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Employment (2)

Osaka University: Suita, Osaka, JP

Associate Professor (Graduate School of Medicine)
Employment
Source: Self-asserted source
Keisuke Nimura

Gunma University: Maebashi, Gunma, JP

2023-04-01 to present | Professor (Gunma University Initiative for Advanced Research)
Employment
Source: Self-asserted source
Keisuke Nimura

Education and qualifications (1)

Osaka University: Suita, JP

2003-04-01 to 2007-03-31 | Ph.D. (Graduate School of Medicine)
Education
Source: Self-asserted source
Keisuke Nimura

Works (40)

GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation.

Oncogene
2023-09 | Journal article
DOI: 10.1038/s41388-023-02803-6
PMID: 37658191
PMC: PMC10575781
Contributors: Shinzawa K; Matsumoto S; Sada R; Harada A; Saitoh K; Kato K; Ikeda S; Hirayama A; Yokoi K; Tanemura A et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Distinct Transcriptional Profiles in the Different Phenotypes of Neurofibroma from the Same Subject with Neurofibromatosis 1.

The Journal of investigative dermatology
2023-06 | Journal article
DOI: 10.1016/j.jid.2023.03.1688
PMID: 37301319
Contributors: Wang WN; Koguchi-Yoshioka H; Nimura K; Watanabe R; Tanemura A; Fujimoto M; Wataya-Kaneda M
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment.

Bioorganic & medicinal chemistry letters
2023-05 | Journal article
DOI: 10.1016/j.bmcl.2023.129333
PMID: 37207846
Contributors: Hirabayashi S; Tsuyuguchi Y; Li Y; Ohta N; Yoshikawa Y; Lin B; Fumimoto M; Nunomura K; Suzuki T; Haruta J et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

DNA barcoding and gene expression recording reveal the presence of cancer cells with unique properties during tumor progression.

Cellular and molecular life sciences : CMLS
2022-12 | Journal article
DOI: 10.1007/s00018-022-04640-4
PMID: 36564568
PMC: PMC9789022
Contributors: Umeki Y; Ogawa N; Uegaki Y; Saga K; Kaneda Y; Nimura K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Pilot study for the treatment of cutaneous neurofibromas in neurofibromatosis type 1 patients using topical sirolimus gel.

Journal of the American Academy of Dermatology
2022-11 | Journal article
DOI: 10.1016/j.jaad.2022.08.066
PMID: 36334988
Contributors: Wataya-Kaneda M; Watanabe Y; Nakamura A; Yamamoto K; Okada K; Maeda S; Nimura K; Saga K; Katayama I
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing.

Cancers
2022-07 | Journal article
DOI: 10.3390/cancers14153580
PMID: 35892844
PMC: PMC9331511
Contributors: Sumitani N; Ishida K; Sawada K; Kimura T; Kaneda Y; Nimura K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma.

Cell & bioscience
2022-06 | Journal article
DOI: 10.1186/s13578-022-00812-8
PMID: 35715826
PMC: PMC9206271
Contributors: Kitamura K; Suzuki H; Abe R; Inohara H; Kaneda Y; Takahashi H; Nimura K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Author Correction: Evaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens.

Scientific reports
2021-06 | Journal article
DOI: 10.1038/s41598-021-91694-2
PMID: 34088968
PMC: PMC8178410
Contributors: Kitamura K; Nimura K; Ito R; Saga K; Inohara H; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer.

Cells
2021-04 | Journal article
DOI: 10.3390/cells10040923
PMID: 33923658
PMC: PMC8073995
Contributors: Kitamura K; Nimura K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

A simple method using CRISPR-Cas9 to knock-out genes in murine cancerous cell lines.

Scientific reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-79303-0
PMID: 33339985
PMC: PMC7749119
Contributors: Ishibashi A; Saga K; Hisatomi Y; Li Y; Kaneda Y; Nimura K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Evaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens.

Scientific reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-78345-8
PMID: 33335126
PMC: PMC7747560
Contributors: Kitamura K; Nimura K; Ito R; Saga K; Inohara H; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Design and Synthesis of 1,2-Deoxy-pyranose Derivatives of Spliceostatin A toward Prostate Cancer Treatment.

ACS medicinal chemistry letters
2020-05 | Journal article
DOI: 10.1021/acsmedchemlett.0c00153
PMID: 32551017
PMC: PMC7294732
Contributors: Yoshikawa Y; Ishibashi A; Takehara T; Suzuki T; Murai K; Kaneda Y; Nimura K; Arisawa M
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis.

