consistent with Negative Co-Operativity in FKBP12 Binding to the RyR1 Tetramer

Cells
2025-01-21 | Journal article
Contributors: Spencer J. Richardson; Chris G. Thekkedam; Marco G. Casarotto; Nicole A. Beard; Angela F. Dulhunty
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Biophysical reviews top five: voltage-dependent charge movement in nerve and muscle

Biophysical Reviews
2023-12 | Journal article
Contributors: Angela F. Dulhunty
Source: check_circle
Crossref

The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle Contractile Properties and RyR1 Ion Channel Gating

International Journal of Molecular Sciences
2023-12-28 | Journal article
Contributors: Chris G. Thekkedam; Travis L. Dutka; Chris Van der Poel; Gaetan Burgio; Angela F. Dulhunty
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Feedback contributions to excitation–contraction coupling in native functioning striated muscle

Philosophical Transactions of the Royal Society B: Biological Sciences
2023-06-19 | Journal article
Contributors: Samantha C. Salvage; Angela F. Dulhunty; Kamalan Jeevaratnam; Antony P. Jackson; Christopher L.-H. Huang
Source: check_circle
Crossref

FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease

Philosophical Transactions of the Royal Society B: Biological Sciences
2023-06-19 | Journal article
Contributors: S. J. Richardson; C. G. Thekkedam; M. G. Casarotto; N. A. Beard; A. F. Dulhunty
Source: check_circle
Crossref

How does flecainide impact RyR2 channel function?

Journal of General Physiology
2022-09-05 | Journal article
Contributors: Samantha C. Salvage; Christopher L.-H. Huang; James A. Fraser; Angela F. Dulhunty
Source: check_circle
Crossref

Activation of RyR2 by class I kinase inhibitors

British Journal of Pharmacology
2019 | Journal article
EID:

2-s2.0-85060982282

Contributors: Chakraborty, A.D.; Gonano, L.A.; Munro, M.L.; Smith, L.J.; Thekkedam, C.; Staudacher, V.; Gamble, A.B.; Macquaide, N.; Dulhunty, A.F.; Jones, P.P.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse

Journal of Cell Science
2019-05-15 | Journal article
Contributors: Samantha C. Salvage; Esther M. Gallant; Nicole A. Beard; Shiraz Ahmad; Haseeb Valli; James A. Fraser; Christopher L.-H. Huang; Angela F. Dulhunty
Source: check_circle
Crossref

Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels

ChemMedChem
2018 | Journal article
EID:

2-s2.0-85052817860

Contributors: Robinson, K.; Easton, C.J.; Dulhunty, A.F.; Casarotto, M.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β<inf>1a</inf> subunit (CACNB1)

American Journal of Physiology - Cell Physiology
2018 | Journal article
EID:

2-s2.0-85043596048

Contributors: Perez, C.F.; Eltit, J.M.; Lopez, J.R.; Bodnár, D.; Dulhunty, A.F.; Aditya, S.; Casarotto, M.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

British Journal of Pharmacology
2018 | Journal article
EID:

2-s2.0-85019123612

Contributors: Salvage, S.C.; Chandrasekharan, K.H.; Jeevaratnam, K.; Dulhunty, A.F.; Thompson, A.J.; Jackson, A.P.; Huang, C.L.-H.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier
grade
Preferred source (of 2)‎

Ryanodine receptor Ca<sup>2+</sup> release channel post-translational modification: Central player in cardiac and skeletal muscle disease

International Journal of Biochemistry and Cell Biology
2018 | Journal article
EID:

2-s2.0-85047653876

Contributors: Denniss, A.; Dulhunty, A.F.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling [version 1; referees: 4 approved]

2018-11-27 | Journal article
Part of ISSN: 2046-1402
Contributors: Angela F. Dulhunty; Nicole A. Beard; Marco G. Casarotto
Source: check_circle
F1000
grade
Preferred source (of 3)‎

Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding

Journal of Cell Science
2017 | Journal article
EID:

2-s2.0-85031401248

Contributors: Richardson, S.J.; Steele, G.A.; Gallant, E.M.; Lam, A.; Schwartz, C.E.; Board, P.G.; Casarotto, M.G.; Beard, N.A.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier
grade
Preferred source (of 2)‎

Core skeletal muscle ryanodine receptor calcium release complex

Clinical and Experimental Pharmacology and Physiology
2017 | Journal article
EID:

2-s2.0-85007203355

Contributors: Dulhunty, A.F.; Wei-LaPierre, L.; Casarotto, M.G.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels

Advances in Pharmacology
2017 | Book
EID:

2-s2.0-85013376969

Contributors: Dulhunty, A.F.; Board, P.G.; Beard, N.A.; Casarotto, M.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Ryanodine receptor modification and regulation by intracellular Ca<sup>2 +</sup> and Mg<sup>2 +</sup> in healthy and failing human hearts

