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liquid biopsy, clonal evolution, pancreatic cancer, tumor heterogeneity
France

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Employment (2)

Institut de Cancérologie de Lorraine: Vandœuvre-lès-Nancy, FR

2024-01-01 to present | Group Leader (Service de Médecine de Précision)
Employment
Source: Self-asserted source
Alexandre Harlé

Université de Lorraine: Nancy, FR

2013-01-01 to present | Professor (Faculté de Pharmacie)
Employment
Source: Self-asserted source
Alexandre Harlé

Works (50 of 62)

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Page 1 of 2

Critical assay parameters facilitating confident detection of expression changes, fusions and short variants in RNA isolated from tissue

2024-11 | Preprint
Contributors: Kubik S; Matyszczak I; Toda N; Magrinelli E; Helleboid P; Smith E; Bezrukov F; Ryder C; Lopez J; Harlé A et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Analytical Validation of a Pan-Cancer NGS Assay for In-House Liquid Biopsy Testing: An International Multicenter Study

2024-10 | Preprint
Contributors: Lescuyer G; Harlé A; Kumar HS; Constantoulakis P; Pfarr N; Heitzer E; Michon C; Russo G; Speel EM; Piecyk M et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib.

Cell death discovery
2024-09 | Journal article
Contributors: Dardare J; Witz A; Betz M; François A; Lamy L; Husson M; Demange J; Rouyer M; Lambert A; Merlin JL et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Impact of Positive Resection Margins on Recurrence and Survival Following Resection and Adjuvant Chemotherapy in Pancreatic Cancer: Results of the PRODIGE 24-CCTG PA-6 Randomized Controlled Trial.

Annals of surgery
2024-07 | Journal article
Contributors: Lambert A; Salleron J; Harlé A; Biagi JJ; Leroux A; Thomas J; Monard L; Cros J; Marchal F; Ayav A et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

REGN5093-M114: can an antibody-drug conjugate overcome the challenge of resistance to epidermal growth factor receptor and mesenchymal epithelial transition tyrosine kinase inhibitors in non-small cell lung cancer?

Translational lung cancer research
2024-07 | Journal article
Contributors: Dardare J; Witz A; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Development and validation of AI-assisted transcriptomic signatures to personalize adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology
2024-06 | Journal article
Contributors: Fraunhoffer N; Hammel P; Conroy T; Nicolle R; Bachet JB; Harlé A; Rebours V; Turpin A; Ben Abdelghani M; Mitry E et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial

Journal of Clinical Oncology
2024-03-20 | Journal article
Contributors: Rémy Nicolle; Jean-Baptiste Bachet; Alexandre Harlé; Juan Iovanna; Pascal Hammel; Vinciane Rebours; Anthony Turpin; Meher Ben Abdelghani; Alice Wei; Emmanuel Mitry et al.
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Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?

Clinical and experimental medicine
2024-01 | Journal article
Contributors: Witz A; Dardare J; Betz M; Gilson P; Merlin JL; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles.

Cell reports. Medicine
2023-12 | Journal article
Contributors: Pozzorini C; Andre G; Coletta T; Buisson A; Bieler J; Ferrer L; Kempfer R; Saintigny P; Harlé A; Vacirca D et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Integrated Molecular Characterization of HER2-Low Breast Cancer Using Next Generation Sequencing (NGS)

Biomedicines
2023-11-28 | Journal article
Contributors: Jean-Louis Merlin; Marie Husson; Nassim Sahki; Pauline Gilson; Vincent Massard; Alexandre Harlé; Agnès Leroux
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CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines.

Scientific reports
2023-10 | Journal article
Contributors: Witz A; Dardare J; Francois A; Husson M; Rouyer M; Demange J; Merlin JL; Gilson P; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

ESR1 Gene Mutations and Liquid Biopsy in ER-Positive Breast Cancers: A Small Step Forward, a Giant Leap for Personalization of Endocrine Therapy?

Cancers
2023-10-27 | Journal article
Contributors: Margaux Betz; Vincent Massard; Pauline Gilson; Andréa Witz; Julie Dardare; Alexandre Harlé; Jean-Louis Merlin
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Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers.

Scientific reports
2023-08 | Journal article
Contributors: Gilson P; Pouget C; Belmonte R; Fadil S; Demange J; Rouyer M; Lacour J; Betz M; Dardare J; Witz A et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Personalized follow-up of circulating DNA in resected stage III/IV melanoma: PERCIMEL multicentric prospective study protocol.

BMC cancer
2023-06 | Journal article
Contributors: Geoffrois L; Harlé A; Sahki N; Sikanja A; Granel-Brocard F; Hervieu A; Mortier L; Jeudy G; Michel C; Nardin C et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy.