Journal of experimental & clinical cancer research : CR
2019-10 | Journal article
DOI: 10.1186/s13046-019-1429-z
PMID: 31619256
PMC: PMC6796413
Contributors: Saga K; Park J; Nimura K; Kawamura N; Ishibashi A; Nonomura N; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression.

Cancer research
2019-08 | Journal article
DOI: 10.1158/0008-5472.can-18-3965
PMID: 31431456
Contributors: Kawamura N; Nimura K; Saga K; Ishibashi A; Kitamura K; Nagano H; Yoshikawa Y; Ishida K; Nonomura N; Arisawa M et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation.

Molecular cell
2017-08 | Journal article
DOI: 10.1016/j.molcel.2017.07.013
PMID: 28803781
PMC: PMC5854204
Contributors: Kieffer-Kwon KR; Nimura K; Rao SSP; Xu J; Jung S; Pekowska A; Dose M; Stevens E; Mathe E; Dong P et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.

Cell reports
2017-05 | Journal article
DOI: 10.1016/j.celrep.2017.04.069
PMID: 28538178
PMC: PMC5510986
Contributors: Campos-Sanchez E; Deleyto-Seldas N; Dominguez V; Carrillo-de-Santa-Pau E; Ura K; Rocha PP; Kim J; Aljoufi A; Esteve-Codina A; Dabad M et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development.

eLife
2016-06 | Journal article
DOI: 10.7554/elife.16030
PMID: 27331609
PMC: PMC4982761
Contributors: Nimura K; Yamamoto M; Takeichi M; Saga K; Takaoka K; Kawamura N; Nitta H; Nagano H; Ishino S; Tanaka T et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells.

Oncotarget
2015-09 | Journal article
DOI: 10.18632/oncotarget.4293
PMID: 26087476
PMC: PMC4673169
Contributors: Kawamura N; Nimura K; Nagano H; Yamaguchi S; Nonomura N; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Differences in histone modifications between slow- and fast-twitch muscle of adult rats and following overload, denervation, or valproic acid administration.

Journal of applied physiology (Bethesda, Md. : 1985)
2015-09 | Journal article
DOI: 10.1152/japplphysiol.00289.2015
PMID: 26404615
Contributors: Kawano F; Nimura K; Ishino S; Nakai N; Nakata K; Ohira Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Elucidating the mechanisms of transcription regulation during heart development by next-generation sequencing.

Journal of human genetics
2015-07 | Journal article
DOI: 10.1038/jhg.2015.84
PMID: 26202577
Contributors: Nimura K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Endogenous mesenchymal stromal cells in bone marrow are required to preserve muscle function in mdx mice.

Stem cells (Dayton, Ohio)
2015-03 | Journal article
DOI: 10.1002/stem.1900
PMID: 25408548
Contributors: Fujita R; Tamai K; Aikawa E; Nimura K; Ishino S; Kikuchi Y; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes.

PloS one
2014-09 | Journal article
DOI: 10.1371/journal.pone.0106661
PMID: 25188294
PMC: PMC4154728
Contributors: Lee YF; Nimura K; Lo WN; Saga K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes.

PloS one
2013-10 | Journal article
DOI: 10.1371/journal.pone.0076416
PMID: 24098495
PMC: PMC3789663
Contributors: Umegaki-Arao N; Tamai K; Nimura K; Serada S; Naka T; Nakano H; Katayama I
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.

The EMBO journal
2013-08 | Journal article
DOI: 10.1038/emboj.2013.176
PMID: 23921552
PMC: PMC3770338
Contributors: Sarai N; Nimura K; Tamura T; Kanno T; Patel MC; Heightman TD; Ura K; Ozato K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc.

Molecular cancer research : MCR
2013-06 | Journal article
DOI: 10.1158/1541-7786.mcr-13-0029-t
PMID: 23788635
Contributors: Hatano K; Yamaguchi S; Nimura K; Murakami K; Nagahara A; Fujita K; Uemura M; Nakai Y; Tsuchiya M; Nakayama M et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells.

PloS one
2013-02 | Journal article
DOI: 10.1371/journal.pone.0057829
PMID: 23469079
PMC: PMC3585213
Contributors: Takeichi M; Nimura K; Mori M; Nakagami H; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Essential role for miR-196a in brown adipogenesis of white fat progenitor cells.