Journal of Molecular and Cellular Cardiology
2017 | Journal article
EID:

2-s2.0-85012297974

Contributors: Walweel, K.; Molenaar, P.; Imtiaz, M.S.; Denniss, A.; dos Remedios, C.; van Helden, D.F.; Dulhunty, A.F.; Laver, D.R.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β<inf>1a</inf> reveal critical roles of domain interactions for stability

Journal of Biological Chemistry
2017 | Journal article
EID:

2-s2.0-85019637978

Contributors: Norris, N.C.; Joseph, S.; Aditya, S.; Karunasekara, Y.; Board, P.G.; Dulhunty, A.F.; Oakley, A.J.; Casarotto, M.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

The anthracycline metabolite doxorubicinol abolishes ryr2 sensitivity to physiological changes in luminal Ca<sup>21</sup> through an interaction with calsequestrin

Molecular Pharmacology
2017 | Journal article
EID:

2-s2.0-85031800515

Contributors: Hanna, A.D.; Lam, A.; Thekkedam, C.; Willemse, H.; Dulhunty, A.F.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Core skeletal muscle ryanodine receptor calcium release complex.

Clin Exp Pharmacol Physiol
2017-01 | Journal article
Source: Self-asserted source
Angela Dulhunty

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.

J Mol Cell Cardiol
2017-01-26 | Journal article
Source: Self-asserted source
Angela Dulhunty

Correction: Cardiac ryanodine receptor activation by a high Ca<sup>2+</sup> store load is reversed in a reducing cytoplasmic redox environment [J. Cell Sci., 127, (2016) (4531-4541)] DOI: 10.1242/jcs.156760

Journal of Cell Science
2016 | Journal article
EID:

2-s2.0-84995947104

Contributors: Hanna, A.D.; Lam, A.; Thekkedam, C.; Gallant, E.M.; Beard, N.A.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

The GSTM2 C-Terminal domain depresses contractility and Ca<sup>2+</sup> transients in neonatal rat ventricular cardiomyocytes

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84990911215

Contributors: Hewawasam, R.P.; Liu, D.; Casarotto, M.G.; Board, P.G.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors

Pflugers Archiv European Journal of Physiology
2016 | Journal article
EID:

2-s2.0-84991070383

Contributors: Wium, E.; Dulhunty, A.F.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition

Pflugers Archiv European Journal of Physiology
2016 | Journal article
EID:

2-s2.0-84954389063

Contributors: Willemse, H.; Theodoratos, A.; Smith, P.N.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors.

Pflugers Arch
2016-11 | Journal article
Source: Self-asserted source
Angela Dulhunty

The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.

PLoS One
2016-09-09 | Journal article
Source: Self-asserted source
Angela Dulhunty

Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition

Pflugers Arch
2016-02 | Journal article
Source: Self-asserted source
Angela Dulhunty

A new cytoplasmic interaction between junctin and ryanodine receptor Ca<sup>2+</sup> release channels

Journal of Cell Science
2015 | Journal article
EID:

2-s2.0-84924855388

Contributors: Li, L.; Mirza, S.; Richardson, S.J.; Gallant, E.M.; Thekkedam, C.; Pace, S.M.; Zorzato, F.; Liu, D.; Beard, N.A.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition

Skeletal Muscle
2015 | Journal article
EID:

2-s2.0-84926340609

Contributors: Beard, N.A.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes

Biochemical Pharmacology
2015 | Journal article
EID:

2-s2.0-84941808905

Contributors: Samarasinghe, K.; Liu, D.; Tummala, P.; Cappello, J.; Pace, S.M.; Arnolda, L.; Casarotto, M.G.; Dulhunty, A.F.; Board, P.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β&lt;inf&gt;1a&lt;/inf&gt; subunit

Skeletal Muscle
2015 | Journal article
EID:

2-s2.0-84937694066

Contributors: Rebbeck, R.T.; Willemse, H.; Groom, L.; Casarotto, M.G.; Board, P.G.; Beard, N.A.; Dirksen, R.T.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A

Molecular Pharmacology
2014 | Journal article
EID:

2-s2.0-84907918245

Contributors: Hanna, A.D.; Lam, A.; Tham, S.; Dulhunty, A.F.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Cardiac ryanodine receptor activation by a high Ca<sup>2+</sup> store load is reversed in a reducing cytoplasmic redox environment

Journal of Cell Science
2014 | Journal article
EID:

2-s2.0-84918494029

Contributors: Hanna, A.D.; Lam, A.; Thekkedam, C.; Gallant, E.M.; Beard, N.A.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Differences in the regulation of RyR2 from human, sheep, and rat by Ca<sup>2+</sup> and Mg<sup>2+</sup> in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Journal of General Physiology
2014 | Journal article
EID:

2-s2.0-84907311139

Contributors: Walweel, K.; Li, J.; Molenaar, P.; Imtiaz, M.S.; Quail, A.; dos Remedios, C.G.; Beard, N.A.; Dulhunty, A.F.; van Helden, D.F.; Laver, D.R.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Skeletal muscle excitation-contraction coupling: Who are the dancing partners?