Frontiers in oncology
2022-12 | Journal article
Contributors: Dardare J; Witz A; Betz M; Francois A; Meras M; Lamy L; Lambert A; Grandemange S; Husson M; Rouyer M et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Development of a Clinical–Biological Model to Assess Tumor Progression in Metastatic Pancreatic Cancer: Post Hoc Analysis of the PRODIGE4/ACCORD11 Trial

Cancers
2022-10-16 | Journal article
Contributors: Julie Egea; Julia Salleron; Sophie Gourgou; Ahmet Ayav; Valérie Laurent; Béata Juzyna; Alexandre Harlé; Thierry Conroy; Aurélien Lambert
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CRISPR/Cas9-Mediated Knockdown Of BRCA1/2 Restores Response To Olaparib In Pancreatic Cancer Cell Lines

2022-03 | Preprint
Contributors: Witz A; Dardare J; Francois A; Husson M; Rouyer M; Demange J; Gilson P; Merlin J; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Deciphering Tumour Heterogeneity: From Tissue to Liquid Biopsy

Cancers
2022-03-08 | Journal article
Contributors: Pauline Gilson; Jean-Louis Merlin; Alexandre Harlé
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Intraoperative prediction of non-sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis.

Molecular and clinical oncology
2022-01 | Journal article
Contributors: Pina H; Salleron J; Gilson P; Husson M; Rouyer M; Leroux A; Rauch P; Marchal F; Käppeli M; Merlin JL et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

A NGS-based Blood Test For the Diagnosis of Invasive HPV-associated Carcinomas with Extensive Viral Genomic Characterization.

Clinical cancer research : an official journal of the American Association for Cancer Research
2021-10 | Journal article
Contributors: Sastre-Garau X; Diop M; Martin F; Dolivet G; Marchal F; Charra-Brunaud C; Peiffert D; Leufflen L; Dembélé B; Demange J et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Standardisation of pathogenicity classification for somatic alterations in solid tumours and haematologic malignancies.

European journal of cancer (Oxford, England : 1990)
2021-10 | Journal article
Contributors: Koeppel F; Muller E; Harlé A; Guien C; Sujobert P; Trabelsi Grati O; Kosmider O; Miguet L; Mauvieux L; Cayre A et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities

Pharmaceuticals
2021-07-29 | Journal article
Contributors: Julie Dardare; Andréa Witz; Jean-Louis Merlin; Agathe Bochnakian; Paul Toussaint; Pauline Gilson; Alexandre Harlé
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Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers.

Scientific reports
2021-05 | Journal article
Contributors: Gilson P; Saurel C; Salleron J; Husson M; Demange J; Merlin JL; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Detection of Microsatellite Instability: State of the Art and Future Applications in Circulating Tumour DNA (ctDNA)

Cancers
2021-03-24 | Journal article
Contributors: Pauline Gilson; Jean-Louis Merlin; Alexandre Harlé
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Pathology of HPV-Associated Head and Neck Carcinomas: Recent Data and Perspectives for the Development of Specific Tumor Markers.

Frontiers in oncology
2020-11 | Journal article
Contributors: Sastre-Garau X; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Comparison of Pathogenicity Prediction Tools on Somatic Variants.

The Journal of molecular diagnostics : JMD
2020-10 | Journal article
Contributors: Suybeng V; Koeppel F; Harlé A; Rouleau E
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers.

Scientific reports
2020-10 | Journal article
Contributors: Gilson P; Levy J; Rouyer M; Demange J; Husson M; Bonnet C; Salleron J; Leroux A; Merlin JL; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.

Cell reports
2020-05 | Journal article
Contributors: Litchfield K; Stanislaw S; Spain L; Gallegos LL; Rowan A; Schnidrig D; Rosenbaum H; Harle A; Au L; Hill SM et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma

International Journal of Molecular Sciences
2020-05-16 | Journal article
Contributors: Julie Dardare; Andréa Witz; Jean-Louis Merlin; Pauline Gilson; Alexandre Harlé
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Cell-Free DNA in the Management of Colorectal Cancer.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
2020-01 | Journal article
Contributors: Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

PloS one
2020-01 | Journal article
Contributors: Franczak C; Witz A; Geoffroy K; Demange J; Rouyer M; Husson M; Massard V; Gavoille C; Lambert A; Gilson P et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Identification of Specific Tumor Markers in Vulvar Carcinoma Through Extensive Human Papillomavirus DNA Characterization Using Next Generation Sequencing Method.