PLoS biology
2012-04 | Journal article
DOI: 10.1371/journal.pbio.1001314
PMID: 22545021
PMC: PMC3335871
Contributors: Mori M; Nakagami H; Rodriguez-Araujo G; Nimura K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Androgen-regulated transcriptional control of sialyltransferases in prostate cancer cells.

PloS one
2012-02 | Journal article
DOI: 10.1371/journal.pone.0031234
PMID: 22347453
PMC: PMC3275626
Contributors: Hatano K; Miyamoto Y; Mori M; Nimura K; Nakai Y; Nonomura N; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

[Epigenetic regulation of transcription in heart development].

Seikagaku. The Journal of Japanese Biochemical Society
2011-11 | Journal article
PMID: 22256602
Contributors: Nimura K
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia.

Proceedings of the National Academy of Sciences of the United States of America
2011-04 | Journal article
DOI: 10.1073/pnas.1016753108
PMID: 21464317
PMC: PMC3081004
Contributors: Tamai K; Yamazaki T; Chino T; Ishii M; Otsuru S; Kikuchi Y; Iinuma S; Saga K; Nimura K; Shimbo T et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

DNA methyltransferase 3b preferentially associates with condensed chromatin.

Nucleic acids research
2010-10 | Journal article
DOI: 10.1093/nar/gkq870
PMID: 20923784
PMC: PMC3035464
Contributors: Kashiwagi K; Nimura K; Ura K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Histone methyltransferases: regulation of transcription and contribution to human disease.

Journal of molecular medicine (Berlin, Germany)
2010-08 | Journal article
DOI: 10.1007/s00109-010-0668-4
PMID: 20714703
Contributors: Nimura K; Ura K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma.

Journal of neuro-oncology
2010-08 | Journal article
DOI: 10.1007/s11060-010-0355-x
PMID: 20730616
Contributors: Matsuda M; Nimura K; Shimbo T; Hamasaki T; Yamamoto T; Matsumura A; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.

Nature
2009-05 | Journal article
DOI: 10.1038/nature08086
PMID: 19483677
Contributors: Nimura K; Ura K; Shiratori H; Ikawa M; Okabe M; Schwartz RJ; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.

Stem cells (Dayton, Ohio)
2009-04 | Journal article
DOI: 10.1002/stem.14
PMID: 19350679
Contributors: Yuri S; Fujimura S; Nimura K; Takeda N; Toyooka Y; Fujimura Y; Aburatani H; Ura K; Koseki H; Niwa H et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance.

The American journal of pathology
2008-08 | Journal article
DOI: 10.2353/ajpath.2008.070977
PMID: 18688022
PMC: PMC2527073
Contributors: Chino T; Tamai K; Yamazaki T; Otsuru S; Kikuchi Y; Nimura K; Endo M; Nagai M; Uitto J; Kitajima Y et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Development of tissue-targeting hemagglutinating virus of Japan envelope vector for successful delivery of therapeutic gene to mouse skin.

Human gene therapy
2007-10 | Journal article
DOI: 10.1089/hum.2007.046
PMID: 17892442
Contributors: Kawachi M; Tamai K; Saga K; Yamazaki T; Fujita H; Shimbo T; Kikuchi Y; Nimura K; Nishifuji K; Amagai M et al.
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling.

Journal of cell science
2007-03 | Journal article
DOI: 10.1242/jcs.000067
PMID: 17374642
Contributors: Hayashi M; Nimura K; Kashiwagi K; Harada T; Takaoka K; Kato H; Tamai K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.

Genes to cells : devoted to molecular & cellular mechanisms
2006-10 | Journal article
DOI: 10.1111/j.1365-2443.2006.01012.x
PMID: 16999741
Contributors: Nimura K; Ishida C; Koriyama H; Hata K; Yamanaka S; Li E; Ura K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin.

The journal of gene medicine
2005-08 | Journal article
DOI: 10.1002/jgm.753
PMID: 15756713
Contributors: Ito M; Yamamoto S; Nimura K; Hiraoka K; Tamai K; Kaneda Y
Source: Self-asserted source
Keisuke Nimura via Europe PubMed Central

Peer review (6 reviews for 3 publications/grants)

Review activity for Cancer gene therapy. (1)
Review activity for Cellular & Molecular Biology Letters. (2)
Review activity for Journal of experimental & clinical cancer research. (3)
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