International Journal of Biochemistry and Cell Biology
2014 | Journal article
EID:

2-s2.0-84892653310

Contributors: Rebbeck, R.T.; Karunasekara, Y.; Board, P.G.; Beard, N.A.; Casarotto, M.G.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

β1a490-508, a 19-residue peptide from C-terminal tail of Cav1.1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers

Biophysical Journal
2014 | Journal article
EID:

2-s2.0-84893484194

Contributors: Hernández-Ochoa, E.O.; Olojo, R.O.; Rebbeck, R.T.; Dulhunty, A.F.; Schneider, M.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Multiple actions of f-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
EID:

2-s2.0-84878468402

Contributors: Smith, J.J.; Vetter, I.; Lewis, R.J.; Peigneur, S.; Tytgat, J.; Lam, A.; Gallant, E.M.; Beard, N.A.; Alewood, P.F.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca<sup>2+</sup> and Mg<sup>2+</sup> Regulation

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84875282170

Contributors: Li, J.; Imtiaz, M.S.; Beard, N.A.; Dulhunty, A.F.; Thorne, R.; vanHelden, D.F.; Laver, D.R.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

A skeletal muscle ryanodine receptor interaction domain in triadin

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84865288571

Contributors: Wium, E.; Dulhunty, A.F.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

An x-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity

Human Molecular Genetics
2012 | Journal article
EID:

2-s2.0-84867115345

Contributors: Takano, K.; Liu, D.; Tarpey, P.; Gallant, E.; Lam, A.; Witham, S.; Alexov, E.; Chaubey, A.; Stevenson, R.E.; Schwartz, C.E. et al.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

An α-helical C-terminal tail segment of the skeletal L-type Ca 2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface

FASEB Journal
2012 | Journal article
EID:

2-s2.0-84870385652

Contributors: Karunasekara, Y.; Rebbeck, R.T.; Weaver, L.M.; Board, P.G.; Dulhunty, A.F.; Casarotto, M.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output

Clinical and Experimental Pharmacology and Physiology
2012 | Journal article
EID:

2-s2.0-84860261837

Contributors: Dulhunty, A.F.; Wium, E.; Li, L.; Hanna, A.D.; Mirza, S.; Talukder, S.; Ghazali, N.A.A.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease

Journal of General Physiology
2012 | Journal article
EID:

2-s2.0-84866149411

Contributors: Dulhunty, A.F.; Beard, N.A.; Hanna, A.D.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

Biochemical Pharmacology
2012 | Journal article
EID:

2-s2.0-84862782702

Contributors: Liu, D.; Hewawasam, R.; Karunasekara, Y.; Casarotto, M.G.; Dulhunty, A.F.; Board, P.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

3D mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM

PLoS ONE
2011 | Journal article
EID:

2-s2.0-80053610620

Contributors: Perálvarez-Marín, A.; Tae, H.; Board, P.G.; Casarotto, M.G.; Dulhunty, A.F.; Samsó, M.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Cyclization of the intrinsically disordered α<inf>1S</inf> dihydropyridine receptor II-III loop enhances secondary structure and in vitro function

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-79959352257

Contributors: Tae, H.-S.; Cui, Y.; Karunasekara, Y.; Board, P.G.; Dulhunty, A.F.; Casarotto, M.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors

Molecular Pharmacology
2011 | Journal article
EID:

2-s2.0-80051982074

Contributors: Hanna, A.D.; Janczura, M.; Cho, E.; Dulhunty, A.F.; Beard, N.A.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

Regulation of the cardiac muscle ryanodine receptor by glutathione transferases

Drug Metabolism Reviews
2011 | Journal article
EID:

2-s2.0-79954625549

Contributors: Dulhunty, A.F.; Hewawasam, R.; Liu, D.; Casarotto, M.G.; Board, P.G.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier

The elusive role of the SPRY2 domain in RyR1

Channels
2011 | Journal article
EID:

2-s2.0-79952551568

Contributors: Tae, H.; Wei, L.; Willemse, H.; Mirza, S.; Gallant, E.M.; Board, P.G.; Dirksen, R.T.; Casarotto, M.G.; Dulhunty, A.F.
Source: Self-asserted source
Angela Dulhunty via Scopus - Elsevier
Items per page:
Page 1 of 4

Peer review (2 reviews for 1 publication/grant)

Review activity for Nature communications (2)