Personal information

Molecular Biology
United States

Activities

Employment (5)

University of Nebraska Medical Center: Omaha, Nebraska, US

2020-07-01 to present | Assistant Professor (Ophthalmology and Visual Sciences)
Employment
Source: Self-asserted source
Bhavana Chhunchha

University of Nebraska Medical Center: Omaha, NE, US

2017-01-01 to 2020-06-30 | Instructor (Ophthalmology and Visual Sciences)
Employment
Source: Self-asserted source
Bhavana Chhunchha

University of Nebraska Medical Center: Omaha, NE, US

2015-01-01 to 2016-12-31 | Senior Research Associate (Ophthalmology and Visual Sciences)
Employment
Source: Self-asserted source
Bhavana Chhunchha

University of Nebraska Medical Center: Omaha, NE, US

2010-10-01 to 2014-12-31 | Postdoctoral Research fellow (Ophthalmology and Visual Sciences)
Employment
Source: Self-asserted source
Bhavana Chhunchha

University of Nebraska Medical Center: Omaha, NE, US

2009-09-01 to 2010-09-30 | Research Associate (Ophthalmology and Visual Sciences)
Employment
Source: Self-asserted source
Bhavana Chhunchha

Education and qualifications (3)

Gujarat University: Ahmedabad, Gujarat, IN

2005-06-01 to 2010-08-10 | Ph.D. (Zoology)
Education
Source: Self-asserted source
Bhavana Chhunchha

Gujarat University: Ahmedabad, Gujarat, IN

2003-06-01 to 2005-05-15 | Master of Science (Zoology)
Education
Source: Self-asserted source
Bhavana Chhunchha

Gujarat University: Ahmedabad, Gujarat, IN

2000-05-15 to 2003-04-30 | Bachelor of Science
Education
Source: Self-asserted source
Bhavana Chhunchha

Professional activities (2)

Society for Redox Biology and Medicine: Indianapolis, IN, US

2011-05-09 to present
Membership
Source: Self-asserted source
Bhavana Chhunchha

Arvo Foundation for Eye Research: Rockville, MD, US

2009-03-09 to present
Membership
Source: Self-asserted source
Bhavana Chhunchha

Works (25)

Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells

International Journal of Molecular Sciences
2023-11-13 | Journal article
Contributors: Bhavana Chhunchha; Rakesh Kumar; Eri Kubo; Priyanka Thakur; Dhirendra P. Singh
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Crossref
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EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods

Journal of General Physiology
2023-09-04 | Journal article
Contributors: Wallace B. Thoreson; Bhavana Chhunchha
Source: check_circle
Crossref

Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response

Antioxidants
2023-01-06 | Journal article
Contributors: Bhavana Chhunchha; Eri Kubo; Ronald R. Krueger; Dhirendra P. Singh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity

Cells
2022-09-27 | Journal article
Contributors: Bhavana Chhunchha; Eri Kubo; Dhirendra P. Singh
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Crossref
grade
Preferred source (of 2)‎

Switching of Redox Signaling by Prdx6 Expression Decides Cellular Fate by Hormetic Phenomena Involving Nrf2 and Reactive Oxygen Species

Cells
2022-04-08 | Journal article
Contributors: Bhavana Chhunchha; Eri Kubo; Dhirendra P. Singh
Source: check_circle
Crossref
grade
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Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity

Antioxidants
2021-08-04 | Journal article
Contributors: Bhavana Chhunchha; Eri Kubo; Uday B. Kompella; Dhirendra P. Singh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

Cells
2020-08-08 | Journal article
Contributors: Bhavana Chhunchha; Eri Kubo; Dhirendra P. Singh
Source: check_circle
Crossref

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells.

Cells
2019-09-27 | Journal article
Source: Self-asserted source
Bhavana Chhunchha
grade
Preferred source (of 3)‎

Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities.

International journal of molecular sciences
2018-11-08 | Journal article
Source: Self-asserted source
Bhavana Chhunchha
grade
Preferred source (of 2)‎

Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress.

Aging
2018-09-01 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress.

Scientific reports
2017-10-26 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Prdx6 retards senescence and restores trabecular meshwork cell health by regulating reactive oxygen species.

Cell Death Discovery
2017-09-11 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation.

Cell death & disease
2017-01-05 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells.

American journal of physiology. Cell physiology
2015-10-07 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription.

The FEBS journal
2014-07-01 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.

Epigenetics
2013-02-05 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation.

American journal of physiology. Cell physiology
2013-01-30 | Journal article
Source: Self-asserted source
Bhavana Chhunchha
grade
Preferred source (of 2)‎

Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response.

The FEBS journal
2012-07-16 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.

Cell death & disease
2012-05-31 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter.

PloS one
2012-05-16 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.

Cell death & disease
2011-11-24 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis.

American journal of physiology. Cell physiology
2011-06-15 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage.

BMC neuroscience
2010-10-05 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
2009-07-01 | Journal article
Source: Self-asserted source
Bhavana Chhunchha

Effects of melatonin on mercury induced endocrine toxicity in the rat

Journal of Herbal Medicine and Toxicology
2009-01-01 | Journal article
Source: Self-asserted source
Bhavana Chhunchha