Journal of lower genital tract disease
2020-01 | Journal article
Contributors: Thomas J; Leufflen L; Chesnais V; Diry S; Demange J; Depardieu C; Bani MA; Marchal F; Charra-Brunaud C; Merlin JL et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Emerging Roles of DDB2 in Cancer

International Journal of Molecular Sciences
2019-10-18 | Journal article
Contributors: Pauline Gilson; Guillaume Drouot; Andréa Witz; Jean-Louis Merlin; Philippe Becuwe; Alexandre Harlé
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Somatic substitution signature as an innovative tool in lung cancer diagnosis

Scientific Reports
2019-10-10 | Journal article
Contributors: Stéphane Busca; Julia Salleron; Romain Boidot; Jean-Louis Merlin; Alexandre Harlé
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Comparison of Three Real-Time PCR Assays for the Detection of PIK3CA Somatic Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Breast Carcinomas

Pathology & Oncology Research
2019-07-13 | Journal article
Contributors: A. Lambert; J. Salleron; M. Lion; M. Rouyer; N. Lozano; A. Leroux; J. L. Merlin; Alexandre Harlé
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Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation

PLOS ONE
2019-07-02 | Journal article
Contributors: Pauline Gilson; Hiromu Suzuki; Claire Franczak; Ludovic Dubouis; Marie Husson; Marie Rouyer; Jessica Demange; Marie Perceau; Agnès Leroux; Jean-Louis Merlin et al.
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Crossref

Dual Epigenetic Regulation of ERα36 Expression in Breast Cancer Cells

International Journal of Molecular Sciences
2019-05-29 | Journal article
Contributors: Charlène Thiebaut; Amand Chesnel; Jean-Louis Merlin; Maelle Chesnel; Agnès Leroux; Alexandre Harlé; Hélène Dumond
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Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing

Scientific Reports
2019-05-08 | Journal article
Contributors: Claire Franczak; Shaun M. Kandathil; Pauline Gilson; Marie Husson; Marie Rouyer; Jessica Demange; Agnès Leroux; Jean-Louis Merlin; Alexandre Harlé
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Crossref

HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report.

BMC cancer
2019-03 | Journal article
Contributors: Harlé A; Guillet J; Thomas J; Demange J; Dolivet G; Peiffert D; Leroux A; Sastre-Garau X
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma

PLOS ONE
2019-02-27 | Journal article
Contributors: Claire Franczak; Giancarlo Troncone; Ludovic Dubouis; Pauline Gilson; Marie Husson; Marie Rouyer; Jessica Demange; Agnès Leroux; Jean-Louis Merlin; Alexandre Harlé
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Crossref

Technical considerations for circulating tumor DNA detection in oncology.

Expert review of molecular diagnostics
2019-01 | Journal article
Contributors: Franczak C; Filhine-Tresarrieu P; Gilson P; Merlin JL; Au L; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas.

Genes, chromosomes & cancer
2018-09 | Journal article
Contributors: Jeannot E; Harlé A; Holmes A; Sastre-Garau X; Sastre-Garau X
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation.

Oncotarget
2018-08 | Journal article
Contributors: Vogin G; Merlin JL; Rousseau A; Peiffert D; Harlé A; Husson M; Hajj LE; Levitchi M; Simon T; Simon JM
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Accelerated <i>BRAF</i> mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma.

Oncotarget
2018-08 | Journal article
Contributors: Serre D; Salleron J; Husson M; Leroux A; Gilson P; Merlin JL; Geoffrois L; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Clinical Interest of Circulating Tumor DNA in Oncology.

Archives of medical research
2018-07 | Journal article
Contributors: Franczak C; Filhine-Tressarieu P; Broséus J; Gilson P; Merlin JL; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples

Scientific Reports
2018-07-27 | Journal article
Contributors: Alexandre Harlé; Julie Guillet; Jacques Thomas; Xavier Sastre-Garau; Marie Rouyer; Carole Ramacci; Pauline Gilson; Cindy Dubois; Gilles Dolivet; Agnès Leroux et al.
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Crossref

[Dihydropyrimidine déhydrogenase (DPD) deficiency screening and securing of fluoropyrimidine-based chemotherapies: Update and recommendations of the French GPCO-Unicancer and RNPGx networks].

Bulletin du cancer
2018-02 | Journal article
Contributors: Loriot MA; Ciccolini J; Thomas F; Barin-Le-Guellec C; Royer B; Milano G; Picard N; Becquemont L; Verstuyft C; Narjoz C et al.
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Authors' Reply to Uguen: "Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma".

Molecular diagnosis & therapy
2017-12 | Journal article
Contributors: Harlé A; Franczak C
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.

Molecular diagnosis & therapy
2017-04 | Journal article
Contributors: Franczak C; Salleron J; Dubois C; Filhine-Trésarrieu P; Leroux A; Merlin JL; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central

Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets.

Oncology letters
2016-09 | Journal article
Contributors: Chen S; Cavazza E; Barlier C; Salleron J; Filhine-Tresarrieu P; Gavoilles C; Merlin JL; Harlé A
Source: Self-asserted source
Alexandre Harlé via Europe PubMed Central
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Page 1 of 2

Peer review (3 reviews for 2 publications/grants)

Review activity for BMC cancer (2)
Review activity for Molecular biology reports. (1)